25 BLEND MEGA COMBO (Save 59%)

February 20, 2019

FEBRUARY SPECIAL! 18 Blend Combo Sampler (Save 56%) $1750 value for $777! Comes with Interstellar Mug!

March 30, 2019

SUPER TONIC HAIR 200:1

Rated 5.00 out of 5 based on 27 customer ratings

(27 customer reviews)

$275.00

SKU: N/A Categories: Exclusive Products, Featured

Description
Additional information
Reviews (27)

INTRODUCING

INTERSTELLAR BLEND

SUPER TONIC HAIR

200:1 concentration (100 Grams)

Pairs perfectly with

APIGENIN

PINE POLLEN

SPICE

PEEL

INHIBITS GRAYING

PROMOTES HAIR GROWTH

Directions: Start 1-2 tsp a day for 2 weeks then maintain with 1/4-1/2 tsp daily.

INGREDIENTS: Andrographolide (Andrographis paniculata) • Anthocyanins • Apigenin • Arctigenin (from Fructus Arctii) • Asiasari radix • Astragali radix • Baicalin • Brazilian propolis extract powder • Buxus wallichiana Baill (Buxaceae) • Capparis spinosa • Carnosol • Ceratonia siliqua pod extract • Chrysanthemum zawadskii • Cordycepin • Cranberry peel • Curcumin • Cyanidin • Cycloastragenol • DHEA • Dragon’s Blood from Croton lechleri • Eclipta prostrata • EGCG • Ellagic acid • Emodin • Equisetum arvense • Fermented barley extract • Ferulic acid • Fucoxanthin • Ginseng radix • Glycyrrhiza glabra root extract • Grape seed proanthocyanidin extract • Hesperidin • Hibiscus rosa-sinensis L. flowers • Houttuynia cordata • Hydroxytyrosol • Icariin • Isorhapontigenin • kaempferol • Kolaviron • Kurarinone (From roots of Sophora • Ligustri fructus • Lonicera japonica flower • Luteolin • Metasequoia glyptostroboides leaves &bark extract • Myricetin • N-acetyl- glucosamine • Naringenin • Naringin • Paeoniflorin • Perilla frutescens var. acuta (PFVA) • Pinocembrin • Piper nigrum extract (Piperaceae) • Plectranthus barbatus extract • Polyporus umbellatus • Pomegranate peel extract • Procyanidins from apple peel • Psoralea corylifolia (psoralidin) • Pterostilbene • Quercetin • Radix Angelicae sinensis • Rehmannia glutinosa • Resveratrol • Sanguisorba officinalis • Silibinin • Sophora flavescens root • Tripterygium wilfordii (Celastrol) extract triptolide • Ursolic acid • Urtica dioica

Age‐induced hair greying – the multiple effects of oxidative stress

An obvious sign of ageing is hair greying, or the loss of pigment production and deposition within the hair shafts. Numerous mechanisms, acting at different levels and follicular locations, contribute to hair greying, ranging from melanocyte stem cells defects to follicular melanocyte death. One key issue that is in common to these processes is oxidative damage. At the hair follicle stem cells niche, oxidative stress, accelerated by B‐cell lymphoma 2 gene (BCL‐2) depletion, leads to selective apoptosis and diminution of melanocyte stem cells, reducing the repopulation of newly formed anagen follicles. Melanotic bulbar melanocytes express high levels of BCL‐2 to enable survival from melanogenesis‐ and ultraviolet A (UVA)‐induced reactive oxygen species (ROS) attacks. With ageing, the bulbar melanocyte expression of anti‐oxidant proteins such as BCL‐2, and possibly TRP‐2, is reduced, and the dedicated enzymatic anti‐oxidant defence system throughout the follicle weakens, resulting in enhanced oxidative stress. A marked reduction in catalase expression and activity results in millimolar accumulation of hydrogen peroxide, contributing to bulbar melanocyte malfunction and death. Interestingly, amelanotic melanocytes at the outer root sheath (ORS) are somewhat less affected by these processes and survive for longer time even within the white, ageing hair follicles. Better understanding of the overtime susceptibility of melanocytes to oxidative stress at the different follicular locations might yield clues to possible therapies for the prevention and reversal of hair greying.

Oxidative Stress in Ageing of Hair

Experimental evidence supports the hypothesis that oxidative stress plays a major role in the ageing process. Reactive oxygen species are generated by a multitude of endogenous and environmental challenges. Reactive oxygen species or free radicals are highly reactive molecules that can directly damage cellular structural membranes, lipids, proteins, and DNA. The body possesses endogenous defence mechanisms, such as antioxidative enzymes and non-enzymatic antioxidative molecules, protecting it from free radicals by reducing and neutralizing them. With age, the production of free radicals increases, while the endogenous defence mechanisms decrease. This imbalance leads to the progressive damage of cellular structures, presumably resulting in the ageing phenotype. Ageing of hair manifests as decrease of melanocyte function or graying, and decrease in hair production or alopecia. There is circumstantial evidence that oxidative stress may be a pivotal mechanism contributing to hair graying and hair loss. New insights into the role and prevention of oxidative stress could open new strategies for intervention and reversal of the hair graying process and age-dependent alopecia.

Age-Induced Hair Graying and Oxidative Stress

Age-induced hair graying (canities), or the age-induced loss of melanin synthesis and deposition within the hair shafts, is a noticeable and undesired sign of the aging process. Numerous mechanisms contribute to age-induced hair graying, affecting both follicular and stem cell melanocytes and acting at different follicular locations. Many of these processes are induced, directly or indirectly, by oxidative insults and damage. Melanin-producing bulbar melanocytes express high levels of BCL-2 to survive reactive oxygen species (ROS) attacks, which are induced by the melanogenic process itself and by ultraviolet A (UVA) irradiation. With aging, the expression of BCL-2, and possibly of TRP-2, is reduced, and the endogenous, enzymatic antioxidant defense system declines, resulting in greater oxidative stress. In particular, catalase expression and activity are markedly reduced with aging, leading to millimolar accumulation of hydrogen peroxide within the hair follicle and contributing to bulbar melanocyte failure and death. Additionally, exposure of melanocyte stem cells to cumulative oxidative damage, combined with reduced BCL-2 protective levels, results in apoptosis and therefore decreases the number of melanocytes that could repopulate the newly formed anagen follicles. Altogether, oxidative stress may contribute to age-induced hair graying via multiple pathways. Better understanding of the different processes, sources, and types of oxidative stress within the follicular environment, and the different susceptibilities of melanocytes to oxidative stress at the different follicular locations, might yield clues to possible interventions for prevention or reversal of hair graying.

a “free radical theory of graying”

Here we provide unique evidence for oxidative stress induced loss of melanocytes from the human hair follicle during aging. In detail, we show for the first time that:1)a decreased number of viable melanocytes in the aging hair follicle bulge and bulb and an increased incidence of hair bulb melanocyte apoptosis in aging individuals are associated with oxidative stress in the pigmentary unit;2)the aging hair follicle is characterized by the absence of oxidative stress-protectors, such as Bcl-2, and melanocyte growth factors, such as c-Kit;3)a higher frequency of oxidative stress associated mitochondrial DNA damage occurs in graying hair follicles, while unpigmented hair follicles prove to be not “older” than pigmented hair follicles;4)melanocytes of the pigmentary unit are highly and selectively susceptible to exogenous oxidative stress damage.One major route, by which oxidative stress leads to permanent melanocyte damage, appears to pass by the mitochondria, since their DNA is not so well protected as genomic DNA. The accumulation of mutations, therefore, correlates with age and is indicative of general exposure and generation of oxidative stress, (39⤻, 40)⤻caused for example by psychoemotional stress, inflammation, UV-light, and others. In summary, our findings support the proposed hypothesis of a “free radical theory of graying” and suggest that melanocytes in the hair follicle are highly susceptible to endogenous oxidative stress. Exogenous oxidative stress can trigger and hasten this process and provoke permanent damage selectively and prematurely in hair bulb melanocytes.

Age-related hair pigment loss

Humans are social animals that communicate disproportionately via potent genetic signals imbued in the skin and hair, including racial, ethnic, health, gender, and age status. For the vast majority of us, age-related hair pigment loss becomes the inescapable signal of our disappearing youth. The hair follicle (HF) pigmentary unit is a wonderful tissue for studying mechanisms generally regulating aging, often before this becomes evident elsewhere in the body. Given that follicular melanocytes (unlike those in the epidermis) are regulated by the hair growth cycle, this cycle is likely to impact the process of aging in the HF pigmentary unit. The formal identification of melanocyte stem cells in the mouse skin has spurred a flurry of reports on the potential involvement of melanocyte stem cell depletion in hair graying (i.e., canities). Caution is recommended, however, against simple extrapolation of murine data to humans. Regardless, hair graying in both species is likely to involve an age-related imbalance in the tissue’s oxidative stress handling that will impact not only melanogenesis but also melanocyte stem cell and melanocyte homeostasis and survival. There is some emerging evidence that the HF pigmentary unit may have regenerative potential, even after it has begun to produce white hair fibers. It may therefore be feasible to develop strategies to modulate some aging-associated changes to maintain melanin production for longer.

Chronic inflammation induces telomere dysfunction and accelerates ageing

Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1subunit of the transcription factor NF-κB induces premature ageing in mice. We also show that these mice have reduced regeneration in liver and gut. nfkb1^−/−fibroblasts exhibit aggravated cell senescence because of an enhanced autocrine and paracrine feedback through NF-κB, COX-2 and ROS, which stabilizes DNA damage. Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1^−/−tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative potential. Frequencies of senescent cells in liver and intestinal crypts quantitatively predict mean and maximum lifespan in both short- and long-lived mice cohorts. These data indicate that systemic chronic inflammation can accelerate ageing via ROS-mediated exacerbation of telomere dysfunction and cell senescence in the absence of any other genetic or environmental factor.

Aging has a significant impact on the production of circulating cytokines in healthy individuals. The circulating cytokine milieu may contribute to the development of age-restricted conditions. Aging has a significant impact on the production of circulating cytokines. Cytokines dysregulation is demonstrated ex vivo but not after in vitro activation. Pro- and anti-inflammatory cytokines correlate with aging. Th1 cytokines increase whereas Th17 cytokines decrease with age.

Repigmentation and new growth of hairs after anti–interleukin-17 therapy

Repigmentation of hairs is a rare event that has been reported after inflammatory processes, exposure to X-irradiation and psoralen and ultraviolet A, electron beam therapy, and the intake of some drugs.1 We report on a patient with psoriasis who experienced darkening and noticeable increase in scalp hair while he was receiving anti–interleukin (IL)-17 therapy.

Fibroblast growth factor signalling in the hair growth cycle

Using RNA in situ hybridization analysis, we have characterized the expression domains of the four known members of the FGF receptor-tyrosine kinase gene family in the murine hair follicle at various stages of the hair growth cycle. During anagen, we detected Fgfr1 RNA in the dermal papilla, Fgfr2 RNA in hair matrix cells near the dermal papilla, Fgfr3 RNA in pre-cuticle cells in the periphery of the hair bulb, and Fgfr4 RNA in cells in the periphery of the hair bulb and also in the inner and outer root sheath in the lower half of the follicle neck. No RNA expression of these genes was detected during late catagen or telogen. We have previously shown that Fgf5 is expressed in the outer root sheath in the transient portion of the follicle (Hébert et al. [1994] Cell 78:1017-1025). In the present study we have also assayed for the expression of six other members of the FGF ligand gene family, Fgf3, Fgf4, Fgf6, Fgf7, Fgf8, and Fgf9. Among these FGF genes, only Fgf7 was found to be expressed in the hair follicle. Fgf7 RNA is localized to the dermal papilla during anagen, but expression is down-regulated by the late-anagen VI stage. We have also demonstrated that addition of FGF5 protein to the culture medium changes the behavior of dermal papilla cells in vitro, indicating that they are capable of responding to FGF5. Together with previously published data, these results provide a complete analysis of FGF ligand and FGF receptor-tyrosine kinase gene expression in the hair follicle, and suggest that FGF signalling may have several functions in the hair growth cycle

Eclipta prostrata sustains the anagen phase through regulation of FGF-7 & FGF-5

Hair shaft producing cells were proliferated only in the anagen. Many mediators were involved in starting, sustaining and terminating anagen. Among them, we focused on the growth factor FGF-7 and FGF-5. Our results reveal the hair growth enhancing effects of EP were related with the anagen regulating growth factors. mTOR activating the potential of EP in HDPs was signifying that it exerts the positive role in the proliferation of follicular cells during anagen.

FGF5 is a crucial regulator of hair length in humans

Hair length varies dramatically on different body sites and also varies between individuals. Thus, hair length is a quantitative trait, suggesting inherited differences. In this study, we obtained DNA from families segregating excessively long eyelashes consistent with an autosomal recessive trait. We identified mutations in a single gene, fibroblast growth factor 5 (FGF5), which was homozygous in affected family members only. FGF5 has previously been implicated as a regulator of hair lengths in mammals, with mutations resulting in the well-described angoraphenotype. However, until now a human counterpart to this phenotype remained elusive. Here, we present, to our knowledge, the first human counterpart of the angoraphenotype, showing that FGF5 underlies trichomegaly and is a crucial regulator of hair growth in humans.

Oxidative stress management in the hair follicle: Targeting NRF2

Widespread expression of the transcription factor, nuclear factor (erythroid‐derived 2)‐like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy‐induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide‐induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation‐induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging‐associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox‐associated HF disorders are therefore discussed.

The impact of oxidative stress on hair

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system’s ability to detoxify the reactive intermediates or to repair the resulting damage. Reactive oxygen species or free radicals are highly reactive molecules that can directly damage lipids, proteins, and DNA. They are generated by a multitude of endogenous and environmental challenges, while the body possesses endogenous defense mechanisms. With age, production of free radicals increases, while the endogenous defense mechanisms decrease. This imbalance leads to progressive damage of cellular structures, presumably resulting in the aging phenotype. While the role of oxidative stress has been widely discussed in skin aging, little focus has been placed on its impact on hair condition. Moreover, most literature on age‐related hair changes focuses on alopecia, but it is equally important that the hair fibers that emerge from the scalp exhibit significant age‐related changes that have equal impact on the overall cosmetic properties of hair. Sources of oxidative stress with impact on the pre‐emerging fiber include: oxidative metabolism, smoking, UVR, and inflammation from microbial, pollutant, or irritant origins. Sources of oxidative stress with impact on the post‐emerging fiber include: UVR (enhanced by copper), chemical insults, and oxidized scalp lipids. The role of the dermatologist is recognition and treatment of pre‐ and post‐emerging factors for lifetime scalp and hair health.

Repigmentation of hair following adalimumab therapy

Repigmentation of canities, or age-related grey or white hair, is a rare occurrence. Generalized repigmentation of grey-white hair has been reported following inflammatory processes,[1] and heterochromia (localized patches of hair repigmentation) is even more unusual, reported in association with medication use and malignancy.Tumor necrosis factor (TNF) inhibitors are increasingly utilized medications for inflammatory disorders, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Hair loss, or alopecia, has been described among the side effects of these medications,[2] but changes in hair pigmentation in association with this class of drugs have not previously been reported. We describe a patient with hair repigmentation associated with adalimumab therapy.

A Comment on the Science of Hair Aging

In contrast to the skin, aging of the hair has seemingly only recently found the attention of dermatological meetings, mainly promoted by the cosmetic industry for marketing purposes. In fact, basic scientists interested in the biology of hair growth and pigmentation have for some time already exposed the hair follicle as a highly accessible model with unique opportunities for the study of age-related effects. As a result, the science of hair aging focuses on two main streams of interest: the esthetic problem of aging hair and its management, in terms of age-related effects on hair color, quantity, and quality; and the biological problem of aging hair, in terms of microscopic, biochemical, and molecular changes underlying the aging process. Ultimately, the aim of hair anti-aging is to delay, lessen, or reverse the effects of aging on hair. According to the complex nature of the aging process, the treatment for lifetime scalp and hair health has to be holistic to include the multitude of contributing factors in a polyhedral and patient-specific manner. It comprises both medical treatments and hair cosmetics. Accordingly, the discovery of pharmacological targets and the development of safe and effective drugs for treatment of hair loss indicate strategies of the drug industry for maintenance of hair growth and quantity, while the hair care industry has become capable of delivering active compounds directed toward meeting the consumer demand for maintenance of hair cosmesis and quality. “Where there’s life, there’s hope” (Ecclesiastes 9:3-5).

Three Streams for the Mechanism of Hair Graying

Hair graying is an obvious sign of human aging. Although graying has been investigated extensively, the mechanism remains unclear. Here, we reviewed previous studies on the mechanism of graying and seek to offer some new insights. The traditional view is that hair graying is caused by exhaustion of the pigmentary potential of the melanocytes of hair bulbs. Melanocyte dysfunction may be attributable to the effects of toxic reactive oxygen species on melanocyte nuclei and mitochondria. A recent study suggests that bulge melanocyte stem cells (MSCs) are the key cells in play. Graying may be caused by defective MSC self-maintenance, not by any deficiency in bulbar melanocytes. Our previous study suggested that graying may be principally attributable to active hair growth. Active hair growth may produce oxidative or genotoxic stress in hair bulge. These internal stress may cause eventually depletion of MSC in the hair follicles. Taken together, hair graying may be caused by MSC depletion by genotoxic stress in the hair bulge. Hair graying may also be sometimes caused by dysfunction of the melanocytes by oxidative stress in the hair bulb. In addition, hair graying may be attributable to MSC depletion by active hair growth.

Pharmacologic interventions in aging hair

The appearance of hair plays an important role in people’s overall physical appearance and self-perception. With today’s increasing life-expectations, the desire to look youthful plays a bigger role than ever. The hair care industry has become aware of this and is delivering active products directed towards meeting this consumer demand. The discovery of pharmacological targets and the development of safe and effective drugs also indicate strategies of the drug industry for maintenance of healthy and beautiful hair. Hair aging comprises weathering of the hair shaft, decrease of melanocyte function, and decrease in hair production. The scalp is subject to intrinsic and extrinsic aging. Intrinsic factors are related to individual genetic and epigenetic mechanisms with interindividual variation: prototypes are familial premature graying, and androgenetic alopecia. Currently available pharmacologic treatment modalities with proven efficacy for treatment of androgenetic alopecia are topical minoxidil and oral finasteride. Extrinsic factors include ultraviolet radiation and air pollution. Experimental evidence supports the hypothesis that oxidative stress also plays a role in hair aging. Topical anti-aging compounds include photoprotectors and antioxidants. In the absence of another way to reverse hair graying, hair colorants remain the mainstay of recovering lost hair color. Topical liposome targeting for melanins, genes, and proteins selectively to hair follicles are currently under investigation.

Hair growth inhibition by psychoemotional stress

Stress has long been discussed controversially as a cause of hair loss. However, solid proof of stress‐induced hair growth inhibition had long been missing. If psychoemotional stress can affect hair growth, this must be mediated via definable neurorendocrine and/or neuroimmunological signaling pathways. Revisiting and up‐dating relevant background data on neural mechanisms of hair growth control, we sketch essentials of hair follicle (HF) neurobiology and discuss the modulation of murine hair growth by neuropeptides, neurotransmitters, neurotrophins, and mast cells. Exploiting an established mouse model for stress, we summarize recent evidence that sonic stress triggers a cascade of molecular events including plasticity of the peptidergic peri‐ and interfollicular innervation and neuroimmune crosstalk. Substance P (SP) and NGF (nerve growth factor) are recruited as key mediators of stress‐induced hair growth‐inhibitory effects. These effects include perifollicular neurogenic inflammation, HF keratinocyte apoptosis, inhibition of proliferation within the HF epithelium, and premature HF regression (catagen induction). Intriguingly, most of these effects can be abrogated by treatment of stressed mice with SP‐receptor neurokinin‐1 receptor (NK‐1) antagonists or NGF‐neutralizing antibodies – as well as, surprisingly, by topical minoxidil. Thus there is now solid in vivo‐evidence for the existence of a defined brain‐ HF axis. This axis can be utilized by psychoemotional and other stressors to prematurely terminate hair growth. Stress‐induced hair growth inhibition can therefore serve as a highly instructive model for exploring the brain‐skin connection and provides a unique experimental model for dissecting general principles of skin neuroendocrinology and neuroimmunology well beyond the HF.

Hair cycle and hair pigmentation ASSOCIATED WITH AGING

The tight coupling of hair follicle melanogenesis to the hair growth cycle dramatically distinguishes follicular melanogenesis from the continuous melanogenesis of the epidermis. Cyclic re-construction of an intact hair follicle pigmentary unit occurs optimally in all scalp hair follicles during only the first 10 hair cycles, i.e. by approximately 40 years of age. Thereafter there appears to be a genetically regulated exhaustion of the pigmentary potential of each individual hair follicle leading to the formation of true gray and white hair. Pigment dilution results primarily from a reduction in tyrosinase activity within hair bulbar melanocytes. Thereafter, sub-optimal melanocyte–cortical keratinocyte interactions, and defective migration of melanocytes from a reservoir in the upper outer root sheath to the pigment-permitting microenvironment close to the follicular papilla of the hair bulb, will all disrupt normal function of the pigmentary unit. Evidence from studies on epidermal melanocyte aging suggest that reactive oxygen species-mediated damage to nuclear and mitochondrial DNA may lead to mutation accumulation in bulbar melanocytes. Parallel dysregulation of anti-oxidant mechanisms or pro/anti-apoptotic factors is also likely to occur within the cells. Pigment loss in canities may also affect keratinocyte proliferation and differentiation, providing the tantalizing suggestion that melanocytes in the hair follicle contribute far more that packages of pigment alone. Here, we review the current state of knowledge of the development, regulation and control of the aging human hair follicle pigmentary system in relation with hair cycling. The exploitation of recently available methodologies to manipulate hair follicle melanocytes in vitro, and the observations that melanocytes remain in senile white hair follicles that can be induced to pigment in culture, raises the possibility of someday reversing canities. The perspective of rejuvenation of the whole hair follicle apparatus are still part of the dream but optimising its functional properties is clinically relevant and is close to reality. Finally as hair color influences its visibility when optical methods such as scalp photography are used to count hair fibers, the attention is drawn to possible interpretations of statistically significant changes in visible hair. Such changes may not exclusively be related to improved hair growth itself but also to changes in natural hair color that makes the hair more visible with the method used to count hairs.

Human hair pigmentation – biological aspects

Skin and hair colour contribute significantly to our overall visual appearance and to social/sexual communication. Despite their shared origins in the embryologic neural crest, the hair follicle and epidermal pigmentary units occupy distinct, although open, cutaneous compartments. They can be distinguished principally on the basis of the former’s stringent coupling to the hair growth cycle compared with the latter’s continuous melanogenesis. The biosynthesis of melanin and its subsequent transfer from melanocyte to hair bulb keratinocytes depend on the availability of melanin precursors and on a raft of signal transduction pathways that are both highly complex and commonly redundant. These signalling pathways can be both dependent and independent of receptors, act through auto‐, para‐ or intracrine mechanisms and can be modified by hormonal signals. Despite many shared features, follicular melanocytes appear to be more sensitive than epidermal melanocytes to ageing influences. This can be seen most dramatically in hair greying/canities and this is likely to reflect significant differences in the epidermal and follicular microenvironments. The hair follicle pigmentary unit may also serve as an important environmental sensor, whereby hair pigment contributes to the rapid excretion of heavy metals, chemicals and toxins from the body by their selective binding to melanin; rendering the hair fibre a useful barometer of exposures. The recent availability of advanced cell culture methodologies for isolated hair follicle melanocytes and for intact anagen hair follicle organ culture should provide the research tools necessary to elucidate the regulatory mechanisms of hair follicle pigmentation. In the longer term, it may be feasible to develop hair colour modifiers of a biological nature to accompany those based on chemicals.

Histopathology of aging of the hair follicle

Hair follicles experience several changes with aging, the most noticeable of which is graying of the hair shaft due to loss of melanin. Additional changes in the diameter and length of the hair have contributed to the concept of senescent alopecia, which is different from androgenetic alopecia according to most. Graying happens in most individuals, although in different grades and starting at different ages. It is related to a decrease in the number and activity of the melanocytes of the hair bulb, which eventually completely disappear from the bulb of the white hair. Residual non‐active melanocytes remain in the outer root sheath and in the bulge, which allows for repigmentation of the hair under certain stimuli or conditions.

the etiologies, clinical characteristics, and treatment of grey hair

Hair pigmentation is regulated by follicular melanogenesis, in which the process consists of melanin formation and transfer to keratinocytes in the hair shaft. Human hair follicles contain two types of melanin: the brown‐black eumelanin and yellow‐red pheomelanin. Eumelanin is commonly present in black and brown hair while pheomelanin is found in auburn and blonde hair. Hair follicle melanogenesis is under cyclical control and is concurrently coupled to hair growth. Many factors including intrinsic and extrinsic factors affect the follicular melanogenesis. Though many studies have been conducted to identify the pathogenesis and regulation of hair pigmentation, the etiology of canities and hair pigmentation is still unclear. The pathogenesis of canities or gray hair is believed to occur either from insufficient melanin formation due to melanocyte degeneration or a defect in melanosomal transfer. Canities is an aging sign which often interferes with one’s socio‐cultural adjustment. On the other hand, premature canities correlate with diseases such as osteopenia and cardiovascular disease. Risk factors associated with canities are not only genetic but also external causes. For example, smoking, alcohol consumption, and stress are among the most common factors. Camouflage techniques are still used as the primary treatment of canities. Further treatments for canities are being developed to achieve the true reversal of hair pigmentation.

Aging of the Hair Follicle Pigmentation System

Skin and hair phenotypes are powerful cues in human communication. They impart much information, not least about our racial, ethnic, health, gender and age status. In the case of the latter parameter, we experience significant change in pigmentation in our journey from birth to puberty and through to young adulthood, middle age and beyond. The hair follicle pigmentary unit is perhaps one of our most visible, accessible and potent aging sensors, with marked dilution of pigment intensity occurring long before even subtle changes are seen in the epidermis. This dichotomy is of interest as both skin compartments contain melanocyte subpopulations of similar embryologic (i.e., neural crest) origin. Research groups are actively pursuing the study of the differential aging of melanocytes in the hair bulb versus the epidermis and in particular are examining whether this is in part linked to the stringent coupling of follicular melanocytes to the hair growth cycle. Whether some follicular melanocyte subpopulations are affected, like epidermal melanocytes, by UV irradiation is not yet clear. A particular target of research into hair graying or canities is the nature of the melanocyte stem compartment and whether this is depleted due to reactive oxygen species-associated damage, coupled with an impaired antioxidant status, and a failure of melanocyte stem cell renewal. Over the last few years, we and others have developed advanced in vitro models and assay systems for isolated hair follicle melanocytes and for intact anagen hair follicle organ culture which may provide research tools to elucidate the regulatory mechanisms of hair follicle pigmentation. Long term, it may be feasible to develop strategies to modulate some of these aging-associated changes in the hair follicle that impinge particularly on the melanocyte populations.

Dihydrotestosterone-inducible IL-6 inhibits elongation of human hair shafts by suppressing matrix cell proliferation and promotes regression

Autocrine and paracrine factors are produced by balding dermal papilla (DP) cells following dihydrotestosterone (DHT)-driven alterations and are believed to be key factors involved in male pattern baldness. Herein we report that the IL-6 is upregulated in balding DP cells compared with non-balding DP cells. IL-6 was upregulated 3 hours after 10-100 nM DHT treatment, and ELISA showed that IL-6 was secreted from balding DP cells in response to DHT. IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) were expressed in follicular keratinocytes, including matrix cells. Recombinant human IL-6 (rhIL-6) inhibited hair shaft elongation and suppressed proliferation of matrix cells in cultured human hair follicles. Moreover, rhIL-6 injection into the hypodermis of mice during anagen caused premature onset of catagen. Taken together, our data strongly suggest that DHT-inducible IL-6 inhibits hair growth as a paracrine mediator from the DP.

Cytokines and Other Mediators in Alopecia Areata

Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN-, interleukins, TNF-, are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments.

INGREDIENTS & SCIENCE

Andrographis Paniculata

Anthocyanins

Apigenin

Arctigenin

Asiasari Radix

astilbin

Astragali Radix

Baicalin

Brazilian propolis

Buxus Wallichiana Baill

Capparis spinosa

Carnosol

Ceratonia Siliqua

Chrysanthemum Zawadskii

cordycepin

Vaccinium oxycoccos

Curcumin

Cyanidin

Cycloastragenol

DHEA

Dragon’s blood (Croton lechleri)

Eclipta Prostrata

Egcg

ellagic acid

Emodin

Equisetum arvense

Hordeum vulgare

Ferulic acid

fisetin

Fisetin Promotes Hair Growth by Augmenting TERT Expression

Fucoxanthin

Ginseng radix

Glycyrrhiza glabra

proanthocyanidin

Hesperidin

Hibiscus rosa-sinensis

Houttuynia cordata

hydroxytyrosol

Icariin

Isorhapontigenin

Kaempferol

Kolaviron

Kurarinone

Ligustri fructus

Lonicera japonica

Luteolin

Metasequoia glyptostroboides

Myricetin

Naringenin

naringin

Oleuropein

Paeoniflorin

Perilla frutescens

Pinocembrin

Piper nigrum

Plectranthus barbatus

Polyporus umbellatus

Punica granatum

Procyanidins B1 B2 and c1

psoralidin

Pterostilbene

Quercetin

Radix Angelicae

Rehmannia glutinosa

Resveratrol

Sanguisorba officinalis

Silibinin

Sophora flavescens

Eriodictyon angustifolium

Reduction in human hair graying by sterubin, an active flavonoid of Eriodictyon angustifolium

Hair pigmentation could be improved by altering melanocyte number and gene activity. Cytokines such as Kitl and Endothelins are known to promote the proliferation of melanocytes and upregulate their pigmentation genes. Recently, the WNT/β catenin produced by the follicular keratinocytes was found to function as an attractant of follicular melanocytes and activate microphthalmia-associated transcription factor (MITF), the master regulator of pigmentation genes of melanocytes. Based on these notions, many synthetic or natural compounds, including plant extracts, that can upregulate pigmentation genes have been screened. Depletion of follicular MSCs causes persistent loss of functional melanocytes from the hair matrix leading to graying, with no recovery expected. Gray hair-containing follicles that are depleted of MSCs increase along with the cumulative progression of the hair cycle with age.

Loss of proliferative ability of follicular keratinocytes, rather than MSCs, has also been reported in radiation-induced hair graying suggesting the involvement of keratinocytes in hair graying and their potential as a practical target for its prevention. Thus, owing to the complexity of the mechanisms underlying hair graying, a combination of in vitro and in vivoevaluation methods is necessary for screening effective molecules for the prevention and reduction of hair graying.

Sterubin is an active anti-inflammatory component of Yerba Santa (Eriodictyon angustifolium) Yerba Santa is a plant that grows on the west coast of North America and has been used for several years as a traditional medicine by the indigenous population. To investigate its ability to stimulate melanogenesis, we treated the human melanoma cell line HMVII with 5–10 μM of synthetic sterubin. The sterubin-treated cells showed 1.47- to 1.65-fold concentration-dependent increase (**p < 0.01) in melanin content after 7 days of exposure (Fig. 1A). Immunohistochemistry revealed nuclear translocation of β-catenin, which is indicative of WNT signaling activation, and nearly 1.4-fold increase in nuclear MITF expression (**p < 0.01) and 4.6-fold increase in cytoplasmic TYR expression (***p < 0.001) were observed in the treated cells (Fig. 1B-E).

Fig. 1In vitro effects of sterubin in the prevention of hair graying. (A) Melanin content of the HMVII melanoma cell line increased in a concentration-dependent manner following sterubin treatment. (B, C, D, E) Nuclear translocation of β-catenin and increased intensity of nuclear MITF and TYR staining after exposure to sterubin revealed by the immunocytochemistry. (F) NHEKs pretreated with the sterubin were exposed to 20 Gy X-ray and cell viability was determined. (G and H) γH2AX foci was measured in X-ray exposed NHEKs pretreated with sterubin.

Age-associated hair graying and radiation-induced hair graying have been suggested to share common cellular mechanisms [

9]. In addition, follicular keratinocytes that provide a niche for melanocytes have been suggested to have indispensable roles for age-associated and radiation-induced hair graying [

7]. To investigate the involvement of keratinocytes in radiation-induced hair graying, normal human epidermal keratinocytes (NHEKs, Kurabo, Osaka, Japan) were exposed to 30–100 μM of synthetic sterubin. As shown in Fig. 1F, viability of the cells irradiated with 20 Gy X-ray (DMSO: 32.5%) was recovered up to 51.8% in the presence of 100 μM sterubin. In addition, exposure of NHEKs to sterubin for 1 h before irradiation significantly decreased the number of phosphorylated H2AX foci per cell (Fig. 1 G and H), which is indicative of reduced DNA damage.

Next, using the 2′,7′-dichlorofluorescein diacetate (DCF-DA) assay, we investigated whether sterubin could scavenge radiation-induced intracellular ROS. After exposure to 20 Gy of X-ray, increased fluorescence intensity of DCF was observed in NHEKs (DMSO-treated cells in Fig. 2A). As shown in Fig. 2A and B, 100 μM of synthetic sterubin significantly suppressed the radiation-induced generation of ROS from 33.4 to nearly the level observed in non-irradiated control cells (Sterubin + 20 Gy: 13.7, ***p < 0.001). ROS attack mitochondrial DNA and membrane proteins, thereby impairing mitochondrial function. Mito-tracker staining revealed that 100 μM of synthetic sterubin treatment for 1 h before irradiation significantly prevented severe deformation of the mitochondrial mass of NHEKs (DMSO + 20 Gy: 46.3, Sterubin + 20 Gy : 71.8, **p < 0.01) (Fig. 2C, D). These data suggest that sterubin contains active components that could effectively prevent hair graying by protecting follicular keratinocytes from age- and radiation-induced damage.

Thuja orientalis

Tripterygium wilfordii

triptolide

Ursolic acid

Urtica Dioica

Mandatory FDA Disclaimer:

As with any supplement, consult your medical practitioner prior to using this product if you are pregnant, may become pregnant, breastfeeding, taking medication, other dietary supplements or have a medical condition.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. *Daily Value has not been established.

Size	100g

27 reviews for SUPER TONIC HAIR 200:1

Rated 5 out of 5

Shelly – August 5, 2019

Wow! I am truly amazed at how quickly my scalp stopped itching only a few days of using this product! Gavin and his crew are stellar in what they do, I am a lifetime customer. This new Super HairTonic will not leave you disappointed! Once again, Interstellar crushed it!!!! Thank you for always providing quality top notch products!
Rated 5 out of 5

Chad – August 15, 2019

I ordered Super tonic hair as soon as it became available. First off, the taste when mixed into coffee makes the coffee taste better. This product is one you will look forward to buying again and again. After using for a week not only did my energy levels increase, but also my hair seems to be shiny, thicker and generally easier to work with. I wish that I had this product a year ago. Would’ve saved me a lot of money buying other hair products that didn’t work well. What an extraordinary product! Thank you Interstellar!! For the quality products and customer service!!!!
Rated 5 out of 5

Rich Ryan – September 10, 2019

I’ve always had thin hair and after about age 40 I started getting more and more hair in my combs and brushes. I wasn’t going bald, but my hair was breaking very easily. Haircuts became optional as my hair would only grow to shoulder length before breaking off. My hair and beard felt brittle and dry, and the skin underneath my beard dried out and itched constantly unless treated with something. Also most of my beard is grey now. I can see SuperHair slowly improving all these things. There’s less hair in my comb, my hair and beard feels softer and less brittle, and my scalp and facial skin under the beard feels healthier and itches considerably less. The grey hasn’t reversed yet, but I’ve only been on the blend for a couple weeks. I’ll post an update in a year or so when the blend has had a chance to work. Once again, an incredible product from Interstellar Blends!
Rated 5 out of 5

Tanya – September 14, 2019

I’ve been waiting a little to post a review on this product as I try to provide as much honest and authentic detail as possible. I have never been that girl with amazing hair. I’m not saying it’s bad but it’s fine and lacks volume. Combine that with thyroid issues and it had been dry and broken in the past. I’ve been on this blend about a month and this past week I’ve started to have great hair days. (Previously I may have had one great hair day per year! My hair is fuller, has more volume and shine. I’m totally sold on this blend. This one does take a little time I think – so give it an honest go
Rated 5 out of 5

Soma Felfoldi (verified owner) – September 29, 2019

First of all, I would just like to say that Im extremely grateful to Gavin! I have been in this health field for almost half a decade and tried numerous supplements on the market but I barely got any reaction to them sadly. I already started experimenting with the dry fast thank to this site and since my Peel, Super hair and pine pollen arrived the whole dry fasting became just so easy that I feel like I never want to go back to eating. And its only 9-10 days that I have been using them! What will happen after spending some months on the protocol? Holy Moly Im excited!! After I take the blends my brain just clears out, and I am able to use the brain just like when I was in my high school years- sharp, quick math calculations, more talkative and more convincing which is very important at my work! Since mentally Im working better it seems I can do much better at my hobby which is DIY little works for homes and carpentering. I totally believe that hands skills are coordinated by the brain and my improved performance is thanks to the mental clarity.

The main reason why I got into the blends and protocol is that I have hair and skin issues since the age of 17. Now Im 27 and I dont want to shout too early but the nasty dermatitis seems to fade away finally from my face. I cant pinpoint exactly which herb does help with that but I dont even have to. I trust Gavin and the combo blends are created to work synergestically so they cannot not work! I always knew fruits and fruits skins are healthy but were never able to eat enough of them due to getting bloating. Now finally I can take the active substance from the fruits without getting bloated and this removed a huge mental burden from me that I finally get my anti oxidants. Since stressing used to increase my dermatitis and I havent had a flare up since the last 10 days!

I still have way to go on this health journey as my body temperature is lower than it should be and Im very interested in the Thermo blend and 1-2 others suggested by some members of the dry fasting group. I know my protocol is not complete yet but if its working already this well, I cant wait what will happen once I could get my hands on some more blends! Gavin, thank you for setting up such a supportive community which gives people hope and finally something which is rarely achieved: success and results!
Rated 5 out of 5

Paula DeNote Zering – October 21, 2019

I am a hairstylist. I have my own salon and have been doing hair for over 25 years. My hair is semi fine, breaks easy and of course I want it longer. I have been on the blends for other reason as well. I take several but added Super Tonic Hair for the sole purpose of it not falling out when I lose weight. Today my daughter was applying my color and asked me what was going on with the front of my hair. It is usually all white. I told her I was taking the blends and it’s supposed to help with grey. She laughed and said I now have dark hairs growing where there was all white a few months ago. She couldn’t believe it. Neither could I. While this is great for some, we need to keep this on the down low! Lol! I make my living on coloring white hair back. Just kidding. This stuff is amazing!
Rated 5 out of 5

Amelia Jara – November 30, 2019

I strongly believe that God is uncovering things like Interstellar blends to prepare our minds for the tough time we are facing. People are full of anxiety and fear that release toxins in the brain and damage it and consequently not able to think straight and make right choices. I have been practicing fasting for many years for the positive effect it does to my mind, and for weight lost . However, it was very hard to do and the pounds I lost would come back right after I resume my eating.. I started using interstellar blend in July 2019 and it’s been one of the most amazing thing I have done in my life. They are autophagy activating herbs. Auto means self and phagy means eating. Those herbs activate a system in the body that takes broken proteins ,cells that are weak and bacteria’s that are creating problems and metabolize them and feeds the body with them.. Even though you are not eating, your body is feeding you breakfast , lunch and dinner with the raw material it contains . I love all the blends but the ones that I am the most excited about are Autophagy, Super Hair, pine pollen and Niagara. Autophagy suppresses my hunger like crazy for the same reason I just stated. My body is feeding me. Isn’t that awesome. I am always calm and my stress level is very low .. Niagara’s is awesome. My libido was very low because of problems with my hormones. The first week after I started using Niagara , my intimacy with my husband increased tremendously ,sex libido and stamina increased and painful sex disappeared. Super hair combined with pine pollen are amazing. I have very dry and curly hair that never grow. Now my hair is growing and is more manageable . I also see some black hair coming out of my white hair. When I first called Gavin, he immediately sent me some samples of Thermo, nebula,trinity, peel, spice , Seven Sages ,Shilajit and matcha green tea. The first week using them revolutionized my entire body and soul. I was losing so much weight that my husband started to complain. I moved from size medium to small and extra small. My pants size are from youth 3 to 5 and that’s because I eat a lot when I eat because my husband doesn’t like it when I am too skinny. Almost a month after I started using the herbs I went to a resort at the beach eating 3 huge meals a day and snacking and drinking in between meals for 10 days and when I came back to my normal fasting routine with the blends , the first week my body looked like if I didn’t go on vacation. I am always with a strong sense of hope and good expectations for the future. I don’t get tired or sick. Praise God! I added ACB and Luteolin. My mind is so sharp that I can dream for a better future with the expectancy of living a long and happy life. Every week I either do 88/8 or 66/6 which means don’t eat food for 88 hours and just take the blends every 4 hours , then feed for 8 hours. Then the other 2 days I do intermitting fasting. This is life saving for me. I lose a lot of weight , my mind is sharp at work and I don’t have to go to the stress of preparing food to take to work. Now I am not worried
about gaining weight. My body only craves for healthy food and I am never tempted to eat the unhealthy food. My body is free from pain and inflammation and I am always looking forward to fast with the interstellar blends because of the sense of strength and encouragement I experience during the fast. I feel the presence of God in a strong way and I feel that I am stronger than the problems I face. I am always waiting for the next day with joy and positive expectations . Your body is your best friend that will be with you for the rest of your life and it is the vehicle that takes you to the places that bring you satisfaction and fulfillment in life. Therefore give it the best. Give it Intersteller blends. Your body will thank you and rejoice with you.
Rated 5 out of 5

Rochelle Vitler (verified owner) – February 9, 2020

I started using Auto, Thermo, Trinity, Super Hair and Pine Pollen approximately six weeks ago to support my overall health, mood and weight loss journey whilst undertaking a combination of 48-72 hour dry and water fasts.

I had already been fasting for approximately two months at this point but almost straightaway after introducing the blends the fasting became a breeze. I have the energy and inclination to exercise every day; I enjoy a big meal every two to three days and the desire to eat outside of these times is simply not there.

I have played around with the timing and combination of blends that works best for me and now believe I’ve got it just right. The best way to describe my mental state at the moment is “joyful”. I honestly feel happy, hopeful and uplifted, regardless of what stressors may be present in my life, and definitely attribute this to the blends.

Added bonus: I have new hair growth all around my hairline. I feel my hair overall is thicker and in much better condition but the hairline is particularly noticeable.

I can’t wait to try the next batch of blends I have ordered and will gradually add others. These blends really have made a big difference to my life and after seeing the benefits I wouldn’t want to be without them.
Rated 5 out of 5

Claudia Gonzalez (verified owner) – March 12, 2020

I purchased Superhair Tonic back in December. I had been water fasting (without blends) since August and managed to lose 30 lbs. However, by December I noticed I had started to shed tons of hair. Taking a shower caused severe anxiety since its when I saw the most hair fall out. Hand fulls of my long 30 inch hair were falling out. I had just come across the Facebook group and saw this blend. I ordered immediately. I took this combined with the Pine Pollen and within two weeks all hair loss had stopped. I was so amazed and thrilled.

I think the water fasting has also stunned my hair growth. I hadn’t seen much growth in the last couple of months. After a couple of weeks on the Superhair Tonic and Pine Pollen I noticed that my hair was growing again. I documented the growth and from the end of December to February my hair grew 3 inches! Not only that but I have tons of baby hair already growing in replacing all the hair I lost. I was afraid I would have to chop off my waist long hair with all the hair loss. But I am so happy to report that these wonderful blends have saved my hair and the 3 years that I have dedicated to growing and caring for it.

I also wanted to talk about Niagra. I’m 34 years old and have always had issues with irregular menstrual cycles. Early on they diagnosed me with PCOS. However, recently, with blood work they couldn’t really determine if that was the cause. I could go even 6-8 months without a period. I also started taking Niagra early in January. I was amazed that shortly after this I had a menstrual cycle, and then 34 days later another! No cramping, no pain, just a minor discomfort which I appreciated to know it was coming. I am so wowed at how fast this acted on regulating my cycle. I’ve felt great and will continue to take this.

I am taking other blends, like Trinity and Luteolin at nigh and my sleep has been wonderful. I truly recommend all the blends!
Rated 5 out of 5

Qaz (verified owner) – May 23, 2020

Ok finally I get to do a review! I discovered interstellar blends 3 months ago when I was searching about a certain herb. At first I thought this website was too good to be true but I looked at the hundreds of good reviews and also the reviews people have left on Facebook and I knew I had to give this a try. Now I am lucky to have great hair genetics in my family both sides of my family have a great head of hair and my dad who 52 still has a full head of hair. For me sadly I still have my full hair of hair but my scalp gets oily in one day which makes my hair brittle and fine. I’ve been taking the super hair tonic for only 3 weeks along with pine pollen and OMG, the greasy hair hasn’t gone completely yet but There’s a big improvement and it’s only been 3 weeks! Not to mention how much energy pine pollen gives me as its such a powerful super food. It’s best to take both of them together in warm water. Looking forward to trying your other blends Thank you so much a Gavin !!!
Rated 5 out of 5

Nick K (verified owner) – May 28, 2020

I’ve been taking the super hair blend as well as the spice & peel blends for about a month now.
Im impressed with the ingredient list, first and foremost. I’ve tried everything from pills to masks for my hair, and nothing comes close to this ingredient profile.

The flavor is amazing, similar to a herbal tea.
Mixing it with the Spice and Peel makes it that much better. I make it with hot water and drink it first thing in the morning.

Since taking it, I’ve noticed an increase in both thickness and shine. I’m in the process of growing my hair out, and this is one step I now realize I need to get my hair where I want it to be. I’m excited to see the progress continue over the next few months, pairing the blends with fasting and an antioxidant based diet.
Rated 5 out of 5

anil badhan (verified owner) – August 4, 2020

Amazing product, worth every penny! From the first tea I made, I felt amazing and gave me some goosebumps. The guys sent me sample of trinity also, which i combined both herbs together which made the experience way better and will be purchasing trinity next!

After few days using the herbs, I noticed how shiny my hair got. Every time I had a shower, my hair used to fall out, during and drying it. I’ve tried so many shampoos, conditioners, hair masks and oils to prevent the hair loss. This product is the best by far that I have used for hair loss.

I would recommend this to anyone with hair problems (one guy has already placed an order). Super happy how things are going and can’t wait to see the results at the end of the herbs. 100% returning back to buy more herbs! Thank you guys ! Cant wait to try new herbs! Life time customer !

Enough Love
Rated 5 out of 5

Gloria Ho (verified owner) – October 23, 2020

I love this blend. It is so easy to take this with any of my drinks twice daily. As of today, I have used the product for two weeks and have noticed a change in my hair and scalp. I do hard labor, so I sweat often and at the end of the night, I feel that my scalp is dry and itchy. When it does, hair falls out. I have tried numerous products and nothing works as well as this blend.

Since using the super hair formula, I’ve noticed my hair have stopped falling out. In addition, I’ve noticed that the necessity of my hair to be washed is less frequent because I do no experience scalp dryness or itchiness anymore. I know that washing my hair every day induces the falling out of hair, and since using this product, I can now wash my hair less frequently as well as seeing less hair fall out of my head. I really love that I can see the results right away and don’t have to take multiple pills a day in hopes that my hair would grow out. I’ve also noticed a bit of hair growth, and see baby hairs growing where there was an area in my hairline receding.

This formula is super easy to take. Every morning I mix it with my coffee and drink it easily and it does not leave a bad aftertaste. It really blends well with coffee. I also take it later in the day with any drink and I like that after today, I can reduce the intake amount. I’m very happy I got this blend and that it’s actually working. You come so many products that advertise online and promise you hair growth and you purchase it for ridiculous amount of money and subscribe to them, taking them over the.months without seeing results. With this super hair formula, I was able to feel and see the results almost immediately and am speechless with the end result.

I will definitely be a returning customer and continue to use this product alongside Pine Pollen which I also bought. This prevents hair loss and replaces so many products such as pills, shampoos, conditioners, and other home remedies I’ve tried. It is by far the best hair loss product I’ve ever used. Thank you to Interstellar for the research and effort that they have put into in order to create such a fantastic blend for hair. I can’t wait to try the other blends. I’ve also got the Triinity, Thermo, and Supernova blends, and they are fantastic as well and helps me with intermittent fasting! Thank you so much for creating this product and finding such a great blend of herbs! I’m excited to get my hair where I want it to be.

Best Regards! You’ll be hearing from me soon with additional purchases! Fantastic work you’ve done here!
Rated 5 out of 5

Nirali (verified owner) – October 30, 2020

First thing First, Interstellar blends are a game changer. I ordered Super Hair Tonic and have been taking it for about 3 weeks now and I can already see the difference.I have Wavy curls, and my hair were pretty well until I moved to Canada. After moving to Canada, I started experiencing grey hair, Hair-Fall, low hair volume and my hair started to break very easily. I tried so many supplements and hair care products but all in vain. I was so frustrated and stopped caring about my hair at all.
Then my friend introduced me to Interstellar Blends. I reached out to Gavin and he recommended Super Tonic Hair. I was very skeptical at first as everything i’ve tried until now had shown no result but I thought of giving it a try. The order came in just few days of ordering it. I have been taking the Super Tonic Hair for 3 weeks and I can literally see the difference in my hair. They are now getting longer, less hair-fall and I can also see new hairs growing. And its not just about the hair but after I started taking Super Tonic Hair, my whole body feels so different, Very light and always at ease. This blends are really life changing and I can’t thank Gavin enough for creating this blend. He is very knwoledgable and answers any question that I have right away. The Customer service is very SPOT-ON.
Over-all I am very happy with the result and I am really glad that I gave interstellar blends a try. I can’t wait to explore other blends and reset my body.
I have just become the lifetime customer of Interstellar Blends.
Rated 5 out of 5

jennifer (verified owner) – March 17, 2021

I have always had good hair, thick and wavy. but it doesn’t seem to grow much past shoulders. And despite having a good diet and pampering my hair with ‘good ” hair products, it would still get a bit dry and frizzy… after a month of using the Super Hair Tonic, my hair grew, I’m seeing new hair growth and its not dry. It looks thick and nourished. the best its ever looked and other people are noticing too… but its not just about my hair…. I feel better in general. This is the first blend bought. I’ve since bought Trinity, Nebula and have received samples of seven sages and super nova.. all amazing. I never want to be without these products. I love how I feel on them… sometimes I fast with them… but even when I don’t. I still feel the positive effects of the blends.
Rated 5 out of 5

S.R. (verified owner) – June 5, 2021

Where to begin…. I have fasted, both wet and dry, for years prior to coming across Interstellar Blends over a year ago. Like most, I lurked and read testimonial after testimonial wondering if there was actually truth to what I was reading. I am a great lover of science, so Gavin’s website was a treasure trove for me. There was article upon article convincing me that the testimonials I was reading could actually be true.

I reached out to Gavin and he quickly responded to my inquiry. That alone spoke volumes about his integrity. I then placed an order and received it within a couple of days. The packaging was SUPERB! It was so beautiful that I didn’t even want to open it out of fear of messing it up, but boy am I glad I did.

I was never a fan of coffee because it gave me the jitters, but I still followed the instructions. The blends tasted horrible so I quickly became grateful for the coffee that helped mask the taste. Within a few minutes, I started to feel different. There was something happening, but I wasn’t sure what or how to explain it. I was feeling an “opening” going on in my chest and head. Soon, my body began to crave the blends, nasty tasting and all!

I have already tried most blends, but I want to focus on Super Tonic Hair and Pine Pollen. As I mentioned previously, I was no stranger to fasting; and as most would know, that usually means hairloss. My hair had become so thin and brittle that I felt it was a lost cause. I began taking Super Tonic Hair and Pine Pollen, and within a month, I began to get compliments on my hair’s fullness and shine. I no longer had to choose between fasting and my hair. With Interstellar Blends, I can have it all!!

Thank you Gavin for sharing your wealth of knowledge and your products with the world. You and your whole team are positively impacting and changing lives worldwide!!!
Rated 5 out of 5

Kevin (verified owner) – August 15, 2021

After I noticed my hair thinned out really quick I decided to order super tonic hair, I was like: nothing to lose right, so why not try it out? After a week I immediately noticed my hair didn’t fall off easily anymore and I’m just a week in!

Also I noticed that beside growing back thicker and less falling out that the quality became better. Also it tastes really good! Like a light version of coffee which makes it part of my morning routine.

Can’t wait for what the coming months will bring, but I sure do now that I will order now right away another one.
Rated 5 out of 5

Bal Purewal (verified owner) – October 5, 2021

I feel very blessed and grateful that i started taking super hair tonic 4 weeks ago. To be honest – it was not my hair that was a priority for me as i have other issues to deal with. However , I purchased the combo pack of blends ( thought that was my best way forward to take all the blends as per Gavins 22:2 protocol . Like i said at the beginning – my hair was not really my main priority for now – main reason being i fell out with my hair 30 years ago when i got my first grey hair (i was 13 years old) – i knew this wa genetic as my family members also started going grey as children – by the time i was 27 years old i succumbed to dying my hair ( so next 24 years was a big commitment to dying my hair every 4 weeks) , in that time – i knew the hair dyes were no good – toxic and carcinogenic – i kept dying my hair as could not leave my house if i saw one white hair!!!! Then we had the first lockdown March 2020- and thats the ush i needed to stop dying my hair – however – i felt that the damage had already been done to my hair – it was thin – lacked lustre and i had over the years developed 2 very very thin (almost bald ) patches on my hairline (above my temples ) which i felt i had to accept as never grew back- Now back to the super tonic hair – started taking 4 weeks ago – one quarter teaspoon once a day only – and my hair seems to have thickened considerably – the bald patches do not look as bald anymore and I’m feeling so much confident with my hair and not afraid to go out . At this time of writing this review- i personally not sure if my grey hairs are reducing and my natural colour coming back ( it appears like it is) – i will write another update in couple months time . Needless to say i have now purchased a 100g bag – without batting an eyelid – i would advise anyone who cares about their hair – STOP GOING TO THE HAIR DRESSERS – DONT ALLOW CARCINIGENS IN HAIR DYES-AND HAIR PRODUCTS ANYWHERE NEAR YOUR SCALP AND HAIR – THE MONEY YOU SAVE NOT GOING TO HAIRDRESSERS WILL BE MORE THAN YOU NEED FOR THE SUPERTONIC HAIR – you will never go back – for the first time in my life – i love my hair – even the greys – i call myself the OCEAN PRINCESS
Rated 5 out of 5

Suzanne Kici (verified owner) – December 7, 2021

I have been using this product for approximately 12 months and I cannot believe how healthy my hair is. My stylist said that it is so much thicker and has more volume and is not dry like it used to be. I absolutely love this product!
Rated 5 out of 5

Valerie Cade (verified owner) – December 22, 2021

As a woman who is 53 with thinning hair due to menopause hormonal issues, Super Hair Tonic truly restored my thinning hair to the fullness I’d experienced before ~ and within on week. My mistake was only ordering the sample; I now realize ordering the full package is the key as this blend is a staple for me moving forward (along with peel and spice for every day muscle aches and pains; these are gone, trinity for focus and motivation and autophagy for controlling hunger as I continue to lose weight and not have any cravings). Super Hair Tonic exceeded my expectations!
Rated 5 out of 5

Harry Aplin (verified owner) – July 7, 2022

I’ve been using this product for the last two weeks and I’m very impressed.. it took about 5 days for me to notice a change, with the strands of my hair looking much thicker and healthy..after a couple of weeks I noticed my eye lashes got really long too! I’ve never seen them so long before!

I used to suffer from an itchy scalp before using this product but now it feels so good to be free of that, super happy with the results and will be buying more for sure, also keen to try out some of the other products!
Thankyou Gavin!
Rated 5 out of 5

Patricia (verified owner) – August 19, 2022

I’ve been taking the blends for over a year. LET ME TELL YOU, these are by far the BEST thing I stumbled upon. I have always been into alternative medicine and am never willing to take what big Pharma is pushing on me. I am a retired Registered Nurse and have pushed back against Pharma my entire career…weird right but my eyes were opened.

I have suffered with arthritis, pain, low energy but feeling of impending doom, thinning hair, and high blood pressure. Let me tell you….I tried many supplements to try and reverse these symptoms and nothing worked. Again by the Grace of God, I came across Gavin and his life saving blends. What a game changer!!

Here’s my results. By taking Peel and Spice for Arthritis, I have function back in my wrists and pain is under control. Low Energy and impending doom? GONE with NEBULA and TRINITY…I have never felt so calm and let things pass in my entire life! I use to be high strung and everything effected me. After having what I think was COVID..(never got tested) I started loosing my hair. How disturbing to me. I have been taking the hair blend and is thankfully growing back. Last but not least, EKG has brought my blood pressure into normal range. At every annual physical, my blood pressure was so high sometimes they didn’t want me to leave the clinic. This is a game changer for me. So happy I’m not in the critical zone anymore.

I could go on and on about the blends. Purge, Glucose Blocker, Anti Adipogenic, Thermo, and Autophagy for loosing weight…OFF THE CHARTS. I lost 10 pounds and have kept it off for over a year.

This is getting long so just try them….you’ll never go back! Thank You Gavin so much for your life saving and beautiful blends. They are filled with Love.
Rated 5 out of 5

Kristina (verified owner) – September 3, 2022

I have been taking super hair formula for 2 months now. I bought it to mainly help with gray hairs. I am 33 but started getting grays in my late 20’s. My hair has also been thinning and not growing past a particular length. I did not notice results the first 2 weeks, but kept taking the blend since I had it I figured I might as well finish it off. In the 3rd week, I noticed this bump/wart I had at the nape of my hairline disappeared. It had been there for as long as I can remember. I was shocked to run my finger where it used to be and feel smooth skin. I felt encouraged.

I have been wearing tape-in extensions for about 2 years to give myself the appearance of longer, thicker hair. 6 weeks in of taking the blend, I had a routine hair appointment to remove, clean my extensions, re-install them, and get my roots colored. As my hair stylist was removing them, she commented on how much new growth she was seeing. When she finally removed them all, we were both shocked to see my actual hair had grown as long as the extensions!!!! This has never happened before! My hair was also so much thicker. She only installed half as many as I used to get, and for my next appointment in a couple weeks, I am going to remove them altogether.

I have not yet noticed an improvement with the grays, but I think I will be able to analyze results better once I take my extensions out and take a break from hair coloring. I think it may just take longer to see that change, but I feel encouraged because of the amazing results in length and thickness. I will update after a few more months on the improvement of grays! This is a wonderful blend but it takes a few weeks to see the results. Do not be discouraged if you don’t see a change right away! Stick with it and be consistent.
Rated 5 out of 5

Diana Ricco (verified owner) – October 29, 2022

Super Tonic Hair is a life saver!!! I was starting to lose my hair in clumps after I had covid. Not a single remedy worked to stop the hair loss, let alone grow it back. I was super thinned out and I couldnt even pass a comb through my hair without losing a bunch of it. Enter this blend!

Within a month of taking it, i was sprouting fresh new hairs all over my head. My existing hair felt stronger and less brittle, AND i havent seen any random strands of grey hair since I started taking this blend. I am a repeat customer already and its been about a year now. My hair is thicker than before. It is stronger than before. It feels and looks way healthier than before.

Even my hairdressers are shocked by the drastic change in thickness and hair growth that theyve all been asking me for the name of this blend. They tell me they have NEVER seen anything like the results theyve seen on me, and they see people’s hair every day. It is truly life changing. It brought me from being stressed and depressed to being confident agian. I dont think I will ever not buy this blend for as long as I live. Thank you, Gavin.
Rated 5 out of 5

Konstantin K (verified owner) – May 3, 2023

One month ago I placed my first order and boy was I not disappointed! First of all, I can feel all of them, each has a very pronounced effect. Supernova makes me super focused and alert, gainz significantly increases my muscle mass and strength, the rest just make me feel better in general. I’ve been experimenting with all sorts of different supplements and practices over the last 2-3 years but I have never felt such prominent effects.

Although, in this review I’d like to particularly highlight Super Hair. I’ve been dealing with slowly receding hairline since I was 20. I started fighting it right when it started, doing all sorts of things from natural toos like microneedling and rosemary oil to more kind of pahrma things like minoxidil. Last few years even though I’ve been doing a lot, the receding hairline started to win the battle. I’ve been seriously thinking about doing hair transplant in the next couple of months.

Hard to put in words how amazed I was with the results I got from Super Hair. Never have I ever seen such a FAST and PRONOUNCED effect. One week in I could see new hairs growing and old ones getting thicker. No other hair solution or compound works that fast. Minoxidil takes around 8 weeks to see the first tiny results. Hats off to Gavin for creating such a powerful and natural solution. 👏👏👏
Rated 5 out of 5

Lori Cramer – July 30, 2023

I have been using this blend a little over a month, so I can’t give a full review as yet but I am liking what I see. Fuller thicker hair ..i definitely see a difference from before. So im pretty excited to keep using and see more results. I am definitely excited to try other blends.
Rated 5 out of 5

Jennifer W – November 9, 2023

It’s funny how you get used to feeling a certain way so that’s just what you accept of yourself. Or you aren’t aware that something is wrong with you until you feel better. I didn’t realize how exhausted I get during the day. I didn’t realize how low energy I am. I just go through my day and anxiously await a proper time to go to bed. Or…. what’s it feel like not to have a headache? I don’t get migraine headaches, it’s just from not sleeping. I can expect a headache at least four times a week. Stomach aches from poor digestion are awful too. Just overall feeling good… really? Yes!!! Yes!!! Yesssss!!!!

Interstellar Blends to the rescue. So I have several of the blends in sample size. I’ve actually had them quite a while and I would take some here, take some there. I really got serious about it this past week and I have taken them at least twice daily and sometimes three times daily. WOW is all I can say. The blends certainly have a way of pointing out just how poorly I felt by making me feel amazing!!

I have been taking a concoction of plush, nebula, super hair, spice, niagra, super nova, and several more. The first thing I noticed was that I can actually breathe through my nose. I have absolutely no congestion. I suffer with seasonal allergies and allergens from indoors. I work in an over 100 year old building and there’s stuff everywhere in there. I have zero congestion and zero allergy symptoms.

Energy? Ha!!! I’m freaking annoying because I have so much energy. Sleep and blends!! No more headaches. Not a single one this week. An overall mellow mood and I’m nice. I’m so, so nice now!!! LOL Digestion issues gone!! When I take steps to feel better I don’t want to put the crap in my body so I’m eating a better diet too. I’m fasting and taking the blends with coffee or tea.

The blends go above and beyond what they’re intended to help you with. All this and I haven’t even tried the blends for sleep. Since I’m headed into the weekend I will give that a shot…just so I can adjust the amount so I will get up in the morning for work when Monday rolls around.

The Interstellar Blend website is so amazing. I love the updated “choose your own symptom” scrolling technology provided. It makes choosing blends so convenient.

Thank you Gavin and Interstellar Blends. I haven’t felt this good in a very long time…. Possibly ever!!

Add a review

25 BLEND MEGA COMBO (Save 59%)

FEBRUARY SPECIAL! 18 Blend Combo Sampler (Save 56%) $1750 value for $777! Comes with Interstellar Mug!

SUPER TONIC HAIR 200:1

27 reviews for SUPER TONIC HAIR 200:1

Related products

INTERSTELLAR “PEEL” Flavonoid Powerhouse 200:1

AUTOPHAGY ACTIVATOR 200:1

THUNDER 200:1

AUTONOMOUS : Nootropic Tour De Force 200:1

E K G : Cardioprotective 200:1

INTERSTELLAR “SPICE” Polyphenol Powerhouse 200:1