CARBONYL SCAVENGER
February 2, 2022PUFAS
February 2, 2022
- SIRT1 and insulin resistance
- The ups and downs of SIRT1
- SIRT1: recent lessons from mouse models
- Phosphorylation of HuR by Chk2 regulates SIRT1 expression
- Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
- Phosphorylation regulates SIRT1 function
- Protective roles of SIRT1 in atherosclerosis
- Mammalian SIRT1: insights on its biological functions
- SIRT1 regulates aging and resistance to oxidative stress in the heart
- Mechanism of human SIRT1 activation by resveratrol
- JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
- Regulation of SIRT1 in cellular functions: role of polyphenols
- Metabolic benefits from SIRT1 and SIRT1 activators
- A review of SIRT1 and SIRT1 modulators in cardiovascular and metabolic diseases
- SIRT1 is significantly elevated in mouse and human prostate cancer
- AMPK and SIRT1: a long-standing partnership?
- How does SIRT1 affect metabolism, senescence and cancer?
- Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
- SIRT1 and endocrine signaling
- DBC1 is a negative regulator of SIRT1
- SIRT1 and neuronal diseases
- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦
- Tissue-specific regulation of SIRT1 by calorie restriction
- Shear stress, SIRT1, and vascular homeostasis
- JNK2-dependent regulation of SIRT1 protein stability
- SIRT1 regulates adipose tissue inflammation
- The critical role of the class III histone deacetylase SIRT1 in cancer
- SIRT1 controls endothelial angiogenic functions during vascular growth
- Function of the SIRT1 protein deacetylase in cancer
- SIRT1: roles in aging and cancer
- Cellular regulation of SIRT1
- A role for the NAD-dependent deacetylase SIRT1 in the regulation of autophagy
- Increase in activity during calorie restriction requires SIRT1
- Regulation of SIRT1 protein levels by nutrient availability
- A novel pathway regulates memory and plasticity via SIRT1 and miR-134
- SIRT1 is essential for normal cognitive function and synaptic plasticity
- Biochemical effects of SIRT1 activators
- Progressive loss of SIRT1 with cell cycle withdrawal
- Emerging roles of SIRT1 in vascular endothelial homeostasis
- SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
- SIRT1, is it a tumor promoter or tumor suppressor?
- Metabolic adaptations through the PGC-1α and SIRT1 pathways
- Resveratrol is not a direct activator of SIRT1 enzyme activity
- Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
- SIRT1 and p53, effect on cancer, senescence and beyond
- SIRT1 protects against high-fat diet-induced metabolic damage
- SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
- Cytoplasm‐localized SIRT1 enhances apoptosis
- Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
- SIRT1 regulation of apoptosis of human chondrocytes
- Caloric restriction, SIRT1 and longevity
- Protective role of SIRT1 in diabetic vascular dysfunction
- Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
- Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
- SIRT1 is a novel regulator of key pathways of human labor
- Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
- Expression and role of SIRT1 in hepatocellular carcinoma
- Brain SIRT1: anatomical distribution and regulation by energy availability
- Calorie restriction, SIRT1 and metabolism: understanding longevity
- Mammalian SIRT1 represses forkhead transcription factors
- Hormonal control of androgen receptor function through SIRT1
- SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
- SIRT1 transgenic mice show phenotypes resembling calorie restriction
- SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
- SIRT1 shows no substrate specificity in vitro
- SIRT1 regulates energy metabolism and response to caloric restriction in mice
- SIRT1 modulation as a novel approach to the treatment of diseases of aging
- SIRT1 is an inhibitor of proliferation and tumor formation in colon cancer
- SIRT1 gain of function increases energy efficiency and prevents diabetes in mice
- Dietary activators of SIRT1
- miR-34a repression of SIRT1 regulates apoptosis
- SIRT1-null mice develop an autoimmune-like condition
- SIRT1: regulation of longevity via autophagy
- SIRT1 negatively regulates the mammalian target of rapamycin
- The interaction between FOXO and SIRT1: tipping the balance towards survival
- STAT3 inhibition of gluconeogenesis is downregulated by SIRT1
- SIRT1 stimulation by polyphenols is affected by their stability and metabolism
- Negative regulation of the deacetylase SIRT1 by DBC1
- SIRT1 improves healthy ageing and protects from metabolic syndrome-associated cancer
- SIRT1 modulates premature senescence-like phenotype in human endothelial cells
- Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
- SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
- Exercise training promotes SIRT1 activity in aged rats
- SIRT1 regulates the function of the Nijmegen breakage syndrome protein
- Interactions between E2F1 and SIRT1 regulate apoptotic response to DNA damage
- A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
- The physiological roles of SIRT1 in skeletal muscle
- SIRT1 acts as a modulator of neointima formation following vascular injury in mice
- FoxO1 mediates an autofeedback loop regulating SIRT1 expression
- SIRT1 deacetylates and positively regulates the nuclear receptor LXR
- Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
- Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
- Stabilization of Suv39H1 by SIRT1 is part of oxidative stress response and ensures genome protection
- SIRT1-mediated acute cardioprotection
- Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
- SIRT1 regulates circadian clock gene expression through PER2 deacetylation
- SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
- Role of SIRT1 in homologous recombination
- SIRT1 promotes differentiation of normal human keratinocytes
- SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
- Inhibition of transcriptional activity of c-JUN by SIRT1
- Age‐associated loss of SIRT1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific SIRT1‐overexpressing (BESTO) mice
- Hypothalamic SIRT1 regulates food intake in a rodent model system
- Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
- SIRT1 genetic variation is related to BMI and risk of obesity
- Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
- Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
- Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
- SIRT1: a metabolic master switch that modulates lifespan
- miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
- SIRT1 contributes critically to the redox-dependent fate of neural progenitors
- A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
- SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
- Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
- SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
- The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
- A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9
- SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- Controlling SIRT1 expression by microRNAs in health and metabolic disease
- Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
- The anti-aging, metabolism potential of SIRT1.
- PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
- SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
- SIRT1 activation protects the mouse renal medulla from oxidative injury
- SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR♦
- SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
- Function of SIRT1 in physiology
- SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
- Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
- SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
- SIRT1 increases skeletal muscle precursor cell proliferation
- SIRT1 promotes DNA repair activity and deacetylation of Ku70
- Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
- Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
- SIRT1 regulates HIV transcription via Tat deacetylation
- DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
- SIRT1 protects the heart from aging and stress
- SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
- SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
- SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
- Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
- Human SIRT1 interacts with histone H1 and promotes formation of facultative heterochromatin
- Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
- Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
- Age related changes in NAD+ metabolism oxidative stress and SIRT1 activity in wistar rats
- The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
- SIRT1 deficiency attenuates spermatogenesis and germ cell function
- SIRT1 in muscle physiology and disease: lessons from mouse models
- SIRT1 involvement in rd10 mouse retinal degeneration
- High-intensity interval training increases SIRT1 activity in human skeletal muscle
- Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
- Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma
- SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
- Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma
- Association of SIRT1 gene variation with visceral obesity
- Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
- Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
- SIRT1 regulates UV-induced DNA repair through deacetylating XPA
- Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
- Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
- Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
- Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
- The role of SIRT1 in tumorigenesis
- Low SIRT1 expression, which is upregulated by fasting, in human adipose tissue from obese women
- SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/-mice
- The type III histone deacetylase SIRT1 is essential for maintenance of T cell tolerance in mice
- Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
- Deacetylation of cortactin by SIRT1 promotes cell migration
- SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
- SIRT1 gene is associated with major depressive disorder in the Japanese population
- SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
- SIRT1 contributes to telomere maintenance and augments global homologous recombination
- Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
- SIRT1 deacetylates APE1 and regulates cellular base excision repair
- Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
- SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
- Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα
- SIRT1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
- SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
- SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma
- SIRT1: tumor promoter or tumor suppressor?
- SIRT1 activation confers neuroprotection in experimental optic neuritis
- Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
- Resveratrol regulates human adipocyte number and function in a SIRT1-dependent manner
- SIRT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
- Activation of SIRT1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1
- Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
- The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
- Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
- SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
- Peptide switch is essential for SIRT1 deacetylase activity
- SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
- Activation of SIRT1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts
- SIRT1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
- Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
- The direct involvement of SIRT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
- Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
- Physiological and pathophysiological functions of SIRT1
- Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
- SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1, 2 and HMGCS1, 2
- SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
- Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
- Roles of SIRT1 in the acute and restorative phases following induction of inflammation
- SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model
- Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance
- SIRT1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
- Modulation of SIRT1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
- SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
- The NAD World: a new systemic regulatory network for metabolism and aging—SIRT1, systemic NAD biosynthesis, and their importance
- Balance between SIRT1 and DBC1 expression is lost in breast cancer
- Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters
- Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
- Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson’s disease
- Human SIRT1: a potential biomarker for tumorigenesis?
- RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
- SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
- Overexpression of SIRT1 protects pancreatic β-cells against cytokine toxicity by suppressing the nuclear factor-κB signaling pathway
- SIRT1 is a circadian deacetylase for core clock components
- SIRT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
- SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance
- SIRT1-dependent regulation of chromatin and transcription: linking NAD+ metabolism and signaling to the control of cellular functions
- SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1: possible role in AMP-activated protein kinase activation
- Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems
- SIRT1 fails to affect p53‐mediated biological functions
- Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
- High glucose downregulates endothelial progenitor cell number via SIRT1
- Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
- SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiology
- SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells
- Neurogenesis directed by SIRT1
- Lysine deacetylation in ischaemic preconditioning: the role of SIRT1
- miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
- SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
- Regulation of cartilage-specific gene expression in human chondrocytes by SIRT1 and nicotinamide phosphoribosyltransferase
- Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
- Kidney-specific overexpression of SIRT1 protects against acute kidney injury by retaining peroxisome function
- Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
- Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
- Resveratrol protects human endothelium from H2O2-induced oxidative stress and senescence via SIRT1 activation
- Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
- Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
- Roles of FoxO1 and SIRT1 in the central regulation of food intake
- SIRT1 is a redox‐sensitive deacetylase that is post‐translationally modified by oxidants and carbonyl stress
- Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
- SIRT1 deacetylates c-Myc and promotes c-Myc/Max association
- Calorie restriction enhances cell adaptation to hypoxia through SIRT1-dependent mitochondrial autophagy in mouse aged kidney
- Translating cell survival and cell longevity into treatment strategies with SIRT1
- Deacetylation of FoxO by SIRT1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
- Macrophage α1 AMP-activated protein kinase (α1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
- The controversial links among calorie restriction, SIRT1, and resveratrol
- Resveratrol inhibits insulin responses in a SIRT1-independent pathway
- SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein α transcriptional complex
- SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1
- The role of SIRT1: at the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology
- Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation
- Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
- SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
- SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer
- FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
- Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
- Role of sirtuin histone deacetylase SIRT1 in prostate cancer: a target for prostate cancer management via its inhibition?
- Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection
- ΔNp63&alpha overexpression induces downregulation of SIRT1 and an accelerated aging phenotype in the mouse
- Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
- Impact of SIRT1 on mammalian aging
- Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
- SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
- Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
- A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
- Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
- The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+
- SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis
- PPARα-SIRT1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway
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- Hepatic SIRT1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity
- SIRT1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
- Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the SIRT1 pathway
- SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
- SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
- SIRT1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
- Melatonin, a novel SIRT1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
- The SIRT1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
- SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60
- SIRT1 hyperexpression in SHR heart related to left ventricular hypertrophy
- Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: implication in pathogenesis of COPD
- Relationship between SIRT1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
- Regulation of MEF2 by histone deacetylase 4-and SIRT1 deacetylase-mediated lysine modifications
- SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
- Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
- Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1
- Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin
- Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
- Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
- SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
- Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
- SIRT1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
- PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
- SIRT1 regulates oxidant-and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol
- SIRT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
- Cilostazol inhibits oxidative stress–induced premature senescence via upregulation of SIRT1 in human endothelial cells
- NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance
- SIRT1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets
- SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts
- SIRT1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor
- Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
- Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
- SIRT1 longevity factor suppresses NF‐κB‐driven immune responses: regulation of aging via NF‐κB acetylation?
- Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway
- SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol
- SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
- Interference between PARPs and SIRT1: a novel approach to healthy ageing?
- Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
- Agrp neurons mediate SIRT1‘s action on the melanocortin system and energy balance: roles for SIRT1 in neuronal firing and synaptic plasticity
- Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
- Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
- Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene SIRT1
- Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
- Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
- CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
- SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
- Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
- CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
- SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
- Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α expression in experimental stroke
- Metabolic regulation of SIRT1 transcription via a HIC1: CtBP corepressor complex
- Tumor necrosis factor α–mediated cleavage and inactivation of SIRT1 in human osteoarthritic chondrocytes
- Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SIRT1 expression
- Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
- Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
- SIRT1: a novel target to prevent atherosclerosis
- SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
- Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
- Do we age on SIRT1 expression?
- SIRT1—a metabolic sensor that controls blood vessel growth
- Proatherogenic abnormalities of lipid metabolism in SIRT1 transgenic mice are mediated through Creb deacetylation
- Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
- SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
- SIRT1, stem cells, aging, and stem cell aging
- Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
- SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
- Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
- The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation
- Role of p53 in the anti-proliferative effects of SIRT1 inhibition in prostate cancer cells
- C/EBPα regulates SIRT1 expression during adipogenesis
- The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
- Activation of SIRT1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
- SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
- A role for SIRT1 in the hypoxic response
- Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
- SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts
- Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
- Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells
- SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
- Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients
- SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
- Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1
- SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin‐like growth factor receptor …
- Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis
- Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway
- SIRT1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells
- Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
- H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion
- SIRT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
- Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
- Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type‐2 diabetes
- Nutrient-dependent regulation of PGC-1α’s acetylation state and metabolic function through the enzymatic activities of SIRT1/GCN5
- SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
- Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase
- SIRT1 associates with eIF2-alpha and regulates the cellular stress response
- SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis
- SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
- Comparative and pharmacophore model for deacetylase SIRT1
- Mediobasal hypothalamic SIRT1 is essential for resveratrol’s effects on insulin action in rats
- SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription
- Induction of hypothalamic SIRT1 leads to cessation of feeding via agouti-related peptide
- SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
- Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans
- SIRT1 stabilizes PML promoting its sumoylation
- Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells
- The LXXLL motif of murine forkhead transcription factor FoxO1 mediates SIRT1-dependent transcriptional activity
- Effect of estrogens on bone marrow adipogenesis and SIRT1 in aging C57BL/6J mice
- Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
- Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti‐aging and metabolic effects of sirtuins
- SIRT1 variants are associated with aging in a healthy Han Chinese population
- Stimulation of SIRT1-regulated FoxO protein function by the ligand-bound vitamin D receptor
- The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
- The time of metabolism: NAD+, SIRT1, and the circadian clock
- SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in skeletal muscle through the PGC-1α …
- The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
- Silencing insulin resistance through SIRT1
- Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS …
- PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
- Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells
- SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA
- SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy
- Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via SIRT1–FOXO1 signaling pathway
- Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress
- SIRT1 brings stemness closer to cancer and aging
- Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition
- The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling
- Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E β-cells and human islets through a SIRT1-dependent mechanism
- … Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically …
- SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
- Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1-and HEY2-mediated transcriptional repression
- Early apoptotic vascular signaling is determined by SIRT1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation
- Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
- Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al 2 O 3 ) …
- SIRT1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol
- MST1 promotes apoptosis through regulating SIRT1-dependent p53 deacetylation
- Role of SIRT1 in heat stress-and lipopolysaccharide-induced immune and defense gene expression in human dental pulp cells
- Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway
- Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
- Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors
- SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons
- FoxO1 and SIRT1 regulate β-cell responses to nitric oxide
- Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network
- Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1
- Resveratrol is neuroprotective because it is not a direct activator of SIRT1—A hypothesis
- Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1–3 mRNA expression in human visceral adipocytes
- Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of SIRT1 in diabetic Wistar …
- Disruption of a SIRT1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation
- Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
- #VALUE!
- p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic …
- Inhibition of SIRT1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
- Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
- SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells
- Downregulation of SIRT1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells
- SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians
- SIRT1 modulates high‐mobility group box 1‐induced osteoclastogenic cytokines in human periodontal ligament cells
- Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats
- SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome
- A functional link between SIRT1 deacetylase and NBS1 in DNA damage response
- SIRT1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
- Could SIRT1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
- SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty
- Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells
- Induction of SIRT1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response
- SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
- Distribution of the longevity gene product, SIRT1, in developing mouse organs
- A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression
- Roles of SIRT1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis
- Activating SIRT1: a new strategy to prevent atherosclerosis?
- Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional …
- Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via SIRT1 expression
- SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase
- SIRT1—a sensor for monitoring self-renewal and aging process in retinal stem cells
- Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
- Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2α)
- Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic …
- Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) …
- Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically‐obese db/db …
- SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
- SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study
- Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
- FoxO-dependent and-independent mechanisms mediate SIRT1 effects on IGFBP-1 gene expression
- A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells
- Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase
- Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1
- Genetic study between SIRT1, PPARD, PGC-1 α genes and Alzheimer’s disease
- SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age‐related neoplasms
- SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestion
- Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival …
- Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
- Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by SIRT1 and FoxO1
- Proteomic analyses of SIRT1-mediated cisplatin resistance in OSCC cell line
- AROuSing SIRT1: identification of a novel endogenous SIRT1 activator
- SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
- Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation
- Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates β-catenin signaling and NFκB-specific transcription activity leading to MDR1 and Bcl-xL gene …
- Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function
- Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1‐independent sensitization to TRAIL‐induced apoptosis
- SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications
- Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin-and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile
- SIRT1 links CIITA deacetylation to MHC II activation
- Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2
- Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells
- Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function
- Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2
- SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
- SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kγ activity through deacetylation of specific lysine residues in mammals
- SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention–the TULIP Study
- The type III histone deacetylase SIRT1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation
- Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
- Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1
- Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of SIRT1 and Ku70
- NO targets SIRT1: a novel signaling network in endothelial senescence
- Low-frequency electroacupuncture improves insulin sensitivity in obese diabetic mice through activation of SIRT1/PGC-1 in skeletal muscle
- SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree
- Delivery of Oct4 and SIRT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium
- SIRT1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
- Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis
- PARP-2 regulates SIRT1 expression and whole-body energy expenditure
- Involvement of the p65/RelA subunit of NF-κB in TNF-α-induced SIRT1 expression in vascular smooth muscle cells
- Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells
- BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
- Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells
- SIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity
- SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction
- Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice
- Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue …
- Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic …
- SIRT1: a guardian at the gates of adipose tissue inflammation
- Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor γ transactivation
- Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells
- Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
- The role of SIRT1 in renal rejuvenation and resistance to stress
- Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
- Tat-SIRT1 tango
- Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
- Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells
- Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
- Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
- Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
- A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide
- Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts
- Serum withdrawal up‐regulates human SIRT1 gene expression in a p53‐dependent manner
- Hexosamines stimulate apoptosis by altering SIRT1 action and levels in rodent pancreatic β-cells.
- Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML
- Nicotinamide phosphoribosyltransferase is essential for interleukin-1β-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal …
- Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes
- Limited role of SIRT1 in cancer protection by dietary restriction
- Zyxin is a novel interacting partner for SIRT1
- Influence of aging and hemorrhage injury on SIRT1 expression: possible role of myc-SIRT1 regulation in mitochondrial function
- From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian SIRT1 and systemic NAD biosynthesis
- Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the α-myosin heavy chain expression
- Is SIRT1 a miracle bullet for longevity?
- Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2
- … receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1
- Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice
- Does hypothalamic SIRT1 regulate aging?
- Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
- Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin’s protection against UV-induced A375-S2 cell apoptosis
- WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis
- Metabolic signals regulate SIRT1 expression
- Old drug acquires new target: metformin and SIRT1
- Resveratrol induces SIRT1-and energy–stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment
- MiR-34, SIRT1, and p53: the feedback loop
- Food restriction improves glucose and lipid metabolism through SIRT1 expression: a study using a new rat model with obesity and severe hypertension
- Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats?
- Calorie restriction and obesity under the regulation of SIRT1
- Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SIRT1 activity
- Resveratrol (trans‐3, 5, 4′‐trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF‐κB
- SIRT1 performs a balancing act on the tight-rope toward longevity
- p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
- SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells
- Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca 2+ and AMPK/SIRT1
- SIRT1 protein levels in cancer: Tuning SIRT1 to the needs of a cancer cell
- Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation
- Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1
- Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
- CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes
- Regulatory role of SIRT1 on the gene expression of fatty acid‐binding protein 3 in cultured porcine adipocytes
- Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats
- Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1
- Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
- MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating SIRT1
- Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1
- Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors
- Is systemic activation of SIRT1 beneficial for ageing-associated metabolic disorders?
- TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SIRT1
- Poly (ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
- Red wine decreases asymmetric dimethylarginine via SIRT1 induction in human endothelial cells
- Anticancer Effects of 15d-Prostaglandin-J2 in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC
- Pharmacophore mapping and virtual screening for SIRT1 activators
- Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
- Sirtuin 1 (SIRT1) the misunderstood HDAC
- Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
- Substrate specificity of SIRT1-catalyzed lysine Nε-deacetylation reaction probed with the side chain modified Nε-acetyl-lysine analogs
- Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats
- Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers
- … peroxisome proliferator-activated receptor γ regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in …
- MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SIRT1
- Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and SIRT1
- A nutrient‐sensitive interaction between SIRT1 and HNF‐1α regulates Crp expression
- High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression
- Dual targeting of the antagonistic pathways mediated by SIRT1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions
- Cisplatin induces SIRT1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
- Determinants of serum-induced SIRT1 expression in older men: the CHAMP study
- Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death
- Anti-aging protein SIRT1: A role in cervical cancer?
- SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview
- Dysregulation of Myeloid‐specific Transcription Factors in Congenital Neutropenia: Rescue by NAMPT/NAD+/SIRT1
- SIRT1 inhibitory diterpenoids from the Vietnamese medicinal plant Croton tonkinensis
- Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear SIRT1
- The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
- Comparative deacetylase activity of wild type and mutants of SIRT1
- Discovery of oxazolo [4, 5-b] pyridines and related heterocyclic analogs as novel SIRT1 activators
- SIRT1, notch and stem cell” age asymmetry”
- Glucagon-like peptide 1 inhibits the sirtuin deacetylase SIRT1 to stimulate pancreatic β-cell mass expansion
- PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
- Protection by EGb 761 against β-amyloid-induced neurotoxicity: involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
- Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD+-dependent SIRT1 activity
- Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
- Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors
- Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology
- A novel role of SIRT1 in sildenafil induced cardioprotection in mice
- p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells
- Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase
- Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats
- Silencing metabolic disorders by novel SIRT1 activators
- WldS Reduces Paraquat-Induced Cytotoxicity via SIRT1 in Non-Neuronal Cells by Attenuating the Depletion of NAD
- Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells
- High fat diet increases and the polyphenol, S17834, decreases acetylation of the SIRT1-dependent lysine-382 on p53 and apoptotic signaling in …
- Effects of resveratrol on pig primary preadipocytes proliferation, differentiation and transcription expression of SIRT1 gene
- SIRT1 promotes DNA damage repair and cellular survival
- Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
- Negative regulation of stress‐induced matrix metalloproteinase‐9 by SIRT1 in skin tissue
- Leptin gene transfer regulates fibromuscular development and lipid deposition in muscles via SIRT1, FOXO3a and PGC-1α in mice in vivo
- A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of SIRT1 in the metabolic regulation of caspase-2
- Functional interplay between Parp-1 and SIRT1 in genome integrity and chromatin-based processes
- Correction: Corrigendum: SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
- Intra-arterial targeted islet-specific expression of SIRT1 protects β cells from streptozotocin-induced apoptosis in mice
- Poly (ADP‐ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes
- SIRT1 as a key regulator orchestrating the response to caloric restriction
- Isolation of megastigmane sesquiterpenes from the silkworm (Bombyx mori L.) droppings and their promotion activity on HO-1 and SIRT1
- SIRT1 Activation Mediates Sildenafil-Induced Cardioprotection Against Ischemia/Reperfusion Injury in Mice
- Effects of baicalin against oxidative stress injury of SH-SY5Y cells by up-regulating SIRT1
- … acid B protects beta-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2–HO-1 and SIRT1
- SIRT1 as a new therapeutic target in metabolic and age-related diseases
- EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1
- Real-time fluorescence imaging of SIRT1 cytosolic translocation under the treatment of growth factor deprivation
- SIRT1, p53 and mitotic chromosomes
- High-affinity Na+-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1
- #VALUE!
- Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification …
- Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD+ level, SIRT1 activity and replicative lifespan of human Hs68 cells
- No significant association between SIRT1 gene and methamphetamine‐induced psychosis in the Japanese population
- Myocardial SIRT1 expression following endurance and resistance exercise training in young and old rats
- SIRT1 and neurodegenerative diseases
- Targeting SIRT1-a multitasker
- Genetic and expression analysis of the SIRT1 gene in gastric cancers
- Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in …
- Resveratrol (trans-3, 5, 4′-trihydroxystilbene) induces SIRT1 and down-regulates NF-κB activation to abrogate DSS-induced colitis
- Identification of single nucleotide polymorphisms of SCD and SIRT1 and evaluation of their genetic diversities in chickens
- Not miR-ly aging: SIRT1 boosts memory via a microRNA-dependent mechanism
- Inhibition of SIRT1 increases EZH2 protein level and enhances the repression of EZH2 on target gene expression
- Effect of SIRT1 gene on cardiac function and life
- SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing PTP1B and activating the IGF receptor pathway
- Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells
- Nicotinamide, a Recognized Inhibitor of SIRT1, Promotes Expansion in Ex Vivo Cultures of Short and Long-Term Repopulating Cells.
- SIRT1 inhibits IL-1β mRNA transcription in lipopolysaccharide tolerant THP-1 cells
- Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1
- SIRT1 increases satellite cell cycle progression
- 3D-QSAR of SIRT1 activators targeting against diet-induced metabolic syndrome
- Research progression of deacetylase (SIRT1)
- Disruption of Igfbp1 fails to rescue the phenotype of SIRT1−/− mice
- iNOS inactivates SIRT1, a key regulator of stress resistance and metabolism, by S-Nitrosylation
- Abstract SY11-03: SIRT1 transgenic and cancer models
- Effects of resveratrol on SIRT1 expression, eNOS activity and NO secretion of hyperlipid cultured HUVEC
- SIRT1: a novel adipocyte and myocyte regulatory factor
- Toward productive aging: SIRT1, systemic NAD biosynthesis, and the NAD world
- Expression of SIRT1 in primary human uveal melanoma
- Involvement of SIRT1 in mouse myocardial hypertrophy induced by isorenin [J]
- Modeling miRNA regulation in signaling networks: miR-34a regulation of the p53/SIRT1 module
- SIRT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
- The antioxidative role of SIRT1/PGC-1α pathway in Parkinson disease
- SIRT1 activators promote p65 deacetylation and suppress TNFa stimulated NF‐kB activation
- Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SIRT1-independent pathway in LβT2 gonadotrope cells
- Overexpression of SIRT1, a Longevity Gene-Encoded Protein, and Induction of Apoptosis by Its Inhibition In Adult T-Cell Leukemia Cells
- #VALUE!
- SIRT1 expression in adult acute leukemia and its clinical significance [J]
- Overexpression of the Sirtuin SIRT1 Increases Insulin Sensitivity in Aging Mice.
- Development of Fluorescent Quantitative PCR Assay for Porcine SIRT1 Gene
- Nox4 regulates cellular survival by modulating FoxO3a activity and SIRT1 expression
- Neuroprotective mechanisms of SIRT1
- Mechanism of SIRT1 acting on tumor formation
- SIRT1, a Stress-responsive Deacetylase is Required for Development of Compensatory Cardiac Hypertrophy
- The race to control aging and diseases: Sir2/SIRT1 against Ras, TOR and Akt/S6K
- SIRT1 overexpression modifies cardiac energy metabolism
- SIRT1 activator SRT1720 suppresses inflammatory reaction in OVA-induced asthma model mouse
- SIRT1 is not required for exercise‐induced mitochondrial biogenesis, but maintains basal organelle content and function
- Both the Activity and Stability of the Transcriptional Repressor PLZF Are Modified by the Class III Histone Deacetylase SIRT1.
- Long-Term Calorie Restriction increases SIRT1 expression and Inhibits Vascular Senescence in Mice
- Reduced SIRT1 leads to increased Th2 cytokine expression via hyper-acetylation of GATA3
- SIRT1 and adult stem cell senescence
- Mechanism of regulating deacetylase SIRT1 expression and activity.
- SIRT1 Deficiency Suppresses the Maintenance of Hematopoietic Stem Cell Pool.
- SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.
- The Longevity Factor SIRT1 Protects Heart from Ischemia/Reperfusion Stress
- SIRT1 and Ku70 expression in acute leukemia and its clinical significance
- SIRT1 regulates human vascular smooth muscle cell Lifespan
- Upregulation of SIRT1 protects lens epithelial cells in oxidative conditions and cataract formation in humans
- Role of SIRT1 in Proliferation and Self-Renewal of Mouse Embryonic Stem Cells.
- SIRT1 controls endothelial angiogenic functions during vascular growth and maturation
- SIRT1 diminishes atherogenesis by suppressing NF-kB signaling-mediated pro-inflammatory events
- Role of SIRT1 histone deacetylase in melanoma: A target for melanoma management via its inhibition
- Abstract# 4441: c-Myc/SIRT1 feedback loop: A novel regulation of c-Myc induced cellular transformation
- SIRT1 overexpression in pancreatic adenocarcinomas correlates with shortened patient survival and small molecule inhibition as well as target knockdown of SIRT1 …
- Caloric restriction and SIRT1 modulate APP metabolism in vitro and in vivo
- Nuclear shuttling of SIRT1 is associated with caloric restriction-induced cardioprotection
- In silico evidence supports a role for DNA methylation in SIRT1-mediated effects of dietary restriction
- Regulation of translation and transcription by SIRT1: Potential novel mechanisms for regulating stress response and aging
- Treatment with the SIRT1 activator SRT1720 reduces large elastic artery stiffness, superoxide production and inflammation in old mice
- SIRT1 Activators Attenuate Retinal Ganglion Cell Loss During Acute Optic Neuritis
- BDNF-deficiency downregulates SIRT1 and upregulates SIRT2 expression in aging mouse retina
- Chronic treatment with SIRT1 activator SRT1720 ameliorates age-associated vascular endothelial dysfunction in B6D2F1 mice
- SIRT1 inhibition induces apoptosis in human CML progenitors by enhancing p53 acetylation and activation
- A novel SIRT1 activator SIRT1720 triggers in vitro and in vivo cytotoxicity in multiple myeloma via ATM-dependent mechanism
- SIRT1-Mediated Deacetylation Promotes Akt Membrane Localization and Activation During Development of Cardiac Hypertrophy.
- The Role of SIRT1 in Reproduction.
- SIRT1 Regulates PTEN/Akt/FOXO1 Pathway to Trigger ROS-Induced Apoptosis In Mouse Embryonic Stem Cells.
- Pharmacological inhibition of the stress-related deacetylase SIRT1 enhances eradication of cml stem cells
- SIRT1 modulates foxo-dependent transcription and prevents smooth muscle cell apoptosis in response to oxidative stress
- SIRT1 and Heart Disease [J]
- SIRT1 takes down tumors
- Study on the clinicopathologic significance and expression of SIRT1
- Brain space for SIRT1
- SIRT1 and Tumorigenesis
- Resveratrol, an Activator of Protein Deacetylase SIRT1, Suppresses Oxidative Stress-Induced Cell Death by Upregulating MnSOD Expression through Transactivation …
- SIRT1 keeps escapees quiet
- SIRT1 in transcription regulation
- Significance of SIRT1 expression in breast cancer
- The SIRT1 Activator Resveratrol Suppresses Cardiomyocyte Hypertrophy by Promoting Histone H3 Lys9 Deacetylation and Tri-methylation
- Response to Gomez-Cabrera et al: update on SIRT1 signaling
- SIRT1 and cell migration
- Abstract# 5092: Inhibition of SIRT1 by sirtinol causes p53-independent activation of FoxO1 in human prostate cancer cells.
- Inhibition of FoxO1-SIRT1 Signaling by Sustained Acetylation of PGC-1 Alpha Promotes Angiotensin II-Induced Vascular Senescence
- Expression and significance of SIRT1 in breast cancer with diabetes meilitus
- SIRT1 and neoplasms
- Abstract# 4126: SIRT1 is required for normal prostate gland development and androgen signaling in vivo
- Evidence for a Common Mechanism of SIRT1 Regulation by
- The skinny on SIRT1 regulation
- SIRT1 and neoplasms.
- The regulatory effect of SIRT1 on CⅡTA under hypoxia
- 152. Involvement of Trp53 in SIRT1 function during embryo development
- Identification of DNA Targets for SIRT1 in Human Cells
- Authentic SIRT1 activators? No, for Sirtin
- SIRT1 Gene Eukaryotic Eexpression of SD Rat
- SIRT1 Fluorometric Drug Discovery Kit
- Protective Roles of SIRT1 in Vascular Diseases
- SIRT1 Phosphorylation and Cell Proliferation
- Effect of SIRT1 on insulin secretion in MIN6 cell line and its mechanism
- SIRT1 Rabbit Polyclonal Antibody
- The Correlation of SIRT1 and Skin Senescence
- A potential tumor suppressive role of SIRT1 in Cancer
- Nuclear SIRT1 activity regulates oxidative capacity
- SIRT1 Regulates Notch4 Signaling In Endothelial Cells
- SIRT1 promotes DNA repair activity in response to radiation
- The Regulation of SIRT1 in Endocrine and Metabolism
- Effects of dairy consumption on SIRT1 and metabolic risk in humans
- Inhibition of SIRT1 Catalytic Activity
- SIRT1 promotes differentiation of normal human keratinocytes
- SIRT1, metabolism and calorie restriction
- The role of SIRT1 in restricted energy intake
- Expression and significance of SIRT1 in breast cancer with diabetes mellitus
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- Expression of SIRT1 in Retinoblastoma: A Potential Therapeutic Target
- Cancer Connection: Tumor-fighter throttles life-extending protein SIRT1
- Identification of a novel SIRT1/FEN1 interaction and their regulation by karyopherins
- SIRT1 DIMINISHES ATHEROGENESIS BY SUPPRESSING NF-‐ΚB SIGNALING-‐MEDIATED PRO-‐INFLAMMATORY EVENTS
- The SIRT1 mRNA expression in human intervertebral disc
- SIRT1 Involvement in Mouse and Human Retinal Development and Function
- miR-200a targets SIRT1 for malignant transformation
- The Role of SIRT1 in Resveratrol Toxicity
- Role of SIRT1 in Smooth Muscle Cell Function and Vascular Remodeling
- SIRT1 enhances drug resistance of CML K562 cells
- On the role of TLR2 and SIRT1 in the development of diabetes mellitus
- Effect of SIRT1 on the Transcription of HIV-1 Induced by Tat
- Abstract B46: Essential roles of SIRT1 for BCR‐ABL transformation and genetic mutations
- Effects of CR on H_2O_2-Induced Stress Injury and Expression of SIRT1 in PC12 Cells
- The SIRT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells
- SIRT1 Gene Silencing: A Potential Therapeutic Strategy for Pancreatic Cancer
- Molecular mechanisms of a disease susceptibility variant of SIRT1: Genotoxic stress‐induced, CTCF‐dependent activation of SIRT1 gene expression
- Deficiency Of SIRT1 Enhances Elastase-induced Emphysema In Mice
- SIRT1 ACTIVATION SEEMS TO PROMOTE APOPTOSIS OF HUMAN OSTEOSARCOMA CELLS
- Characterization of the role of SIRT1 and its potential as a chemotherapeutic target in breast cancer
- SIRT1 Regulates the Mouse Gastric Emptying and Intestinal Growth
- Roles of SIRT1 in neuronal oxidative damage and brain function
- Negative Regulation of STAT3-mediated Cellular Respiration by SIRT1
- SIRT1 Inhibits VSMC Proliferation and Migration Underlying Neointima Formation Following Vascular Injury
- Effects of calorie restriction on expression of SIRT1 and SIRT2
- SIRT1 modulates E2/ERα-associated oncogenic signaling in human breast cancer
- The Research Progression of NAD~+, Nampt and SIRT1 [J]
- Phosphorylation of Thr522 activates SIRT1 and is required for DYRK‐mediated cell survival in response to DNA damage
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- Establishment of Stable SIRT1 Gene-Downregulated Hepatocarcinoma Cell Lines by Lentiviral Vector
- Constitutive SIRT1 Overexpression Impairs Mitochondrial Function in Mice
- SIRT1 deacetylation regulates NFAT transcriptional activity
- Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
- FoxO1 Mediates an Auto-feedback Loop Regulation of SIRT1 Expression
- PPARalpha-SIRT1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
- Effects of silencing SIRT1 gene expression on proliferation and apoptosis of pancreatic cancer cell line PANC1
- SIRT1 Is Critical for Pdx1 Transcription and β‐Cell Formation
- Th lf Si t1 i The role of SIRT1 in restricted energy intake
- Involvement of SIRT1 in ultraviolet radiation mediated damages and transformation of skin keratinocytes
- SIRT1 Regulates Hyperglycemia-Induced Vascular Senescence
- Expressions of SIRT1 as prognostic biomarker on resectable gastric cancer patient
- Expression of SIRT1 during axonal degeneration by NAD.
- Muscle‐Specific Disruption of SIRT1 Reduces Mitochondrial Function and Increases Reactive Oxygen Species Production
- SIRT1 Is Required for Mouse Embroyonic Stem Cell Commitment to Hematopoietic Cell Differentiation.
- Expression of SIRT1 mRNA in abdominal aorta in rats with spontaneous type 2 diabetic mellitus
- Growth factor deprivation induces cytosolic translocation of SIRT1
- SIRT1 Mediates Pressure Overload-Induced Cardiac Hypertrophy and Failure in vivo
- SIRT1-Dependent and-Independent Effects of Resveratrol on Cardiovascular Oxidative Stress
- Nutrient and hormonal control of the protein deacetylase SIRT1
- The Development of Choroidal Neovascular Membranes in Patients With AMD Is a SIRT1-Independent Process
- SIRT1 Activation Affects the Transmission of Photoperiodic Information by Melatonin
- SIRT1 and AMPK: the Seesaw Effect in Regulating Endothelial Sene-scence
- Effect of SIRT1 and telomerase on stem cells
- Histone deacetylase SIRT1 promotes the differentiation of P19CL6 cells into cardiomyocytes
- Research Progress of the Nonalcoholic Fatty Liver Based on the SIRT1 Target Spot
- SIRT1 REGULATES CIGARETTE SMOKE-MEDIATED IMPAIRMENT OF ENDOTHELIAL CELL SIGNALING
- The pro-apoptotic effect of vitamin C on colon cancer cell lines, HCT116 via the regulation of SIRT1 expression (165.11)
- Stress and survival: Possible role of SIRT1 in the diencephalon during fasting
- Role of the longevity gene hSir2 (SIRT1) in cancer resistance to chemotherapy
- SIRT1 Decreases Lox-1 Mediated Foam Cell Formation in Atherogenesis
- Transcriptional control of glucose homeostasis through SIRT1 and PGC-1alpha
- HIGH LEVELS OF E-SELECTIN ARE ASSOCIATED WITH A REDUCTION OF SIRT1 EXPRESSION IN LYMPHOMONOCYTES FROM SUBJECTS WITH METABOLIC …
- SIRT1 Overexpression Modulates Cardiac Metabolic Genes Expression and Induces Dilated Cardiomyopathy
- Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
- Resveratrol upregulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
- Overexpression of SIRT1 and induction of apoptosis by its inhibition in adult T-cell leukemia cells
- Investigation on SIRT1 in Peripheral Blood Mononuclear Cell (PBMC) and Relationship with Pathogenesis of Psoriasis
- Primary study on the association of expression between SIRT1 and FOXO1 in B cells of islet in rat.
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- Regulation of the NAD+‐dependent histone deacetylase SIRT1 in conditions of muscle use and disuse
- Regulation of SIRT1 protein in cancer metabolism and ribosome biogenesis
- Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
- Characterization and investigation of seven SIRT proteins in human cell aging: down-regulation of SIRT1 extends cellular lifespan
- Role of SIRT1 and Sirt6 Expression in the Pathophysiology of the rd10 Mouse Retinal Degeneration
- Alcohol consumption and Western style diet alter colonic SIRT1 gene expression during aging
- SIRT1 is expressed in prostatic adenocarcinomas and increases tumor cell invasion when overexpressed in DU145 cells
- SIRT1 Stabilizes PML promoting its Sumoylation
- Transcription Regulator SIRT1 Protects Choroidal Endothelial Cells from Oxidative Stress
- Effects of resveratrol on cardiomyocyte apoptosis induced by anoxia and the expression of SIRT1
- Modulation of Angiogenesis and Postnatal Vascular Growth by the NAD-Dependent Histone Deacetylase SIRT1
- SIRT1 Activation Restores Cardioprotection in the Aged Heart Against Ischemia/Reperfusion Injury
- PPARalpha-SIRT1 Complex Downregulates Mitochondrial Gene Expression Through Suppression of the ERR Response Element in the Heart Under Pressure …
- Selenoprotein S Suppression Enhances the Late Stage Differentiation of Proerythrocytes Via SIRT1
- The Longevity Factor SIRT1 Exacerbates LV Dysfunction and Energy Depletion in Response to Pressure Overload
- SIRT1 represses MMP13 expression in human articular chondrocytes.
- The role of TNFα in circadian rhythmic responses and regulation of metabolic regulator SIRT1 in liver
- Effects of CR on H2O2-induced stress injury and expression of SIRT1 in PC12 cells.
- Aging and vascular endothelial cell senescence: potential role of SIRT1 in development of inflammation and dysfunction
- Abstract P233: PPARα-SIRT1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
- NAD-Dependent Histone Deacetylase, SIRT1, Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells.
- Impaired Nucleocytoplasmic Shuttling of SIRT1 in the Senescent Heart in Response to Ischemic Stress
- SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein
- SIRT1 ACTIVATES CELL PROLIFERATION ACTIVITY OF HUMAN INTERVERTEBRAL DISC BOTH IN LOW NUTRITIONAL AND CHEMICAL HYPOXIC CONDITIONS …
- SIRT1 blocks apoptosis in human chondrocytes via activation of the IGF-1 Receptor/Akt pathway
- Uncoupling Insulin: SIRT1 boosts insulin release by blocking mitochondrial protein
- The Role of SIRT1 Activation of AMP-Activated Protein Kinase in the Effect of Polyphenols on Lipid Metabolism in HepG2 Cells Exposed to High Glucose.
- SIRT1 deficiency compromises mouse embryonic stem cell differentiation, and embryonic and adult hematopoiesis in the mouse
- Impaired Nucleocytoplasmic Shuttling and Activity of SIRT1 in Response to Ischemic Stress in the Senescent Heart
- Identification of novel mechanisms regulating the NAD+-dependent deacetylase SIRT1
- The SIRT1 activator resveratrol inhibits the mTOR-p70/S6K pathway
- GENETIC VARIANTS IN THE SIRT1 GENE MAY AFFECT DIABETES RISK IN INTERACTION WITH PRENATAL EXPOSURE TO FAMINE: 7E. 01
- p63 overexpression induces downregulation of SIRT1 and accelerated aging phenotypes in the mouse
- Oral SIRT1 Activators Are Neuroprotective for Retinal Ganglion Cells in Experimental Optic Neuritis
- Increased Nuclear Translocation of SIRT1 and MnSOD Up-regulation in Failing Hearts: A Novel Mechanism of the Cardiomyocyte Death Suppression
- AMPKα2 deletion leads to marked alterations in SIRT1 activity, CPT1 expression and basal FA muscle metabolism in high‐fat‐fed mice
- The protective effect of resveratrol on myocardial ischemia-reperfusion injury by SIRT1-p53 pathway in rats
- SIRT1 Activator 3 Potently Induces Apoptosis in Multiple Myeloma Cell Lines and in Primary Human Multiple Myeloma Cells.
- Construction and identification of eukaryotic plasmid expression vectors encoding the short hairpin RNA targeting human SIRT1
- Resveratrol and Other SIRT1 Activators Exert Similar Neuroprotective Effects in Experimental Optic Neuritis
- The NAD-dependent protein deacetylase SIRT1 regulates POMC transcription and ACTH synthesis
- Sirtuin histone deacetylases SIRT1 and SIRT2 as novel targets for the management of prostate cancer
- Interactions between SIRT1 and AP1 reveal a mechanistic insight into the growth promoting properties of alumina…
- The effect of resveratrol intervention on the expression of SIRT1 in the atrial tissues in pigs with chronic atrial fibrillation induced by right atrial tachypacing
- Effect of High Fat and High Energy Diet on Expression of SIRT1/FOXO1 in White Fat Tissue of Young Rats
- Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its
- The NAD-dependent protein deacetylase SIRT1 is present in the human anterior pituitary gland where it plays a role in GH transcription
- AMP-Activated Protein Kinase Activity Is Altered by Changes in Redox State in HepG2 Cells by a SIRT1-Dependent Mechanism.
- Identification of cofactor network, including SIRT1 and SRC-3, which converges on energy expenditure through PGC-1α
- SIRT1 Limits Endothelial Notch Signaling During Blood Vessel Growth Through NICD Deacetylation
- Effects of SIRT1 inhibition by lentivirus-mediated shRNA vector on apoptosis of porcine preadipocytes.
- A targeted knockdown of sirtuin histone deacetylase SIRT1 imparts significant growth inhibitory effects in human prostate cancer cells.
- SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity Swami R. Narala, Richard C. Allsopp† …
- SIRT1 activator SRT1720 promotes tumor cell migration and lung metastasis in mouse models of breast cancer
- The role of NAMPT/SIRT1/FOXO3a pathway for the leukemic transformation in severe congenital neutropenia (CN) patients.
- p22phox-Based Nox4 Regulates Cellular Survival by Modulating FOXO3A Activity and SIRT1 Expression
- Expression of senescence-associated miR-34c and SIRT1 in premature senescence of human skin fibroblasts induced by ultraviolet B
- Regulatory Role of Resveratrol on SIRT1-mediated Metabolic Syndrome and Significance of SIRT Family Proteins for Prevention and Treatment of Metabolic …
- Role of the SIRT1 Deacetylase in Survival and Imatinib Resistance of CML CD34+ Progenitors.
- Activation of the Longevity Factor, SIRT1 Deacetylase Blocks the Phenylephrine-induced Cardiomyocyte Hypertrophy
- Effects of SIRT1 Hyper-expression Induced by Calorie Restriction on Life Span of β Cells and Insulin Secretion
- Atorvastatin Affects Expression of SIRT1 via Microrna-34a in Circulating Their Progenitor Cells Get Pirated From be with Coronary Artery Disease
- SIRT1 Mediated Deacetylation of Foxo1 Is Involved in Starvation Induced Autophagy in the Heart
- Signal-Responsive Repression of Notch1 Signaling by the SIRT1 Deacetylase Regulates Sprouting Angiogenesis
- Dual role of SIRT1 as a regulator of retinal development and a therapeutic target in age-related macular degeneration
- SIRT1 signalling promotes lipopolysaccharide-induced TNF-a expression in cardiomyocytes
- Endothelial Biology/Homeostasis: The Roles of AMPK and SIRT1 in eNOS Phosphorylation and Deacetylation
- Erratum to “SIRT1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol”[Exp. Mol. Path. 85 (2008) 155–159]
- Fetal Hepatic SIRT1, a Histone H3 Deacetylase, Is Decreased in a Nonhuman Primate Model of Maternal Obesity.
- Treatment with a SIRT1 Activator Resveratrol Prevents Cardiomyopathy in Dystrophin-Deficient Mice
- Cisplatin induces SIRT1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
- Activation of SIRT1, a Longevity Gene, Prevents the Development of Diabetic Vasculopathy by Inhibiting Endothelial Senescence
- Expression and function of SIRT1, Sirt4, and glutamate dehydrogenase 1 within the central nervous system
- Nicotinamide Phosphoribosyltransferase (Nampt) Induces NAD+ / SIRT1 Mediated Deacetylation of p53 in Myeloid Cells.
- Activation of a Protein Deacetylase, SIRT1, by Resveratrol Suppresses Progression of Heart Failure and Improves Survival by Up-Regulation of Mn-SOD
- Melatonin, a novel SIRT1 inhibitor, imparts anti-proliferative effects against PCa in vitro in cell culture and in vivo in transgenic adenocarcinoma of mouse prostate …
- SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγgamma Activity through Deacetylation of Specific Lysine Residues in Mammals
- Enhanced cell viability and decreased expression of a senescence marker exhibited in SIRT1-induced human skin cells Claude dal Farra, PhD, Vincience, Sophia …
- Nicotinamide Phosphoribosyltransferase (Nampt) Induces NAD+/SIRT1 Mediated Deacetylation of FOXO3a in Myeloid Cells.
- Activation of a Class-III Histone Deacetylase, SIRT1, Prevents the Oxidative-stress Mediated Cell-death by Suppressing the Activity of Poly (ADP) Ribose Polymerase …
- Long-Term Treatment with the SIRT1 Activator Resveratrol Ameliorates Cardiomyopathy in Dystrophin-Deficient Mice
- Control of Notch Signaling by Reversible Acetylation Through the Antagonistic Activities of p300/PCAF and SIRT1 in Endothelial Cells
- Activation of SIRT1 Suppresses Hypertrophic Response of Cardiomyocytes by Inhibition of H3K9 Acetylation via Proteasome-mediated p300 Degradation.
- Modulation of the longevity proteins FOXO3a and SIRT1 by chorionic gonadotropin prevents hepatocellular injury during acute liver inflammation
- Down‐regulation of MnSOD via SIRT1/FoxO3a complex increase oxidative stress with cardiac overexpression of Type 5 Adenylyl Cyclase
- Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph− Acute Lymphoblastic Leukemia Cells Alone and in …
- Increased SIRT1 following repetitive hypoxic preconditioning: A mechanism for mediating long-term tolerance (LTT) to focal stroke in adult mouse brain
- Apo-10′-lycopenoic acid increases both mRNA and protein levels of SIRT1 as well as decreasing the fat accumulation in the livers of ob/ob mice
- Hepatitis B virus X (HBX) Protein Inhibits the Expression of SIRT1 Deacetylase, Leading to Up-regulation of Survivin for the Survival of Hepatocellular Carcinoma Cells
- Nicotinamide activates the p53/miR-34a/SIRT1 tumor suppressor network leading to apoptosis of chronic lymphocytic leukemia cells
- Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation
- Resveratrol Induces Cell Growth Arrest and Cell Death of Adult T-Cell Leukemia Cells Via Deacetylation of STAT3 by SIRT1
- … protein kinase α1 silencing provides evidence for a Metformin‐induced decrease in FA uptake and oxidation and increase in glucose uptake and SIRT1 activity in L6 …
- Endothelial Cell Polyploidization Induces an Atherogenic Phenotype and is Prevented by Activating the Nampt-SIRT1 Axis
- 441 INTRAUTERINE GROWTH RETARDATION MODULATES SIRT1 DEACETYLASE, FOXO3 TRANSCRIPTION FACTOR, AND SUPEROXIDE DISMUTASE 2 …
- Acetyltransfer in gene regulation: Structural and biochemical studies of human SIRT1 deacetylase, its FoxO1 substrate, and archaeal PAT acetyltransferase
- Nicotinamide Promotes Apoptosis In Chronic Lymphocytic Leukemia through Activation of the p53/Mir-34a/SIRT1 Tumor Suppressor Network
- Cardiac protective effects of resveratrol and SIRT1 in old rat with emphysema induced by cigarette smoke-expose and lipopolysaccharide instillation: attenuation of …
- Abstract# 183: SIRT1 contributes to tumorigenicity and radioresistance in glioblastoma CD133+ cells
- SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
- SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via …
- Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007)
- 875 RESVERATROL, A POLYPHENOLIC SIRT1 ACTIVATOR, IMPROVES ERECTILE FUNCTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS
- TR-FRET Assay for Sirtuin 1 (SIRT1) Inhibitor Screening
- Co-Upregulation of Peroxisome Proliferator-Activated Receptor-Alpha (PPARalpha) and Silent Information Regulator 1 (SIRT1) Negatively Regulates Cardiac Function …
- Sirtuin 1 (SIRT1) regulates the HSF1-dependent pro-survival mechanism in neurons
- Interplay Between Hypoxia-inducible Factor 1 [alpha] and SIRT1 Protein Deacetylase in Hypoxic Cancer Cells
- 57: Histone deacetylase SIRT1 alterations parallel fetal epigenetic and metabolic reprogramming in response to a maternal high fat (MHF) diet
- Abstract# 3569: Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates\# 946;-Catenin signaling and NF\# 954; B-specific transcription activity leading …
- 032 A REDUCTION IN SIRT1 LEVELS IN OA ARTICULAR CARTILAGE IS ASSOCIATED WITH AN INCREASE IN PTP1B, MMP13 AND CHONDROCYTE APOPTOSIS
- Regulation of the transcription factor GATA-3 within T cells-Involvement of SIRT1, a class III histone deacetylase
- Activation of the AKT Pathway Mediates Upregulation of Hif-1α and SIRT1 via Downregulation of miR-199a and is Neutralized by Beta-adrenergic Stimulation
- Abstract LB-427: Differential effects of resveratrol-induced SIRT1 in prostate cancer: A novel therapeutic target
- Influence of AP endonuclease 1 deacetylation by protein deacetylase SIRT1 on DNA base excision repair
- Microrna-195 Promotes Apoptosis in Cardiomyocytes by Down-Regulating SIRT1
- Influence of Ethnicity in Association of UCP2‐866G/A, PGC1α (Gly 482 Ser) and SIRT1‐1400T/C Polymorphisms in North Indian Punjabi Population Groups
- Abstract LB-185: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1 and polycomb members to promoter CpG islands
- SIRT1 and energy metabolism
- The roles of SIRT1 in cancer
- The ways and means that fine tune SIRT1 activity
- MicroRNA regulation of SIRT1
- Negative regulation of inflammation by SIRT1
- SIRT1 in type 2 diabetes: mechanisms and therapeutic potential
- Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets
- Evidence for a common mechanism of SIRT1 regulation by allosteric activators
- Crosstalk between oxidative stress and SIRT1: impact on the aging process
- The role of SIRT1 in ocular aging
- Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress
- Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
- SIRT1: new avenues of discovery for disorders of oxidative stress
- SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
- SIRT1, metabolism and cancer
- Identification of a SIRT1 mutation in a family with type 1 diabetes
- Regulation of SIRT1 by microRNAs
- Targeting cardiovascular disease with novel SIRT1 pathways
- SIRT1 and SIRT2: emerging targets in neurodegeneration
- Janus-faced role of SIRT1 in tumorigenesis
- SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
- Redox regulation of SIRT1 in inflammation and cellular senescence
- SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
- Stress inducibility of SIRT1 and its role in cytoprotection and cancer
- Regulation of SIRT1 activity by genotoxic stress
- Emerging roles of SIRT1 in cancer drug resistance
- Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets
- SIRT1 is required for long-term growth of human mesenchymal stem cells
- Towards elucidating the role of SIRT1 in osteoarthritis.
- Roles of SIRT1 in leukemogenesis
- SIRT1: regulator of p53 deacetylation
- The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
- Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
- SIRT1 in metabolic syndrome: where to target matters
- SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
- Brown remodeling of white adipose tissue by SIRT1-dependent deacetylation of Pparγ
- Brain activation of SIRT1: role in neuropathology
- SIRT1 activation by resveratrol is substrate sequence-selective
- Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways
- High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction
- The effects of SIRT1 on Alzheimer’s disease models
- SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis
- Deacetylation by SIRT1 reprograms inflammation and cancer
- The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
- Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo
- SIRT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex
- SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
- SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis
- Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
- SIRT1 protects against α-synuclein aggregation by activating molecular chaperones
- MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
- Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
- SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
- SIRT1 expression is associated with good prognosis in colorectal cancer
- Metabolic actions of hypothalamic SIRT1
- SIRT1 regulates dendritic development in hippocampal neurons
- SIRT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain
- SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60
- Peripheral blood monocyte SIRT1 expression is reduced in patients with coronary artery disease
- Dilated cardiomyopathy and mitochondrial dysfunction in SIRT1-deficient mice: a role for SIRT1-Mef2 in adult heart
- Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions
- Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
- The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
- SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
- SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
- SIRT1-deficient mice exhibit an altered cartilage phenotype
- SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity
- SIRT1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
- Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
- SIRT1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
- SIRT1 contains N-and C-terminal regions that potentiate deacetylase activity
- Anti-aging molecule, SIRT1: a novel therapeutic target for diabetic nephropathy
- Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex
- Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
- Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
- Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
- SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
- SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
- SIRT1 regulation modulates stroke outcome
- Renal tubular SIRT1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
- The role of SIRT1 in muscle mitochondrial turnover
- Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction
- A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis
- Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
- SIRT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
- SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
- SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
- Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
- SIRT1: Def-eating senescence?
- SIRT1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3
- Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium
- SIRT1-an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis
- SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas
- Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation
- Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SIRT1 mice
- USP22 antagonizes p53 transcriptional activation by deubiquitinating SIRT1 to suppress cell apoptosis and is required for mouse embryonic development
- New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity
- A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
- A maternal high‐fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
- SIRT1 is a highly networked protein that mediates the adaptation to chronic physiological stress
- SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
- SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
- Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
- SIRT1 signaling as potential modulator of skeletal muscle diseases
- Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
- Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
- SIRT1 Polymorphism, Long-Term Survival and Glucose Tolerance in the General Population
- SIRT1 enhances matrix metalloproteinase‐2 expression and tumor cell invasion in prostate cancer cells
- A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers
- SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging
- High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
- SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines
- SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions
- Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation
- SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
- AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
- SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-κB/Cyclin D1 signaling
- Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
- SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
- SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells
- Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
- SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth
- Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
- SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC
- The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
- A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
- Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
- SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
- Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action
- SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
- Neuronal SIRT1 deficiency increases insulin sensitivity in both brain and peripheral tissues
- Genetic analysis of the SIRT1 gene promoter in myocardial infarction
- miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
- Genetic analysis of SIRT1 gene promoter in sporadic Parkinson’s disease
- SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
- Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas
- SIRT1 regulates endothelial Notch signaling in lung cancer
- SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway
- Autophagy induced by the class III histone deacetylase SIRT1 prevents prion peptide neurotoxicity
- Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway
- Extranuclear localization of SIRT1 and PGC-1α: an insight into possible roles in diseases associated with mitochondrial dysfunction
- Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of SIRT1
- PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells
- Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
- Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation
- High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells
- Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways
- Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
- SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
- Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of SIRT1
- Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
- SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity
- SIRT1 regulates cd40 expression induced by tnf-α via nf-ĸb pathway in endothelial cells
- Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
- Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction
- Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4,PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver
- Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and …
- SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice
- The loss of SIRT1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing
- Resveratrol‐mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
- Cross-talk between SIRT1 and p66Shc in vascular diseases
- Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
- SIRT1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
- SIRT1 promotes RGC survival and delays loss of function following optic nerve crush
- SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
- Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
- SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients
- Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
- Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle
- Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
- NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
- Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
- Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway
- SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway
- Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
- Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a SIRT1-dependent manner
- Resveratrol activates SIRT1 in a Lamin A-dependent manner
- SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human …
- SIRT1 gene polymorphisms are associated with growth traits in Nanyang cattle
- Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer
- Identification of a small molecule activator of SIRT1 gene expression
- SIRT1, p66Shc, and Set7/9 in vascular hyperglycemic memory: bringing all the strands together
- Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high‐fat‐diet feeding
- BCL6 controls neurogenesis through SIRT1-dependent epigenetic repression of selective Notch targets
- SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
- SIRT1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenanceSIRT1 in adult stem cell homeostasis
- Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine
- Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal SIRT1
- Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway
- Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
- SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase …
- Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation
- PPARα and SIRT1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders
- Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells
- Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
- SIRT1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis
- Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance
- SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein
- SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
- Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects
- Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes
- Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle
- The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1
- Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase
- Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway
- Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate
- Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1
- CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1
- Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear …
- SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells
- Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis
- A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
- SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression
- Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating SIRT1
- Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
- Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1
- SIRT1 regulates adaptive response of the growth hormone–insulin-like growth factor-I axis under fasting conditions in liver
- Regulation of SIRT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability
- SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration
- mIGF‐1/JNK1/SIRT1 signaling confers protection against oxidative stress in the heart
- Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression
- Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence
- DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
- Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein*[S]
- TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes
- A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
- SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence
- The role of SIRT1 on angiogenic and odontogenic potential in human dental pulp cells
- SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway
- Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1
- The Interactive Effect of SIRT1 Promoter Region Polymorphism on Type 2 Diabetes Susceptibility in the North Indian Population
- Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
- Terpenylated Coumarins As SIRT1 Activators Isolated from Ailanthus altissima
- Resveratrol induces SIRT1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
- The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent
- Fortifying the link between SIRT1, resveratrol, and mitochondrial function
- SIRT1 prevents atherosclerosis via liver‑X‑receptor and NF‑κB signaling in a U937 cell model
- Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice
- Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice
- Association of SIRT1 expression with shear stress induced endothelial progenitor cell differentiation
- The involvement of SIRT1 and transcription factor NF-κB (p50/p65) in regulation of porcine ovarian cell function
- Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC+/min Mouse Model
- The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response
- Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3, 2′-quinazolines
- Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
- SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β …
- SIRT1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure
- A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes
- Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis
- SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1
- … protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1
- Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in …
- Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1–AMPK signaling pathway
- SIRT1 as a novel potential treatment target for vascular aging and age-related vascular diseases
- 17‐β Oestradiol prevents cardiovascular dysfunction in post‐menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation
- SIRT1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway
- Nicotinamide‑mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis
- SIRT1 attenuates diabetic albuminuria
- Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice
- … in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 …
- Overexpression of SIRT1 Promotes High Glucose–Attenuated Corneal Epithelial Wound Healing via p53 Regulation of the IGFBP3/IGF-1R/AKT Pathway
- Pharmacological activation of SIRT1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy
- Suppression of ERR targets by a PPARα/SIRT1 complex in the failing heart
- SIRT1 represses estrogen-signaling, ligand-independent ERα-mediated transcription, and cell proliferation in estrogen-responsive breast cells
- SIRT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions
- Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway
- SIRT1-mediated FoxO1 deacetylation is essential for multidrug resistance-associated protein 2 expression in tamoxifen-resistant breast cancer cells
- Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation
- SIRT1 regulates the human alveolar epithelial A549 cell apoptosis induced by Pseudomonas aeruginosa lipopolysaccharide
- Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1
- The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
- Effects of SIRT1 on DNA methylation and expression of genes affected by dietary restriction
- SIRT1 inhibits akt2-mediated porcine adipogenesis potentially by direct protein-protein interaction
- The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel …
- When is SIRT1 activity bad for dying neurons?
- Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
- Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair
- IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARδ, SIRT1, PGC-1α, and PGC-1β expression in male mice
- Identification and characterization of novel indole based small molecules as anticancer agents through SIRT1 inhibition
- Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SIRT1 axis
- Enantioselective Synthesis of Cyclohepta[b]indoles: Gram-Scale Synthesis of (S)-SIRT1-Inhibitor IV
- Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1
- Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway
- Rejuvenating SIRT1 activators
- Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: a pilot study
- Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase
- Metabolic energy sensors (AMPK and SIRT1), protein carbonylation and cardiac failure as biomarkers of thermal stress in an intertidal limpet: linking energetic …
- The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats
- c-MYC and SIRT1 locked in a vicious cycle
- SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats
- The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells
- Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation
- SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation
- SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells
- SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue
- Involvement of SIRT1 in hypoxic down-regulation of c-Myc and β-catenin and hypoxic preconditioning effect of polyphenols
- WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1
- The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes
- Carvacrol protects against hepatic steatosis in mice fed a high-fat diet by enhancing SIRT1-AMPK signaling
- SIRT1 Regulation—It Ain’t All NAD
- β-Cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
- Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by SIRT1 Protein-mediated Deacetylation♦
- Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
- Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice
- Expression of SIRT1 and DBC1 in developing and adult retinas
- Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats
- Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1
- Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients
- Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins
- Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways
- SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling
- Expression of SIRT1 in choroidal neovascular membranes
- Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro
- Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro
- Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late …
- Activation of SIRT1 by resveratrol requires lamin A
- Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells
- Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi
- MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
- SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κ B/STAT3 complex to its promoter in …
- PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1
- Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?
- Anti-correlation between longevity gene SIRT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease
- MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS
- Exendin-4 improves steatohepatitis by increasing SIRT1 expression in high-fat diet-induced obese C57BL/6J mice
- DBC1 does not function as a negative regulator of SIRT1 in liver cancer
- SIRT1–Claudin-1 crosstalk regulates renal function
- Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma
- PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway
- SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: implications for cell survival after irradiation
- Molecular architecture of the human protein deacetylase SIRT1 and its regulation by AROS and resveratrol
- Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic …
- Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
- SIRT1 inhibits the mouse intestinal motility and epithelial proliferation
- … and anti‐inflammatory effects of melatonin in hydrogen peroxide‐stimulated CHON‐001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 …
- Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis
- Vitamin D protects human endothelial cells from H 2 O 2 oxidant injury through the Mek/Erk-SIRT1 axis activation
- The identification of the SIRT1 activator SRT2104 as a clinical candidate
- The brain: A new organ for the metabolic actions of SIRT1
- SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells
- SIRT1 and the clock gene machinery in colorectal cancer
- Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer
- Molecular dissection of the interaction between HIC1 and SIRT1
- Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation
- Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats
- … Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 …
- Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor …
- Expression of SIRT1 in ocular surface squamous neoplasia
- SIRT1 inhibits resistin expression in aortic stenosis
- Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
- Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise
- Modeling miRNA regulation in cancer signaling systems: miR-34a regulation of the p53/SIRT1 signaling module
- Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/SIRT1 signaling in mice
- Insulin signal meets SIRT1 at Akt
- SIRT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells
- hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SIRT1
- #VALUE!
- Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats
- Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
- SIRT1, p53, and p38MAPK Are Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells with Max Expression Ablation
- Androgen depletion in humans leads to cavernous tissue reorganization and upregulation of SIRT1–eNOS axis
- The time-dependent autophagy protects against apoptosis with possible involvement of SIRT1 protein in multiple myeloma under nutrient depletion
- Activation of AMPK–SIRT1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects
- SIRT1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes
- Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism
- SIRT1 mediates the protective function of Nkx2. 5 during stress in cardiomyocytes
- Metabolic stress modulates Alzheimer’s β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
- MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
- Pentamethylquercetin reduces fat deposition via SIRT1-mediated pathways in male obese mice induced by a high fat diet
- The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a SIRT1‐dependent mechanism in mice
- Late-onset running biphasically improves redox balance, energy-and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus
- The expression of SIRT1 and DBC1 in laryngeal and hypopharyngeal carcinomas
- An autoregulatory loop reverts the mechanosensitive SIRT1 induction by EGR1 in skeletal muscle cells
- SIRT1 attenuates neointima formation by inhibiting HIF-1α expression in neointimal lesion of a murine wire-injured femoral artery
- MiR-34a is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation through the SIRT1/NFκB pathway
- Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study
- SIRT1 deacetylates SATB1 to facilitate MAR HS2 -MAR ε interaction and promote ε-globin expression
- Diet-induced obesity promotes murine gastric cancer growth through a nampt/SIRT1/c-myc positive feedback loop
- MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
- Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1 …
- SIRT1 exerts anti-inflammatory effects and promotes steroidogenesis in Leydig cells
- The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of SIRT1 in hepatocellular carcinoma
- SIRT1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells
- SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis
- The mitochondrial SIRT1–PGC-1α axis in podocyte injury
- SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for …
- Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of SIRT1 and AMPK in rats
- SIRT1 and Connexin40 Mediate the normal shear stress-induced inhibition of the proliferation of endothelial cells co-cultured with vascular smooth muscle cells
- Growth inhibition and apoptosis-inducing effects of cudraflavone B in human oral cancer cells via MAPK, NF-κB, and SIRT1 signaling pathway
- Synergistic actions of insulin-sensitive and SIRT1-mediated pathways in the differentiation of mouse embryonic stem cells to osteoblast
- α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
- Investigation of silent information regulator 1 (SIRT1) agonists from Traditional Chinese Medicine
- Involvement of SIRT1–AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet
- MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1
- Genetic analysis of the SIRT1 gene promoter in ventricular septal defects
- Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1
- SIRT1 activators: the evidence STACks up
- Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta
- miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in …
- Omentin-1, a new adipokine, promotes apoptosis through regulating SIRT1-dependent p53 deacetylation in hepatocellular carcinoma cells
- SIRT1 expression and activity are up-regulated in the brain tissue of epileptic patients and rat models
- The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels …
- Active regulator of SIRT1 is required for ribosome biogenesis and function
- Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells
- … -associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells
- Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes
- Sirt7 promotes adipogenesis by binding to and inhibiting SIRT1
- Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells
- Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells
- Angiogenic Dysfunction in Bone Marrow‐Derived Early Outgrowth Cells from Diabetic Animals Is Attenuated by SIRT1 Activation
- Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced …
- SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer
- Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression
- MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
- Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation
- Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells
- Identification of benzofuran-3-yl (phenyl) methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action
- Bisdemethoxycurcumin increases SIRT1 to antagonize t-BHP-induced premature senescence in WI38 fibroblast cells
- Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1
- Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau
- Effect of breed on the expression of Sirtuins (SIRT1-7) and antioxidant capacity in porcine brain
- Ginkgolide B reduces LOX-1 expression by inhibiting Akt phosphorylation and increasing SIRT1 expression in oxidized LDL-stimulated human umbilical vein …
- Lentivirus-mediated SIRT1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway
- Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells
- Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver
- Functional Complementation of sir2Δ Yeast Mutation by the Human Orthologous Gene SIRT1
- Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
- Fragmentation studies of SIRT1‐activating drugs and their detection in human plasma for doping control purposes
- Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation
- Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and …
- Inverse Regulation of the Cytosolic Ca2+ Buffer Parvalbumin and Mitochondrial Volume in Muscle Cells via SIRT1/PGC-1α Axis
- SIRT1 suppresses cellular accumulation of β-TrCP E3 ligase via protein degradation
- Novel SIRT1 mutation linked to autoimmune diabetes in humans
- Upregulation of SIRT1 in carbon-tetrachloride–induced acute liver injury
- Hypothalamic SIRT1 and regulation of food intake
- Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice
- Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene
- MicroRNA-217 promotes angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A
- Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer
- Methods to investigate the role of SIRT1 in endothelial senescence
- Electroconvulsive shock increases SIRT1 immunoreactivity in the mouse hippocampus and hypothalamus
- SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett’s esophagus
- Resveratrol-poor red wines modulate SIRT1 in human renal cells
- SRT1720, a SIRT1 activator, aggravates bleomycin-induced lung injury in mice
- Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is SIRT1-independent
- Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS
- SILAC-based quantification of SIRT1-responsive lysine acetylome
- MicroRNAs in the growth plate are responsive to nutritional cues: association between miR-140 and SIRT1
- Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells
- Dissecting the Roles of the N‐and C‐Flanking Residues of Acetyllysine Substrates for SIRT1 Activity
- RETRACTED ARTICLE: MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting SIRT1
- Accelerating cancer evolution: a dark side of SIRT1 in genome maintenance
- Commentaries on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments …
- MicroRNA-142 reduces monoamine oxidase A expression and activity in neuronal cells by downregulating SIRT1
- Nephroprotective action of sirtuin 1 (SIRT1)
- Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation
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- Measles virus nucleocapsid protein, a key contributor to Paget’s disease, increases IL-6 expression via down-regulation of FoxO3/SIRT1 signaling
- Mechanism of temozolomide-induced anti-tumor effects on glioblastoma cells in vitro is via ROS-dependent SIRT1 signaling pathway
- GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (SIRT1)
- Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes
- Relative quantitative comparison between lipotoxicity and glucotoxicity affecting the PARP-NAD-SIRT1 pathway in hepatocytes
- Metformin, metabolic stress, and mitochondria. Focus on “A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein …
- Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
- Deacetylase SIRT1 and vascular endothelial function
- PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1
- Involvement of SIRT1 in Zn2+, streptozotocin, non-obese diabetic, and cytokine-mediated toxicities of β-cells
- Cloning expression and purification of human truncated SIRT1
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- SIRT1 inhibits p53 but not NF-κB transcriptional activity during differentiation of mouse embryonic stem cells into embryoid bodies
- Yet another role for SIRT1: reduction of α-synuclein aggregation in stressed neurons
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- Last Word on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?
- SIRT1 and anxiety
- A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation
- Resveratrol stimulates extracellular matrix synthesis in degenerative nucleus pulposus cells via upregulation of SIRT1
- SIRT1 suppresses activating transcription factor 4 (ATF4) expression in response to proteasome inhibition
- Incretin-stimulated interaction between β-cell Kv1. 5 and Kvβ2 channel proteins involves acetylation/deacetylation by CBP/SIRT1
- Discovery and Characterization of Protein‐Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors
- SIRT1 negatively regulates the protein stability of HIPK2
- Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo
- Expression and significance of SIRT1 and survivin in endometrial carcinoma
- Effects of exercise training duration on SIRT1 and eNOS expression in rat aortas
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- SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model
- Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver
- miR-520c and miR-373 target mTOR and SIRT1, activate the Ras/Raf/MEK/Erk pathway and NF-κB, with up-regulation of MMP9 in human fibrosarcoma cells
- The modulation of SIRT1 expression by different types of high fat state in hepatocytes
- AMPK-SIRT1-PGC-1α signaling regulates mitochondrial function in human articular chondrocytes
- Role of SIRT1 in Resistance Exercise‐Induced Changes in Vascular Function
- SIRT1 knockout impairs the differentiation of adipocyte in C57BL/6J mice and its underlying mechanism
- Research progress of SIRT1 and osteoporosis
- Implications of a novel point mutation of SIRT1 in T1DM
- The role of SIRT1 in the activation of innate immune responses during RSV infection (68.6)
- Expressions and clinical significance of SIRT1, P53 and P-gp in gastric carcinoma.
- SIRT1 Activators in Development
- SIRT1‐independent epigenetic effects of resveratrol mediated through the estrogen receptor
- Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis …
- Is a deceptive role of IGF-1 in SIRT1–PARP1 interactions the primary step of postnatal regression of hypertrophic cardiomyopathy in infants of diabetic mothers?
- Role of SIRT1/UCP2 signaling pathway in resveratrol-induced inhibition of oxidative injury in vascular endothelial cells
- Reproductive effects of SIRT1 expression in astrocytes
- Abstract P2-06-02: Pparg deacetylation by SIRT1 determines breast tumor lipid synthesis and growth
- Mammalian target of rapamycin (mTOR) sigaling pathway involved in the inhibition of silence information regulator1 (SIRT1) on fat deposition of mice.
- Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of MnSOD via the SIRT1/FoxO3a pathway
- Mutual inhibition between miR-34a and SIRT1 contributes to regulation of DNA double-strand break repair
- Importance of NAMPT-mediated NAD-biosynthesis and NAD-dependent deacetylase SIRT1 in the crosstalk between circadian rhythm and metabolism
- Electrochemical Immunosensor Based on AuNPs/PDDA-GO for Detection of SIRT1
- Expression of SIRT1 and P55PIK in Gastric Cancer and Clinical Significance
- SIRT1 deacetylase is essential for hematopoietic stem cell activity
- Metformin modulates hyperglycemia‐induced endothelial dysfunction through SIRT1
- PPARalpha/SIRT1 Complex is Involved in the Deterioration of Fatty Acid Metabolism During the Pathological Development of Heart Failure
- SIRT1 protects cortical neurons from shear stress induced mechanical injury
- GSPE enhance eNOS expression through AMPK/SIRT1–KLF2 pathway and modulate blood pressure in ouabain induced hypertensive rats
- Inhibition of SIRT1 Transcription in Resveratrol-differentiated Medulloblastoma Cells
- Construction of recombinant lentiviral vector of shRNA targeting SIRT1 gene and its effects on the proliferation of breast cancer cell
- SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3.
- The role of melatonin in SIRT1 and p-AMPK regulation in HT-29 cell line
- Inhibition studies of SIRT1
- Leucine modulation of AMPK and mitochondrial biogenesis in C2C12 myotubes is SIRT1 dependent
- Relationship between SIRT1 expression in atrial tissue and atrial fibrosis in patients with atrial fibrillation
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- Research on the Morphological Changes of Ischemic Cell Mediated via SIRT1 Pathway in the Intervention with Xuefu Zhuyu Capsules
- Conjugated linoleic acid (CLA) activates PGC‐1alpha via AMPK and SIRT1 in C2C12 myotubes
- Hepatic deletion of SIRT1 decreases HNF1α/FXR signaling and induces formation of cholesterol gallstones in mice
- Caloric restriction ameliorates myocardial ischemia/reperfusion injury by suppressing complement activation in a SIRT1-dependent manner
- Research on Effect of SIRT1 on Ameliorating Lipid Metabolism Disorder of Type 2 Diabetic Rats after Exercise and Oral Resveratrol [J]
- Ezetimibe Inhibit Hyperacetylation of SREBP-1c in Lipid-Loaded Cells Derived from VSMC Required for SIRT1 [J]
- Tafluprost Protects Human Trabecular Meshwork Cells From Oxidative Stress Through The Activation Of C-myc/SIRT1 Transcription Pathway
- The Role of SIRT1 in Central Nervous System
- Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI …
- Adiponectin induces autophagic cell death in breast cancer cells through SIRT1 mediated deacetylation of LKB1 leading to ATG1 activation.
- Effects of SIRT1 on material metabolism and influence factors
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- Abstract A37: Beta-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J …
- THU0033 SET7/9 and SIRT1 induce promoter-driven collagen 2ALPHA1 expression in 3D cultured human chodrocytes
- SIRT1 limits the function and fate of myeloid-derived suppressor cells in
- SIRT1 as a Potential Therapeutic Target in Breast Cancer
- Research progress of SIRT1 in suppressing inflammatory response.
- Activation of SIRT1 by an N-terminal Regulatory Domain
- Examination of the reproductive effects of SIRT1 expression in neurons
- The deacetylase SIRT1 is down-regulated in gastric cancer and leads to G1 phase
- Role of SIRT1 in inflammation-associated carcinogenesis
- SIRT1: A novel target for treatment in cardiovascular diseases
- Roles of SIRT1 in tumorigenesis and tumor progression
- Expression of SIRT1 in tissues of patients with gastric carcinoma
- GW24-e2135 SIRT1 significantly influences Old sourced MSCs aging and proliferation
- Deciphering the role of 75kDa SIRT1 fragment in osteoarthritis
- The Role of SIRT1 in Preventing Mitochondrial Dysfunction with Obesity and Aging
- Research advances in SIRT1 regulating microRNA
- SIRT1-mediated suppression of cell death in breast cancer.
- Co-location of SIRT1 and IR in the adult mouse brain
- SIRT1 against breast cancer through downregulating Bcl-2 protein.
- Unravelling New Roles for SIRT1 in Mitochondrial Biollogy
- GW24-e3662 The comparative study on expression of SIRT1 signal transduction by Xuefuzhuyu capsule
- Functional complementation of sir2Δ yeast mutation by the human orthologous gene SIRT1
- THE LIPID SECOND MESSENGER PHOSPHATIDYLINOSITOL-5-PHOSPHATE STIMULATES SIRT1 DEACETYLASE ACTIVITY
- Isolation and Characterization of New Sirtuin1 (SIRT1) Activators from Medicinal Plants
- SIRT1 Inactivation Reduces Tumor Growth in Colon Cancer Model
- Role of adipose SIRT1 in regulating systemic energy metabolism
- Constitutive SIRT1 overexpression impairs mitochondria and
- Influence of Mailuoning on SIRT1 expression of brain tissue in Alzheimer′ s disease rat model
- The impact of SIRT1 inhibition on zebrafish morphology and behavior
- Recent Advances of Deacetylase SIRT1 on Apoptosis Regulation
- FLT3-ITD+ AML Stem/Progenitor Cells Demonstrate Increased SIRT1 Expression and Enhanced Sensitivity to SIRT1 Inhibition
- Supression of SIRT1 in angiogenesis of endothelial cells induced by HCMV infection
- Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
- PPARdelta-SIRT1 Interaction Protects Endothelial Function in Diabetic Mice
- The neuroprotective effects of SIRT1 on NMDA-induced excitotoxicity
- Red Wine Molecule Makes a Comeback to Activate SIRT1
- Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus
- SIRT1 Mediated Mitochondrial Biogenesis for The Protection of RGC-5 Cell During Oxidative Stress
- Leptin-induced SIRT1 expression: a potential linker between obesity and cancer
- Role of SIRT1 in regulation of hepatic gene expression by thyroid hormone
- The Role Of SIRT1 In The Pathogenesis Of Dry Age-related Macular Degeneration
- The Effects of SIRT1 SiRNA on the Bloodfat and Actived Platelets in Insulin Resistance Mice
- SIRT1 enhances Th17 cell generation by deacetylating RORγt (P1163)
- Expression of SIRT1 and p27 during progression of human cervical cancer
- Transgenic Mice Lacking SIRT1 or SIRT1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia
- SIRT1 enhances endothelium‐dependent relaxation through an eNOS‐independent mechanism
- Original article SIRT1-deficient mice exhibit an altered cartilage phenotype
- Immunomodulation and Mechanism of Protein Deacetylase SIRT1
- Screening of SIRT1 activating compounds and their cytotoxicity in prostate cancer cell lines.
- PPARa Activation Inhibits Inflammatory Response in Endothelial Cells via the SIRT1-dependent Signaling Pathway
- Contrasting Effects of Enhanced SIRT1 Activity in Normal and BCR-ABL1-Depedent Haematopoiesis
- Regularity analysis of deacetylase SIRT1 expression in different pig organs and tissues
- Keratinocyte-specific deletion in mice reveals gene dose-dependent function of SIRT1 in tumorigenesis.
- Variant analysis of the Sirtuin [SIRT1] gene in multiple sclerosis
- AMPK-SIRT1 axis: a potential therapeutic target for prostate cancer management.
- Cloning and prokaryotic expression of SIRT1 gene from torafugu Takifugu rubripes
- SIRT1 silencing confers neuroprotection through IGF-1 pathway activation
- Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF
- Interactions of SIRT1 with Acetyl Substrate, NAD+ or Nicotinamide
- Adipocyte-selective disruption of SIRT1 accelerates high fat diet
- Does resveratrol act independently of SIRT1 to affect genes relevant to ageing?
- Preliminary research of the relationship between coronary artery atherosclerosis and the genetic expression of AMPK and SIRT1
- MicroRNA-29c functions as a tumor suppressor by direct targeting endogenous SIRT1 in hepatocarcinogenesis
- SIRT1 Delays RGC Loss Following Optic Nerve Crush By Reducing Oxidative Stress
- SIRT1 links tumor suppressive NOTCH signaling to p53
- Mechanism of anti-proliferative effects of SIRT1 inhibition in melanoma cells: a proteomics approach.
- Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus
- INHIBITION OF SIRT1 INDUCES APOPTOSIS IN BREAST CANCER STEM CELLS; POSTER PRESENTATION
- The signal pathway of SIRT1 underlying the neuroprotection in NMDA-induced excitotoxicity
- The novel SIRT1 activator srt3025 provides atheroprotection through increased hepatic low-density lipoprotein receptor expression
- Regulation of Skeletal Muscle Insulin Action by SIRT1 and STAT3
- Impact of SIRT1 silencing on DNA damage repair and chemoradiotherapy resistance in human pancreatic cancer
- Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1ᴳ⁹³ᴬ transgenic mice as an in vivo model of amyotrophic …
- Amelioration of Age-Related Vascular Dysfunction with SIRT1 Activation
- Changes of PGC-1α and SIRT1 expression in hippocampus of type 2 diabetes mellitus rats and its significance
- Effects of Endurance Exercise on Hepatic SIRT1 and PGC-1α Protein Expression in Ovariectomized Rats
- Metformin regulates hyperglycemia-induced vascular senescence through SIRT1
- Anti-aging Effects of Simvastatin on ox-LDL Induced Endothelial Cells Via Upregulation of SIRT1
- Strategies of SIRT1 enhancement against frailty in aging and neurodegeneration
- CDK5-MEDIATED HYPERPHOSPHORYLATION CONTRIBUTES TO THE LOSS-OF-SIRT1 FUNCTION DURING THE DEVELOPMENT OF ENDOTHELIAL …
- FRI0036 Epigallocatechin gallate modulates SIRT1 expression in CPP crystal-induced inflammation
- SIRT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1a complex in vascular endothelial cells
- Evaluation of energy requirement in growing Lanyu pigs and the role of hepatic SIRT1 under different caloric levels.
- Neuroprotective Role of Sirtuin (SIRT1) Against Hypoxia in Retinal Ganglion Cells
- GW24-e0624 Impairted cardiac SIRT1 activity by carbonyl stress increase susceptibility of aged hearts to ischaemia reperfusion injury
- Obesity Accelerates Ovarian Follicle Development and Loss through Supressing SIRT1 Signaling in Rats
- The Relation between Resveratrol, SIRT1, mTOR and Autophagy
- SIRT1 Protects Against Lung Endothelial Cell Dysfunction Following Particulate Matter Exposure
- Influence of chidamide on proliferation, apoptosis with expression of Notch1 and SIRT1 in gastric carcinoma cell line SGC-7901
- Eicosapentaenoic acid enhances nitric oxide production through up‐regulating SIRT1 expression in human endothelial cells
- Disruption of SIRT1 in chondrocytes causes accelerated development of osteoarthritis induced by joint instability in the mouse
- SIRT1 acutely modulates glucose sensing of POMC neurons in the hypothalamus
- SIRT1 Regulation of the Heat Shock Response in an HSF1-Dependent Manner and the Impact of Caloric Restriction
- Exploring the Possibility of Changes in SIRT1 Activity in Lipotoxicity-mediated β-cell Dysfunction
- Correction: SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
- Improvement Of Corneal Staining By A SIRT1 Activator In A Mouse Model Of Dry Eye
- NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
- MicroRNA-34a regulates diabetes-induced impaired angiogenesis: Role of SIRT1
- Significance and expression of SIRT1 gene in human cervical endplate chondrocyte in vitro degeneration
- Silencing of Pericyte MicroRNA-132 Reduces Renal Fibrosis and Myofibroblast Proliferation and is Associated with Altered SIRT1 and Cox2 Expression
- The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells.
- Expression Of FLT3-ITD Dysregulates The DBC1-SIRT1-p53 Signaling and Promotes Therapy Resistance
- Targeted inhibition of SIRT1 histone deacetylase by small-molecule inhibitor Tenovin-1 imparts significant anti-proliferative effects in human melanoma cells
- Cloning and prokaryotic expression of SIRT1 gene from torafugu Takifugu rubripes.
- The CREB SIRT1 axis mediates Neural Stem Cells modulation by nutrient availability
- Duration-and concentration-dependent induction of SIRT1 on human degenerative endplate chondrocytes by Resveratrol
- Supplementary Figures The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
- The Histone Deacetylase SIRT1 Modulates STAT3 Activity and Prevents De-differentiation and Proliferation of Vascular Smooth Muscle Cells
- Sirtuin1 (SIRT1) regulates HBV transcription and replication by targeting transcription factor AP-1.
- OP0256 SIRT1 Regulates Cigarette Smoke-Induced IL8 Expression and TNFA-Mediated Il6 Release in Rheumatoid Arthritis Synovial Fibroblasts
- SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
- New molecular insights in APE1 binding to nCaRE elements of gene promoters: identification of SIRT1 as novel target gene
- Abolished Daily Expression Patterns of SIRT1, SIRT2, and SIRT5 in Human Chronic Myeloid Leukemia
- SIRT1 is Associated with Age-related Susceptibility to Acute Kidney Injury caused by Ischemia-reperfusion in Mice
- The growth arrest and apoptosis of adult T-cell leukemia cell lines MT2 induced by SIRT1 deacetylases inhibitor.
- Moderate alcohol consumption alters hepatic AdipoR1/SREBP‐1c and SIRT1 activity in rats with pre‐existing NASH
- SIRT1 regulates cigarette smoke-induced production of reactive oxygen species in myocardial mitochondria: Role of resveratrol [J]
- Correlation between estrogen secretion and SIRT1 gene expression levels in porcine ovarian granulosa cells.
- SIRT1 Activators Attenuate RGC Cell Loss By Reducing Oxidative Stress In MHV-A59 Induced Optic Neuritis
- PGE2 cigarette smoke-induced modulates endothelial tissue factor: role of EP1 receptor and SIRT1
- Combined Effect of Flow‐Mediated Shear Stress and Resveratrol on SIRT1/PGC‐1α Pathway in Vascular Endothelial Cells.
- A SUMOylation-dependent pathway regulates SIRT1 transcription and cancer metastasis
- Dimer Conversion of PPARalpha/RXR To PPARalpha/SIRT1 Suppresses Fatty Acid Oxidation Genes
- Abstract A86: SIRT1 regulates Rac1-GTPase activation via the guanine nucleotide exchange factor TIAM1
- SIRT1 antagonizes Stra13 Mediated p53 Acetylation and Senescence
- Overcoming of radiochemoresistance in glioblastoma stem cells via inhibition of lipid catabolism and SIRT1 deacetylase.
- Fullerenol Protects RPE cells from Oxidative-stress Induced Premature Senescence via Activation of SIRT1
- Accelerated Senescence of Cord Blood Endothelial Progenitor Cells From Premature Neonates is Driven by SIRT1 Decreased Expression
- Sirtuin (SIRT1/Sirt2) protect human pluripotent stem cells from DNA damage-induced apoptosis
- AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver
- Age-Associated Reduction of SIRT1 in Vascular Smooth Muscle Accelerates Angiotensin II-Induced Vascular Aging and Abdominal Aortic Aneurysm in Mice
- SIRT1 Activation with SRT1720 Reverses Impaired Endothelium‐Dependent Dilation in Old Mice by Augmenting COX‐2 Mediated Vasodilation
- The Role of SIRT1 in Exercise-and Resveratrol-induced Muscle Mitochondrial Biogenesis
- Inflammation and apoptosis in the synovium of patients with rheumatoid arthritis: the role of SIRT1 and microRNA-34a
- Resveratrol Displays Cardioprotection in Postinfarction Remodeling Through Autophagic Activation Associated With Ampk but not SIRT1 Pathway
- Epigenetic Regulation of p66Shc by SIRT1 Causes Persistent Myocardial Oxidative Stress and Inflammation Despite Optimal Glycemic Control in Diabetes
- Quercetin can increase mRNA expression of PGC-1α and SIRT1, and mtDNA and cytochrome c in both skeletal muscle and brain.
- Thrombosis Protection In Klkb1-/- (Prekallikrein KO) Mice Is Mediated By Increased Renal Mas Receptor, Plasma Prostacyclin, and Aortic SIRT1
- Inhibition of SIRT1 Sensitizes TRAIL-Resistant MCF-7 Cells by Upregulation of DR5 and Inhibition of c-FLIP
- The stability and bifurcation of modeling micro RNA regulation in signaling networks: miR-34a regulation of the p53/SIRT1 module
- NAMPT/NAD+/SIRT1-Triggered Deacetylation Of Hematopoietic Cell-Specific Lyn-Substrate 1 (HCLS1) In Congenital Neutropenia
- Resveratrol-induced activation of the SIRT1/AMPK axis in human CD4 T cells triggers replicative stress and an ATR-dependent cell cycle arrest
- Abstract LB-133: A novel tumor suppressor role for SIRT1 inhibiting mitophagy in prostate mouse tissue.
- Abstract LB-266: SIRT1 governs GnRH neuron migration and The Kallmann syndrome phenotype.
- H2S and L‐Cysteine Increase the Glucose Utilization via the PIP3 Mediated Insulin Dependent (PI3K/AKT) and the Insulin Independent (SIRT1/AMPK/PPAR gamma) …
- 496 Transgenic Mice Lacking SIRT1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia
- Lycopene metabolite, apo‐10′‐lycopenoic acid, inhibits diet‐induced obesity‐promoted liver carcinogenesis via the up‐regulation of SIRT1 signaling and the …
- POLY (ADP‐RIBOSE) POLYMERASE‐2 DEPLETION REDUCES DOXORUBICIN‐INDUCED DAMAGE THROUGH SIRT1 INDUCTION
- Hematopoietic-specific lyn-substrate 1 (HCLS) is deacetylated by NAMPT/NAD+/SIRT1 pathway
- HEMATOPOIETIC-SPECIFIC LYN-SUBSTRATE 1 (HCLS) IS DEACETYLAT-ED BY NAMPT/NAD+/SIRT1 PATHWAY
- Phosphodiesterase-5 (PDE-5) Inhibitor, Tadalafil, Activates NO/SIRT1/PGC-1 Signaling And Attenuates Mitochondrial Dysfunction In Type 2 Diabetic Hearts
- Linking lipids to acetylation novel roles of of PI (5) P and PIP4K in SIRT1 regulation and development
- PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4 KINASE BETA (PIP4Kβ) BINDS TO AND IS DEACETYLATED BY SIRT1
- Resveratrol Inhibits IL-6-induced STAT3 Activation in Human Colon Epithelial Cells: SIRT1 as a Potential Target
- the effects of GLP-1 on SIRT1 and on the related metabolic pathways in vascular endothelial cells: potential effects on vascular injury in diabetic patients
- Effect of crocin-1 on learning, memory, and expression of SIRT1 in hippocampus of rats under acute hypoxia
- Angiogenesis Inhibitor Vasohibin-1 Prevents Paraquat-Induced Lung Injury Via The Induction Of SOD2 And SIRT1
- Linking the pro‐oxidant influences of epigallocatechin gallate (EGCG) to intestinal cholesterol metabolism via alterations in sirtuin 1 (SIRT1) using Caco‐2 cells
- Set7/9 represses SIRT1 to induce collagen type II expression in 3D cultured human chodrocytes
- Identification of Novel Acetylation Sites in Nrf1 (NFE2L1) and Their Regulation by Sirtuin 1 (SIRT1)
- Endothelial Overexpression of LOX-1 Protects From in vivo Arterial Thrombosis and Modulates Oct-1 and SIRT1 Expression
- TP 40 Implication of SIRT1 and its downstream pathways in dystrophic process
- … pancreatic beta cells from cytokine-induced apoptosis by both alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2\2013HO-1 and SIRT1
- Sharp-1 Mediates p53-dependent cellular senescence through antagonism of SIRT1
- Structural and functional analysis of human SIRT1
- SIRT1 and other sirtuins in metabolism
- SIRT1 in cardiovascular aging
- Multifaceted modulation of SIRT1 in cancer and inflammation
- SIRT1 in neurodevelopment and brain senescence
- SIRT1 metabolic actions: integrating recent advances from mouse models
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases
- SIRT1: role in cardiovascular biology
- The role of SIRT1 in cancer: the saga continues
- SIRT1 and NAD as regulators of ageing
- The role of SIRT1 in diabetic kidney disease
- SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases
- SIRT1 in cerebral ischemia
- Diverse roles of SIRT1 in cancer biology and lipid metabolism
- SIRT1 and kidney function
- SIRT1 is decreased during relapses in patients with multiple sclerosis
- The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
- SIRT1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy
- A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human
- Downregulation of SIRT1 as aging change in advanced heart failure
- Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
- High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
- SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress
- P53 and SIRT1: routes of metabolism and genome stability
- SIRT1 deacetylates RORγt and enhances Th17 cell generation
- Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
- An exploratory double‐blind, randomized clinical trial with selisistat, a SIRT1 inhibitor, in patients with H untington’s disease
- Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
- Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21
- SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
- Molecular links between caloric restriction and Sir2/SIRT1 activation
- The N-terminal domain of SIRT1 is a positive regulator of endogenous SIRT1-dependent deacetylation and transcriptional outputs
- NAD+-dependent activation of SIRT1 corrects the phenotype in a mouse model of mitochondrial disease
- SIRT1 restrains lung inflammasome activation in a murine model of sepsis
- SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
- SIRT1/PGC1α-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer
- SIRT1 in the brain—connections with aging-associated disorders and lifespan
- MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
- Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
- Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
- Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
- Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
- Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
- SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
- SIRT1 activation ameliorates renal fibrosis by inhibiting the TGF‐β/Smad3 pathway
- Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes
- Disruption of SIRT1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
- SIRT1 suppresses doxorubicin-induced cardiotoxicity by regulating the oxidative stress and p38MAPK pathways
- The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer
- Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: A mechanism including AMPKα1/SIRT1 [S]
- Adversity in childhood and depression: linked through SIRT1
- SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging
- SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
- Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis
- SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
- Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
- Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut
- Age-related loss of SIRT1 expression results in dysregulated human vascular smooth muscle cell function
- The NAD+-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells
- Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through SIRT1 protein stabilization
- SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer
- Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
- A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators
- CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
- Spinal SIRT1 activation attenuates neuropathic pain in mice
- Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells
- Shear stress regulates endothelial cell autophagy via redox regulation and SIRT1 expression
- Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice
- Identification, stability and expression of SIRT1 antisense long non-coding RNA
- A high-fat diet and NAD+ activate SIRT1 to rescue premature aging in cockayne syndrome
- SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
- SIRT1 is required in the male germ cell for differentiation and fecundity in mice
- Relationship between mitochondrial DNA copy number and SIRT1 expression in porcine oocytes
- Role of SIRT1 during the ageing process: relevance to protection of synapses in the brain
- Age-dependent tissue expression patterns of SIRT1 in senescence-accelerated mice
- Expression of SIRT1 and oxidative stress in diabetic dry eye
- SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
- Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats
- Effects of exercise and body temperature on eNOS, SIRT1, SIRT3 and Hsp70 expression in rat plantaris muscles (1164.6)
- The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
- SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD+ and function in mice
- SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β
- The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
- Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
- SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation
- Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1
- NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells
- SIRT1 expression is associated with poor prognosis of lung adenocarcinoma
- SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
- Intercellular interplay between SIRT1 signalling and cell metabolism in immune cell biology
- mTOR, AMPK, and SIRT1: key players in metabolic stress management
- Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver
- Dual role of SIRT1 in UVB-induced skin tumorigenesis
- SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia
- AMPK-dependent phosphorylation of GAPDH triggers SIRT1 activation and is necessary for autophagy upon glucose starvation
- Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
- SIRT1 protects pig oocyte against in vitro aging
- Radioprotective and antioxidant effect of resveratrol in hippocampus by activating SIRT1
- Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
- SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264. 7 cells
- New indole–isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studies
- Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
- SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: an insight into endoplasmic reticulum stress response mechanism
- SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma
- SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer
- Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes
- Resveratrol activates duodenal SIRT1 to reverse insulin resistance in rats through a neuronal network
- NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
- SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
- SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells
- Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
- SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
- Role of SIRT1 in autoimmune demyelination and neurodegeneration
- Association of genetic variants of SIRT1 with type 2 diabetes mellitus
- SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo
- Expression of SIRT1 and SIRT3 varies according to age in mice
- Caloric restriction, resveratrol and melatonin: role of SIRT1 and implications for aging and related-diseases
- Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia
- SIRT1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury
- SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α–dependent glycolysis
- Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1‐BMAL1 pathway
- SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
- A randomized, placebo-controlled study of SRT2104, a SIRT1 activator, in patients with moderate to severe psoriasis
- … resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and …
- SIRT1 directly regulates SOX2 to maintain self‐renewal and multipotency in bone marrow‐derived mesenchymal stem cells
- The SIRT1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
- Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
- Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells
- SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
- SIRT1 in B [a] P-induced lung tumorigenesis
- The deacetylase SIRT1 is an essential regulator of Aire-mediated induction of central immunological tolerance
- SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens
- Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy
- SIRT1 and AMPK mediate hypoxia-induced resistance of non–small cell lung cancers to cisplatin and doxorubicin
- SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells
- SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
- Age-associated weight gain, leptin, and SIRT1: a possible role for hypothalamic SIRT1 in the prevention of weight gain and aging through modulation of leptin …
- SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and …
- DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
- The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy
- SIRT1 knockdown promotes neural differentiation and attenuates the heat shock response
- Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness
- ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling
- SIRT1 regulates lamellipodium extension and migration of melanoma cells
- SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow
- Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance
- Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and SIRT1
- Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
- In vivo RNA interference models of inducible and reversible SIRT1 knockdown in kidney cells
- PRMT1 and PRMT4 regulate oxidative stress-induced retinal pigment epithelial cell damage in SIRT1-dependent and SIRT1-independent manners
- SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer
- A phase II, randomized, placebo‐controlled, double‐blind, multi‐dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes
- Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
- SIRT1 counteracted the activation of STAT3 and NF-κB to repress the gastric cancer growth
- Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression
- Differential roles of SIRT1 in HIF-1α and HIF-2α mediated hypoxic responses
- Sirtuin1 (SIRT1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors
- Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a SIRT1‐independent manner
- SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells
- Fasting protects liver from ischemic injury through SIRT1-mediated downregulation of circulating HMGB1 in mice
- The p53/miR-34a/SIRT1 positive feedback loop in quercetin-induced apoptosis
- Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1
- Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
- Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
- SIRT1 protects against oxidative stress‐induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation
- Piceatannol and its metabolite, isorhapontigenin, induce SIRT1 expression in THP-1 human monocytic cell line
- Oxidative stress-induced inhibition of SIRT1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
- Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SIRT1 and AMPK
- The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1
- Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway
- Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
- Association between the SIRT1 mRNA expression and acute coronary syndrome
- SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells
- Overexpression of SIRT1 induced by resveratrol and inhibitor of miR-204 suppresses activation and proliferation of microglia
- SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis
- Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic …
- High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression
- NAD+-dependent SIRT1 deactivation has a key role on ischemia–reperfusion-induced apoptosis
- Attenuation of β‐amyloid‐induced tauopathy via activation of CK2α/SIRT1: Targeting for cilostazol
- Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5
- Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating SIRT1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat …
- Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1
- Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway
- Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease
- Linking DNA damage, NAD+/SIRT1, and aging
- SIRT1 plays a protective role in intervertebral disc degeneration in a puncture-induced rodent model
- Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat
- Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue …
- Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma
- Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis
- Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/SIRT1/PGC-1α signaling
- Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice
- Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
- Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of SIRT1 and Mn-SOD pathway
- SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation
- SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease
- Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-κB activation
- Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the SIRT1/AMPK and the Nrf2/antioxidant defense pathways in a …
- Metformin induces microRNA-34a to downregulate the SIRT1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress …
- Ligand and structure-based approaches for the identification of SIRT1 activators
- Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- Resveratrol protects against doxorubicin‐induced cardiotoxicity in aged hearts through the SIRT1‐USP7 axis
- Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet
- Ketosis may promote brain macroautophagy by activating SIRT1 and hypoxia-inducible factor-1
- Specific turn-on fluorescent probe with aggregation-induced emission characteristics for SIRT1 modulator screening and living-cell imaging
- SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
- SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis
- Over-expression of SIRT1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC)
- Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through SIRT1‐mediated deacetylation
- MicroRNA-34a induces vascular smooth muscle cells senescence by SIRT1 downregulation and promotes the expression of age-associated pro-inflammatory …
- Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes
- Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells
- Safety, pharmacokinetics, pharmacogenomics and QT concentration− effect modelling of the SIRT1 inhibitor selisistat in healthy volunteers
- Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype
- Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1
- Resveratrol induced premature senescence is associated with DNA damage mediated SIRT1 and SIRT2 down-regulation
- … -specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways
- Reduced thrombosis in Klkb1−/− mice is mediated by increased Mas receptor, prostacyclin, SIRT1, and KLF4 and decreased tissue factor
- Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the SIRT1 …
- … of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways
- SIRT1 is a tumor promoter in lung adenocarcinoma
- Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation
- Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis
- SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus
- High glucose induces renal tubular epithelial injury via SIRT1/NF-kappaB/microR-29/Keap1 signal pathway
- SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization
- SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
- Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
- Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α
- Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats
- Polydatin alleviates small intestine injury during hemorrhagic shock as a SIRT1 activator
- Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway
- Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss
- SIRT1-deficiency causes defective protein quality control
- Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/SIRT1 activation
- Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach
- Loss of SIRT1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer
- Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model
- SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling
- Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1/p300/p53/p21 pathway
- Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1
- miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
- Minireview: central SIRT1 regulates energy balance via the melanocortin system and alternate pathways
- SIRT1 relays nutritional inputs to the circadian clock through the Sf1 neurons of the ventromedial hypothalamus
- rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1
- The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy
- Pyrroloquinoline quinone increases the expression and activity of SIRT1 and-3 genes in HepG2 cells
- A divergent role of the SIRT1-TopBP1 axis in regulating metabolic checkpoint and DNA damage checkpoint
- SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression
- SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth
- TNF‐α and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells
- Macrophage‐specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP‐9 pathways
- miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
- Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis
- Hypothalamic SIRT1 in aging
- ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation
- Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia
- The SIRT1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response
- High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased …
- Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure
- Effect of resveratrol, a SIRT1 activator, on the interactions of the CLOCK/BMAL1 complex
- A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population
- … acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
- Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease
- Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
- SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation
- Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes
- Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort
- Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovary
- Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts
- SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss
- α-Mangostin regulates hepatic steatosis and obesity through SIRT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice
- Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin 3
- Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide
- Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc …
- Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis
- SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection in angiotensin II-induced heart hypertrophy
- SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage
- Loss of SIRT1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria
- Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice
- Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress
- SIRT1 suppresses human T-cell leukemia virus type 1 transcription
- SIRT1 Polymorphisms Associate with Seasonal Weight Variation, Depressive Disorders, and Diastolic Blood Pressure in the General Population
- MiR-34a inhibits migration and invasion by regulating the SIRT1/p53 pathway in human SW480 cells
- Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1
- SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids
- A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling
- SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes
- The effect of alcohol on SIRT1 expression and function in animal and human models of hepatocellular carcinoma (HCC)
- GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity
- Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis
- Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation
- AROS has a context-dependent effect on SIRT1
- Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis
- … antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of SIRT1-Sirt3-Foxo3-PINK1 …
- SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells
- Liquid fructose downregulates SIRT1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
- Involvement of AMPK/SIRT1 pathway in anti-allodynic effect of troxerutin in CCI-induced neuropathic pain
- Simiao pill ameliorates renal glomerular injury via increasing SIRT1 expression and suppressing NF-κB/NLRP3 inflammasome activation in high fructose-fed rats
- FoxM1 regulates SIRT1 expression in glioma cells
- Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1
- Fullerenol protects retinal pigment epithelial cells from oxidative stress–induced premature senescence via activating SIRT1
- … SIRT1 activators SRT2183 and SRT3025 inhibit RANKL-induced osteoclastogenesis in bone marrow-derived macrophages and down-regulate Sirt3 in SIRT1 …
- AGEs-RAGE system down-regulates SIRT1 through the ubiquitin-proteasome pathway to promote FN and TGF-β1 expression in male rat glomerular mesangial cells
- SIRT1-metabolite binding histone macroH2A1. 1 protects hepatocytes against lipid accumulation
- SIRT1 inhibition affects angiogenic properties of human MSCs
- Intestine-specific deletion of SIRT1 in mice impairs DCoH2–HNF-1α–FXR signaling and alters systemic bile acid homeostasis
- Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of SIRT1-mediated apoptosis
- Short‑term calorie restriction activates SIRT1‑4 and‑7 in cardiomyocytes in vivo and in vitro
- Curcumin attenuates hydrogen peroxide-induced premature senescence via the activation of SIRT1 in human umbilical vein endothelial cells
- Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors
- Pancreas-specific SIRT1-deficiency in mice compromises beta-cell function without development of hyperglycemia
- Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes
- HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA
- SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27
- Isocaloric pair-fed high-carbohydrate diet induced more hepatic steatosis and inflammation than high-fat diet mediated by miR-34a/SIRT1 axis in mice
- Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation
- Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRα signaling in THP-1 macrophage-derived foam cells
- Regulation of cell cycle regulators by SIRT1 contributes to resveratrol-mediated prevention of pulmonary arterial hypertension
- Nutraceutical activators of AMPK/SIRT1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection
- Investigating the role of SIRT1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson’s disease
- Humulus japonicus extract exhibits antioxidative and anti‑aging effects via modulation of the AMPK‑SIRT1 pathway
- SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing
- SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling
- KAP1 deacetylation by SIRT1 promotes non-homologous end-joining repair
- SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis
- Histone/protein deacetylase SIRT1 is an anticancer therapeutic target
- New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng
- The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin
- Cilostazol upregulates autophagy via SIRT1 activation: reducing amyloid-β peptide and APP-CTFβ levels in neuronal cells
- SIRT1 gene variants are related to risk of childhood obesity
- Set7/9 Impacts COL2A1 Expression Through Binding and Repression of SIRT1 Histone Deacetylation
- Defective mitophagy in XPA via PARP-1 hyperactivation and NAD+/SIRT1 reduction
- Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax ginseng
- Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer …
- Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet …
- MicroRNAs and SIRT1: a strategy for stem cell renewal and clinical development?
- Calorie restriction prevents metabolic aging caused by abnormal SIRT1 function in adipose tissues
- The metabolic sensors FXRα, PGC‐1 α, and SIRT1 cooperatively regulate hepatitis B virus transcription
- Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells
- Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent SIRT1 upregulation
- Aspirin targets SIRT1 and AMPK to induce senescence of colorectal carcinoma cells
- SIRT1 and FOXO mediate contractile differentiation of vascular smooth muscle cells under cyclic stretch
- SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner
- Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis
- Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β‐amyloid through activation of SIRT1/Akt1 pathway
- Antagonistic crosstalk between SIRT1, PARP-1, and-2 in the regulation of chronic inflammation associated with aging and metabolic diseases
- Protective effects of icariin‑mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion‑induced acute lung injury
- Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice
- SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through …
- Fisetin induces SIRT1 expression while inhibiting early adipogenesis in 3T3-L1 cells
- Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition
- Modulation of the AMPK/SIRT1 axis during neuronal infection by herpes simplex virus type 1
- Electroacupuncture upregulates SIRT1-dependent PGC-1α expression in SAMP8 Mice
- Peripheral leukocyte expression of the potential biomarker proteins Bdnf, SIRT1, and Psen1 is not regulated by promoter methylation in Alzheimer’s disease patients
- Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling
- Prognostic role of SIRT1 in hepatocellular carcinoma
- Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells
- Palmitate inhibits SIRT1-dependent BMAL1/CLOCK interaction and disrupts circadian gene oscillations in hepatocytes
- Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death
- Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin
- TNFα regulates SIRT1 cleavage during ocular autoimmune disease
- Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway
- SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: effect of starvation
- SIRT1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation
- MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of SIRT1
- Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway
- Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of SIRT1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells
- Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1
- Chronic pancreatitis and pancreatic cancer demonstrate active epithelial–mesenchymal transition profile, regulated by miR-217-SIRT1 pathway
- Visfatin/Nampt and SIRT1
- Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1
- BET inhibition upregulates SIRT1 and alleviates inflammatory responses
- SIRT1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet
- SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner
- Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia
- Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure
- Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation
- Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure
- Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors
- Programmed hyperphagia secondary to increased hypothalamic SIRT1
- Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle
- Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance
- Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i
- The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells
- Differential SIRT1 expression in hepatocellular carcinomas and cholangiocarcinoma of the liver
- Guignardins A–F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp. KcF8 as a new class of PTP1B and SIRT1 inhibitors
- Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo
- Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats
- Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1
- SIRT1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration
- Fentanyl increases colorectal carcinoma cell apoptosis by inhibition of NF-κB in a SIRT1-dependent manner
- Vitamin C protected human retinal pigmented epithelium from oxidant injury depending on regulating SIRT1
- The miR-29b–SIRT1 axis regulates self-renewal of mouse embryonic stem cells in response to reactive oxygen species
- Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
- CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression
- Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway
- Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders
- SIRT1 and STAT3 protect retinal pigmented epithelium cells against oxidative stress
- SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes
- SIRT1 gene is associated with cardiovascular disease in the Iranian population
- SIRT1 Overexpression Maintains Cell Phenotype and Function of Endothelial Cells Derived from Induced Pluripotent Stem Cells
- Coumestrol induces mitochondrial biogenesis by activating SIRT1 in cultured skeletal muscle cells
- The comparative study on expression of SIRT1 signal transduction by Xuefuzhuyu capsule
- Globular adiponectin causes tolerance to LPS-induced TNF-α expression via autophagy induction in RAW 264.7 macrophages: involvement of SIRT1/FoxO3A …
- Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells
- Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1
- The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/SIRT1/PGC-1α signaling
- Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1
- Effect of shikonin on multidrug resistance in HepG2: The role of SIRT1
- SIRT1 rescues the obesity induced by insulin‐resistant constitutively‐nuclear FoxO1 in POMC neurons of male mice
- Licochalcone suppresses LXRα-induced hepatic lipogenic gene expression through AMPK/SIRT1 pathway activation
- Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, SIRT1 and mitogen-activated protein kinase signalling …
- Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice
- Acetylcholinesterase inhibitors and compounds promoting SIRT1 expression from Curcuma xanthorrhiza
- Correction: SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
- Butyric acid-induced rat jugular blood cytosolic oxidative stress is associated with SIRT1 decrease
- … ‐3‐glucoside protects human umbilical vein endothelial cells against oxidized low‐density lipoprotein‐induced injury by autophagy upregulation via the AMPK/SIRT1 …
- MicroRNA-204-5p–mediated regulation of SIRT1 contributes to the delay of epithelial cell cycle traversal in diabetic corneas
- … functions as a potent suppressor of oncogene‐induced senescence in prostate cancer via its transcriptional co‐regulation of the CDKN1A (p21WAF1/CIP1) and SIRT1 …
- SIRT1 mediates a primed response to immune challenge after traumatic lung injury
- SIRT1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers
- Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β
- Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway
- SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II–V functions in individual …
- The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle
- Silent information regulator 1 (SIRT1) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway
- Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats
- MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function
- RhNRG-1β protects the myocardium against irradiation-induced damage via the ErbB2-ERK-SIRT1 signaling pathway
- The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest
- Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial …
- A novel role of SIRT1 in gammaherpesvirus latency and replication
- Cooperative action of Cdk1/cyclin B and SIRT1 is required for mitotic repression of rRNA synthesis
- SIRT1 mediates the effects of a short-term high-fat diet on the heart
- Celecoxib Sensitizes Staphylococcus aureus to Antibiotics in Macrophages by Modulating SIRT1
- Silencing angiopoietin‐like protein 4 (ANGPTL4) protects against lipopolysaccharide‐induced acute lung injury via regulating SIRT1/NF‐kB pathway
- Dysregulated miR-34a–SIRT1–acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of …
- Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes
- Hepatic SIRT1-dependent gain of function of stearoyl-CoA desaturase-1 conveys dysmetabolic and tumor progression functions
- Endoplasmic reticulum (ER) stress induces sirtuin 1 (SIRT1) expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury
- Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation and mitochondrial dysfunction in the testis
- SIRT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation
- The SIRT1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice
- Reversible acetylation of Lin28 mediated by PCAF and SIRT1
- WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance
- Visfatin is involved in TNFα-mediated insulin resistance via an NAD+/SIRT1/PTP1B pathway in 3T3-L1 adipocytes
- SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing
- SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells
- SIRT1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice
- SIRT1 synchs satellite cell metabolism with stem cell fate
- Fructose mediated non-alcoholic fatty liver is attenuated by HO-1-SIRT1 module in murine hepatocytes and mice fed a high fructose diet
- Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis
- A novel mutation in SIRT1-AS leading to a decreased risk of HCC
- Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
- Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress
- Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells
- Effects of nitric oxide synthase inhibition on fiber-type composition, mitochondrial biogenesis, and SIRT1 expression in rat skeletal muscle
- SIRT1 activation ameliorates aldara-induced psoriasiform phenotype and histology in mice
- Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells
- Potato protein hydrolysate attenuates high fat diet-induced cardiac apoptosis through SIRT1/PGC-1a/Akt signalling
- Functional sequence variants within the SIRT1 gene promoter in indirect inguinal hernia
- Central SIRT1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced …
- Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells
- AAV8-mediated SIRT1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease
- Enhancement in efferocytosis of oxidized low‑density lipoprotein-induced apoptotic RAW264. 7 cells through SIRT1-mediated autophagy
- Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat
- Gene expression profiling of SIRT1, FoxO1, and PPARγ in backfat tissues and subcutaneous adipocytes of Lilu bulls
- Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer
- Methylation gets into rhythm with NAD+-SIRT1
- Quantitative insights for the design of substrate-based SIRT1 inhibitors
- SIRT1 regulates autophagy and diploidization in parthenogenetic haploid embryonic stem cells
- Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival
- Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis
- Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer
- Stem cell transplantation upregulates SIRT1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice
- Regulation of HepG2 cell apoptosis by hepatitis C virus (HCV) core protein via the SIRT1–p53–bax pathway
- Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews
- 5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-SIRT1 axis
- Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy
- Resveratrol relieves hydrogen peroxide-induced premature senescence associated with SIRT1 in human mesenchymal stem cells
- Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord
- Molecular characterization, expression profiles, and analysis of Qinchuan cattle SIRT1 gene association with meat quality and body measurement traits (Bos taurus)
- Endothelial cell senescence increases traction forces due to age-associated changes in the glycocalyx and SIRT1
- SIRT1 modulates miRNA processing defects in p53-mutated human keratinocytes
- Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, SIRT1, and mitochondrial function
- Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc
- Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer
- Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract
- Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1
- SIRT1 interacts with and deacetylates ATP6V1B2 in mature adipocytes
- Central SIRT1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced …
- Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs
- Acetylome analysis identifies SIRT1 targets in mRNA-processing and chromatin-remodeling in mouse liver
- Resveratrol Regulates the Quiescence‐Like Induction of Activated Stellate Cells by Modulating the PPARγ/SIRT1 Ratio
- Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of SIRT1
- Suppression of RANKL-induced osteoclast differentiation by cilostazol via SIRT1-induced RANK inhibition
- MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic …
- Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy
- Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora
- Nicotinamide and resveratrol regulate bovine adipogenesis through a SIRT1-dependent mechanism
- Mass spectrometric studies on the in vivo metabolism and excretion of SIRT1 activating drugs in rat urine, dried blood spots, and plasma samples for doping control …
- Expression of SIRT1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: implications for immune dysregulation, prognosis and …
- JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression
- The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling
- Taurine attenuates amyloid β 1–42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells
- Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
- MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular …
- MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1
- Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro
- Myeloid-specific deletion of SIRT1 increases hepatic steatosis and hypothalamic inflammation in mice fed a high-fat diet
- The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells
- Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway
- Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway
- Effect of nasal CPAP on SIRT1 and endothelial function in obstructive sleep apnea syndrome
- SIRT1 and HMGB1 Regulate the AGE-Induced Pro-Inflammatory Cytokines in Human Retinal Cells.
- miR-27b overexpression improves mitochondrial function in a SIRT1-dependent manner
- CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a SIRT1-independent manner
- Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model
- Myeloid-specific SIRT1 deletion aggravates hepatic inflammation and steatosis in high-fat diet-fed mice
- Role of SIRT1 in the protection of intestinal epithelial barrier under hypoxia and its mechanism
- SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair
- Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation
- SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma
- … peroxisome proliferator-activated receptor-δ and-γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1
- SIRT1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis
- Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of SIRT1/Mn-SOD and GRP78/caspase-12 pathways
- … ‑enriched exopolysaccharides produced by Enterobacter cloacae Z0206 alleviate adipose inflammation in diabetic KKAy mice through the AMPK/SIRT1 …
- Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities
- Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells
- Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target
- Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/SIRT1/Pgc1α pathway
- Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1alpha pathway in mice with NASH
- Alteration in bioenergetic regulators, SIRT1 and Parp1 expression precedes oxidative stress in rats subjected to transient cerebral focal ischemia: molecular and …
- MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1
- Fuzhisan, a chinese herbal medicine, suppresses beta-secretase gene transcription via upregulation of SIRT1 expression in N2a-APP695 cells
- SIRT1 is reduced in gastric adenocarcinoma and acts as a potential tumor suppressor in gastric cancer
- Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem
- Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma
- Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals: A Case …
- CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase
- Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-κB pathways and expressions of IGF-1R, SIRT1, COX-2, and FASN in peripheral …
- SIRT1 regulates microtubule dynamics through negative regulation of Plk1 in mitosis
- Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD+/NADH Ratio and SIRT1
- … the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-deacetylase and peroxisome …
- The Effect of SIRT1 Gene Polymorphisms on Ambulatory Blood Pressure of Hypertensive Patients in the Kazakh Population
- Interaction between NLRP3 inflammasome and SIRT1/6: metabolomics approach
- Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1
- IL-15 is required for postexercise induction of the pro-oxidative mediators PPARδ and SIRT1 in male mice
- The effect of SIRT1 protein knock down on PGC-1α acetylation during skeletal muscle contraction
- Role of SIRT1 in Streptococcus pneumoniae-induced human β-defensin-2 and interleukin-8 expression in A549 cell
- The role of SIRT1 in bile acid regulation during calorie restriction in mice
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- A Nampt inhibitor FK866 mimics vitamin B 3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD+-SIRT1 signaling
- SIRT1 promote GTM cell DSBs repair and resist cellular senescence
- PPARα agonist WY-14643 induces SIRT1 activity in rat fatty liver ischemia-reperfusion injury
- 3, 5, 4′-Tri-O-acetylresveratrol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via MAPK/SIRT1 pathway
- VEGF receptor-2–linked PI3K/calpain/SIRT1 activation mediates retinal arteriolar dilations to VEGF and shear stress
- Resveratrol: brain effects on SIRT1, GPR50 and photoperiodic signaling
- Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced …
- Differential effect of estradiol and bisphenol A on Set8 and SIRT1 expression in prostate cancer
- Nontoxic-dose of deguelin induce NPMC+ aml cell differentiation by selectively targeting MT NPM1/SIRT1 instead of HDAC1/3
- Inflammation contributes to NKX3. 1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression
- Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and SIRT1 expression
- CYP epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity through SIRT1
- … acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon …
- Vitamin D (VD) prevents oxidative stress via regulating NOX4/Nrf2/Trx signaling cascade and upregulates SIRT1‐mediated AMPK/IRS1/GLUT4 pathway and glucose …
- The effect of the SIRT1 2827 A> G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease
- Up-regulation of the Sirtuin 1 (SIRT1) and Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Genes in White Adipose Tissue of Id1 Protein-deficient …
- Photobiomodulation on Bax and Bcl-2 Proteins and SIRT1/PGC-1α Axis mRNA Expression Levels of Aging Rat Skeletal Muscle
- Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells
- The SIRT1 promoter polymorphic site rs12778366 increases IL-6 related human mortality in the prospective study “Treviso Longeva (TRELONG)”
- Upregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy
- Improved Expression of SIRT1 on Thymic Epithelial Cells of SAMP10 after Intrabone Marrow–Bone Marrow Transplantation
- β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
- SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights
- MiR-34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte FGF21 signaling and SIRT1 function
- SIRT1 silencing suppresses prostate cancer growth and metastasis in an orthotopic prostate cancer mouse model
- SIRT1 inhibition suppresses multiple sclerosis
- The cytokine homeostasis was regulated by over-expression of SIRT1 in collagen-induced arthritis mice
- The role of SIRT1 in the treatment of diabetic nephropathy
- Structure–activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole
- The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1α (Gly482Ser), UCP2− 866 G/A and SIRT1− 1400 T/C polymorphisms with T2D in …
- Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue
- Effects of Vam3 on sodium nitroprusside-induced apoptosis and SIRT1 and p53 expression in rat articular chondrocytes
- RETRACTED: Role of mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes
- Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
- SIRT1 and rRNA in the nucleolus: regulating the regulator
- Effect of SIRT1 on cellular apoptosis and steroidogenesis in bovine ovarian granulosa cells in vitro
- Effects of single and combined genotypes of SIRT1 and SIRT2 genes on meat quality traits in Qinchuan cattle.
- Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA …
- CD150− Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1
- Docosahexaenoic acid inhibits white Adipogenesis and enhances mitochondrial biogenesis through SIRT1 and Hh signaling
- SIRT1 and Osteoarthritis. Comments on the Paper by Gabay Et Al.:” SIRT1-deficient Mice Exhibit an Altered Cartilage Phenotype”, Joint Bone Spine 2013
- Novel therapies for cancer treatment: designing high affinity and selectivity ligands against SIRT1
- A knockout Combo: eradicating AML Stem Cells with TKI plus SIRT1 inhibition
- Valproic acid suppresses SIRT1 inducing hepatotoxicity
- SIRT1, IGFBP-3 and CAV1 promoter DNA methylation in aging
- Benzothiazole derivatives upregulate SIRT1 and relevant genes in high-fat fed C57BL/6J mice
- Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity
- Synthesis of four SIRT1 activators based on an imidazo [1, 2-b] thiazole structure, in vitro derived metabolites and deuterated analogs
- Cigarette smoke impairs SIRT1 activity and promotes pro-inflammatory responses in bronchial epithelial cells
- microRNA‐34a mediates impaired angiogenesis in diabetes: role of SIRT1 and metformin (1051.2)
- Effect of a new dietary SIRT1 activator on high fat diet‐induced obesity and the involvement of microRNAs
- Cinnamon polyphenols increase oxygen‐glucose deprivation of decreased PGE2 production by upregulation of SIRT1 and alleviation of the anti‐inflammatory effects …
- Correlation between polymorphisms of SIRT1 gene and carcass traits in beef cattle.
- Mammary gland-specific deletion of SIRT1 delays mammary tumor growth and progression
- Analysis of expression Of SIRT1 gene in patients with chronic myeloid leukemia resistant to imatinib mesylate
- Correction: SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264. 7 Cells
- High dose of epigallocatechin-3-gallate inhibits proliferation and induces apoptosis of H9C2 cardiomyocytes through down-regulation of SIRT1
- A TiO 2-Au–polymer hybrid system for the photoelectrochemical immunoassay of SIRT1
- SIRT1 as a key factor for histone code establishment in early embryo, from a perspective of assisted reproduction
- Danshensu delays the senescence of rat aortic endothelial cells via activation of SIRT1-SOD pathway
- GW25-e1653 SIRT1 enhances therapeutic efficacy of aged mesenchymal stem cells in rat myocardial infarction via lightening MSCs aging and heightening stress …
- Genistein promotes a gene expression profile characteristic of brown rather than white adipocytes and increases SIRT1 expression in mouse NIH3T3‐L1 cells (372.7)
- Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1
- 17β-Estradiol attenuates hematoma expansion through ERα/SIRT1/NF-κB pathway in hyperglycemic intracerebral hemorrhage mice
- GW25-e2369 Lipoic acid inhibits oxidative stress-induced premature senescence via upregulation of SIRT1 in human umbilical vascular endothelial cells
- OP0216 Resveratrol ameliorates pulmonary fibrosis and inhibits human lung fibroblasts activation VIA modulating SIRT1 and GLI1 signaling
- Research progress on SIRT1-FoxO-autophagy pathway
- Crystallographic Structure of a Small Molecule SIRT1 Activator/Enzyme Complex
- Correction: Globular Adiponectin Causes Tolerance to LPS-Induced TNF-α Expression via Autophagy Induction in RAW 264.7 Macrophages: Involvement of SIRT1 …
- SIRT1 and Inflammaging in Chronic Obstructive Pulmonary Disease
- P79 SIRT1 modulates endoplasmic reticulum stress-induced autophagy in heart.
- Effects of dietary restriction on antioxidant capacity and SIRT1 expression in hyperlipideima mice
- Construction of elderly SIRT1 gene knockout mouse models of knee osteoarthritis
- Tetramethylpyrazine (TMP) switches energy signalling from the PKCζ-GLUT4-glucose pathway back to the SIRT1-CD36-fatty acid pathway similar to …
- PPARα Association With SIRT1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart
- AB199. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
- Jamming Up the “β-Staple”: Regulation of SIRT1 Activity by Its C-Terminal Regulatory Segment (CTR)
- GW25-e3514 resveratrol alleviates diabetic cardiomyopathy through improvement of mitochondrial biogenesis and function in a SIRT1-dependent manner
- Protective effect of SIRT1 on rat mesangial cells by decreasing high glu-cose-induced acetylation of NF-κB p65
- Hyperoxia induces reactive oxygen species production and promotes SIRT1 nucleocytoplasmic shuttling of peripheral blood mononuclear cells in premature infants in …
- Podocyte SIRT1 Deficiency Contributes to Albuminuria and Renal Fibrosis in Diabetic Kidney Damage in Mice
- Research progression of SIRT1
- SIRT1 inhibits related protein expression of endoplasmic reticulum stress in myocardial ischemic/reperfusion by activation of ERK1/2 pathway in rat
- Expression of SIRT1, Sirt2, Sirt5, and Sirt6 in the Mouse Testis
- ChREBP, SIRT1 and ethanol metabolism–a complicated network in alcohol-induced hepatic steatosis
- A high-fat meal alters post-prandial mRNA expression of SIRT1, SIRT4, and SIRT6
- Expression of SIRT1 in mouse testes
- Leucine-Metformin Synergy Activates the AMPK/SIRT1 Pathway to Increase Insulin Sensitivity in Skeletal Muscle and Glucose and Lipid Metabolism and Lifespan …
- Upregulation of Cardiac MicroRNA 34a, SIRT1, and Notch1 Following Oral Ingestion of Beetroot Juice and Doxorubicin Treatment: A Novel Protective Signaling Against …
- Synthesis of a SIRT1 Inhibitor
- SIRT1 in vascular related diseases: its progress
- Functional mechanism of SIRT1 gene in tumor
- Prognostic role of SIRT1 in hepatocellular carcinoma
- Expression and clinical significance of SIRT1 in hepatocellular carcinoma
- Research Progress of SIRT1 in Hepatic Injury
- Abstract P2-06-08: SIRT1 inhibitors significantly reduce cancer stem cells and block epithelial mesenchymal transformation in breast cancer cells
- Expression and its significance of SIRT1-FL and its alternative splicing variant SIRT1-△ Exon7 in rat hippocampus and cortex
- AB200. SIRT1 expression is elevated in human prostate cancer
- Construction of SIRT1 promoter expression vector and its activity analysis as well as influence of AML1-ETO on transcriptional regulation of SIRT1 gene
- SIRT1: A New Promising Drug Target
- The expression of SIRT1 in brainstem of rats in different types of hypoxia and its significance
- Study on the Differential Expressions of SIRT1 Gene in Ovine Tissues and Organs
- Construction and verification of SIRT1 and its mutant T200I, E420K eukaryotic expression vector
- The role of SIRT1 for regulating VEGF in human RPE
- SIRT1 is decreased during relapses in patients with multiple sclerosis
- Role of SIRT1 in Vascular Complications of Diabetes
- Expression of SIRT1 in bone marrow biopsy tissues and its clinical significance among children with acute myeloid leukemia
- A novel small-molecule SIRT1 inhibitor induces apoptosis in leukemic cell lines
- The progress in the study of SIRT1 effect on the bone repair of mesenchymal stem cells
- MicroRNA-455 targets SIRT1
- The Study of SIRT1 Regulatory Mechanism in DNA Repair Pathway Choice
- SIRT1 Negatively Regulates Cardiac Inflammation Induced by Metabolic Stress
- Effect of Estrogen on Expression of SIRT1 in Ovariectomized Rats
- SIRT1 differently regulates oncogenesis by diverse p53 types in hepatocellular carcinoma
- Age-related Expression of SIRT1 in the Cochlea of C57BL/6 Mice
- Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
- Corrigendum to “SIRT1 Inhibition Affects Angiogenic Properties of Human MSCs”
- Effect of SIRT1 siRNA interference on the expression of IL-6 after radiation
- Research Progress of Estrogen Upregulation of SIRT1 Activity in Anti-aging
- The roles played by the transcriptional regulators PPARalpha, HIF-1alpha and SIRT1 in the control of cardiac metabolism
- Progress in Stat3 and SIRT1 gene in the pathogenesis of rheumatoid arthristis
- Regulation of Acute KSHV Infection by SIRT1
- 1, 25 Dihydroxyvitamin D3 protects the heart against pressure overload-induced hypertrophy without affecting SIRT1 mRNA level
- SIRT1 Overexpression Together with EX527 Reduce Excitotoxicity-Induced Neuronal Loss in Cortical Neurons
- Action machanism of SIRT1 involves TNF-α-induced intestinal epithelial barrier destroy
- SIRT1 nutrient signaling regulates fetal programming of nephrogenesis (1033.10)
- SIRT1, A Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
- Loss of SIRT1 Function Improves Intestinal Anti-Bacterial Defense and Protects
- Protein Deacetylases SIRT1 and Epigenetic Modification of Matrix Metalloproteinase-9 in Diabetic Retinopathy
- SIRT1 mRNA Phasic Expresson During C2C12 Myoblast Proliferation
- SIRT1 gene variants are related to risk of childhood obesity
- Suppression of HTLV-1 transcription by SIRT1 deacetylase
- Effects of SIRT1 mutation or over-expression in astrocytes on metabolism and reproduction
- Effect of SIRT1 on cell proliferation and senescence of human pancreaticβ-cells CRL-1837
- Role of genetic variations at SIRT1 and FOXO1 genes in carotid atherosclerosis
- The nuclear protein bovine SIRT1 is regulated by resveratrol and nicotinamide
- Dysregulation of SIRT1 Activity in the Pathogenesis of Huntington’s Disease
- Maturation conditions do not affect Myst1, Hat1, and SIRT1 mRNA abundance in horse oocytes
- Preventing disease and preserving health with moxibustion and ‘longevity gene’SIRT1
- Role of SIRT1 During the Ageing Process: Relevance to Protection of Synapses in the Brain
- Differential roles of SIRT1 in HIF‐1a and HIF‐2a mediated hypoxic responses (LB269)
- Expression of SIRT1 and Related Oxidative Stress in Diabetic Dry Eye Mouse
- P0913Astrocytic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Extremely Low Frequency Electromagnetic Field through Modulating SIRT1
- Evaluating cathepsin activity and SIRT1 cleavage in experimental osteoarthritis
- The role of an NAD-dependent deacetylase SIRT1 in cellular response to kidney injury
- SIRT1 upregulators from high‐throughput screening as anti‐proliferation and anti‐migration agents in vascular smooth muscle cells (654.2)
- Cardiac SIRT1 Deficiency Sensitizes Myocardium to Ischemia and Reperfusion Injury
- DNA sequences differentially associated with SIRT1 and Dnmt3b during melanoma progression
- Expression of c-Myc, SIRT1 and acetyl-p53 in breast carcinoma and prognostic significance
- Relationship between expression of SIRT1 and SIRT6 genes and the response to ovarian stimulation
- SIRT1 contributes to LPS-induced lung injury through interaction with mitochondrial ROS generation
- GW26-e1360 Effects of SIRT1 on Protection Against Atherosclerosis Plaque via Anti-angiogenesis in Mice
- Apolipoprotein E4 and SIRT1 Interaction in Alzheimer’s Disease
- Modulating the Vascular Healing Response via SIRT1 Transgene Delivery
- Targeting SIRT1 and Its Pathway for Therapeutic Intervention of Cancer: Drug Design and Biological Evaluation
- The Protective Role of SIRT1 Activator in Renal Tubulointerstitial Fibrosis and Its Mechanism
- ANALYSIS OF EXPRESSION OF SIRT1 GENE IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA RESISTANT TO IMATINIB MESYLATE
- Metformin alleviates hepatosteatosis through SIRT1-mediated autophagy induction
- Correction: Functional Complementation of sir2Δ Yeast Mutation by the Human Orthologous Gene SIRT1
- The tissue specific role of SIRT1 in joint inflammation and anabolic cartilage gene expression
- SRT1720, a SIRT1 activator, Attenuates Organ Injury and Inflammatory Response in Sepsis
- Synthesis and SIRT1 modulation studies of amides and hydrazides of benzoic acid incorporating a (2-trifluoromethylpyridin-4-yl) amino moiety
- #VALUE!
- The role of SIRT1 on the crosstalk of p65 and NFATS in U937 monocytes under hyperosmotic stress
- Effect of SIRT1 regulating cholesterol synthesis in repairing retinal ganglion cells after optic nerve injury in rats
- SIRT1 as a Novel Regulator of Cardiac Na+ Channels: A Potential Therapeutic Target for Arrhythmia
- B46 HEALTH EFFECTS OF AIR POLLUTION AND NANOPARTICLES: SIRT1 Protects Against Particulate Matter-Induced Lung Injury
- Survival of colorectal cancer cells following chemotherapy relies on a SIRT1-dependent increase in oxidative phosphorylation
- The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation SIRT1
- Research on Effect of SIRT1 on Ameliorating Hepatic Lipid Metabolism Disorder of APOE~(-/-) after Aerobic Exercise
- SIRT1 in the Cardiomyocyte Counteracts Doxorubicin Cardiotoxicity in vivo
- SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
- Role of SIRT1 in renal ischemia-reperfusion injury and its effect on NF-κBp65-PGC-1α signal pathway in mice
- A novel potential prognostic marker SIRT1 on tumor invasion and metastasis, and tumor recurrence in triple negative breast cancer
- Moderate SIRT1 Overexpression Protects against High Fat Diet Induced Insulin Resistance and Mitochondrial Dysfunction
- OP0267 SIRT1 Regulates Canonical Tgf-Beta Signaling to Control Fibroblast Activation and Tissue Fibrosis
- Effects of NLRP3 and IL-1β on radiation-induced expression through SIRT1 gene silencing
- Design and Synthesis of 2-Arylbenzothiazole Analogues as Novel SIRT1 Activators
- Starvation-Mediated Autophagy Attenuates Liver Ischemia Reperfusion Injury By SIRT1 in Mice.: Abstract# C1644
- Danshensu Delays the Senescence of Rat Aortic Endothelial Cells through SIRT1-SOD Signal Pathway
- #VALUE!
- Differential roles of SIRT1 in HIF-1αand HIF-2αmediated hypoxic responses
- A Clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy
- Expression of apoptosis factors in porcine ovarian granulosa cells affected by SIRT1.
- SIRT1 Expression Is Higher in Human Follicular Lymphoma and Correlates with Ki67 and Bcl-6 Overexpression
- Functional analysis of SIRT1-interacting protein JAZ (Znf346) in neurons
- Sirtuin1 (SIRT1) is a Neuroprotectin D1 (NPD1) target in retinal pigment epithelial cell survival signaling
- A60 OUTCOMES OF SLEEP DISORDERED BREATHING AND SLEEP LOSS: Effect Of Treatment By Nasal Cpap On SIRT1 And Endothelial Function In Obstructive …
- SIRT1 Regulates Cell Survival, Collagen VI Expression of Human TM Cells and Permeability Of Endothelial Cells of Schlemm’s Canal
- The effects of SIRT1 on hypoxia induced by cobalt chloride in human fetal retinal pigment epithelial cells
- SIRT1 overexpression ameliorates TGF-β_1-induced human kidney proximal tubular cell apoptosis by inhibiting CTGF
- A21 THE MESENCHYME AND THE EPITHELIUM IN AIRWAY INFLAMMATION: SIRT1 Attenuates Nasal Polypogenesis By Suppressing Hypoxia-Inducible Factor-1 …
- SIRT1 deacetylates RORγt and enhances Th17 cell generation
- SIRT1 activators promote neuronal differentiation in human bone marrow mesenchymal stem cells
- SIRT1 overexpression protects against high fat diet‐induced cerebral artery endothelial dysfunction (1070.10)
- The Protective Role of AMPK/SIRT1/PGC-1α Signalling in Retinal Astrocytes
- SIRT1 Expression in B-Cell Acute Lymphoblastic Leukemia and Dose-Dependent Effect of Vorinostat
- SIRT1 in the Ventromedial Hypothalamus: A Nutrient Sensor Input Into the Internal Timekeeper
- Investigating the Potential Role of SIRT1 in Glioblastoma Multiforme: A Comparison Between Glioma and Normal Astrocyte Cells in Culture
- Effect of SIRT1 on high glucose-induced NF-κB p65 subunit acetylation and MCP-1 expression in rat mesangial cells
- Abstract PR10: Inhibition of deacetylase SIRT1 offers a novel treatment option in metastatic Ewing sarcoma
- SIRT1 and SIRT2 Gene Expression in Peripheral Blood Mononuclear Cells of Obese Children and Adolescents and their Relationship with Metabolic …
- SIRT1-responsive microRNA-182 contributes to a regulatory loop for recovery of peripheral nerve injury in experimental diabetic neuropathy
- Identification of SIRT1 as a novel regulator of NFAT5 dependent aldose reductase expression under osmatic stress
- Atorvastatin Inhibits High Glucose-induced Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells by SIRT1/NADPH Oxidase Pathway
- THU0471 Myeloid Deletion of SIRT1 Suppresses Collagen-Induced Arthritis in Mice by Modulating Dendritic Cell Function
- PPARalpha/SIRT1 Heterodimer Suppresses Fatty Acid Oxidation Genes in the Heart Under Pressure Overload
- EXOGENOUS SIRT1 INHIBITION OF APOPTOSIS VIA AUTOPHAGY UNDER LOW NUTRITIONAL CONDITION IN HUMAN NUCLEUS PULPOSUS CELLS: GP52.
- SIRT1 Suppresses Self-Renewal of Adult Hippocampal Neural Stem Cells
- Changes in expression of Ac-H3 and SIRT1 in dorsal root ganglions in a rat model of negative phenotype neuropathic pain
- Expression of deacetylase SIRT1 in porcine different developmental stages of follicular granulosa cells.
- Epigallocatechin gallate inhibited proliferation and induced apoptosis of nasopharyngeal carcinoma cells by inhibiting expression of SIRT1
- Resveratrol protects oxygen-glucose deprivation rat cortical neurons by regulating SIRT1/AMPK signaling pathways
- KSY-PH1 Prevents UVB-Induced Damage and Promotes Wound Healing In Skin Cells via Coregulation of SIRT1 and Pin1
- SIRT1 Expression Related with Sarcoma Growth after Stem Cell Transplantation Combined with Depletion of Myeloid-Derived Suppressor Cells
- Abstract T P247: Neuronal SIRT1 Activation Negatively Regulates Rho Kinase in Photothrombotic Stroke
- Insulin Antagonizes SIRT1 and NF‐κB Signaling in Skeletal Muscle of Neonatal Pigs during Chronic Infection
- C108 AGING: THE COMMON DENOMINATOR: SIRT1 eduction Is Involved In Clock Dysfunction, Telomere Attrition, And Inflammosenescence In COPD
- The SIRT1 Activator, SRT1720, Attenuates Cardiac Hypertrophy and Fibrosis in a Rodent Pressure Overload Model
- Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
- SIRT1-Mediated Inhibition of p66shc Expression Alleviates Liver Ischemia/Reperfusion Injury
- Study on Effect of Buqi-Tongluo-Jiedu Decoction on Protein Concentration of HIC1/SIRT1 of Pancreatic Cancer Model Mice
- SIRT1 regulates the function of the KRAB-associated protein 1 (KAP1) in DNA damage response signaling
- SIRT1 activator SRT3025 provides atheroprotection in ApoE⁻/⁻ mice by increasing hepatic LDL receptor
- SIRT1 Modulates Varicella Zoster Virus Replication in the Rat Dorsal Root Ganglion Neurons
- GW26-e0716 Forestalling SIRT1 Carbonyl Stress by ALDH2 Restores Autophagy in Aged Heart
- Shear Stress-Induced SIRT1 Activation: Effects on Mitochondrial Biogenesis and Endothelial Senescence.
- Protective Effect of Photoreceptor Outer Segments Phagocytosis for Retinal Pigment Epithelial Cells by PGC-1α/SIRT1
- Activation of C/EBPa Myeloid-Specific Transcription Factor By NAMPT/SIRT1-Triggered Deacetylation
- Melatonin improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha
- ATGL‐catalyzed lipolysis regulates SIRT1 to control PGC‐1a/PPAR‐a signaling
- Metabolic adaptation of tumor cells under chronic acidosis: role of the SIRT1/HIF2alpha axis to drive reductive glutamine metabolism
- Design and Synthesis of 2-Arylbenzimidazole Analogues as Novel SIRT1 Activators for the Treatment of Type II Diabetes
- Increased p53 Acetylation By SIRT1 Inhibition Is Required for Optimal Activation of p53 Activity and Significantly Enhances the Ability of HDM2 Inhibitors to Target …
- Metabolic adaptation of tumor cells under chronic acidosis: a shift towards reductive glutamine metabolism driven by the SIRT1/HIF2α axis
- C71 THORACIC CANCER: PATHOGENESIS, PREVENTION, AND TREATMENT: Down-Regulated SIRT1 By Non-Steroidal Anti-Inflammatory Drugs Is To Inhibit Tgf …
- Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via SIRT1
- Cardiac SIRT1 Mediates the Cardioprotective Effect of Caloric Restriction by Suppressing Local Complement System Activation after Ischemia/Reperfusion
- ANTI-APOPTOTIC EFFECT OF FERULIC ACID THROUGH MODIFICATION OF SIRT1, SIRT7 AND CASPASE 6 GENE EXPRESSION
- Decreased PGC‐1α‐SIRT1 Signaling Leads to Impaired Angiogenesis in Persistent Pulmonary Hypertension of the Newborn (PPHN)
- GW25-e1534 SIRT1 protects against oxidative stress-induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation
- α-Mangostin Regulates Hepatic Steatosis and Obesity through SIRT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice
- … IMPROVES INSULIN SENSITIVITY IN HIGH-FAT-DIET-INDUCED INSULIN RESISTANCE RATS VIA ACTIVATION OF SIRT1 AND GLUT4 IN QUADRICEPS …
- NMN, a NAD+ Precursor, Can Rescue Age-associated Susceptibility to Cisplatin-induced Acute Kidney Injury in a SIRT1-dependent Manner
- High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased …
- 1018: SIRT1 ACTIVATORS ALTER TRANSCRIPTIONAL PROFILES OF INFLAMMATORY RESPONSE & IMPROVE OUTCOME IN SEPSIS
- Fast Track: Editor’s choice: The SIRT1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr …
- Low-Dose Deguelin, Selective Targeting of Mt NPM1, Induces Differentiation in NPMc+ AML Cells By Regulation the Axis of SIRT1/CEBPβ/G-CSFR, Instead …
- Correction: Nurr1 Represses Tyrosine Hydroxylase Expression via SIRT1 in Human Neural Stem Cells
- Nicotinic acid synergizes with leucine to stimulate AMPK/SIRT1 signaling and regulates lipid accumulation and lifespan in C. elegans (269.7)
- GW26-e1025 Fenofibrate Prevention of Diabetic Cardiomyopathy Is Mediated by FGF21 Via SIRT1-Dependent Autophagy Modulation
- Liquid fructose downregulates SIRT1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
- Regulatory interactions between the metabolic sensors SIRT1 and AMPK in modulating PPARα linked functions, in obesity-dependent type 2 diabetes mellitus
- GW25-e4428 Exogenous Hydrogen Sulfide Delays Nicotinamide-Induced Premature Senescence via SIRT1 pathway in Human Umbilical Vein Endothelial Cells
- SIRT1, SIRT2, SIRT6 and P21 gene expression in the lungs of mice chronically exposed to ambient particulate matter
- … fibrosis and atrial fibrillation in a canine atrial tachycardia model with left ventricular dysfunction: association with p53-microRNA34a-SIRT1 feedback-loop pathway
- Effects of core temperature on exercise-induced mitochondrial biogenesis: Potential role of PGC-1α, AMPK eNOS, SIRT1, and SIRT3
- Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced …
- Resveratrol stimulation of SIRT1 & exogenous delivery of FGF21 mimics metformin’s ability to alleviate non-alcoholic fatty liver disease caused by diet-induced obesity
- Thematic Poster: TP-30; SIRT1 Contributes to the Pathogenesis of LPS-Induced Lung Injury through the Modulation of PI3K-HIF-VEGF Pathway
- SIRT1 dependent IRS1 phosphorylation mediates the effect of vitamin D on GLUT4 translocation and glucose utilization via PI3K/PTEN/PTP1B/PIP3/AKT/PKCζ/λ …
- PS-1570; Pulmonary Infection: SIRT1 Contributes to the Pathogenesis of LPS-Induced Lung Injury through the Modulation of PI3K-HIF-VEGF Pathway
- Adiponectin suppress T helper 17 differentiation and limits autoimmune CNS inflammation via SIRT1/PPARγ/RORγt singling
- RNA interference of silent mating type information regulation 2 homolog 1 SIRT1 arrests cell cycle progress of prostate cancer PC3 cells
- OP-144 Attenuated SIRT1 Expression Correlates with Enhanced Oxidative Stress in Compensated and Decompensated Heart Failure
- Arginase 1 regulates SIRT1 activity and endothelial senescence in diabetes (1051.1)
- 7: Increased SIRT1 Positive Lymphocytes in Acute Cellular Cardiac Allograft Rejection: Contributor to Pathogenesis and a Therapeutic Target
- Abstract LB-167: The role of SIRT1 in tumorigenesis
- Calycosin Promotes Apoptosis of Breast Cancer Cells MCF-7 through Inhibiting SIRT1
- HO‐1 Induction Attenuates Fructose Mediated Non‐alcoholic Fatty Liver in Hepatocytes and Obese Mice: Involves SIRT1
- Free Paper Presentation: F-141; Mitochondrial ROS Induces Up-regulation of SIRT1 in LPS-Induced Acute Lung Injury
- Slide Session: OS-115; Pulmonary Infection: The Interplay Between Mitochondrial ROS and SIRT1 in LPS-Induced Lung Injury of Mice
- Free Paper Presentation: OS-115; The Interplay Between Mitochondrial ROS and SIRT1 in LPS-Induced Lung Injury of Mice
- Role of silent information regulator 1 (SIRT1) in the malignant biological behavior of prostate cancer
- The Korean Academy of Tuberculosis and Respiratory Diseases: Slide Session; OS-066: Lung Cancer; Down-Regulated SIRT1 by Non-Steroidal Anti-Infl ammatory …
- Free Paper Presentation: OS-66; Down-Regulated SIRT1 by Non-Steroidal Anti-Inflammatory Drugs Is to Inhibit TGF-β1-Induced Epithelial-Mesenchymal Transition …
- 1, 25 dihydroxyvitamin D3 protects the heart against pressure overload-induced hypertrophy without affecting SIRT1 mRNA level
- #VALUE!
- Expression of silence information regulator 1 (SIRT1) in B cells in peripheral venous blood of subacute cutaneous lupus erythematosus
- Homology modeling, Molecular Dynamic Simulation and in silico screening of Activator for the Intensification of human sirtuin type 1 (SIRT1) by novel 1, 3, 4 …
- Endothelial LOX-1 Protects Against Arterial Thrombosis via Activation of the Oct-1/SIRT1 Pathway
- GW26-e2385 Tetrahydroxystilbene Involve HSP-70 and SIRT1 in Preventing the Progression of Diabetic Cardiomyopathy
- … Receptor 2 improves therapeutic efficacy of Adipose-Derived Mesenchymal Stem Cells to alleviate myocardial ischemia injury through AMPK/SIRT1 and TLR4/NF-κB …
- 3, 5, 4 [variant prime]-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway
- Taurine attenuates amyloid β 1â 42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells
- Effects of metformin on SIRT1, Nrf2 and AhR expression in cancer cells
- SIRT1 and the mitochondria
- SIRT1 and insulin resistance
- Emerging roles of SIRT1 in fatty liver diseases
- The role of SIRT1 in epileptogenesis
- SIRT1 inhibits oxidative stress in vascular endothelial cells
- Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis
- The role of SIRT1 in diabetic cardiomyopathy
- SIRT1: role under the condition of ischemia/hypoxia
- How much successful are the medicinal chemists in modulation of SIRT1: A critical review
- Obesity weighs down memory through a mechanism involving the neuroepigenetic dysregulation of SIRT1
- The protective role of SIRT1 in vascular tissue: its relationship to vascular aging and atherosclerosis
- SIRT1, 2, 3 protect mouse oocytes from postovulatory aging
- SIRT1 regulates macrophage self‐renewal
- Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species
- Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells
- LncRNA HULC triggers autophagy via stabilizing SIRT1 and attenuates the chemosensitivity of HCC cells
- SIRT1 mediates depression-like behaviors in the nucleus accumbens
- The prognostic role of SIRT1 expression in solid malignancies: a meta-analysis
- Down-Regulation of SIRT1 Gene Expression in Major Depressive Disorder
- SIRT1 as a therapeutic target for Alzheimer’s disease
- SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis
- Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells
- Negative reciprocal regulation between SIRT1 and Per2 modulates the circadian clock and aging
- SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease
- SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson’s disease
- SIRT1 regulates DNA methylation and differentiation potential of embryonic stem cells by antagonizing Dnmt3l
- SIRT1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis
- Association between SIRT1 gene polymorphisms and breast cancer in Egyptians
- SIRT1 enhances the survival of human embryonic stem cells by promoting DNA repair
- Histone deacetylase SIRT1 negatively regulates the differentiation of interleukin-9-producing CD4+ T cells
- SIRT1 promotes epithelial–mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression
- Effect of exercise training on skeletal muscle SIRT1 and PGC-1α expression levels in rats of different age
- Aquatide activation of SIRT1 reduces cellular senescence through a SIRT1-FOXO1-autophagy axis
- SIRT1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells
- SIRT1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice
- SIRT1 activation by resveratrol alleviates cardiac dysfunction via mitochondrial regulation in diabetic cardiomyopathy mice
- SIRT1 inhibits the catabolic effect of IL-1β through TLR2/SIRT1/NF-κB pathway in human degenerative nucleus pulposus cells
- Overexpression of SIRT1 is associated with poor outcomes in patients with ovarian carcinoma
- SIRT1 improves VSMC functions in atherosclerosis
- The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
- SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells
- SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells
- O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
- Specific SIRT1 activator-mediated improvement in glucose homeostasis requires SIRT1-independent activation of AMPK
- SIRT1/3 activation by resveratrol attenuates acute kidney injury in a septic rat model
- QSAR differential model for prediction of SIRT1 modulation using Monte Carlo method
- SIRT1 protects the heart from ER stress-induced cell death through eIF2 α deacetylation
- Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation
- Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of SIRT1
- mTORC1 and SIRT1 cooperate to foster expansion of gut adult stem cells during calorie restriction
- SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2
- Mitochondria elongation is mediated through SIRT1-mediated MFN1 stabilization
- CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice
- ATGL promotes autophagy/lipophagy via SIRT1 to control hepatic lipid droplet catabolism
- SIRT1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a
- Activation and overexpression of SIRT1 attenuates lung fibrosis via P300
- Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits
- Quercetin improves glucose and lipid metabolism of diabetic rats: involvement of Akt signaling and SIRT1
- Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts
- Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro
- SIRT1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms
- Epidermal SIRT1 regulates inflammation, cell migration, and wound healing
- Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes
- Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1, and eNOS
- Mir-29b regulates oxidative stress by targeting SIRT1 in ovarian cancer cells
- SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving …
- Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression
- SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats
- Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of SIRT1 signaling
- SIRT1 inhibition promotes atherosclerosis through impaired autophagy
- SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia–reperfusion injury
- SIRT1 promotes metastasis of human osteosarcoma cells
- SIRT1 activates the expression of fetal hemoglobin genes
- SIRT1 and neural cell fate determination
- SIRT1 regulates the chemoresistance and invasiveness of ovarian carcinoma cells
- Celastrol ameliorates liver metabolic damage caused by a high-fat diet through SIRT1
- SIRT1‐mediated transcriptional regulation of SOX2 is important for self‐renewal of liver cancer stem cells
- The anti-ageing molecule SIRT1 mediates beneficial effects of cardiac rehabilitation
- Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice
- The NAD+/PARP1/SIRT1 axis in aging
- Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through SIRT1-dependent autophagy induction
- SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy
- Modulation of mitochondrial membrane potential and ROS generation by nicotinamide in a manner independent of SIRT1 and mitophagy
- SIRT1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins
- Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With SIRT1
- Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver
- O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway
- HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism
- Expression and clinical significance of SIRT1 in colorectal cancer
- SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p
- Berberine suppresses LPS-induced inflammation through modulating SIRT1/NF-κB signaling pathway in RAW264. 7 cells
- SIRT1 suppresses adipogenesis by activating Wnt/β-catenin signaling in vivo and in vitro
- SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway
- Reduction in podocyte SIRT1 accelerates kidney injury in aging mice
- The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model
- SIRT1 was involved in TNF-α-promoted osteogenic differentiation of human DPSCs through Wnt/β-catenin signal
- Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development
- SIRT1 protects endothelial cells against LPS-induced barrier dysfunction
- Role of SIRT1 plays in nucleus pulposus cells and intervertebral disc degeneration
- Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1
- Sirtuin1 (SIRT1) in the acetylation of downstream target proteins
- SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
- Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
- Moving to the rhythm with clock (circadian) genes, autophagy, mTOR, and SIRT1 in degenerative disease and cancer
- Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway
- Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
- Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription
- Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome
- Resveratrol inhibits proliferation and migration through SIRT1 mediated post‑translational modification of PI3K/AKT signaling in hepatocellular carcinoma …
- MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting SIRT1
- Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway
- SIRT1 in endothelial cells as a novel target for the prevention of early vascular aging
- Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway
- SIRT1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
- Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes
- Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat …
- SIRT1 limits adipocyte hyperplasia through c-Myc inhibition
- The SIRT1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress
- BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1
- Interactions between SIRT1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo
- Screening SIRT1 activators from medicinal plants as bioactive compounds against oxidative damage in mitochondrial function
- Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats
- The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
- Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis
- SIRT1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat
- Neuronal SIRT1 (silent information regulator 2 homologue 1) regulates glycolysis and mediates resveratrol-induced ischemic tolerance
- Resveratrol alleviates MPTP‐induced motor impairments and pathological changes by autophagic degradation of α‐synuclein via SIRT1‐deacetylated LC3
- Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress
- SIRT1 may play a crucial role in overload‐induced hypertrophy of skeletal muscle
- miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway
- Cellular localization of NRF2 determines the self-renewal and osteogenic differentiation potential of human MSCs via the P53–SIRT1 axis
- SIRT1 polymorphisms and serum-induced SIRT1 protein expression in aging and frailty: the CHAMP study
- The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia
- Use of the Monte Carlo Method for OECD Principles‐Guided QSAR Modeling of SIRT1 Inhibitors
- Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: Role of SIRT1‐mediated autophagy regulation
- Salmonella Typhimurium disrupts SIRT1/AMPK checkpoint control of mTOR to impair autophagy
- Harnessing the power of SIRT1 and non-coding RNAs in vascular disease
- The epigenetic regulation of HIF-1α by SIRT1 in MPP+ treated SH-SY5Y cells
- SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro
- Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer
- AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia
- The effect of lead exposure on expression of SIRT1 in the rat hippocampus
- SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride
- Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of SIRT1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning
- Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity
- SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis
- KRAS activation and over-expression of SIRT1/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance
- miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling
- Resveratrol enhances autophagic flux and promotes Ox-LDL degradation in HUVECs via upregulation of SIRT1
- MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis
- Circulating SIRT1 increases after intragastric balloon fat loss in obese patients
- SIRT1‐mediated ERβ suppression in the endothelium contributes to vascular aging
- LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive …
- SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells
- Regulation of SIRT1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity
- Galangin induces autophagy via deacetylation of LC3 by SIRT1 in HepG2 cells
- Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect
- Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats
- An agonist of the protective factor SIRT1 improves functional recovery and promotes neuronal survival by attenuating inflammation after spinal cord injury
- SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis
- Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy
- Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway
- SIRT1 ameliorates systemic sclerosis by targeting the mTOR pathway
- NAMPT regulates senescence, proliferation, and migration of endothelial progenitor cells through the SIRT1 AS lncRNA/miR-22/SIRT1 pathway
- Histone deacetylase SIRT1 controls proliferation, circadian rhythm, and lipid metabolism during liver regeneration in mice
- SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells
- CKII-SIRT1-SM22α loop evokes a self-limited inflammatory response in vascular smooth muscle cells
- Epigenetic regulation through SIRT1 in podocytes
- The effect of exercise, resveratrol or their combination on Sarcopenia in aged rats via regulation of AMPK/SIRT1 pathway
- SIRT1 disruption in human fetal hepatocytes leads to increased accumulation of glucose and lipids
- Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs
- Ginsenoside Rb2 alleviates hepatic lipid accumulation by restoring autophagy via induction of SIRT1 and activation of AMPK
- Association of SIRT1 and HMGA1 expression in non-small cell lung cancer
- Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice
- Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats
- Inflammation downregulates UCP1 expression in brown adipocytes potentially via SIRT1 and DBC1 interaction
- LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes
- SIRT1 regulates Mxd1 during malignant melanoma progression
- Weight Loss Is Associated With Increased NAD+/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue
- Melatonin facilitates adipose‐derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway
- The prognostic role of SIRT1-autophagy axis in gastric cancer
- Overexpression of SIRT1 prevents hypoxia‑induced apoptosis in osteoblast cells
- SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions
- Silibinin restores NAD+ levels and induces the SIRT1/AMPK pathway in non-alcoholic fatty liver
- Lysophosphatidic acid promotes epithelial to mesenchymal transition in ovarian cancer cells by repressing SIRT1
- Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity
- SIRT1 regulates cognitive performance and ability of learning and memory in diabetic and nondiabetic models
- MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1
- SIRT1: a novel target for the treatment of muscular dystrophies
- SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid
- Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways
- Restoration of SIRT1 function by pterostilbene attenuates hypoxia-reoxygenation injury in cardiomyocytes
- miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation
- SIRT1/HSF1/HSP pathway is essential for exenatide‐alleviated, lipid‐induced hepatic endoplasmic reticulum stress
- Activation of miR-34a-5p/SIRT1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity
- A CREB-SIRT1-Hes1 circuitry mediates neural stem cell response to glucose availability
- The crosstalk between SIRT1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular …
- Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway
- IRF8 is the target of SIRT1 for the inflammation response in macrophages
- SIRT1/adenosine monophosphate-activated protein kinase α signaling enhances macrophage polarization to an anti-inflammatory phenotype in rheumatoid …
- SIRT1 gain of function does not mimic or enhance the adaptations to intermittent fasting
- From the Cover: l-Carnitine via PPARγ- and SIRT1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by …
- Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
- SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model
- SIRT1 regulates the inflammatory response of vascular adventitial fibroblasts through autophagy and related signaling pathway
- miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway
- SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review
- SIRT1 functions as a negative regulator of eukaryotic poly (A) RNA transport
- SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status
- Vitamin D insufficiency exacerbates adipose tissue macrophage infiltration and decreases AMPK/SIRT1 activity in obese rats
- Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1
- SIRT1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
- The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening
- Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer
- Dioscin alleviates BDL-and DMN-induced hepatic fibrosis via SIRT1/Nrf2-mediated inhibition of p38 MAPK pathway
- Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in …
- SIRT1 deacetylates the cardiac transcription factor Nkx2. 5 and inhibits its transcriptional activity
- Cilostazol modulates autophagic degradation of β-amyloid peptide via SIRT1-coupled LKB1/AMPKα signaling in neuronal cells
- Suppression of SIRT1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis
- Berberine protects against ischemia/reperfusion injury after orthotopic liver transplantation via activating SIRT1/FoxO3α induced autophagy
- Forkhead transcription factor FOXO1 inhibits angiogenesis in gastric cancer in relation to SIRT1
- Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients
- USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway
- Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: involvement of SIRT1 and SIRT6
- Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling
- Resveratrol prevents ROS-induced apoptosis in high glucose-treated retinal capillary endothelial cells via the activation of AMPK/SIRT1/PGC-1α pathway
- CD38 deficiency protects the heart from ischemia/reperfusion injury through activating SIRT1/FOXOs-mediated antioxidative stress pathway
- Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SIRT1 axis
- Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of SIRT1 in hippocampus
- Reducing Smad3/ATF4 was essential for SIRT1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue
- The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity
- Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1
- SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy
- SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells
- SIRT1‐SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide
- Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of …
- Up-regulation of SIRT1 reduces endoplasmic reticulum stress and renal fibrosis
- Resveratrol ameliorates palmitate‐induced inflammation in skeletal muscle cells by attenuating oxidative stress and JNK/NF‐κB pathway in a SIRT1‐independent …
- Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia
- Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice: an in vitro and in vivo study
- Effect of genistein on expression of pancreatic SIRT1, inflammatory cytokines and histological changes in ovariectomized diabetic rat
- Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats
- SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury
- Activation of SIRT1/FXR signaling pathway attenuates triptolide-induced hepatotoxicity in rats
- SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α-and β-zearalenol through an autophagy-dependent pathway
- SIRT1 protects human lens epithelial cells against oxidative stress by inhibiting p53-dependent apoptosis
- The neuroprotective effects of SIRT1 on NMDA-induced excitotoxicity
- Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury
- miR-133b inhibits glioma cell proliferation and invasion by targeting SIRT1
- P66 Shc-SIRT1 Regulation of Oxidative Stress Protects Against Cardio-cerebral Vascular Disease
- SIRT1 enzymatically potentiates 1, 25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation
- iNOS as a driver of inflammation and apoptosis in mouse skeletal muscle after burn injury: possible involvement of SIRT1 S-nitrosylation-mediated acetylation …
- Polydatin protecting kidneys against hemorrhagic shock-induced mitochondrial dysfunction via SIRT1 activation and p53 deacetylation
- miR-200a-3p promotes β-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer’s disease
- Exendin-4 upregulates adiponectin level in adipocytes via SIRT1/Foxo-1 signaling pathway
- … glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting SIRT1 and Sirt3 expression
- SIRT1-activating compounds (STAC) negatively regulate pancreatic cancer cell growth and viability through a SIRT1 lysosomal-dependent pathway
- SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening
- Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity
- LncRNA H19 promotes the differentiation of bovine skeletal muscle satellite cells by suppressing SIRT1/FoxO1
- SIRT1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease
- SIRT1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice [S]
- Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating SIRT1/AMPKα/SREBP1 signaling pathway
- SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis
- Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration
- Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as …
- Early-life exposure to lead induces cognitive impairment in elder mice targeting SIRT1 phosphorylation and oxidative alterations
- Genistein ameliorates ischemia/reperfusion-induced renal injury in a SIRT1-dependent manner
- The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells
- Melatonin protects premature ovarian insufficiency induced by tripterygium glycosides: role of SIRT1
- Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats
- Salidroside attenuates ventilation induced lung injury via SIRT1-dependent inhibition of NLRP3 inflammasome
- Rutin protects rat articular chondrocytes against oxidative stress induced by hydrogen peroxide through SIRT1 activation
- Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the SIRT1/AMPK/PGC-1α pathway
- The deacetylase SIRT1 regulates the replication properties of human papillomavirus 16 E1 and E2
- Suppression of miR-34a expression in the myocardium protects against ischemia–reperfusion injury through SIRT1 protective pathway
- Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells
- Mir‐217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via SIRT1/HIF‐1α signaling pathway
- A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53
- Combination treatment with quercetin and resveratrol attenuates high fat diet‑induced obesity and associated inflammation in rats via the AMPKα1/SIRT1 …
- Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling
- Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer
- Tucum-do-Cerrado (Bactris setosa Mart.) may promote anti-aging effect by upregulating SIRT1-Nrf2 pathway and attenuating oxidative stress and inflammation
- Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer
- Protective effect of trans-δ-viniferin against high glucose-induced oxidative stress in human umbilical vein endothelial cells through the SIRT1 pathway
- Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway
- SIRT1 regulates apoptosis and extracellular matrix degradation in resveratrol‑treated osteoarthritis chondrocytes via the Wnt/β‑catenin signaling pathways
- Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway
- Effects of BMAL1–SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS
- Inhibition of microRNA-449a prevents IL-1β-induced cartilage destruction via SIRT1
- SIRT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16
- Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer’s disease
- Mechanism of SIRT1 NAD+-dependent protein deacetylase inhibition by cysteine S-nitrosation
- Sir2/SIRT1 links acute inebriation to presynaptic changes and the development of alcohol tolerance, preference, and reward
- Lipopolysaccharide modulates p300 and SIRT1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron
- Pharmacological SIRT1 activation improves mortality and markedly alters transcriptional profiles that accompany experimental sepsis
- Upregulated miR‐132 in Lgr5+ gastric cancer stem cell‐like cells contributes to cisplatin‐resistance via SIRT1/CREB/ABCG2 signaling pathway
- TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression
- Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1
- Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease
- Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization
- Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300
- Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction
- Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS/SIRT1 pathway
- Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1
- SIRT1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice
- The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo
- Resveratrol attenuates triglyceride accumulation associated with upregulation of SIRT1 and lipoprotein lipase in 3T3-L1 adipocytes
- Inactivation of SIRT1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κ B
- Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats
- A study of SIRT1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis
- SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells
- Pterostilbene alleviates polymicrobial sepsis-induced liver injury: possible role of SIRT1 signaling
- Capsaicin inhibits multiple bladder cancer cell phenotypes by inhibiting tumor-associated NADH oxidase (tNOX) and sirtuin1 (SIRT1)
- Obesity-linked phosphorylation of SIRT1 by casein kinase 2 inhibits its nuclear localization and promotes fatty liver
- Activation of the AMPK/SIRT1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism …
- Synthesis and assay of SIRT1-activating compounds
- Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/SIRT1 Pathway in Hyperglycemic Middle Cerebral Artery …
- Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus
- Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury
- Glycyrrhizic acid prevents diabetic nephropathy by activating AMPK/SIRT1/PGC-1α signaling in db/db mice
- Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264. 7 cells and peritoneal macrophages
- … ameliorates non‐alcoholic fatty liver disease by enhancing mitochondrial architecture and promoting autophagy through the SIRT1/SIRT3–FOXO3a pathway
- CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1α activation
- SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients
- Prognostic and clinicopathological significance of SIRT1 expression in NSCLC: a meta-analysis
- Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation
- Melatonin attenuates early brain injury via the melatonin receptor/SIRT1/NF-κB signaling pathway following subarachnoid hemorrhage in mice
- Knockdown of SIRT1 suppresses bladder cancer cell proliferation and migration and induces cell cycle arrest and antioxidant response through FOXO3a …
- Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells
- Short-term starvation attenuates liver ischemia-reperfusion injury (IRI) by SIRT1-autophagy signaling in mice
- Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro
- SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells
- Berberine alleviates oxidative stress in islets of diabetic mice by inhibiting miR‐106b expression and up‐regulating SIRT1
- … Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide–Dependent SIRT1 Activity
- Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 …
- SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway
- The polyphenol oleuropein aglycone modulates the PARP1-SIRT1 interplay: an in vitro and in vivo study
- Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis
- MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling
- MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells …
- Effect of SIRT1 gene on epithelial-mesenchymal transition of human prostate cancer PC-3 cells
- Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation
- Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster
- FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression
- Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability
- SIRT1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription
- Brown and white adipose tissue expression of IL6, UCP1 and SIRT1 are associated with alterations in clinical, metabolic and anthropometric parameters in obese …
- Olmesartan prevents microalbuminuria in db/db diabetic mice through inhibition of angiotensin II/p38/SIRT1-induced podocyte apoptosis
- SIRT1: a novel guardian of brown fat against metabolic damage
- β2‐AR activation induces chemoresistance by modulating p53 acetylation through upregulating SIRT1 in cervical cancer cells
- Vitamin D receptor deficit induces activation of renin angiotensin system via SIRT1 modulation in podocytes
- SIRT1 negatively regulates FcεRI-mediated mast cell activation through AMPK-and PTP1B-dependent processes
- Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways
- Silencing of HJURP induces dysregulation of cell cycle and ROS metabolism in bladder cancer cells via PPARγ-SIRT1 feedback loop
- SIRT1, a class III histone deacetylase, regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol
- CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
- The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition
- Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels
- … augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1
- SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer
- An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3
- Common variants in SIRT1 and human longevity in a Chinese population
- SIRT1 activity is linked to its brain region-specific phosphorylation and is impaired in Huntington’s disease mice
- SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway
- Cardiac SIRT1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion
- SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease
- Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway
- Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma
- Resveratrol promotes human embryonic stem cells self-renewal by targeting SIRT1-ERK signaling pathway
- Resveratrol ameliorates contrast induced nephropathy through the activation of SIRT1-PGC-1α-Foxo1 signaling in mice
- … crocetin and the synthetic tellurium compound AS101 protect the ovary against cyclophosphamide by modulating SIRT1 and mitochondrial markers
- Prognostic and clinical value of SIRT1 expression in gastric cancer: A systematic meta-analysis
- SIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet
- Nampt expression decreases age-related senescence in rat bone marrow mesenchymal stem cells by targeting SIRT1
- (–)-Epicatechin suppresses angiotensin II-induced cardiac hypertrophy via the activation of the SP1/SIRT1 signaling pathway
- Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice
- Resveratrol enhances HBV replication through activating SIRT1-PGC-1α-PPARα pathway
- Dysregulation of the SIRT1/OCT6 axis contributes to environmental stress-induced neural induction defects
- The metabolic sensor SIRT1 and the hypothalamus: Interplay between peptide hormones and pro-hormone convertases
- A novel role of SIRT1/FGF-21 in taurine protection against cafeteria diet-induced steatohepatitis in rats
- Identification of a tissue-restricted isoform of SIRT1 defines a regulatory domain that encodes specificity
- Regulation of stem cell aging by SIRT1–Linking metabolic signaling to epigenetic modifications
- Salidroside inhibits HMGB1 acetylation and release through upregulation of SIRT1 during inflammation
- Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells
- Role of SIRT1 as a Regulator of Autophagy
- VISFATIN (NAMPT) improves in vitro IGF1-induced steroidogenesis and IGF1 receptor signaling through SIRT1 in bovine granulosa cells
- miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age-related hearing loss
- Capsaicin protects cardiomyocytes against anoxia/reoxygenation injury via preventing mitochondrial dysfunction mediated by SIRT1
- Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1
- The UCA1/miR-204/SIRT1 axis modulates docetaxel sensitivity of prostate cancer cells
- … proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1 …
- Treadmill exercise attenuates α-synuclein levels by promoting mitochondrial function and autophagy possibly via SIRT1 in the chronic MPTP/P-induced mouse model …
- Resveratrol attenuates microglial activation via SIRT1-SOCS1 pathway
- Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery …
- Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock …
- MicroRNA-200a is up-regulated in aged rats with erectile dysfunction and could attenuate endothelial function via SIRT1 inhibition
- Identification of new inhibitors for human SIRT1: an in-silico approach
- Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1
- … PC12 cells from tunicamycin-mediated cell death via reactive oxygen species scavenging and modulation of Nrf2-driven gene expression, SIRT1 and MAPK signaling …
- Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma
- Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1
- SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes
- Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and SIRT1
- SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells
- Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenous β-defensin expression through the SIRT1/ERK/90RSK pathway
- SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-κB signaling pathway
- SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development
- Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo
- Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients
- hnRNP A1 antagonizes cellular senescence and senescence‐associated secretory phenotype via regulation of SIRT1 mRNA stability
- SIRT1 confers protection against ischemia/reperfusion injury in cardiomyocytes via regulation of uncoupling protein 2 expression
- SIRT1-mediated deacetylation of PGC1α attributes to the protection of curcumin against glutamate excitotoxicity in cortical neurons
- Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, SIRT1
- HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells
- Identifying human SIRT1 substrates by integrating heterogeneous information from various sources
- Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway
- Long non-coding RNA TUG1 promotes cervical cancer progression by regulating the miR-138-5p-SIRT1 axis
- Adiponectin protects against glutamate-induced excitotoxicity via activating SIRT1-dependent PGC-1 expression in HT22 hippocampal neurons
- Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis
- Acute treatment of resveratrol alleviates doxorubicin-induced myotoxicity in aged skeletal muscle through SIRT1-dependent mechanisms
- SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22
- ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy
- Mst1 regulates hepatic lipid metabolism by inhibiting SIRT1 ubiquitination in mice
- 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via SIRT1 in …
- … compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via SIRT1/PGC-1α pathway
- Carbon Monoxide Potentiation of L-Type Ca2+ Channel Activity Increases HIF-1α-Independent VEGF Expression via an AMPKα/SIRT1-Mediated PGC-1α/ERRα …
- MicroRNA-34a negatively regulates efferocytosis by tissue macrophages in part via SIRT1
- SIRT1 suppresses Wnt/βCatenin signaling in liver cancer cells by targeting βCatenin in a PKAα-dependent manner
- Visfatin attenuates the ox-LDL-induced senescence of endothelial progenitor cells by upregulating SIRT1 expression through the PI3K/Akt/ERK pathway
- Protection of CD4+ T cells from hepatitis C virus infection‐associated senescence via ΔNp63–miR‐181a–SIRT1 pathway
- SIRT1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats
- Adiponectin suppresses T helper 17 cell differentiation and limits autoimmune CNS inflammation via the SIRT1/PPARγ/RORγt pathway
- NFAT5 protects astrocytes against oxygen–glucose–serum deprivation/restoration damage via the SIRT1/Nrf2 pathway
- MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway
- The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway
- Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients
- Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet‐fed middle‐aged mice via a SIRT1‐dependent mechanism
- Hepatitis C virus core protein impairs metabolic disorder of liver cell via HOTAIR-SIRT1 signalling
- SIRT1 increases YAP-and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma
- The SIRT1/NF-kB signaling pathway is involved in regulation of endothelin type B receptors mediated by homocysteine in vascular smooth muscle cells
- Retinoic acid ameliorates high-fat diet-induced liver steatosis through SIRT1
- Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver
- Treatment with NAD+ inhibited experimental autoimmune encephalomyelitis by activating AMPK/SIRT1 signaling pathway and modulating Th1/Th17 immune …
- Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression
- Resveratrol attenuates Aβ 25–35 caused neurotoxicity by inducing autophagy through the TYrRS-PARP1-SIRT1 signaling pathway
- Depigmenting effect of resveratrol is dependent on FOXO3a activation without SIRT1 activation
- Assessing colonic exposure, safety, and clinical activity of SRT2104, a novel oral SIRT1 activator, in patients with mild to moderate ulcerative colitis
- SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation
- Vav1 regulates mesenchymal stem cell differentiation decision between adipocyte and chondrocyte via SIRT1
- Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway
- … myocardial ischemia–reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 …
- Resveratrol inhibits adventitial fibroblast proliferation and induces cell apoptosis through the SIRT1 pathway
- AMPK↔ SIRT1: from a signaling network to a combination drug
- Fibroblast growth factor 21 (FGF21) promotes formation of aerobic myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α pathway
- Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3
- Mesenchymal stem cells with SIRT1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment
- Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: Role of AMPK, SIRT1, and mitochondrial function
- Resveratrol attenuated TNF-α–induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway
- Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
- Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as SIRT1/2 Inhibitor
- MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization
- Mangiferin protects retinal ganglion cells in ischemic mouse retina via SIRT1
- SIRT1 gene polymorphisms and risk of lung cancer
- Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress
- Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through SIRT1/PGC-1α/Mn-SOD signaling pathways
- Ampelopsin attenuates the atrophy of skeletal muscle from d-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade
- miR‐204‐5p targeting SIRT1 regulates hepatocellular carcinoma progression
- Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways
- MicroRNA-133b inhibits cell proliferation and invasion in osteosarcoma by targeting SIRT1
- Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-cell chronic lymphocytic leukemia (CLL)
- Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity
- Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway
- Resveratrol protects against high-fat diet induced renal pathological damage and cell senescence by activating SIRT1
- Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling
- Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and …
- microRNA-182 mediates SIRT1-induced diabetic corneal nerve regeneration
- Hydrogen rich water attenuates renal injury and fibrosis by regulation transforming growth factor-β induced SIRT1
- Anti-fibrotic effect of losartan, an angiotensin II receptor blocker, is mediated through inhibition of ER stress via up-regulation of SIRT1, followed by induction of HO-1 …
- Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway
- Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus
- 1, 4-Dihydropyridines active on the SIRT1/AMPK pathway ameliorate skin repair and mitochondrial function and exhibit inhibition of proliferation in cancer cells
- Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation
- Melatonin inhibits SIRT1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis
- Hydrogen sulfide attenuates inflammatory hepcidin by reducing IL-6 secretion and promoting SIRT1-mediated STAT3 deacetylation
- Emodin suppresses silica-induced lung fibrosis by promoting SIRT1 signaling via direct contact
- Biogenesis of pro-senescent microparticles by endothelial colony forming cells from premature neonates is driven by SIRT1-dependent epigenetic regulation …
- HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis
- Extremely low-frequency electromagnetic field promotes astrocytic differentiation of human bone marrow mesenchymal stem cells by modulating SIRT1 expression
- Underlying mechanism of SIRT1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes
- Rehabilitation training and resveratrol improve the recovery of neurological and motor function in rats after cerebral ischemic injury through the SIRT1 signaling …
- SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma
- Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA
- Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
- Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells
- Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion
- Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory‑fibrosis through the NF‑κB p65 and SIRT1 pathway; NMN alleviates …
- Sevoflurane ameliorates myocardial cell injury by inducing autophagy via the deacetylation of LC3 by SIRT1
- Sirtuin 1 (SIRT1) overexpression in BaF3 cells contributes to cell proliferation promotion, apoptosis resistance and pro-inflammatory cytokine production
- Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise
- The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells
- Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/β-catenin signaling pathway mediated by SIRT1
- SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium
- Juglone up-regulates SIRT1 in skin cells under normal and UVB irradiated conditions
- Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products
- The nutrient and energy sensor SIRT1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the prohormone convertase 2 (PC2) …
- mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway
- Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1
- Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC zeta-GLUT4-glucose pathway in …
- Targeting SIRT1 in a rat model of high‑fat diet‑induced non‑alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol
- miR-543 promotes gastric cancer cell proliferation by targeting SIRT1
- Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-α in patients with obstructive sleep apnea
- Adiponectin upregulates filaggrin expression via SIRT1-mediated signaling in human normal keratinocytes
- Over-expression of heat shock protein 70 protects mice against lung ischemia/reperfusion injury through SIRT1/AMPK/eNOS pathway
- TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence
- Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-κB and activating SIRT1
- Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways
- PDE5 inhibition ameliorates visceral adiposity targeting the miR-22/SIRT1 pathway: evidence from the CECSID trial
- microRNA‑34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma Corrigendum in/10.3892/ol. 2019.11048
- Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas
- Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells
- AML1–ETO promotes SIRT1 expression to enhance leukemogenesis of t (8; 21) acute myeloid leukemia
- Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated …
- MiR-21 regulates TNF-α-induced CD40 expression via the SIRT1-NF-κB pathway in renal inner medullary collecting duct cells
- High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC‐1α/SIRT1 signaling pathway
- Protective effects of isorhamnetin on cardiomyocytes against anoxia/reoxygenation-induced injury is mediated by SIRT1
- … sepsis‑induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF‑α and myocardial apoptosis via activation of SIRT1
- Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
- Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic β cells from apoptosis
- SIRT1 activity is decreased in lesional psoriatic skin
- AAV-mediated SIRT1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance
- Inhibitory effects of SRT1720 on the apoptosis of rabbit chondrocytes by activating SIRT1 via p53/bax and NF-κB/PGC-1α pathways
- Mesenchymal stem cells overexpressing SIRT1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages
- Resveratrol improved the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating SIRT1
- Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent Manner
- Bivalent SIRT1 inhibitors
- miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting SIRT1
- GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1
- SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5′ UTR RNA
- Resveratrol promotes recovery of hearing following intense noise exposure by enhancing cochlear SIRT1 activity
- Leucine-nicotinic acid synergy stimulates AMPK/SIRT1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia …
- Response of BAX, Bcl-2 proteins, and SIRT1/PGC-1α mRNA expression to 8-week treadmill running in the aging rat skeletal muscle
- SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells
- MiR-138-5p promotes TNF-α-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling
- SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the …
- … present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD+/NADH ratio and activating PPARα, AMPK and SIRT1 …
- Alteration of muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscle of growing pigs fed low-protein diets with varying branched …
- Inhibiting microRNA-449 attenuates cisplatin-induced injury in NRK-52E cells possibly via regulating the SIRT1/P53/BAX pathway
- Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice
- … : Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating the SIRT1 …
- Reversible modulation of SIRT1 activity in a mouse strain
- Expression profiles of SIRT1 and APP genes in human neuroblastoma SK-N-SH cells treated with two epigenetic agents
- SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets
- De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells
- miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1
- SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1
- Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1
- Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats
- Resveratrol exerts protective effects on anoxia/reoxygenation injury in cardiomyocytes via miR-34a/SIRT1 signaling pathway
- MicroRNA-141 targets SIRT1 and inhibits autophagy to reduce HBV replication
- MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
- Zerumbone ameliorates high-fat diet-induced adiposity by restoring AMPK-regulated lipogenesis and microRNA-146b/SIRT1-mediated adipogenesis
- … implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly (ADP …
- NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity
- CHFR negatively regulates SIRT1 activity upon oxidative stress
- Omega-3 polyunsaturated fatty acids alleviate hepatic steatosis-induced inflammation through SIRT1-mediated nuclear translocation of NF-κB p65 subunit in …
- CR6-interacting factor 1 deficiency impairs vascular function by inhibiting the SIRT1-endothelial nitric oxide synthase pathway
- Methylene blue alleviates experimental autoimmune encephalomyelitis by modulating AMPK/SIRT1 signaling pathway and Th17/Treg immune response
- Communication from tubular epithelial cells to podocytes through SIRT1 and nicotinic acid metabolism
- MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1
- Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma
- Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1
- The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1
- Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through SIRT1/ERK1/2 signaling pathway
- SIRT1 signaling pathway mediated the protective effects on myocardium of rats after endurance training and acute exhaustive exercise
- miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting SIRT1
- Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients
- 1,25(OH)2D3 improves cardiac dysfunction, hypertrophy, and fibrosis through PARP1/SIRT1/mTOR‐related mechanisms in type 1 diabetes
- Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?
- miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1
- miR-204 regulates the proliferation of dairy goat spermatogonial stem cells via targeting to SIRT1
- miR-22 inhibits mouse ovarian granulosa cell apoptosis by targeting SIRT1
- Lin28a protects against postinfarction myocardial remodeling and dysfunction through SIRT1 activation and autophagy enhancement
- Highly sensitive electrochemical immunoassay integrated with polymeric nanocomposites and enhanced SiO2@ Au core-shell nanobioprobes for SIRT1 determination
- Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1
- Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS
- AdipoR1-mediated miR-3908 inhibits glioblastoma tumorigenicity through downregulation of STAT2 associated with the AMPK/SIRT1 pathway
- Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1α and serum antioxidant enzymes in patients with coronary artery …
- Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review
- MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
- SIRT1‑mediated regulation of oxidative stress induced by Pseudomonas aeruginosa lipopolysaccharides in human alveolar epithelial cells
- Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing’s sarcoma cells: resveratrol suppresses and SRT1720 enhances …
- In patients with coronary artery disease and type 2 diabetes, SIRT1 expression in circulating mononuclear cells is associated with levels of inflammatory …
- SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi’s sarcoma-associated herpesvirus transformed cells
- A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t (8; 21) acute myeloid leukemia
- SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells
- SIRT1 regulates accumulation of oxidized LDL in HUVEC via the autophagy-lysosomal pathway
- Central metabolic sensing remotely controls nutrient-sensitive endocrine response in Drosophila via Sir2/SIRT1–upd2–IIS axis
- The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control
- Metabolism of 20 (S)-Ginsenoside Rg2 by rat liver microsomes: bioactivation to SIRT1-activating metabolites
- Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma
- Differential effects of estradiol and bisphenol A on SET8 and SIRT1 expression in ovarian cancer cells
- … of extracellular calcium influx results in enhanced IL-12 production in LPS-treated murine macrophages by downregulation of the CaMKK-AMPK-SIRT1 …
- Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice
- The aldehyde group of gossypol induces mitochondrial apoptosis via ROS-SIRT1-p53-PUMA pathway in male germline stem cell
- Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1
- Localization of sirtuins (SIRT1-7) in the aged mouse inner ear
- Sirtuin1 (SIRT1) regulates tumor necrosis factor-alpha (TNF-α-Induced) aquaporin-2 (AQP2) expression in renal medullary collecting duct cells through …
- Suppression of miR-301a alleviates LPS-induced inflammatory injury in ATDC5 chondrogenic cells by targeting SIRT1
- Beraprost sodium, a prostacyclin analogue, reduces fructose-induced hepatocellular steatosis in mice and in vitro via the microRNA-200a and SIRT1 signaling …
- Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline
- microRNA-199a-5p mediates high glucose-induced reactive oxygen species production and apoptosis in INS-1 pancreatic ß-cells by targeting SIRT1
- Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors
- Breast cancer metastasis suppressor 1 modulates SIRT1-dependent p53 deacetylation through interacting with DBC1
- Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator
- 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop
- MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1
- Polymorphism in the SIRT1 gene and parameters of metabolic syndrome in a sample of the adult Brazilian population
- MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting SIRT1
- Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius …
- mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy
- Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: A probable linkage between obesity and coronary arterial disease
- SIRT1 expression is refractory to hypoxia and inflammatory cytokines in nucleus pulposus cells: Novel regulation by HIF‐1α and NF‐κB signaling
- SIRT1 controls cell proliferation by regulating contact inhibition
- … (3D-QSAR) modeling combined with virtual screening to identify novel small-molecule inhibitors of silent mating-type information regulation 2 homologue 1 (SIRT1)
- Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (SIRT1)
- Protective effect of unacylated ghrelin on compression-induced skeletal muscle injury mediated by SIRT1-signaling
- Obesity accelerates murine gastric cancer growth by modulating the SIRT1/YAP pathway
- DJ-1 activates SIRT1 through its direct binding to SIRT1
- #VALUE!
- microRNA‑494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer
- Carnosic acid attenuates acute ethanol-induced liver injury via a SIRT1/p66Shc-mediated mitochondrial pathway
- SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
- Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia
- Differential expression of circadian genes in leukemia and a possible role for SIRT1 in restoring the circadian clock in chronic myeloid leukemia
- Is SIRT6 activity neuroprotective and how does it differ from SIRT1 in this regard?
- PU. 1-deficient mice are resistant to thioacetamide-induced hepatic fibrosis: PU. 1 finely regulates SIRT1 expression via transcriptional promotion of miR-34a …
- Tat-mediated induction of miRs-34a &-138 promotes astrocytic activation via downregulation of SIRT1: implications for aging in HAND
- Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1)
- Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression
- Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1
- CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells
- Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting SIRT1
- Overcoming ATM deficiency by activating the NAD+/SIRT1 axis
- G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE−/− mice
- Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK …
- Acetylome study in mouse adipocytes identifies targets of SIRT1 deacetylation in chromatin organization and RNA processing
- NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
- Tris (2‐chloroethyl) phosphate‐induced cell growth arrest via attenuation of SIRT1‐independent PI3K/Akt/mTOR pathway
- Altered microRNA-9 expression level is directly correlated with pathogenesis of nonalcoholic fatty liver disease by targeting Onecut2 and SIRT1
- Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating SIRT1
- Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
- Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK
- Transcriptional coactivator p300 and silent information regulator 1 (SIRT1) gene polymorphism associated with diabetic kidney disease in a Chinese cohort
- Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change
- The silent information regulator 1 (SIRT1) is a positive regulator of the Notch pathway in Drosophila
- Understanding genetic heterogeneity in type 2 diabetes by delineating physiological phenotypes: SIRT1 and its gene network in impaired insulin secretion
- The gender association of the SIRT1 rs7895833 polymorphism with pediatric obesity: a 3-year panel study
- Effect of daisaikoto on expressions of SIRT1 and NF-kappaB of diabetic fatty liver rats induced by high-fat diet and streptozotocin
- 1, 2, 3-Triazole-dithiocarbamate hybrids, a group of novel cell active SIRT1 inhibitors
- To Stay Happy, Keep Your SIRT1 Active
- Paliperidone Protects SH-SY5Y Cells Against MK-801-Induced Neuronal Damage Through Inhibition of Ca2+ Influx and Regulation of SIRT1/miR-134 Signal …
- SIRT1 gene polymorphisms associated with carcass traits in Luxi cattle
- Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine
- Lycium barbarum polysaccharides enhances SIRT1 expression and decreases MMP-9 and HIF-1α expressions in hypoxic pulmonary vascular smooth muscle cells
- SIRT1 Influences the sensitivity of A549 non-small cell lung cancer cell line to cisplatin via modulating the Noxa expression
- Suppressive effect of microRNA-138 on the proliferation and invasion of osteosarcoma cells via targeting SIRT1
- Activation of SIRT1 deacetylase as a therapeutic approach for myelodysplastic syndromes by restoring TET2 function
- miR-138 promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through the SIRT1/p-STAT3 pathway
- Resveratrol suppresses P-selectin, PSGL-1, and VWF through SIRT1 signaling pathway
- Effect of Kangshuanyihao Formula on the Inflammatory Reaction and SIRT1/TLR4/NF-κB Signaling Pathway in Endothelial Injury
- The impact of a 48-h fast on SIRT1 and GCN5 in human skeletal muscle
- Giardia duodenalis GlSir2. 2, homolog of SIRT1, is a nuclear-located and NAD+-dependent deacethylase
- SIRT1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus
- FOXO3a & haematopoietic stem cells: Goodbye PI3K, hello SIRT1?
- A novel Ubc9-dependent pathway regulates SIRT1-ER-α Axis and BRCA1-associated TNBC lung metastasis
- SIRT1-positive lymphocytes in acute cellular cardiac allograft rejection: contributor to pathogenesis and a therapeutic target
- SIRT1 gene polymorphisms and its protein level in colorectal cancer
- Morphoproteomics identifies SIRT1 and EZH2 pathways as commonalities in B-cell acute lymphoblastic leukemia: pathogenetic implications and opportunities for …
- B31 SIRT1 expression, regulation and activity in R6/2 mice
- Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1
- GW28-e0635 Quercetin retards progression of Diabetic cardiomyopathy through modulations of SIRT1 and AMP-activated protein kinase
- The effects of siRNA SIRT1 on the proliferation of human cervical cancer cells
- #VALUE!
- Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease
- KDM2B is a histone H3K79 demethylase and induces transcriptional repression via SIRT1-mediated chromatin silencing
- Protective effects and mechanism of SIRT1 for the regulation of p38 MAPK pathway on retinal ganglion cells in rats with diabetic retinopathy
- Updated roles of SIRT1 in prostate diseases
- SIRT1 in metabolic health and disease
- Guttiferone A aggregates modulate silent information regulator 1 (SIRT1) activity
- SAT0046 Regulation of SIRT1 Maybe A Pioneering Strategy in Treatment of Rheumatoid Arthritis
- SIRT1 puts an embargo on mRNA export
- Alteration of Wnt/β-catenin signaling pathway in type2 diabetic rats’ aorta and regulation of SIRT1
- Loss of SIRT1 impairs autophagy in chondrocytes and is associated with accelerated cartilage aging and experimental osteoarthritis
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- Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice
- Propofol alleviates hepatic ischemia/reperfusion injury via the activation of the SIRT1 pathway
- Whey Protein Attenuates Angiotensin II-Primed Premature Senescence of Vascular Smooth Muscle Cells through Upregulation of SIRT1
- Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
- Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/SIRT1/NF-κB signaling pathway in aging rats
- SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
- Morphoproteomics identifies the EZH2 and SIRT1 pathways as potential blocks to differentiation in yolk sac tumor of the ovary and provides therapeutic options: A …
- Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease
- Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through SIRT1 pathway
- Multi-allele dipstick assay for visual genotyping of four novel SIRT1 gene variant alleles as candidate biomarkers for sporadic Parkinson disease
- Corrigendum to” Restoration of SIRT1 Function by Pterostilbene Attenuates Hypoxia-Reoxygenation Injury in Cardiomyocytes”[Eur. J. Pharmacol. 776 (2016) 26-33]
- Expression of AMPK, SIRT1, and ACC differs between winter-and summer-acclimatized Djungarian Hamsters
- Construction of lentiviral vector containing SIRT1 gene and its expression in retinal ganglion cell
- Anti-inflammatory effect of Chikusetsu oleanane saponin on Raw264. 7 cell through regulating SIRT1 activity
- PPAR gamma coactivator 1 beta (PGC-1β) reduces mammalian target of rapamycin (mTOR) expression via a SIRT1-dependent mechanism in neurons
- Effect of SIRT1 gene silencing on radiosensitivity of diffuse large B-cell lymphoma cells
- AB0107 The modulation of macrophage polarization by SIRT1 maybe new target therapy in rheumatoid arthritis
- Effect of SIRT1 deficiency on function of brown adipose tissue in obese mice
- Role of SIRT1 in C5b-9 mediated oligodendrocyte cell cycle activation
- Survivin and SIRT1: can be two prognostic factors in chronic myeloid leukemia?
- Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers
- The Impact of Ramadan Fasting on SIRT1 mRNA Expression in Peripheral Blood Mononuclear Cells
- A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy …
- SIRT1 is downregulated during peripheral blood stem cell mobilization in healthy donors by granulocyte-colony stimulating factor
- 3 SIRT1—A POSSIBLE MARKER FOR REPRODUCTIVE AGING OF IN VIVO-DERIVED BOVINE OOCYTES?
- SIRT1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response
- Cardiac SIRT1 Has a Protective Role in Lipotoxic Cardiomyopathy through Maintaining Membrane Fatty Acid Composition
- Effect of Qinggan Zishen Chinese Medicine on SIRT1 Protein Expression in Liver Tissue of Spontaneously Hypertensive Rats Fed with High Fat Diet
- Roles of NAD in Protection of Axon against Degeneration via SIRT1 Pathways
- Allosteric SIRT1 activators as putative anti-aging drugs
- AB059. MiR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
- SIRT1 Activator II Protects against Myocardial Injury in High Fat Diet‐Induced Diabetic Mice
- Analysis of silent information regulator 1 (SIRT1) gene polymorphisms in antituberculosis-drug-induced hepatotoxicity in a prospective cohort study
- D-4F decreases the expression of Aβ protein through up-regulating long non coding RNA SIRT1-as in SAMP8 mice
- Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) …
- Myeloid cell-specific SIRT1 knockout impairs innate immune responses against intracellular bacteria infection
- Enhanced Targeting of FLT3-ITD+ AML Stem Cells through Combined Inhibition of SIRT1 and Autophagic Flux
- PI3 K/Akt/SIRT1 signaling pathway mediated hydrogen sulfide postconditioning-induced protection against I/R injury
- Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation
- SIRT1 modulates AID expression, class switch DNA recombination and somatic hypermutation by repressing NF-kB activity
- Effect of telmisartan and insulin on endoplasmic reticulum stress and the expression of SIRT1 in testis of type 1 diabetic rats
- Different patterns of SIRT1, KLF4, DAPK1 and SPG20 methylation in B lymphocytes correlate with the clinical parameters of non-Hodgkin lymphoma subtypes
- Hypermethylation of HIC1 and aberrant expression of HIC1/SIRT1 contribute to papillary thyroid carcinoma
- Corrigendum: transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis
- Effects of Chaihu Shugan powder on hepatic lipid metabolism and AMPK/SIRT1 pathway in rats with non-alcoholic fatty liver disease
- MP369 D PINITOL ALLEVIATES CYCLOSPORINE-INDUCED RENAL FIBROSIS VIA THE ACTIVATION OF SIRT1 AND NRF2 ANTIOXIDANT PATHWAYS
- SIRT1 modulates immunoglobulin class switch DNA recombination and somatic hypermutation by regulating B lymphocyte Aicda expression through NF-kB …
- Mir-217 promotes inflammation and fibrosis induced by high glucose in rat glomerular mesangial cells via SIRT1/HIF-1αsignal pathway
- Gaba-betaine modulates SIRT1 and p16INK4A expression during high-glucose induced endothelial cell senescence
- SIRT1 and tumor resistance
- ROLE OF SIRT1 IN CANCER: A REVIEW
- Silent mating-type information regulator 2 homolog 1 (SIRT1) in Alzheimer’s disease: an update on potential mechanisms
- Consecutive stimulation of HBsAg promotes the viability of the human B lymphoblastoid cell line IM‑9 through regulating the SIRT1‑NF‑κB pathway
- Dihydroartemisinin enhances antitumor effect of 5-fluorouracil against gastric cancer by down-regulating SIRT1 expression
- Synthesis of potential SIRT1 activators
- Baicalin treatment regulates hyperactivity of HPA axis and alters SIRT1 related inflammation in the hypothalamus in a model of depression
- … Angelica Sinensis Ameliorates High-Fat Diet and STZ-induced Hepatic Oxidative Stress and Inflammation in Diabetic Mice by Activating SIRT1-AMPK Pathway”[JNB 43 …
- E1231, an activator of SIRT1, regulates cholesterol and lipid metabolism through SIRT1-LXRALPHA-ABCA1 pathway
- The correlation between SIRT1 and Muller cells in the development of CNV
- The Role of SIRT1 in Muscle Hypertrophy
- Effect of SIRT1 on the proliferation of ovarian cancer CAOV3 cells and its possible mechanism
- GW28-e0071 The Effect of Mild Hypothermia on Neurons Autophagy after Cerebral Ischemia Reperfusion in SIRT1 Knockout Mice
- SIRT1 regulates Mxd1 throughout melanoma progression
- SIRT1 Increases the Expression of Fetal Hemoglobin Genes in Human Adult and Cord Blood Erythroblasts
- The role of SIRT1 in the formation of retinal miroaneurysms during aging
- MODULATION OF SIRT1 AS AN ANTI-AGEING TARGET
- The effect of shRNA interference lentivirus vector targeting rat SIRT1 gene on the expression of SIRT1 in retinal ganglion cell
- Combined Determination of Carbohydrate Antigen 199 and SIRT1 Based on an Electrochemiluminescence Immunosensor
- THE ROLE OF SIRT1 IN AGEING AND FRAILTY
- GW28-e0612 Liver X receptor agonist T0901317 ameliorates sepsis-induced myocardial injury and dysfunction: the role of SIRT1 signaling
- The Impact of Catalytically Inactive SIRT1 on Age-Associated Cardio-Renal Dysfunction
- P220 Depigmenting effect of resveratrol is not dependent on SIRT1 activation
- A role of SIRT1 in the Notch signalling pathway
- Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2, 9 via AMPK-SIRT1 pathway in a non-small cell lung cancer
- ASSOCIATION OF SIRT1 RS3740051 GENE POLYMORPHISM WITH PITUITARY ADENOMA
- Exploring cellular actions and interactions of SIRT1 that may counteract ageing
- SIRT1: Expression in the cornea and its role in corneal wound healing
- Expression Changes and Significance of SIRT1 Alternative Splicing Variants of SIRT1-Exon8 mRNA in the Hippocampus of Young and Aged Mice
- Effects of maternal lead exposure on expression of 8-OHd G and SIRT1 in brain tissue of mice offspring
- SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
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- Spatial Dynamics of SIRT1 Relates to Metabolic Transitions in the Cell Nucleus
- Assessment of SIRT1 gene expression in patients with chronic myeloid leukemia by real time pcr method
- Expression of SIRT1 in a Uveal Melanoma Animal Model
- The Role of SIRT1 In Breast Cancer Stem Cells
- Non-canonical activation of AR signaling by histone deacetylase SIRT1
- Computational model of circadian oscillator in mammals: Interaction with NAD+/SIRT1 system and age-related changes in the expression of circadian oscillator genes
- Influence of EGFR in B [a] P-induced SIRT1 activation in human bronchial epithelial cells
- SIRT1 and Age-Related Macular Degeneration
- SIRT1 activators induced neuroprotection of photoreceptors in rd10 mice
- The effect of SIRT1 inhibition by EX527 on uveal melanoma cells
- Association of SIRT1 rs3740051 gene polymorphism with pituitary adenoma
- Role of variants at SIRT1 gene in pituitary adenoma
- SIRT1 inhibition exhibits decreased pluripotency in cancer stem cells of glioma
- The effects of SIRT1 inhibitors nicotinamide and Ex-527 on lymphoma cells
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- Novel therapies for cancer treatment: designing high affinity selective ligands against SIRT1 enzyme
- Does SIRT1 or cytostasis underlie the anti-ageing activity of trans-stilbenes?
- SIRT1 in Trophoblast Differentiation and Placental Development
- THE ASSOCIATION BETWEEN SIRT1 RS3740051 AND AGE-RELATED MACULAR DEGENERATION
- Knockdown of SIRT1 enhances the sensitivity to cisplatin by inhibiting autophagy in A549 cells
- Effect of supplemental Erchen decoction on role of oxidative stress and SIRT1 in rats with chronic obstructive pulmonary disease
- NAD+-Dependent SIRT1 Reprograms CD11c+ Dendritic Cells and Cd4+ T Cells to Control Immune Polarity During Sepsis
- SIRT1 decreases TLR2-mediated Mac-1 expression in atherosclerosis
- Association of single nucleotide polymorphism of SIRT1 gene with age-related cataract
- Effect of SIRT1 on dynamic expression of AQP4 in early stage of cerebral ischemia in rats
- Spatial Dynamics of SIRT1 Dictate Metabolic Transitions in the Cell Nucleus
- SIRT1 plays a pivotal role in TLR2‐mediated Mac‐1 expression in monocytes
- SIRT1 Regulates the Inflammator\Response of Vascular Adventitial Fibroblasts through Autophag\and Related Signaling Pathwa\
- Persistent global inflammation caused by the loss of SIRT1 protects against experimental osteoarthritis
- Exploring the SIRT1/P53 Pathway in Adipocytes Hyperplasia
- Endothelial SIRT1 Is Required for PGC1α-Induced Angiogenesis in Skeletal Muscle Tissue
- The study of the inhibition effects of SIRT1 on the apoptosis induced by Galangin in HepG2 cells
- Relationship between mechanism of SIRT1-mediated mitophagy in myocardium and Mfn2 in diabetic rats
- SIRT1, 2, 3 protect mouse oocytes from postovulatory aging
- Regulation of IL-4 Gene Expression By SIRT1 in Human Mast Cell
- Aging-related change of erectile function and the expression of SIRT1
- SIRT1 was involved in TNF-α-promoted osteogenic differentiation of human DPSCs through Wnt/β-catenin signal Animal
- Interactions between SIRT1 and STAT3 in the retinal pigmented epithelium cell
- Endothelial-specific SIRT1 Deletion Inhibits Retinal Vascular Endothelial Cell Migration
- SIRT1 suppresses atherosclerosis induced by TLR2-mediated monocyte adhesion to endothelium through MAC-1 expression
- Serum SIRT1 level is higher in male patient with isolated hypogonadotropic hypogonadism: The first study in human
- SIRT1 negatively regulates the expression of Prl2C3, a senescence-associated protein
- The Association between SIRT1 rs3740051 and age-related macular degeneration
- SIRT1 Attenuates Nasal Polypogenesis By Suppressing Epithelial-to-Mesenchymal Transition
- Celastrol protects against fatty liver through SIRT1
- ROS Induced Mitochondrioal Dysfunction Causes Endothelial Dyfunction by Downregulation Of SIRT1
- Effects of Buyang Huanwu Decoction against oxidative stress of rBMECs by up-regulating SIRT1
- Correlation analysis of SIRT1 gene variant and susceptibility to chronic obstructive pulmonary disease
- SIRT1 Activity Is Required For The Protective Effects Of The Female Sex In The Response To Chronic Hypoxia
- Recurrent cigarette smoke exposure impairs SIRT1 shuttling in bronchial epithelial cells
- Effect of SIRT1 on the expression and phosphorylation of Tau protein in neuroblastoma SK-N-SH cells
- CAY10591, a SIRT1 Activator, Suppresses Malignancy of Gingival Epithelial Carcinoma Cells
- SIRT1 Maintains PGC-1α Function Through Periodic Promoter Release
- Endothelial SIRT1 as a drug target for vascular ageing-related diseases.
- ASSESSMENT OF SIRT1 GENE EXPRESSION IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA BY REAL TIME PCR METHOD
- miR-199a-5p enhances expression of myocardial fibrosis-related genes by targeting SIRT1
- Role of SIRT1 in the adaptive response of mouse ovaries to radiotherapy (X ray radiations)
- Impact of expression of SIRT1 and SIRT2 on outcome in the very elderly patients with colorectal cancer.
- SIRT1 Regulates Acrosome Biogenesis by Modulating Autophagic Flux During Spermiogenesis in Mice
- Studies on the mechanism of SIRT1/AMPK signaling pathway between hepatocytes and hepatic stellate cells
- Resveratrol: An Epigenetic Regulator of SIRT1–Is It a Magic Tool to Prevent Cardiovascular Disease?
- Anti‐vascular ageing effects of endothelial SIRT1‐communicating with smooth muscle cells of the arteries
- Age-related structural changes in the liver of old mice with SIRT1 overexpression in conjunction with NMN supplementation
- SIRT1 rs7896005 polymorphism may be related to coronary artery disease in Caucasians with type 2 diabetes, without affecting all-cause mortality.
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- Oscillatory Gene Promoter Regulation by Pgc-1α and SIRT1 in Cardiac Energy Metabolism
- Effects of SIRT1 gene knockout on chronic kidney disease induced by 5/6 nephrectomy in mice and VEGF/Flk-1 signaling pathway
- Regulation of SIRT1 by SREBP-1 in Adipogenic Differentiation of Mesenchymal Stem Cells
- The role of SIRT1 in LPS-induced lung endothelial barrier dysfunction and lung injury in vivo
- SIRT1 protects against radiation-induced lung injury via de-acetylating the Ku70 and P65
- Decreased SIRT1 expression is related to bronchopulmonary dysplasia in premature infants after oxygen exposure
- SIRT1 overexpression inhibits tunicamycin-induced endoplasmic reticulum stress in chondrocytes
- Correction for Shah et al.,“A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of …
- Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease
- Inhibition of CML Development Following Conditional SIRT1 Deletion in Transgenic BCR-ABL Mice
- SIRT1 expression is associated with formation of atherosclerotic plaques in diabetic patients
- ACTIVATION OF THE SIRT1-LXR SIGNALLING PATHWAY IN RETINAL PIGMENTED EPITHELIAL CELLS PROMOTES CHOLESTEROL METBOLISM
- SIRT1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response
- Effect of Helicobacter pylori infection on SIRT1 and Sirt2 gene expression in human gastritis samples
- Circulating SIRT1 Protects Against Atherosclerosis Through Its Modulation of Pcsk9 Activity
- Glycine decarboxylase inhibits proliferation of ovarian cancer cells via SIRT1-mediated apoptosis
- Glycolysis promotes MDSCs and cancer stemness through the interaction between SIRT1 and C/EBPb
- A clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy.
- Effect of Vitamin E on the Expression of SIRT1 and PGC-1α in Mice with Nonalcoholic Fatty Liver Disease
- The evaluation of gene expression and enzyme activity of SIRT1 in peripheral blood mononuclear cells isolated from patients with relapsing-remitting multiple …
- Abstract WMP41: Neuronal SIRT1 is Required for Resveratrol Preconditioning Induced Ischemic Tolerance
- Effect Of Oral Appliance On Circulating Leukocyte Telomere Length And SIRT1 In Obstructive Sleep Apnea Syndrome
- Loss of the longevity gene SIRT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy
- Observation of the articular cartilage of osteoarthritis in SIRT1 gene knock-out mice through single staining and compound staining
- Alleviation of inflammation in human RPE cells by bromodomain inhibitors is independent of SIRT1
- Monomethylfumarate induces NAD+ and SIRT1 in Human Retinal Pigment Epithelial Cells: Relevance to Development of New Therapies for Dry AMD
- Non-invasive molecular imaging of SIRT1-mediated epigenetic regulation in cancer using PET/CT with a novel substrate-type radiotracer 2-[18F] PhAHA
- Adiponectin promotes normal human epidermal keratinocyte differentiation and calcium influx via SIRT1
- Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulatingdendritic cell maturation
- Cardiomyocyte SIRT1 Deficiency Alters Cardiac Substrate Metabolism and Sensitizes Myocardium to Ischemic Insults
- The relationship between serum SIRT1 and EGR1 and other inflammatory cytokines in type 2 diabetic patients with different stages of diabetic nephropathy
- D57 DON’T BE A DO-BADDER: NEW INTERVENTIONS FOR OSA: Effects Of Nasal Cpap On Exhaled SIRT1 And Tumor Necrosis Factor-[alpha] In Patients With …
- Computational Modeling of Calorie Restriction (CR) Mimetics for Age-Related Diseases: Ligands of SIRT1 Target.
- SIRT1 mediates the actions of PPARδ on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells
- Downregulation of the SIRT1 and Liver X Receptor α/β signaling axis promotes diabetic retinopathy pathogenesis
- Down-Regulation of Erk and SIRT1 Signaling May Lead to Reduced Fgf-21 Sensitivity in a Mouse Model of Diabetes
- … to “Rehabilitation Training and Resveratrol Improve the Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through the SIRT1 …
- Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of hippocampal SIRT1
- SIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet
- Anti-tumor effects of metformin: Effects of metformin on SIRT1, Nrf2 and AhR expression in cancer cells
- Inhibition of p53 with its specific inhibitor pifithrin‐α prevents hepatic oxidative stress and inflammation, probably via up‐regulating SIRT1/Nrf2 pathway
- SIRT1 regulates low oxygen induced bovine granulosa cell proliferation through interaction with VEGF-AKT-mTOR pathway
- Computational model for mammalian circadian oscillator: interacting with NAD+/SIRT1 pathway and age-related changes in gene expression of circadian oscillator
- Immunoprecipitation of SIRT1, sirt3 and PGC-1A from rat gastrocnemius and soleus with magnetic beads
- TET2 Activity Is Modulated By SIRT1-Mediated Protein Deacetylation: A Potential Therapeutic Target in Myelodysplastic Syndrome
- Caloric Restriction Increases the Resistance of Aged Heart to Myocardial Ischemia/Reperfusion Injury via Modulating AMPK-SIRT1 Signaling Pathway
- Cardiomyocyte Specific Deletion of SIRT1 Gene Alters Substrate Metabolism and Sensitizes Myocardium to Ischemia and Reperfusion Injury
- SIRT1 Enhances Oxidized Low-density Lipoprotein Induced Autophagy in Human Valve Interstitial Cells
- EFFECT OF HELICOBACTER PYLORI INFECTION ON SIRT1 AND SIRT2 GENE EXPRESSION IN HUMAN GASTRITIS SAMPLES
- Role of SIRT1/FoxO3α signaling pathway in berberine pretreatment-induced reduction of hypoxia/reoxygenation-caused injury to hepatic parenchymal cells
- Oligonol Induces the Expression of the Anti-aging Molecule, SIRT1, via the AMPK-Autophagy Pathway
- GW27-e0410 Effect of astaxanthin intervention on contrast induced acute kidney injury through the SIRT1/FOXO3a signal
- SIRT1 Deacetylase Mediates Klotho Gene Deficiency-induced Arterial Remodeling and Stiffness
- Platycodin D (PD) attenuates myocardial apoptosis mediated by JNK-SIRT1-HSF1-IGF-IIR-Caspase-3 signaling in hypertensive conditions
- Activation of SIRT1 Attenuates Klotho Deficiency‐induced Arterial Stiffness and Hypertension via Enhancing AMPKα and eNOS activity
- Activation of SIRT1 Deacetylase Attenuates Klotho Deficiency-induced Arterial Stiffness and Hypertension
- … ] CALORIC RESTRICTION CAN IMPROVE LEARNING AND MEMORY OF C57/BL MICE PROBABLY VIA REGULATION OF THE SIRT1/AMPK SIGNALING PATHWAY
- Oxidative Stress-Induced Mir-200c Disrupts SIRT1, Foxo1 and Enos Regulatory Loop, Causing Endothelial Dysfunction and Oxidative Stress Increase
- The non-flavonoid polyphenol resveratrol induces anti-obesity effects via SIRT1 dependent improved mitochondrial functioning
- Role of Autophagy Inhibition in Regulating Hepatic Lipid Metabolism: Molecular Cross Talk Between Proteasome Activator REGγ and SIRT1 Signaling
- Associations of SIRT1 rs12778366, FGFR2 rs2981582 and STAT3 rs744166 polymorphisms with early age-related macular degeneration development
- HGF and bFGF Secretion by Human Adipose-derived Stem cells improve Ovarian Function of Natural Aging through Activation of SIRT1-FOXO1 Signaling Pathway
- Tongluo Xingnao Effervescent Tablets ameliorates cognitive function of SAMP8 mice via Nampt/SIRT1/FOXO3 pathway
- TM4SF1 regulates cell cycle and ROS status in bladder cancer cells by targeting FOXO3a via PPARγ-SIRT1 negative feedback loop
- RGS2 and SIRT1 Link Renin Angiotensin Aldosterone System to Alzheimer’s Disease
- Hypermethylation of HIC1 and aberrant expression of HIC1/SIRT1 contribute to papillary thyroid carcinoma
- SIRT1 facilitates initial recruitment of primordial follicles through activating mTOR and AKT transcription
- SIRT1 represses PKC-zeta activation via regulating its acetylation and phosphorylation modification in cardiac hypertrophy
- Effect of SIRT1/nf-κb signal axis on delaying hematopoietic stem cell and progenitor cell senescence with ginsenoside r1 in aging model rat induced by d-galactose
- 100 SIRT1 Activation: A Strategy for Harnessing Endogenous Protection Against SAH-induced Neurovascular Dysfunction
- miR-34a augments immune response through triggering NF-κB/B7-H3/TNF-α feedforward loop via SIRT1 in colorectal carcinoma
- Gallotannin induces senescence and autophagy leading to cell death via SIRT1 inhibition and AMPK activation in hepatocellular carcinoma cells
- Myocardial Senescence Induced by Inactivation Aldh2-SIRT1-GATA4 Pathway Involves in Heart Remolding After Acute Infarction
- Inhibition of glycolysis abolishes microglial inflammatory activation via suppression of TBK1/NF-κB and HIF1α/SIRT1/p65 acetylation
- SIRT1 Inhibitor Enhances Hsp90 Inhibitor-mediated Abrogation of Hsp90 Chaperone Function and Potentiates the Cytotoxicity of Hsp90 Inhibitor in Chemo-resistant …
- Mir-217 promotes inflammation and fibrosis induced by high glucose in rat glomerular mesangial cells via SIRT1/HIF-1α signal pathway
- miR-21 Regulates TNF-α-Induced CD40 Expression via SIRT1-NF-κB Pathway in Renal Inner Medulla Collecting Duct Cells
- PS 07-12 UPREGULATED SGLT2 REDUCES PROXIMAL TUBULAR SIRT1 AND AUGMENTS RENAL GLUCONEOGENESIS IN EARLY STAGE DIABETIC …
- Muscle Through SIRT1-Dependent Mechanisms Thomas K. Sin, Bjorn T. Tam, Angus P. Yu, Shea P. Yip, Benjamin Y. Yung, Lawrence W. Chan, Cesar S. Wong, John …
- Abstract P2-03-06: Dysregulation of miR-34a-SIRT1 axis reduced breast cancer stemness
- Deciphering the PACS-2–SIRT1 interaction site and its relevance in vivo
- MMP-9, HIF-1 and SIRT1 in acute lung injury: a review
- MiR-486 Regulates the Glycometabolism of Hematopoietic Cells by Targeting SIRT1
- EP-2041: Vitamin D protects HUVEC from RT-induced senescence and apoptosis by modulating MAPK/SIRT1 axis
- MicroRNA-9 represses sirtuin 1 (SIRT1) in human keratinocytes
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- Association of serum Mir-217 level with SIRT1 and HIF-1αin type 2 diabetic patients with different urinary albumin excretion rates
- Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma
- THE EFFECT OF 10 WEEKS OF HIGH INTENSITY INTERVAL TRAINING AND GREEN TEA SUPPLEMENTS ON SERUM LEVELS OF SIRT1 AND PGC-1? IN …
- The effect of 10 weeks of high intensity interval training and green tea supplements on serum levels of SIRT1 and PGC-1α in overweight women
- MicroRNA-34a promotes apoptosis of human lens epithelial cells through down-regulation of Bcl-2 and SIRT1
- 3D-QSAR modeling and analysis of Thieno [3, 2-d] pyrimidine-6-carboxamides as potent SIRT1-3 inhibitors
- Abstract P141: GYY4137, a H2S Donor, Normalizes miR-132 Targeted SIRT1 and Ace2 Expression to Improve Kidney Function in Hypertension
- Relationship between microRNA-369-3p, SIRT1, and IL-22 in psoriasis vulgaris
- PS 04-13 CR6-INTERACTING FACTOR 1 DEFICIENCY IMPAIRS VASCULAR FUNCTION BY INHIBITING THE SIRT1-eNOS PATHWAY
- Effects of microRNA-33-agonist and-antagonist on AMPK, SIRT1 & SREBP-2 expression in AMPK-SIRT1 pathway in mice liver
- F-72 Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2, 9 via AMPK-SIRT1 pathway in a non-small cell lung cancer
- Allosteric SIRT1 activators as putative anti-aging drugs
- The role of SIRT1 in diabetic retinopathy
- SIRT1: a guardian of the development of diabetic retinopathy
- Role and possible mechanisms of SIRT1 in depression
- SIRT1 and HIF1α signaling in metabolism and immune responses
- SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection
- Computational and experimental insights into the circadian effects of SIRT1
- SIRT1 as a therapeutic target in diabetic complications
- Brain SIRT1 mediates metabolic homeostasis and neuroprotection
- SIRT1 antisense long noncoding RNA promotes cardiomyocyte proliferation by enhancing the stability of SIRT1
- Metformin is a direct SIRT1-activating compound: computational modeling and experimental validation
- The role of SIRT1 in ischemic stroke: pathogenesis and therapeutic strategies
- SIRT1 deacetylates tau and reduces pathogenic tau spread in a mouse model of tauopathy
- SIRT1 promotes formation of breast cancer through modulating Akt activity
- SIRT1 and microRNAs: The role in breast, lung and prostate cancers
- SIRT1 is a potential drug target for treatment of diabetic kidney disease
- High levels of SIRT1 expression as a protective mechanism against disease-related conditions
- Resveratrol boosts cognitive function by targeting SIRT1
- An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds
- The essential role of SIRT1 in hypothalamic-pituitary axis
- A SIRT1-centered circuitry regulates breast cancer stemness and metastasis
- SIRT1 in secretory organ cancer
- Effects of resveratrol and other polyphenols on SIRT1: relevance to brain function during aging
- SIRT1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia
- SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model
- The interplay of SIRT1 and Wnt signaling in vascular calcification
- Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense
- Resveratrol modulates SIRT1 and DNMT functions and restores LINE-1 methylation levels in ARPE-19 cells under oxidative stress and inflammation
- SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression
- Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer’s disease
- SIRT1 controls acetaminophen hepatotoxicity by modulating inflammation and oxidative stress
- Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’
- SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease
- Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial–mesenchymal transition in cancer cells
- Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1
- Cardiomyocyte-specific deletion of SIRT1 gene sensitizes myocardium to ischaemia and reperfusion injury
- SIRT1 mediates obesity-and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
- SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway
- SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice
- SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells
- SIRT1 activation disrupts maintenance of myelodysplastic syndrome stem and progenitor cells by restoring TET2 function
- LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1
- SIRT1 and estrogen signaling cooperation for breast cancer onset and progression
- SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA
- Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2-and SIRT1-dependent pathways
- CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of SIRT1
- Histone deacetylase SIRT1 targets Plk2 to regulate centriole duplication
- Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells
- Breaking down the contradictory roles of histone deacetylase SIRT1 in human breast cancer
- SIRT1/PGC-1α signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats
- Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats
- Chlorogenic acid protects against oxLDL‐induced oxidative damage and mitochondrial dysfunction by modulating SIRT1 in endothelial cells
- Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation
- SIRT1 regulates nuclear number and domain size in skeletal muscle fibers
- Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1
- Geniposide protects against obesity-related cardiac injury through AMPKα-and SIRT1-dependent mechanisms
- Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1
- SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation
- Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats
- SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma
- Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and …
- Resveratrol improves glucose uptake in insulin-resistant adipocytes via SIRT1
- LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/SIRT1/HIF-1α signaling
- MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma
- H2S to Mitigate Vascular Aging: a SIRT1 connection
- Inflammatory cytokines and SIRT1 levels in subcutaneous abdominal fat: relationship with cardiac performance in overweight pre-diabetics patients
- Oxidative stress induces imbalance of adipogenic/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions
- Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy
- Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD
- Buyang Huanwu decoction targets SIRT1/VEGF pathway to promote angiogenesis after cerebral ischemia/reperfusion injury
- Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SIRT1/PGC-1α/mitochondrial biosynthesis pathway
- MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1
- Disruption of the circadian clock alters antioxidative defense via the SIRT1-BMAL1 pathway in 6-OHDA-induced models of Parkinson’s disease
- Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK
- SIRT1/Nrf2 pathway is involved in oocyte aging by regulating Cyclin B1
- Overexpression of SIRT1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
- Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity
- Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK
- SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway
- Mitochondrial fission is required for angiotensin II-induced cardiomyocyte apoptosis mediated by a SIRT1-p53 signaling pathway
- The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure
- miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy
- Exercise training augments SIRT1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
- Resveratrol ameliorates lipid droplet accumulation in liver through a SIRT1/ATF6-dependent mechanism
- Targeting estrogen receptor beta (ERβ) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ERβ expression and functionality
- Transcriptional regulation of metabolism by SIRT1 and SIRT7
- Thymoquinone attenuates myocardial ischemia/reperfusion injury through activation of SIRT1 signaling
- Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib
- Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
- NAMPT is a potent oncogene in colon cancer progression that modulates cancer stem cell properties and resistance to therapy through SIRT1 and PARP
- SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
- Phenolic plant extracts induce SIRT1 activity and increase antioxidant levels in the rabbit’s heart and liver
- Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway
- miR-30a suppresses lung cancer progression by targeting SIRT1
- Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1
- High-fat diet mediates anxiolytic-like behaviors in a time-dependent manner through the regulation of SIRT1 in the brain
- Regulation of apoptosis and radiation sensitization in lung cancer cells via the SIRT1/NF-κB/Smac pathway
- SIRT1 protects from K‐Ras‐driven lung carcinogenesis
- SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer
- … myocardial ischemia/reperfusion injury in type 1 diabetic rats by reducing oxidative stress and apoptosis through activating the SIRT1-Nrf2 signaling pathway
- Baicalin regulates SIRT1/STAT3 pathway and restrains excessive hepatic glucose production
- SIRT1 protects against oxidative stress-induced apoptosis in fibroblasts from psoriatic patients: A new insight into the pathogenetic mechanisms of psoriasis
- Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells
- SIRT1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4
- Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling …
- Acetylation-dependent regulation of Notch signaling in macrophages by SIRT1 affects sepsis development
- PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis
- MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1
- High glucose up-regulates microRNA-34a-5p to aggravate fibrosis by targeting SIRT1 in HK-2 cells
- The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemia
- Icariin, a flavonoid with anti-cancer effects, alleviated paclitaxel-induced neuropathic pain in a SIRT1-dependent manner
- Ube2v1-mediated ubiquitination and degradation of SIRT1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy
- SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes
- Resveratrol suppresses rotenone‐induced neurotoxicity through activation of SIRT1/Akt1 signaling pathway
- Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression
- Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice
- SIRT1 increases cardiomyocyte binucleation in the heart development
- A p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function
- An insulin-responsive sensor in the SIRT1 disordered region binds DBC1 and PACS-2 to control enzyme activity
- Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway
- Chronic silymarin, quercetin and naringenin treatments increase monoamines synthesis and hippocampal SIRT1 levels improving cognition in aged rats
- Hypothalamic SIRT1 protects terminal Schwann cells and neuromuscular junctions from age‐related morphological changes
- miR-34a promotes vascular smooth muscle cell calcification by downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)
- Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via SIRT1/Nrf2 and p38 MAPK pathways
- Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri
- Novel SIRT1 inhibitor 15-deoxy-Δ12, 14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in …
- Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice
- Long-term l-serine administration reduces food intake and improves oxidative stress and SIRT1/NFκB signaling in the hypothalamus of aging mice
- Physical exercise improves aging-related changes in angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra
- SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis
- Moderate exercise suppresses NF-κB signaling and activates the SIRT1-AMPK-PGC1α axis to attenuate muscle loss in diabetic db/db mice
- Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: SIRT1/miR-134 signalling pathway regulates CREB/BDNF expression in …
- Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington’s disease model
- Spontaneous up‐regulation of SIRT1 during osteogenesis contributes to stem cells’ resistance to oxidative stress
- Paeonol ameliorates diabetic renal fibrosis through promoting the activation of the Nrf2/ARE pathway via up-regulating SIRT1
- Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation
- SIRT1 activity in peripheral blood mononuclear cells correlates with altered lung function in patients with chronic obstructive pulmonary disease
- Inverse association of circulating SIRT1 and adiposity: a study on underweight, normal weight, and obese patients
- Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-κB signaling pathway
- Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1
- SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons
- Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
- PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 …
- Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between …
- Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via SIRT1/AMPK pathway
- SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity
- Flavonones from Penthorum chinense ameliorate hepatic steatosis by activating the SIRT1/AMPK pathway in HepG2 cells
- SIRT1: A novel way to target tau?
- 18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the SIRT1/FXR signaling pathway
- ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via SIRT1/Nrf2 pathway
- FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via SIRT1/AMPK/β1-integrin pathway
- Tangshen formula improves inflammation in renal tissue of diabetic nephropathy through SIRT1/NF-κB pathway
- Fisetin protects against hepatic steatosis through regulation of the SIRT1/AMPK and fatty acid β-oxidation signaling pathway in high-fat diet-induced obese mice
- Enhanced articular cartilage regeneration with SIRT1-activated MSCs using gelatin-based hydrogel
- Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice
- Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells
- SIRT1 inhibits TGF‐β‐induced endothelial‐mesenchymal transition in human endothelial cells with Smad4 deacetylation
- Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase …
- Upregulation of SIRT1 inhibits H2O2‑induced osteoblast apoptosis via FoxO1/β‑catenin pathway
- Tomato powder inhibits hepatic steatosis and inflammation potentially through restoring SIRT1 activity and adiponectin function independent of carotenoid cleavage …
- Bergenin, acting as an agonist of PPARγ, ameliorates experimental colitis in mice through improving expression of SIRT1, and therefore inhibiting NF-κB …
- TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARγ-SIRT1 feedback loop in human bladder cancer cells
- Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1 α complex to activate its deacetylase function
- Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia
- Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through the SIRT1-mediated signaling pathway
- Upregulation of SIRT1 by kartogenin enhances antioxidant functions and promotes osteogenesis in human mesenchymal stem cells
- Geniposide alleviates isoproterenol-induced cardiac fibrosis partially via SIRT1 activation in vivo and in vitro
- … exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial SIRT1 and subsequent Akt …
- SIRT1 contributes to neuroendocrine differentiation of prostate cancer
- … from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1
- SIRT1/HERC4 Locus Associated With Bisphosphonate‐Induced Osteonecrosis of the Jaw: An Exome‐Wide Association Analysis
- Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and SIRT1
- AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol
- Cdk5 suppression blocks SIRT1 degradation via the ubiquitin-proteasome pathway in Parkinson’s disease models
- … the proliferation and migration of human non-small cell lung carcinoma (NSCLC) cells, A549 and H1299, by activating the SIRT1/AMPK signaling pathway
- Chikusetsusaponin V inhibits LPS-activated inflammatory responses via SIRT1/NF-κB signaling pathway in RAW264. 7 cells
- Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated SIRT1/AMPK signaling pathway
- SIRT1 activation attenuates α cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice
- Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions
- MicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated SIRT1/JAK/STAT3 signaling
- … against high fat diet-induced obesity cardiomyopathy and defective autophagy: Role of CaM kinase II, histone H3K9 methyltransferase SUV39H, SIRT1, and PGC-1α …
- SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1)
- Resveratrol induces apoptosis and inhibits adipogenesis by stimulating the SIRT1-AMPKα-FOXO1 signalling pathway in bovine intramuscular adipocytes
- … natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling …
- Activation of the Nrf2-ARE pathway ameliorates hyperglycemia-mediated mitochondrial dysfunction in podocytes partly through SIRT1
- Cudratricusxanthone A attenuates sepsis‐induced liver injury via SIRT1 signaling
- Nrf2 activation induced by SIRT1 ameliorates acute lung injury after intestinal ischemia/reperfusion through NOX4-mediated gene regulation
- Reciprocal regulation between Smad7 and SIRT1 in the gut
- Berberine improves cognitive deficiency and muscular dysfunction via activation of the AMPK/SIRT1/PGC-1a pathway in skeletal muscle from naturally aging rats
- SIRT1 activation by post-ischemic treatment with lumbrokinase protects against myocardial ischemia-reperfusion injury
- Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway
- Upregulation of SIRT1 contributes to the cardioprotective effect of Rutin against myocardial ischemia-reperfusion injury in rats
- 17β-Estradiol via SIRT1/Acetyl-p53/NF-kB signaling pathway rescued postnatal rat brain against acute ethanol intoxication
- Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis
- Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injury
- SIRT1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice
- Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit
- Roles of SIRT1/FoxO1/SREBP-1 in the development of progestin resistance in endometrial cancer
- Deacetylation of NAT10 by SIRT1 promotes the transition from rRNA biogenesis to autophagy upon energy stress
- Resolvin D1 promotes SIRT1 expression to counteract the activation of STAT3 and NF-κB in mice with septic-associated lung injury
- Resveratrol Mitigates High-Fat Diet–Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and SIRT1/ER Pathway
- SIRT1‐dependent anti‐senescence effects of cell‐deposited matrix on human umbilical cord mesenchymal stem cells
- HGF and BFGF secretion by human adipose-derived stem cells improves ovarian function during natural aging via activation of the SIRT1/FOXO1 signaling pathway
- SIRT1 mediates apelin-13 in ameliorating chronic normobaric hypoxia-induced anxiety-like behavior by suppressing NF-κB pathway in mice hippocampus
- SIRT1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice
- Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy
- Stimulation of SIRT1 attenuates the level of oxidative stress in the brains of APP/PS1 double transgenic mice and in primary neurons exposed to oligomers of the …
- Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways
- Gastrodin inhibits high glucose‑induced human retinal endothelial cell apoptosis by regulating the SIRT1/TLR4/NF‑κBp65 signaling pathway
- Resveratrol ameliorates microcystin-LR-induced testis germ cell apoptosis in rats via SIRT1 signaling pathway activation
- Role of p53/miR-155-5p/SIRT1 loop in renal tubular injury of diabetic kidney disease
- Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: a pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF …
- SIRT1 mediates salidroside‐elicited protective effects against MPP+‐induced apoptosis and oxidative stress in SH‐SY5Y cells: involvement in suppressing MAPK …
- SIRT1 involved in the regulation of alternative splicing affects the DNA damage response in neural stem cells
- miR449a/SIRT1/PGC-1α is necessary for mitochondrial biogenesis induced by T-2 toxin
- Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1/AMPK pathway of glucose …
- Erythropoietin alleviates hepatic steatosis by activating SIRT1-mediated autophagy
- Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats
- Protective effect of isoliquiritigenin against ethanol-induced hepatic steatosis by regulating the SIRT1-AMPK pathway
- Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo via the regulation of SIRT1/FOXO3a expression
- SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF‑κB pathway in mouse kupffer cells
- SIRT1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation
- SIRT1-regulated abnormal acetylation of FOXP3 induces regulatory T-cell function defect in Hashimoto’s thyroiditis
- Dysregulation of BSEP and MRP2 may play an important role in isoniazid-induced liver injury via the SIRT1/FXR pathway in rats and HepG2 cells
- … and glycolipid metabolism of blunt snout bream Megalobrama amblycephala fed high-carbohydrate diets by activating the AMPK–SIRT1–PGC-1α network
- Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer’s disease like pathology via maintaining oxidative balance through SIRT1 pathway
- Resveratrol alleviates early brain injury following subarachnoid hemorrhage: possible involvement of the AMPK/SIRT1/autophagy signaling pathway
- Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis
- SIRT1 and NRF2 gene transfer mediate distinct neuroprotective effects upon retinal ganglion cell survival and function in experimental optic neuritis
- SIRT1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway
- Generation and characterization of a site-specific antibody for SIRT1 O-GlcNAcylated at serine 549
- Hypermethylated in cancer 1 (HIC1) mediates high glucose induced ROS accumulation in renal tubular epithelial cells by epigenetically repressing SIRT1 …
- Sitagliptin reduces insulin resistance and improves rat liver steatosis via the SIRT1/AMPKα pathway
- Resveratrol and SIRT1 activators for the treatment of aging and age-related diseases
- Pseudoginsengenin DQ exhibits therapeutic effects in cisplatin-induced acute kidney injury via SIRT1/NF-κB and caspase signaling pathway without compromising its …
- Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria
- SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease
- Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of the SIRT1/NF-κB signaling pathway
- Heme oxygenase-1 induction by rosiglitazone via PKCα/AMPKα/p38 MAPKα/SIRT1/PPARγ pathway suppresses lipopolysaccharide-mediated pulmonary …
- miR-128 targets the SIRT1/ROS/DR5 pathway to sensitize colorectal cancer to TRAIL-induced apoptosis
- RNA interference-mediated knockdown of SIRT1 and/or SIRT2 in melanoma: Identification of downstream targets by large-scale proteomics analysis
- Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy
- Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1
- SIRT1 deacetylates SC35 and suppresses its function in Tau Exon 10 inclusion
- SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-κB …
- … A against oxygen‐glucose deprivation/reperfusion in rat primary cortical neurons by attenuating oxidative stress injury and inflammatory response via the SIRT1/Nrf2 …
- Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation
- AMPK regulates energy metabolism through the SIRT1 signaling pathway to improve myocardial hypertrophy
- Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke
- Amelioration of Huntington’s disease phenotypes by Beta-Lapachone is associated with increases in SIRT1 expression, CREB phosphorylation and PGC-1α …
- Resveratrol activated sonic hedgehog signaling to enhance viability of NIH3T3 cells in vitro via regulation of SIRT1
- CD 38 deficiency suppresses adipogenesis and lipogenesis in adipose tissues through activating SIRT1/PPAR γ signaling pathway
- Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression
- A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKAy mice
- Luteolin decreases atherosclerosis in LDL receptor‑deficient mice via a mechanism including decreasing AMPK‑SIRT1 signaling in macrophages
- SIRT1 deacetylates KLF4 to activate Claudin‐5 transcription in ovarian cancer cells
- Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the …
- D‑Pinitol alleviates cyclosporine A‑induced renal tubulointerstitial fibrosis via activating SIRT1 and Nrf2 antioxidant pathways
- Novel role of PKR in palmitate-induced SIRT1 inactivation and endothelial cell senescence
- Tetrahydroxystilbene glucoside delayed senile symptoms in old mice via regulation of the AMPK/SIRT1/PGC-1α signaling cascade
- SIRT1 rs3758391 and major depressive disorder: new data and meta-analysis
- Functional role of SIRT1-induced HMGB1 expression and acetylation in migration, invasion and angiogenesis of ovarian cancer
- Overexpressed SIRT1 in MSCs promotes dentin formation in Bmi1-deficient mice
- Agathisflavone isolated from Anacardium occidentale suppresses SIRT1‐mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe‐transfected SH …
- Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A
- Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway
- Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans
- SIRT1/Nrf2 signalling pathway prevents cognitive impairment in diabetic rats through anti‑oxidative stress induced by miRNA‑23b‑3p expression
- Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease
- … fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of …
- 1, 25 (OH) 2-vitamin D 3 upregulates glucose uptake mediated by SIRT1/IRS1/GLUT4 signaling cascade in C2C12 myotubes
- Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the SIRT1/LKB1/AMPK pathway
- Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway
- Improvement of lipid and glucose metabolism by capsiate in palmitic acid-treated HepG2 cells via activation of the AMPK/SIRT1 signaling pathway
- SIRT1/Foxo Axis plays a crucial role in the mechanisms of therapeutic effects of Erzhi pill in ovariectomized rats
- Salvianolic acid a attenuates endoplasmic reticulum stress and protects against cholestasis-induced liver fibrosis via the SIRT1/HSF1 pathway
- Neuroprotective mechanisms of resveratrol in Alzheimer’s disease: role of SIRT1
- Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells
- Receptor for advanced glycation end products reveals a mechanism regulating thyroid hormone secretion through the SIRT1/Nrf2 pathway.
- The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis
- Hsp90 Stabilizes SIRT1 orthologs in mammalian cells and C. elegans
- A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer
- Hepatitis C virus core protein induces hepatic steatosis via SIRT1‐dependent pathway
- Berberine protects renal tubular cells against hypoxia/reoxygenation injury via the SIRT1/p53 pathway
- Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK–eIF-2α–CHOP pathway in the unfolded protein response
- Intravenous Vitamin C attenuates hemorrhagic shock-related renal injury through the induction of SIRT1 in rats
- SIRT1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice
- The variable role of SIRT1 in the maintenance and differentiation of mesenchymal stem cells
- Rolipram attenuates early brain injury following experimental subarachnoid hemorrhage in rats: possibly via regulating the SIRT1/nf-κb pathway
- Correlations between SIRT1 gene polymorphisms and diabetic kidney disease
- SIRT1 deletion impairs retinal endothelial cell migration through downregulation of VEGF-A/VEGFR-2 and MMP14
- Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on SIRT1/NRF2 signaling pathways
- The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 …
- BML-111 reduces neuroinflammation and cognitive impairment in mice with sepsis via the SIRT1/NF-κB signaling pathway
- SA1/SA2 cohesion proteins and SIRT1-NAD+ deacetylase modulate telomere homeostasis in cumulus cells and are eligible biomarkers of ovarian aging
- Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via SIRT1/p38 MAPK expression
- Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration
- BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis
- Probing the mechanism of SIRT1 activation by a 1, 4-dihydropyridine
- Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway
- Revert the SIRT: normalizing SIRT1 activity in myelodysplastic stem cells
- MicroRNA-204 protects H9C2 cells against hypoxia/reoxygenation-induced injury through regulating SIRT1-mediated autophagy
- Detection of insertions/deletions within SIRT1, SIRT2 and SIRT3 genes and their associations with body measurement traits in cattle
- HOTAIR participates in hepatic insulin resistance via regulating SIRT1
- Electroacupuncture: A feasible SIRT1 promoter which modulates metainflammation in diet-induced obesity rats
- … of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1‐mediated deacetylation of FXR …
- Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma …
- Tongguan capsule mitigates post-myocardial infarction remodeling by promoting autophagy and inhibiting apoptosis: role of SIRT1
- Flavonoid extract from propolis inhibits cardiac fibrosis triggered by myocardial infarction through upregulation of SIRT1
- CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation
- SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng
- ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition
- Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer
- JAK1-mediated SIRT1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway
- SIRT1 in Colorectal Cancer: A Friend or Foe?
- Fluorofenidone inhibits UV‐A induced senescence in human dermal fibroblasts via the mammalian target of rapamycin‐dependent SIRT1 pathway
- SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression
- Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype
- The association between SIRT1 genetic variation and type 2 diabetes mellitus is influenced by dietary intake in elderly Chinese
- SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent …
- CD38 deficiency promotes inflammatory response through activating SIRT1/NF-κB-mediated inhibition of TLR2 expression in macrophages
- Long non-coding RNA H19 contributes to hypoxia-induced CPC injury by suppressing SIRT1 through miR-200a-3p
- SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
- Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1–nuclear factor-κB/p65 pathway in …
- 17β-estradiol promotes apoptosis in airway smooth muscle cells through CD38/SIRT1/p53 pathway
- Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ-and STZ+ niacinamide-induced diabetic rats
- Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and SIRT1 expression
- FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain Retraction in/10.3892/mmr …
- Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1
- A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage
- Cellular uptake and bioavailability of tocotrienol-rich fraction in SIRT1-inhibited human diploid fibroblasts
- Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 …
- miR‐221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin‐1 (SIRT1)
- Repetitive transcranial magnetic stimulation inhibits SIRT1/MAO-A signaling in the prefrontal cortex in a rat model of depression and cortex-derived astrocytes
- A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1
- miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with …
- ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway
- MiR-138/SIRT1 axis is implicated in impaired learning and memory abilities of cerebral ischemia/reperfusion injured rats
- Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats
- Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The …
- SIRT1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264. 7 cells and endotoxemic mice
- miR-221 participates in the airway epithelial cells injury in asthma via targeting SIRT1
- Delayed puberty by ziram is associated with down regulation of testicular phosphorylated AKT1 and SIRT1/PGC-1α signaling
- The expression and mechanism of SIRT1 and AMPK in nonsmall cell lung cancer
- SIRT1 activation: A potential strategy for harnessing endogenous protection against delayed cerebral ischemia after subarachnoid hemorrhage
- Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1
- Salidroside attenuates hypoxia/reoxygenation‑induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3α pathway
- … efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway
- The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders
- SIRT1 gene expression and gastric epithelial cells tumor stage in patients with Helicobacter pylori infection
- Effect of scuba diving on the oxidant/antioxidant status, SIRT1 and SIRT3 expression in recreational divers after a winter nondive period
- Expression of SIRT1 and P53 in rat Lens epithelial cells in experimentally induced DM
- Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population
- SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population
- … sulfate promotes arterial thrombosis in rat model via increased levels of complex TF/VII, PAI-1, platelet activation as well as decreased contents of SIRT1 and …
- MiR-155 is involved in major depression disorder and antidepressant treatment via targeting SIRT1
- Extra view: SIRT1 acts as a gatekeeper of replication initiation to preserve genomic stability.
- Onjisaponin B (OB) is neuroprotective during cognitive loss through immune-mediated and SIRT1 pathways
- Expression of microRNA-448 and SIRT1 and prognosis of obese type 2 diabetic mellitus patients after laparoscopic bariatric surgery
- Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas
- Anti-SIRT1 autoantibody is elevated in ankylosing spondylitis: a potential disease biomarker
- γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction
- Lutein suppresses hyperglycemia‐induced premature senescence of retinal pigment epithelial cells by upregulating SIRT1
- The role of SIRT1 in autophagy in lipopolysaccharide-induced mouse type II alveolar epithelial cells
- MicroRNA-138 aggravates inflammatory responses of macrophages by targeting SIRT1 and regulating the NF-κB and AKT pathways
- CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2
- All trans retinoic acid attenuates markers of neuroinflammation in rat brain by modulation of SIRT1 and NFκB
- PKA regulates HMGB1 through activation of IGFBP-3 and SIRT1 in human retinal endothelial cells cultured in high glucose
- The role of forkhead box class O3A and SIRT1 gene variants in early-onset psoriasis
- Resveratrol suppresses hyperoxia-induced nucleocytoplasmic shuttling of SIRT1 and ROS production in PBMC from preterm infants in vitro
- Better Nutritional Status Is Positively Associated with mRNA Expression of SIRT1 in Community-Dwelling Older Adults in the Toledo Study for Healthy Aging
- SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition
- Down-regulated miR-448 relieves spinal cord ischemia/reperfusion injury by up-regulating SIRT1
- Food anticipatory activity on a calorie-restricted diet is independent of SIRT1
- Inhibition of mTOR/S6K1/4E-BP1 signaling by nutraceutical SIRT1 modulators
- SIRT7 inhibits SIRT1-mediated activation of SUV39H1
- Targeting endothelial SIRT1 for the prevention of arterial aging
- Elevated levels of serum MiR-152 and miR-24 in uterine sarcoma: potential for inducing autophagy via SIRT1 and deacetylated LC3
- microRNA-212 promotes lipid accumulation and attenuates cholesterol efflux in THP-1 human macrophages by targeting SIRT1
- 2, 3, 5, 4′‐Tetrahydroxystilbene‐2‐O‐β‐glucoside potentiates self‐renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis
- … impairs both non-homologous end joining and homologous recombination DNA damage repair through SHP-1 induced dephosphorylation of SIRT1 in adult T-cell …
- 20 (S)-Ginsenoside Rg2 attenuates myocardial ischemia/reperfusion injury by reducing oxidative stress and inflammation: Role of SIRT1
- 15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxia
- Expression and significance of SIRT1 in renal allografts at the early stage of chronic renal allograft dysfunction
- Insulin PACS a Punch in SIRT1 Activity
- Qing gan zi shen tang alleviates adipose tissue dysfunction with up-regulation of SIRT1 in spontaneously hypertensive rat
- Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic …
- Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 …
- Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1
- Adipoinductive effect of extracellular matrix involves cytoskeleton changes and SIRT1 activity in adipose tissue stem/stromal cells
- Resveratrol down-regulates endothelin type B receptors in vascular smooth muscle cells via SIRT1/ERK1/2/NF-кB signaling pathways
- Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner
- High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of SIRT1
- Correction to: regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’
- Effect of Resveratrol Dimers and Tetramers Isolated from Vitaceous and Dipterocarpaceous Plants on Human SIRT1 Enzyme Activity
- Consensus QSAR modelling of SIRT1 activators using simplex representation of molecular structure
- Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1
- MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1
- BK channel deacetylation by SIRT1 in dentate gyrus regulates anxiety and response to stress
- Downregulation of miR-155 attenuates sepsis-induced acute lung injury by targeting SIRT1
- Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature
- Effect of microRNA-34a/SIRT1/p53 signal pathway on notoginsenoside R₁ delaying vascular endothelial cell senescence
- Integrated ligand and structure-based investigation of structural requirements for silent information regulator 1 (SIRT1) activation
- MiR-449 overexpression inhibits osteogenic differentiation of bone marrow mesenchymal stem cells via suppressing SIRT1/Fra-1 pathway in high glucose and free fatty …
- SIRT1 exhibits antioxidative effects in HT22 cells induced by tert‐butyl alcohol
- Loss of histone deacetylase 2 inhibits oxidative stress induced by high glucose via the HO-1/SIRT1 pathway in endothelial progenitor cells
- Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin
- Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway
- Compounds from the Roots of Codonopsis pilosula and Their SIRT1 Regulatory Activity
- NK cells of the oldest seniors represent constant and resistant to stimulation high expression of cellular protective proteins SIRT1 and HSP70
- … -like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest …
- Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice
- Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through SIRT1 activation
- Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes
- SIRT1 deficiency in CD4+ T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
- The Effect of Eight Weeks of Water Training on SIRT1, Pgc-1α and Body Fat Percentage in Obese Men
- Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation
- … and reperfusion of pancreas-induced acute pancreatitis and remote lung injury through suppressing oxidative stress and inflammation and activation of SIRT1
- SIRT1 protects neural stem cells from apoptosis by decreasing acetylation of histone 3K9
- Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin
- Inhibitory effect of naringenin on LPS-induced skin senescence by SIRT1 regulation in HDFs
- A novel dressing seeded with embryonic artery CD133+ cells and loaded with the SIRT1 agonist SRT1720 accelerates the healing of diabetic ischemic ulcers
- The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma
- Saponins from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the SIRT1/Foxo1/Pgc-1α and Nrf2/antioxidant …
- Resveratrol improves endothelial function in diabetic and obese mice through SIRT1-PPARδ
- Hyperbaric oxygen effects towards SIRT1 level in Sprague dawley with endothelial dysfunction by high-cholesterol diet
- Obesity-induced upregulation of miR-361-5p promotes hepatosteatosis through targeting SIRT1
- Alterations of SIRT1 and mTOR activities in mouse gastrocnemius muscle with sarcopenia
- miR-224 suppresses HBV replication posttranscriptionally through inhibiting SIRT1-mediated autophagy
- SIRT1 Mediates Enhanced Mitochondrial Oxidative Phosphorylation in Chronic Myelogenous Leukemia Stem Cells
- … of dietary fiber from sweet potato (Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways
- Polydatin inhibits cell proliferation and expressions of inflammatory cytokines in THP-1 cells induced by ox-LDL via up-regulating SIRT1
- 2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the …
- Effect of total triterpenoids of Chaenomeles speciosa on PPARγ/SIRT1/NF-κBp65 signaling pathway and intestinal mucosal barrier of ulcerative colitis induced by DSS …
- Total Flavonoids of Epimedium Reduce Inflammatory Reaction via AMPK/SIRT1/NFκB Signaling Pathway in Testes of Natural Aging Rats
- Modulating SIRT1 activity variously affects thymic lymphoma development in mice
- Molecular Dynamics Simulation of SIRT1 Inhibitor from Indonesian Herbal Database
- Osthole enhances doxorubicin-induced apoptosis in p53-wildtype prostate cancer cells by down-regulating SIRT1 expression
- … Attenuates Lung Ischemia and Reperfusion-Induced Pulmonary Barrier Function Impairment by Reducing Oxidative Stress and Activating SIRT1 in an Isolated …
- SIRT1 participates in epithelial-mesenchymal transition of EC-9706 and Eca-109 cells in vitro by regulating Snail expression
- SIRT1 activators and their effects on atherosclerosis progression
- GW29-e0611 Acacetin inhibits doxorubicin–induced cardiotoxicity by activating SIRT1/AMPK/Nrf2 pathway
- P2795 The role of SIRT1 activity in patients with chronic heart failure
- Effect of a period of swimming exercise on SIRT1 and FoxO3a genes expression in lung tissue of wistar rats
- Defective NO/cGMP/PKG signaling downregulates SIRT1 expression in aged osteoblasts
- Data highlighting the expression of two miR-132/212 target genes—SIRT1 and Pten—after chronic stress
- Does SIRT1 gene polymorphisms play a role in pituitary adenoma recurrence?
- The role of SIRT1 in the pathogenesis of Spondyloarthritides
- Effect of LXR agonist T0901317 and miR-33inhibitor on SIRT1-AMPK and circulating HDL-C levels
- Estrogen Protects Artery From Senescence via SIRT1/AMPK/Rab9—Mediated Mitophagy
- SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s
- A NEW MOUSE MODEL TO UNRAVEL THE MECHANISM OF SIRT1 ACTIVATION
- … to: PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity
- [Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain
- Effect of Electroacupuncture at Tinggong and Yifeng on D-galactose-induced Aging of Auditory Cortex through SIRT1/PGC-1α Pathway in Guinea Pigs
- Saturated fat‐enriched diet decreases SIRT1 expression in the mouse hippocampus‐The SIRTain effects of saturated fat in the brain
- Sal B attenuates rat hepatocytes injury induced by hypoxia/reoxygenation via modulation of SIRT1/NF-κB/p53 pathway
- Hydrogen sulfide attenuates human umbilical vein endothelial cell senes-cence via modulation of SIRT1/eNOS pathway
- … DREGS ENHANCES GLUCOSE UPTAKE AND MITIGATES INSULIN RESISTANCE IN HUMAN LIVER CANCER CELL (HEPG2) MODEL VIA AMPK/SIRT1 …
- SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development
- A11086 Study on the signal pathway related to the upregulation of SIRT1 to decrease the apoptosis of human umbilical vein endothelial cells
- MicroRNA 181a-5p reprogrammed glucose and lipid metabolism in lung cancer though regulating SIRT1 and ACSL4
- Role of SIRT1 in mesenchymal stem cell differentiation
- High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
- GW29-e0596 Geniposide protects against pathological cardiac fibrosis in vivo and in vitro: the role of SIRT1 activation
- IDENTIFICATION AND CHARACTERIZATION OF SIRT1 AS A NOVEL TARGET OF NSAIDS CHEMOPREVENTION
- Publisher Correction: SIRT1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice
- Curcumin inhibits colon cancer progression through direct interaction with SIRT1
- GW29-e1860 RSV decreased infarction area in mouse heart via SIRT1 dependent inhibition of senescence and inflammasome
- ROLES OF SIRT1 IN CANCER/AGEING
- A52 SIRT1 is increased in affected brain regions in huntington disease impacting hypothalamic metabolic pathways
- The Investigation of the Apoptose Structural Effects and Mechanism in Leukemic Cells of SIRT1 Inhibitor Sirtinol
- GW29-e0847 CTRP3 protects cardiomyocytes against hypoxia-induced injury by activating SIRT1-mediated autophagy
- Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, SIRT1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and …
- Role of SIRT1 and SIRT6 for the preservation of genetic stability
- The role of SIRT1 activity in patients with chronic heart failure
- DIVERGENT REGULATION OF SIRT1 MEDIATES THE ENDOCRINE RESPONSE TO CALORIE RESTRICTION
- The role of SIRT1 in avoiding AIM2-mediated antiviral defense in cervical cancer
- P2668 Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells
- Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats
- Significant association of SIRT1 rs12765828 T allele with risk of early-onset ischemic stroke
- Novel role for SIRT1 in non-canonical activation of AR signaling
- Visualizing the function of hydroxyl radicals via SIRT1 in brains of mice with stress-induced depression related behaviours
- A6799 Ginsenoside Rb1 alleviate ox-LDL induced HUVEC senescence via SIRT1/Beclin-1/autophagy axis
- Rev1 contributes to proper mitochondrial function via the PARP-NAD (+)-SIRT1-PGC1 alpha axis (vol 7, 2017)
- Technolgical approaches for immortaliztion of human dermal fibrolasts therough SIRT1 and the in volvement of micro-rna
- PKM2 Promotes Malignant Proliferation of Human Liver Cancer Stem Cells by C-myc Through SIRT1-autophagy-premir675-pCDK4 Signaling Pathway
- Mitophagy confers the nephroprotective effect of Berberine in hyperglycemic NRK-52E cells via SIRT1-FoxO3a-Bnip3 axis
- Evaluation of SIRT1 and P53 expression in hepatocellular carcinoma
- Expression of SIRT1 in Synovium of Temporomandibular Joint Osteoarthritis
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- P268 Sex differences in age-related AMPK-SIRT1 axis alteration in human heart
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- Expression levels of SIRT1 and oxidative stress injury markers in a mouse model of deep venous thrombosis
- Effects of Hydroalcoholic Extract of Sargassum Oligocystum on Serum Concentration of SIRT1 and FGF21 in Streptozotocin Induced Diabetic Rat
- Exendin-4 alleviates diabetic cardiomyopathy in mice by regulating SIRT1/PGC1α
- Therapeutic ultrasound potentiates the anti-nociceptive and anti-inflammatory effects of curcumin to postoperative pain via SIRT1/NF-κB signaling pathway
- Prognostic and Clinicopathological Value of SIRT1 Expression in Female Reproductive System Cancer
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- Hepatitis C Virus Core Protein Induces Hepatic Steatosis via SIRT1-Dependent Pathway
- SIRT1 and mTOR interplay in bladder cancer: a potential therapeutic target
- Loss of SIRT1 alters the secretome of breast cancer cells by impairing lysosomal integrity
- Concurrent overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not alter mitochondrial function or insulin sensitivity in mice
- Hyperglycemia Inhibits SIRT1 Expression to Promote Drp1-Mediated Mitochondrial Fission in Diabetic Hearts
- Aberrant renal expression of peroxisome coactivator PGC-1α and its regulators (SIRT1 & GSK3β) in rats with diabetic nephropathy
- Preconditioning of SIRT1 activator improves chondrogenic differentiation potential of mesenchymal stem cell
- Pleiotropic treatment of pro-atherogenic endothelium: are SIRT1 and EZH2 promising candidates?
- Effect of Resveratrol Supplementation and Aerobic Exercise on the Protein SIRT1 and PGC-1α Skeletal Muscle and Subcutaneous Fat Tissue’s UCP-1 Levels in …
- Defective NO/cGMP/PKG Signaling Downregulates SIRT1 Expression in Aging-Associated Osteoporotic Mouse Model
- New drug targets for slowing vascular ageing: SIRT1, SIRT5, JunD and p66Sch
- Functional role of the silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas
- The amelioration on the vascular inflammatory response by evogliptin, a novel dipeptidyl peptidase 4 inhibitor via regulation of SIRT1/NF-KAPPAB interaction
- CR6 INTERACTING FACTOR 1 DEFICIENCY PROMOTES ENDOTHELIAL INFLAMMATION BY SIRT1 DOWNREGULATION
- Effect of a period of submaximal swimming training on SIRT1 and FoxO3a genes expression in lung tissue of wistar rats
- miR-34a inhibits the proliferation and invasion of colon cancer stem cells by regulating SIRT1 expression
- Deletion of SIRT1 in the cardiomyocyte exacerbates doxorubicin-induced cardiotoxicity in mice
- SIRT1 Activation Restores Mitophagy-Mediated Clearance of Damaged Mitochondria and Ameliorates Dystrophic Cardiomyopathy in Mice
- SIRT1 dependent modulation of neuroinflammation led neuroexcitotoxicity in aging rats.
- Influence of Tangshenfang on diabetic liver injury and the expression of SIRT1 and PGC-1αin the liver tissue
- Corrigendum to” Fisetin Induces SIRT1 Expression While Inhibiting Early Adipogenesis in 3T3-L1 Cells”[Biochem. Biophys. Res. Commun. 467 (4)(2015) 638-644]
- A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function
- The knockout of aldose reductase accelerates liver regeneration through AMPK/SIRT1/PGC-1α network
- Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
- Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
- Modulating Effects and Mechanisms of p53-miR-34a-SIRT1 Feedback Loop on Reproductive Senescence of Vascular Endothelial Progenitor Cells
- Relationship between SIRT1-ERK1∕ 2 pathway and chikusetsu saponin IVa-induced reduction of isoflurane-elicited neurotoxicity in fetal rats: an in vitro experiment
- SIRT1 represses PKC-zeta activity via regulating interplay of acetylation and phosphorylation in cardiac hypertrophy
- Lymphoid enhancer binding factor 1-mediated Matrix metalloproteinase 13 gene expression is repressed by SIRT1 in human chondrocytes
- Reactivation of visual cortical plasticity by caloric restriction mediated by AMPK-SIRT1 pathway from monocular deprivation in adult mice
- The Effect of 14 Weeks of Aerobic Training Together with Resveratrol Supplementation on Protein Levels of UCP-1, SIRT1, PGC-1α in Liver Tissue, Subcutaneous Fat …
- 0056 Abnormal Clock Gene Oscillation And Decreased SIRT1 Expression Causes Abnormal Circadian Rhythms In Epileptic Kv1. 1 Knock Out Mice
- The protective effect of Sedum sarmentosum Bunge against DMN-induced liver fibrosis via SIRT1-AMPK-LXR signaling pathway
- Correction to: Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular …
- GENE-03. WILD-TYPE Tp53 UNDERGOES A CELL TYPE-SPECIFIC INACTIVATION BY SIRT1 IN DE NOVO GLIOBLASTOMA
- PO-020 Aerobic Exercise Attenuates Myocardial Injury Through Activation of SIRT1 Signaling in T2DM Rats
- miR-338-5p/SIRT1 signaling pathway involved in black raspberry anthocyanin colorectal cancer chemoprevention
- PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle
- Resveratrol Restores LINE-1 Methylation Levels by Modulating SIRT1 and DNMTs Functions in Cellular Models of Age-Related Macular Degeneration
- Paeonol attenuates high glucose-induced expression of FN and ICAM-1 by promoting the activation of Nrf2/ARE pathway via upregulation of SIRT1 in GMCs
- The effect of high-intensity interval training on the expression levels of mir-149 and SIRT1, PGC1α and Nrf2 genes in doxorubicin-induced cardiac injury in rats
- Retraction notice to:” Role of Mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes” MCE Volume 382, Issue 1, 25 …
- The role of SIRT1 on DNA damage response and epigenetic alterations in cancer
- The role of different SIRT1-mediated signaling pathways in toxic injury
- circ-SIRT1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle …
- SIRT1 regulates metabolism and leukemogenic potential in CML stem cells
- The role of SIRT1 in skeletal muscle function and repair of older mice
- SIRT1 modulators in experimentally induced liver injury
- SIRT1 in the Development and Treatment of Hepatocellular Carcinoma
- RNA-binding protein RPS3 contributes to hepatocarcinogenesis by post-transcriptionally up-regulating SIRT1
- SIRT1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress
- The beneficial roles of SIRT1 in drug-induced liver injury
- 17β-estradiol modulates SIRT1 and halts oxidative stress-mediated cognitive impairment in a male aging mouse model
- Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)
- Dual PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction
- SIRT1–hypoxia‐inducible factor‐1α interaction is a key mediator of tubulointerstitial damage in the aged kidney
- SIRT1 in astrocytes regulates glucose metabolism and reproductive function
- The role and mechanism of SIRT1 in resveratrol-regulated osteoblast autophagy in osteoporosis rats
- SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition
- Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?
- Depressive symptoms in schizophrenia patients: a possible relationship between SIRT1 and BDNF
- Protection of the myocardium against ischemia/reperfusion injury by punicalagin through an SIRT1-NRF-2-HO-1-dependent mechanism
- Berberine ameliorates doxorubicin-induced cardiotoxicity via a SIRT1/p66Shc-mediated pathway
- Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization
- SIRT1 promotes osteogenic differentiation and increases alveolar bone mass via Bmi1 activation in mice
- The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery
- Sorafenib-induced apoptosis in hepatocellular carcinoma is reversed by SIRT1
- Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure
- Adipose-specific knockdown of SIRT1 results in obesity and insulin resistance by promoting exosomes release
- lncRNA miat functions as a ceRNA to upregulate SIRT1 by sponging miR-22-3p in HCC cellular senescence
- Improved motor nerve regeneration by SIRT1/Hif1a-mediated autophagy
- Tetrahydrocurcumin ameliorates diabetic cardiomyopathy by attenuating high glucose-induced oxidative stress and fibrosis via activating the SIRT1 pathway
- Hydroxytyrosol NO regulates oxidative stress and NO production through SIRT1 in diabetic mice and vascular endothelial cells
- Long noncoding RNA FLRL2 alleviated nonalcoholic fatty liver disease through Arntl‐SIRT1 pathway
- Insulin/IGF-1R, SIRT1, and FOXOs pathways—an intriguing interaction platform for bone and osteosarcoma
- A SIRT1 agonist reduces cognitive decline in type 2 diabetic rats through antioxidative and anti‑inflammatory mechanisms
- CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1
- The SIRT1/P53 axis in diabetic intervertebral disc degeneration pathogenesis and therapeutics
- Generation of human fatty livers using custom-engineered induced pluripotent stem cells with modifiable SIRT1 metabolism
- SIRT1 inhibits gouty arthritis via activating PPARγ
- Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice
- SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury
- Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway
- Bergenin activates SIRT1 as a novel therapeutic agent for osteogenesis of bone mesenchymal stem cells
- Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
- Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1–PGC-1α–TFAM pathway
- Catalpol alleviates adriamycin‐induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro
- Premature myocardial infarction: genetic variations in SIRT1 affect disease susceptibility
- miR-9-5p modulates the progression of Parkinson’s disease by targeting SIRT1
- Exercise activates lysosomal function in the brain through AMPK‐SIRT1‐TFEB pathway
- Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR‐181a to modulate SIRT1 expression
- SIRT1 regulates lysosome function and exosome secretion
- Dietary melatonin attenuates chromium-induced lung injury via activating the SIRT1/Pgc-1α/Nrf2 pathway
- CircRNA has_circ_0001946 promotes cell growth in lung adenocarcinoma by regulating miR-135a-5p/SIRT1 axis and activating Wnt/β-catenin signaling …
- Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells
- Pharmacological activation of SIRT1 ameliorates cisplatin-induced acute kidney injury by suppressing apoptosis, oxidative stress, and inflammation in mice
- SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high‐fat feeding
- TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage
- Resveratrol promotes diabetic wound healing via SIRT1-FOXO1-c-Myc signaling pathway-mediated angiogenesis
- SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3
- SIRT1 and gender differences in atherosclerotic cardiovascular disease
- Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy
- SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake
- Characterization of SIRT1/DNMTs functions and LINE-1 methylation in patients with age-related macular degeneration
- SIRT1 promotes a thermogenic gene program in bone marrow adipocytes: from mice to (wo) men
- A Comparative Linear Interaction Energy and MM/PBSA Study on SIRT1–Ligand Binding Free Energy Calculation
- Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis
- MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis
- SIRT1 deficiency interferes with membrane resealing after cell membrane injury
- SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer
- Effect of autophagy regulated by SIRT1/FoxO1 pathway on the release of factors promoting thrombosis from vascular endothelial cells
- In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database
- Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats
- SIRT1: a potential tumour biomarker and therapeutic target
- Deacetylation of β-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells
- Catechin attenuates TNF-α induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes
- SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes
- LncRNA SNHG12 inhibits miR-199a to upregulate SIRT1 to attenuate cerebral ischemia/reperfusion injury through activating AMPK signaling pathway
- SIRT1 knock-in mice preserve ovarian reserve resembling caloric restriction
- Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs
- SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary
- SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP‐13 signaling
- Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse …
- SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease
- Tangshen formula alleviates hepatic steatosis by inducing autophagy through the AMPK/SIRT1 pathway
- SIRT1 protects against apoptosis by promoting autophagy in the oxygen glucose deprivation/reperfusion-induced injury
- LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/SIRT1 pathway
- Aldose reductase regulates hyperglycemia-induced HUVEC death via SIRT1/AMPK-α1/mTOR pathway
- Inducible cardiac-specific deletion of SIRT1 in male mice reveals progressive cardiac dysfunction and sensitization of the heart to pressure overload
- A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks
- Knockout of longevity gene SIRT1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span
- Protective effect of resveratrol against ischemia-reperfusion injury via enhanced high energy compounds and eNOS-SIRT1 expression in type 2 diabetic female rat …
- LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR‐34a in diabetic cardiomyopathy
- Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on SIRT1/Nrf2 signaling pathways
- Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats
- Arbutin attenuates LPS-induced lung injury via SIRT1/Nrf2/NF-κBp65 pathway
- Evidence for SIRT1 mediated HMGB1 release from kidney cells in the early stages of hemorrhagic shock
- Protective effects of dioscin against doxorubicin-induced hepatotoxicity via regulation of SIRT1/FOXO1/NF-κb signal
- MHY2233 attenuates replicative cellular senescence in human endothelial progenitor cells via SIRT1 signaling
- A PARP1–BRG1–SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites
- … environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1/miR-134 signaling …
- SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494
- Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway
- Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα
- Salidroside stimulates the SIRT1/PGC-1α axis and ameliorates diabetic nephropathy in mice
- SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress
- Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells
- Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling*[S]
- Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation
- Quercetin attenuates oxidative stress‐induced apoptosis via SIRT1/AMPK‐mediated inhibition of ER stress in rat chondrocytes and prevents the progression of …
- Melatonin inhibits apoptosis and oxidative stress of mouse Leydig cells via a SIRT1-dependent mechanism
- Suppression of SIRT1 in diabetic conditions induces osteogenic differentiation of human vascular smooth muscle cells via RUNX2 signalling
- Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/β-catenin signaling …
- Ferulic acid regulates muscle fiber type formation through the SIRT1/AMPK signaling pathway
- SIRT1 modulates the sensitivity of prostate cancer cells to vesicular stomatitis virus oncolysis
- … with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha …
- Anagliptin ameliorates high glucose-induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1
- Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells
- SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: a possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic …
- miR‐23b‐3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells
- N-palmitoylethanolamide-oxazoline protects against middle cerebral artery occlusion injury in diabetic rats by regulating the SIRT1 pathway
- Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway
- Down-regulation of SIRT1 expression by mir-23b contributes to lipid accumulation in HepG2 cells
- LncRNA LEGLTBC functions as a ceRNA to antagonize the effects of miR-34a on the downregulation of SIRT1 in glucolipotoxicity-induced INS-1 beta cell …
- Effects of metformin and exenatide on insulin resistance and AMPKα-SIRT1 molecular pathway in PCOS rats
- Melatonin effects on non-alcoholic fatty liver disease are related to microRNA-34a-5p/SIRT1 axis and autophagy
- Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability
- Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway
- Switch of NAD salvage to de novo biosynthesis sustains SIRT1-RelB-dependent inflammatory tolerance
- SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription
- SIRT1 attenuates kidney disorders in male offspring due to maternal high-fat diet
- Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged …
- Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1α pathway
- SIRT1-inducible deacetylation of p21 promotes cardiomyocyte proliferation
- The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in …
- LncRNA MNX1-AS1 promotes progression of esophageal squamous cell carcinoma by regulating miR-34a/SIRT1 axis
- Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1/PGC‐1α/PI3K/Akt signaling
- SIRT1 protects against urban particulate matter-induced airway inflammation
- LncRNA-ANRIL inhibits cell senescence of vascular smooth muscle cells by regulating miR-181a/SIRT1
- Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the SIRT1‐autophagy pathway
- Activators of SIRT1 in wound repair: an animal model study
- PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades
- Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC‐1α mediated attenuation of mitochondrial oxidative stress
- LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis
- Molecular and cellular characterization of SIRT1 allosteric activators
- Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent manner
- EGCG enhances cancer cells sensitivity under 60Coγ radiation based on miR-34a/SIRT1/p53
- SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway
- Cannabisin F from hemp (Cannabis sativa) seed suppresses lipopolysaccharide-induced inflammatory responses in BV2 microglia as SIRT1 modulator
- SIRT1-targeted miR-543 autophagy inhibition and epithelial–mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer
- The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway
- Rutin alleviates hypoxia/reoxygenation-induced injury in myocardial cells by up-regulating SIRT1 expression
- Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines
- SIRT7 promotes thyroid tumorigenesis through phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1 axis
- Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/SIRT1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE
- Ginsenoside Rg1 regulates SIRT1 to ameliorate sepsis-induced lung inflammation and injury via inhibiting endoplasmic reticulum stress and inflammation
- SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders
- Ramadan diurnal intermittent fasting modulates SOD2, TFAM, Nrf2, and sirtuins (SIRT1, SIRT3) gene expressions in subjects with overweight and obesity
- Survival and clinicopathological significance of SIRT1 Expression in cancers: a meta-analysis
- SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride
- Attenuation of palmitic acid–induced lipotoxicity by chlorogenic acid through activation of SIRT1 in hepatocytes
- SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis
- Gynostemma pentaphyllum extract ameliorates high-fat diet-Induced obesity in C57BL/6N mice by upregulating SIRT1
- Lactobacillus sakei Alleviates High‐Fat‐Diet‐Induced Obesity and Anxiety in Mice by Inducing AMPK Activation and SIRT1 Expression and Inhibiting Gut Microbiota …
- microRNA‐34a aggravates coxsackievirus B3‐induced apoptosis of cardiomyocytes through the SIRT1‐p53 pathway
- Long noncoding RNA FOXD3‐AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR …
- Swimming training by affecting the pancreatic Sirtuin1 (SIRT1) and oxidative stress, improves insulin sensitivity in diabetic male rats
- Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+–SIRT1 signaling
- AMPKα1 overexpression improves postoperative cognitive dysfunction in aged rats through AMPK‐SIRT1 and autophagy signaling
- Quercetin improve ischemia/reperfusion‐induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC‐1α signaling
- High-glucose treatment regulates biological functions of human umbilical vein endothelial cells via SIRT1/FOXO3 pathway
- Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial–mesenchymal transition in ovarian carcinoma
- A yeast suppressor screen used to identify mammalian SIRT1 as a proviral factor for Middle East respiratory syndrome coronavirus replication
- Resveratrol, an activator of SIRT1, improves ER stress by increasing clusterin expression in HepG2 cells
- Crocin alleviates myocardial ischemia/reperfusion-induced endoplasmic reticulum stress via regulation of miR-34a/SIRT1/Nrf2 pathway
- Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the SIRT1/AMPK and NF-κB signaling pathways
- Efficacy of 5-aminolevulinic acid–based photodynamic therapy against keloid compromised by downregulation of SIRT1-SIRT3-SOD2-mROS dependent …
- Curcumin inhibits the PERK-eIF2α-CHOP pathway through promoting SIRT1 expression in oxidative stress-induced rat chondrocytes and ameliorates …
- Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice
- The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population
- Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy
- Ferulic acid, a natural polyphenol, protects against osteoporosis by activating SIRT1 and NF-κB in neonatal rats with glucocorticoid-induced osteoporosis
- Sodium/calcium overload and SIRT1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity
- Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response
- Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD+–SIRT1 pathway
- Baicalin reverse depressive‐like behaviors through regulation SIRT1‐NF‐kB signaling pathway in olfactory bulbectomized rats
- … ARTICLE: Long noncoding RNA SNHG15 enhances the development of colorectal carcinoma via functioning as a ceRNA through miR-141/SIRT1/Wnt/β-catenin axis
- EP300 and SIRT1/6 co-regulate lapatinib sensitivity via modulating FOXO3-acetylation and activity in breast cancer
- Estrogen-SIRT1 axis plays a pivotal role in protecting arteries against menopause-induced senescence and atherosclerosis
- Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway
- Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway
- SIRT1 ameliorates monosodium urate crystal–induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway
- Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting SIRT1
- SIRT1 Activation Promotes β‐Cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling‐Mediated Fatty Acid Oxidation
- Protective effect of astaxanthin against contrast-induced acute kidney injury via SIRT1-p53 pathway in rats
- Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer
- Feeding restriction alleviates high carbohydrate diet-induced oxidative stress and inflammation of Megalobrama amblycephala by activating the AMPK-SIRT1 pathway
- Role of SIRT1 in hematologic malignancies
- SIRT1 inhibits HG-induced endothelial injury: Role of Mff-based mitochondrial fission and F‑actin homeostasis-mediated cellular migration
- Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-β1/Smad3 and autophagy …
- Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR‐181b/SIRT1/HO‐1 signaling
- Inhibition of P53/miR‐34a improves diabetic endothelial dysfunction via activation of SIRT1
- SIRT1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury
- ROR alpha protects against LPS-induced inflammation by down-regulating SIRT1/NF-kappa B pathway
- Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease
- Tanshinone IIA attenuates cardiac microvascular ischemia-reperfusion injury via regulating the SIRT1-PGC1α-mitochondrial apoptosis pathway
- Vitamin D ameliorates fat accumulation with AMPK/SIRT1 activity in C2C12 skeletal muscle cells
- … , and mitochondrial content upon glucose withdrawal correlates with a dysregulated mitochondria turnover mediated by the activation of the protein deacetylase SIRT1
- The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-SIRT1-PGC-1α signaling axis mediated anti …
- … induces autophagy and protects brain microvascular endothelial cells against oxygen–glucose deprivation by binding to miR-200c-3p and upregulating SIRT1 …
- Echinacoside protects against MPTP/MPP+-induced neurotoxicity via regulating autophagy pathway mediated by SIRT1
- Sweroside alleviated LPS-induced inflammation via SIRT1 mediating NF-κB and FOXO1 signaling pathways in RAW264. 7 cells
- Resveratrol reduces oxidative stress and apoptosis in podocytes via Sir2-related enzymes, sirtuins1 (SIRT1)/peroxisome proliferator-activated receptor γ co …
- Calycosin-7-O-β-D-glucoside attenuates OGD/R-induced damage by preventing oxidative stress and neuronal apoptosis via the SIRT1/FOXO1/PGC-1α …
- Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress‐induced toxicity by miR‐181/SIRT1/PGC‐1α/Nrf2 signaling pathway in human …
- Serum SIRT1 is associated with frailty and adipokines in older adults
- … and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1
- Hydrogen sulfide inhibits high glucose-induced neuronal senescence by improving autophagic flux via up-regulation of SIRT1
- Cardiac rehabilitation increases SIRT1 activity and β-hydroxybutyrate levels and decreases oxidative stress in patients with HF with preserved ejection …
- Activation of the miR-34a-mediated SIRT1/mTOR signaling pathway by urolithin A attenuates D-galactose-induced brain aging in mice
- The link between the AMPK/SIRT1 axis and a flavonoid‐rich extract of Citrus bergamia juice: A cell‐free, in silico, and in vitro study
- Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling
- SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders
- Distinct roles of the NAD+-SIRT1 and FAD-LSD1 pathways in metabolic response and tissue development
- Detection of polymorphisms in the promoter of bovine SIRT1 gene and their effects on intramuscular fat content in Chinese indigenous cattle
- Pterostilbene prevents hepatocyte epithelial‐mesenchymal transition in fructose‐induced liver fibrosis through suppressing miR‐34a/SIRT1/p53 and TGF‐β1/Smads …
- Evodiamine inhibits migration and invasion by SIRT1-mediated post-translational modulations in colorectal cancer
- … in oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs) via targeting miR-377 and upregulating SIRT1, VEGFA, and BCL-XL
- Irisin alleviates pulmonary epithelial barrier dysfunction in sepsis-induced acute lung injury via activation of AMPK/SIRT1 pathways
- BPDE and B [a] P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in …
- Advanced glycation end‐products induce oxidative stress through the SIRT1/Nrf2 axis by interacting with the receptor of AGEs under diabetic conditions
- Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle …
- Modulation of SIRT1/NF-κB interaction of evogliptin is attributed to inhibition of vascular inflammatory response leading to attenuation of atherosclerotic plaque …
- Role of SIRT1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation
- Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice
- Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression
- Werner helicase control of human papillomavirus 16 E1-E2 DNA replication is regulated by SIRT1 deacetylation
- Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation
- Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (L-serine activates SIRT1 in C2C12 myotubes)
- … Shuai IIRecipe attenuates renal injury and fibrosis in chronic kidney disease by regulating NLRP3 inflammasome and SIRT1/Smad3 deacetylation pathway
- Aralia taibaiensis protects against I/R-induced brain cell injury through the Akt/SIRT1/FOXO3a pathway
- Salvianolic acid B attenuates apoptosis of HUVEC cells treated with high glucose or high fat via SIRT1 activation
- Inhibition of nucleolar stress response by SIRT1: A potential mechanism of acetylation‐independent regulation of p53 accumulation
- SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress
- Nicotinamide overcomes doxorubicin resistance of breast cancer cells through deregulating SIRT1/Akt pathway
- Fucoxanthin Alleviates Oxidative Stress through Akt/SIRT1/FoxO3α Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs
- Brain region specific methylation and SIRT1 binding changes in MAOA promoter is associated with sexual dimorphism in early life stress induced aggressive behavior
- Acetaminophen responsive miR-19b modulates SIRT1/Nrf2 signaling pathway in drug-induced hepatotoxicity
- MiR-138-5p exacerbates hypoxia/reperfusion-induced heart injury through the inactivation of SIRT1-PGC-1α
- Chlorogenic acid prevents paraquat-induced apoptosis via SIRT1-mediated regulation of redox and mitochondrial function
- Moderate-and low-dose of atorvastatin alleviate cognition impairment induced by high-fat diet via SIRT1 activation
- Triptolide improves cognitive dysfunction in rats with vascular dementia by activating the SIRT1/PGC-1α signaling pathway
- SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy
- NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward
- JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic …
- Hepatic DNA damage induced by electronic cigarette exposure is associated with the modulation of NAD+/PARP1/SIRT1 axis
- rhEPO inhibited cell apoptosis to alleviate acute kidney injury in sepsis by AMPK/SIRT1 activated autophagy
- Skeletal muscle miR-34a/SIRT1: AMPK axis is activated in experimental and human non-alcoholic steatohepatitis
- Cartilage Ablation of SIRT1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling
- Vitamin C attenuates sodium fluoride-induced mitochondrial oxidative stress and apoptosis via SIRT1-SOD2 pathway in F9 cells
- Resveratrol inhibits high-glucose-induced inflammatory “metabolic memory” in human retinal vascular endothelial cells through SIRT1-dependent signaling
- Caffeic acid phenethyl ester (CAPE) protects PC12 cells against cisplatin-induced neurotoxicity by activating the AMPK/SIRT1, MAPK/Erk, and PI3k/Akt signaling …
- I157172, a novel inhibitor of cystathionine γ-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3
- … cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling …
- Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway
- Circ ERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis
- AHR regulates metabolic reprogramming to promote SIRT1-dependent keratinocyte differentiation
- Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice
- Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: A molecular and bioinformatic approach
- Genistein protects against ox-LDL-induced senescence through enhancing SIRT1/LKB1/AMPK-mediated autophagy flux in HUVECs
- Renalase attenuates mouse fatty liver ischemia/reperfusion injury through mitigating oxidative stress and mitochondrial damage via activating SIRT1
- SIRT1: The value of functional outcome, stroke-related dementia, anxiety, and depression in patients with acute ischemic stroke
- Chemerin/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS‐SIRT1‐NF‐κB signaling
- SIRT1 activation attenuates bone cancer pain by inhibiting mGluR1/5
- Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of …
- Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway
- Quercetin protected against isoniazide‐induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway
- CD38 deficiency alleviates D-galactose-induced myocardial cell senescence through NAD+/SIRT1 signaling pathway
- Betalain-and betacyanin-rich supplements’ impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients: A …
- … KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/SIRT1 …
- Nicotinamide induces liver regeneration and improves liver function by activating SIRT1
- TIGAR regulates mitochondrial functions through SIRT1‐PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle
- SIRT1/AMPK and Akt/eNOS signaling pathways are involved in endothelial protection of total aralosides of Aralia elata (Miq) Seem against high‐fat diet‐induced …
- Coreopsis tinctoria flowers extract ameliorates D-galactose induced aging in mice via regulation of SIRT1-Nrf2 signaling pathway
- Troxerutin exerts neuroprotection against lipopolysaccharide (LPS) induced oxidative stress and neuroinflammation through targeting SIRT1/SIRT3 signaling pathway
- γ-Mangostin ameliorates free fatty acid-induced lipid accumulation via the SIRT1/LKB1/AMPK pathway in HepG2 and L02 cells
- Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the SIRT1/NF-κB and Nrf-2/HO-1 pathways
- MicroRNA-30c abrogation protects against spinal cord ischemia reperfusion injury through modulating SIRT1
- Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes …
- Unraveling the unbinding pathways of products formed in catalytic reactions involved in SIRT1–3: a random acceleration molecular dynamics simulation study
- Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo
- PKCδ mediates NF-κB inflammatory response and downregulates SIRT1 expression in liver fibrosis
- Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice
- Overexpression of SIRT1 inhibits corticosterone-induced autophagy
- Collateral sensitivity of drug-resistant ABCB5-and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression
- SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission
- Effects of vinclozolin exposure on the expression and activity of SIRT1 and SIRT6 in the porcine ovary
- Role of SIRT1 in Epigenetics
- Long noncoding RNA SNHG7 inhibits high glucose-induced human retinal endothelial cells angiogenesis by regulating miR-543/SIRT1 axis
- SIRT1 (rs3740051) role in pituitary adenoma development
- Melatonin modifies SOX2+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation
- GM1 ameliorates lead-induced cognitive deficits and brain damage through activating the SIRT1/CREB/BDNF pathway in the developing male rat hippocampus
- Chrysophanol alleviates myocardial injury in diabetic db/db mice by regulating the SIRT1/HMGB1/NF‑κB signaling pathway
- Replacing fish meal with cottonseed meal protein hydrolysate affects amino acid metabolism via AMPK/SIRT1 and TOR signaling pathway of Megalobrama …
- Dental pulp stem cells expressing SIRT1 improve new bone formation during distraction osteogenesis
- Gegen qinlian decoction ameliorates hepatic insulin resistance by Silent Information Regulator1 (SIRT1)-dependent deacetylation of Forkhead Box O1 …
- Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double‐blind …
- Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model
- Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2
- A new regulatory mechanism between P53 And YAP crosstalk By SIRT1 mediated deacetylation to regulate cell cycle and apoptosis in A549 cell lines
- MiR-124 sensitizes cisplatin-induced cytotoxicity against CD133+ hepatocellular carcinoma cells by targeting SIRT1/ROS/JNK pathway
- The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target
- Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats
- Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway
- Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3β pathway.
- Porous Se@ SiO2 nanospheres attenuate cisplatin-induced acute kidney injury via activation of SIRT1
- Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway
- Adiponectin enhances human keratinocyte lipid synthesis via SIRT1 and nuclear hormone receptor signaling
- Lonicera caerulea Berry Polyphenols Activate SIRT1, Enhancing Inhibition of Raw264.7 Macrophage Foam Cell Formation and Promoting Cholesterol Efflux
- Depletion of CPEB1 protects against oxidized LDL-induced endothelial apoptosis and inflammation though SIRT1/LOX–1 signalling pathway
- SIRT1 allele frequencies in depressed patients of European descent in Russia
- Modulation of Akt-p38-MAPK/Nrf2/SIRT1 and NF-κB pathways by wine pomace product in hyperglycemic endothelial cell line
- Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by SIRT1 to promote ethanol tolerance
- Inhibition of TLR9 attenuates skeletal muscle fibrosis in aged sarcopenic mice via the p53/SIRT1 pathway
- SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPARα/FoxO1 signaling …
- Palmitic acid-induced NAD+ depletion is associated with the reduced function of SIRT1 and increased expression of BACE1 in hippocampal neurons
- SIRT1 negatively regulates invasive and angiogenic activities of the extravillous trophoblast
- Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1
- Induction of autophagy under nitrosative stress: A complex regulatory interplay between SIRT1 and AMPK in MCF7 cells
- Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway
- Cx43 inhibition attenuates sepsis-induced intestinal injury via downregulating ROS transfer and the activation of the JNK1/SIRT1/FoxO3a signaling pathway
- MCH regulates SIRT1/FoxO1 and reduces POMC neuronal activity to induce hyperphagia, adiposity, and glucose intolerance
- Neuronal SIRT1 regulates metabolic and reproductive function and the response to caloric restriction
- Salidroside attenuates dextran sulfate sodium-induced colitis in mice via SIRT1/FoxOs signaling pathway
- Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression
- MLN4924 exerts a neuroprotective effect against oxidative stress via SIRT1 in spinal cord ischemia-reperfusion injury
- Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity
- Aldosterone stimulation mediates cardiac metabolism remodeling via SIRT1/AMPK signaling in canine model
- S-nitrosylation of the Peroxiredoxin-2 promotes S-nitrosoglutathione-mediated lung cancer cells apoptosis via AMPK-SIRT1 pathway
- Leucine regulates slow‐twitch muscle fibers expression and mitochondrial function by SIRT1/AMPK signaling in porcine skeletal muscle satellite cells
- SIRT1‐ZEB1‐positive feedback promotes epithelial‐mesenchymal transition process and metastasis of osteosarcoma
- Rs1894720 polymorphism in MIAT increased susceptibility to age‐related hearing loss by modulating the activation of miR‐29b/SIRT1/PGC‐1α signaling
- … improves learning and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1α-Tau …
- MCPIP1 alleviated lipopolysaccharide‐induced liver injury by regulating SIRT1 via modulation of microRNA‐9
- Engagement with tNOX (ENOX2) to inhibit SIRT1 and activate p53-dependent and-independent apoptotic pathways by novel 4, 11-diaminoanthra [2, 3-b] furan-5, 10 …
- Modulatory role of SIRT1 and resistin as therapeutic targets in patients with aortic valve stenosis
- Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age
- The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via SIRT1-and Pgc-1α-mediated regulation of Glut2
- SIRT1 is dispensable for maturation of hematopoietic stem cell in the bone marrow niche
- Aloin reduces HMGB1-mediated septic responses and improves survival in septic mice by activation of the SIRT1 and PI3K/Nrf2/HO-1 signaling axis
- The overexpression of sirtuin1 (SIRT1) alleviated lipopolysaccharide (LPS)-induced acute kidney injury (AKI) via Inhibiting the activation of nucleotide-binding …
- Mechanistic evaluation of AMPK/SIRT1/FXR signaling axis, inflammation, and redox status in thioacetamide‐induced liver cirrhosis: The role of Cichorium intybus linn …
- … inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 …
- Does CETP rs5882, rs708272, SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, VEGFA rs833068, IL6 rs1800795 polymorphisms play a role in optic …
- Peripheral maintenance of the axis SIRT1-SIRT3 at youth level may contribute to brain resilience in middle-aged amateur rugby players
- … reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway
- Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation
- Maresin 1 attenuates the inflammatory response and mitochondrial damage in mice with cerebral ischemia/reperfusion in a SIRT1-dependent manner
- The effects of SIRT1/FoxO1 on LPS induced INS-1 cells dysfunction
- Structural analysis of the inhibitory effects of polyphenols,(+)‐hopeaphenol and (−)‐isohopeaphenol, on human SIRT1
- Targeting c-MYC through Interference with NAMPT and SIRT1 and their association to oncogenic drivers in murine serrated intestinal tumorigenesis
- Capsaicin attenuates cell migration via SIRT1 targeting and inhibition to enhance cortactin and β-catenin acetylation in bladder cancer cells
- Nicotinamide phosphoribosyl transferase regulates cell growth via the SIRT1/P53 signaling pathway and is a prognosis marker in colorectal cancer
- SIRT1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload
- Research progress on SIRT1 and sepsis.
- Therapeutic effects of curcumin on age-induced alterations in daily rhythms of clock genes and SIRT1 expression in the SCN of male Wistar rats
- miR‑128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade
- Effect of fenofibrate on diabetic retinopathy in rats via SIRT1/NF-κB signaling pathway
- Gastric bypass surgery improves the skeletal muscle ceramide/S1P ratio and upregulates the AMPK/SIRT1/PGC-1α pathway in zucker diabetic fatty rats
- Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway
- Fatty acid type–specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle
- LncRNA SOX2OT alleviates the high glucose-induced podocytes injury through autophagy induction by the miR-9/SIRT1 axis
- … promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic/high‐glucose conditions, potentially through the SIRT1/HIF‐1/VEGF …
- Silibinin-induced autophagy mediated by PPARα-SIRT1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 …
- Hydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response
- Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1
- ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer
- SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, LIPC rs10468017, rs493258 and LPL rs12678919 genotypes and haplotype evaluation in patients with age …
- Ginkgetin aglycone attenuates neuroinflammation and neuronal injury in the rats with ischemic stroke by modulating STAT3/JAK2/SIRT1
- MicroRNA-183 affects the development of gastric cancer by regulating autophagy via MALAT1-miR-183-SIRT1 axis and PI3K/AKT/mTOR signals
- Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity–breast cancer connection
- Crosstalk of PD-1 signaling with the SIRT1/FOXO-1 axis during the progression of visceral leishmaniasis
- Defect of SIRT1-FoxO3a axis is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated cellular …
- … with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1α pathway
- SIRT1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy
- Downregulation of microRNA‐155 stimulates sevoflurane‐mediated cardioprotection against myocardial ischemia/reperfusion injury by binding to SIRT1 in mice
- Resveratrol attenuates cardiomyocyte apoptosis in rats induced by coronary microembolization through SIRT1-mediated deacetylation of p53
- Suppression of microRNA‐141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression
- SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region
- Tartary buckwheat extract attenuated the obesity-induced inflammation and increased muscle PGC-1a/SIRT1 expression in high fat diet-induced obese rats
- Integration of the deacetylase SIRT1 in the response to nucleolar stress: metabolic implications for neurodegenerative diseases
- Identification of polyphenols that repair the ultraviolet-B-induced DNA damage via SIRT1-dependent XPC/XPA activation
- MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma
- Secukinumab attenuates reactive astrogliosis via IL‐17RA/(C/EBPβ)/SIRT1 pathway in a rat model of germinal matrix hemorrhage
- miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting SIRT1 in non-alcoholic fatty liver disease
- Metformin and tenovin‐6 synergistically induces apoptosis through LKB1‐independent SIRT1 down‐regulation in non‐small cell lung cancer cells
- Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating SIRT1 expression in triple negative breast cancer cells
- The SIRT1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation
- HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice
- AG1031 induces apoptosis through suppressing SIRT1/p53 pathway in human neuroblastoma cells
- Treatment with, resveratrol, a SIRT1 activator, prevents zearalenone-induced lactic acid metabolism disorder in rat sertoli cells
- Recovery of olfactory function after excitotoxic lesion of the olfactory bulbs is associated with increases in bulbar SIRT1 and SIRT4 expressions
- SIRT1 gene polymorphisms are associated with nondiabetic type 1 cardiorenal syndrome
- Maslinic acid protects against obesity‐induced nonalcoholic fatty liver disease in mice through regulation of the SIRT1/AMPK signaling pathway
- The effect of swimming training on oxidative stress, SIRT1 gene expression, and histopathology of hepatic tissue in type 2 diabetic rats
- The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation
- Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells
- Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1α-UCP2 axis
- SIRT1-dependent upregulation of antiglycative defense in HUVECs is essential for resveratrol protection against high glucose stress
- Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the SIRT1‐eNOS pathway
- Mathematical models converge on PGC1α as the key metabolic integrator of SIRT1 and AMPK regulation of the circadian clock
- SIRT1 expression is associated with cell proliferation in angiosarcoma
- Beneficial role of HO-1-SIRT1 axis in attenuating angiotensin II-induced adipocyte dysfunction
- SIRT1 inhibitory compounds from the roots of Codonopsis pilosula
- MicroRNA-128 is involved in dexamethasone-induced lipid accumulation via repressing SIRT1 expression in cultured pig preadipocytes
- Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea
- Camptothecin activates SIRT1 to promote lipid catabolism through AMPK/FoxO1/ATGL pathway in C 2 C 12 myogenic cells
- The contrary effects of SIRT1 on MCF7 cells depend on CD36 expression level
- MicroRNA‑486‑5p functions as a tumor suppressor of proliferation and cancer stem‑like cell properties by targeting SIRT1 in liver cancer
- Metformin inhibits high glucose‐induced mesangial cell proliferation, inflammation and ECM expression through the SIRT1‐FOXO1‐autophagy axis
- MicroRNA‑217 inhibition relieves cerebral ischemia/reperfusion injury by targeting SIRT1
- … -377 suppresses high glucose and hypoxia-induced angiogenesis and inflammation in human retinal endothelial cells by direct up-regulation of target gene SIRT1
- Overexpression of miR‐138‐5p suppresses MnCl2‐induced autophagy by targeting SIRT1 in SH‐SY5Y cells
- DL-3-n-butylphthalide attenuates lipopolysaccharide-induced acute lung injury via SIRT1-dependent and-independent regulation of Nrf2
- Reduction of SIRT1 blunts the protective effects of ischemic post-conditioning in diabetic mice by impairing the Akt signaling pathway
- GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity
- Relationship between SIRT1 gene expression level and disease in age-related cataract cases
- Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin‐1 (SIRT1) …
- Total flavonoids from the Carya cathayensis Sarg. leaves inhibit HUVEC senescence through the miR‐34a/SIRT1 pathway
- MiR-29 regulates de novo lipogenesis in the liver and circulating triglyceride Levels in a SIRT1-dependent manner
- Upregulation of SIRT1 gene in gastric adenocarcinoma
- 1, 25-Dihydroxyvitamin D decreases tertiary butyl-hydrogen peroxide-induced oxidative stress and increases AMPK/SIRT1 activation in C2C12 muscle cells
- … QianYang QuTan Recipe attenuates left ventricular hypertrophy in obese hypertensive rats by improving mitochondrial function through SIRT1/PGC-1α deacetylation …
- miR‑448 promotes progression of non‑small‑cell lung cancer via targeting SIRT1
- … three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility …
- miR-221 promotes lens epithelial cells apoptosis through interacting with SIRT1 and E2F3
- Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles
- Tumor Necrosis Factor-alpha (TNF-α) Enhances miR-155-Mediated Endothelial Senescence by Targeting Sirtuin1 (SIRT1)
- The molecular mechanism of SIRT1 signaling pathway in brain injury of newborn rats exposed to Hyperoxia
- Carnosic acid mitigates early brain injury after subarachnoid hemorrhage: possible involvement of the SIRT1/p66shc signaling pathway
- Salsalate ameliorates the atherosclerotic response through HO-1-and SIRT1-mediated suppression of ER stress and inflammation
- Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in the heart of fructose-fed ovariectomized rats
- CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation
- SIRT1 and p300/CBP regulate the reversible acetylation of serine-threonine kinase NDR2
- Effects of rosuvastatin on neuronal apoptosis in cerebral ischemic stroke rats via SIRT1/NF-kappa B signaling pathway
- Retracted Article: Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway
- 20 (S)-Protopanaxadiol inhibits angiotensin II-induced epithelial-mesenchymal transition by downregulating SIRT1
- Antiproliferative activity of (R)-4′-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) …
- The effect of lentivirus-mediated SIRT1 gene knockdown in the ATDC5 cell line via inhibition of the Wnt signaling pathway
- SIRT1 gene polymorphisms are associated with urinary bladder cancer in an Iranian population
- High mobility group box-1 release from H2O2-injured hepatocytes due to SIRT1 functional inhibition
- Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A …
- Resveratrol reduced liver damage after liver resection in a rat model by upregulating sirtuin 1 (SIRT1) and inhibiting the acetylation of high mobility group box …
- Lentinan protects cardiomyocytes against hypoxia-induced injury by regulation of microRNA-22/SIRT1
- Silent mating type information regulation 2 homolog (SIRT1) influences osteogenic proliferation and differentiation of MC3T3-E1 cells via regulation of miR …
- Effects of SIRT1/Akt pathway on chronic inflammatory response and lung function in patients with asthma
- Propofol attenuates high glucose-induced P66shc expression in human umbilical vein endothelial cells through SIRT1
- MicroRNA-579-3p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of mesenchymal stem cells through regulating SIRT1
- Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-κB signaling pathway
- TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1
- Polymorphism rs7895833 in the SIRT1 gene and its association with dyslipidaemia in the elderly
- Immunohistochemical Expression of SIRT1 in Oral Squamous Cell Carcinoma and its Relationship with Clinical-Pathological Factors
- MicroRNA-506 is involved in regulation of the occurrence of lipopolysaccharides (LPS)-induced pulpitis by sirtuin 1 (SIRT1)
- Overexpression of SIRT1 in urothelial carcinoma of the urinary bladder is associated with local recurrence and poor survival
- Reply to Furlan et al.: The role of SIRT1 in cell autonomous clock function
- AMPK-SIRT1-independent inhibition of ANGPTL3 gene expression is a potential lipid-lowering mechanism of metformin
- Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund’s adjuvant mice
- Omega-3 fatty acids and vitamin E supplementation can affect gene expressions of SIRT1, FOXO1 and UCP-2 in coronary artery disease patients
- Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 single gene polymorphisms in patients with laryngeal …
- Significant association of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) rs3846662 and sirtuin 1 (SIRT1) rs7895833 and apolipoprotein E (APOE) …
- Increase of Hspa1a and Hspa1b genes in the resting B cells of SIRT1 knockout mice
- CD38-NAD+-SIRT1 axis in T cell immunotherapy
- SIRT1 antisense transcript is down-regulated in human tumors
- … -β-Glucopyranoside Alleviates Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cell Injury by Inducing Autophagy Through AMPK/SIRT1 …
- … and oxidative stress in a chronic obstructive pulmonary disease rat model with syndromes of Qi deficiency and phlegm and blood stasis by regulating the SIRT1 …
- SIRT1 signaling pathway in bone metabolism
- SIRT1 activators as novel therapy for cancer
- The impact of SIRT1 serum level and its gene single nucleotide polymorphism (rs7895833) on the prediction of hepatocellular carcinoma in a cohort of cirrhotic …
- MiR-34a promotes myocardial infarction in rats by inhibiting the activity of SIRT1
- BOS is associated with decreased SIRT1 in peripheral blood proinflammatory T, NK, and NKT-like lymphocytes
- Determination of a possible relationship between a single nucleotide polymorphism (SNP) in the promoter region of the SIRT1 gene and production and …
- SIRT1-Mediated Protective Effect of Aralia elata (Miq.) Seem against High-Glucose-Induced Senescence in Human Umbilical Vein Endothelial Cells
- Regulation of LKB1-AMPKα-SIRT1 signal pathway in lipid metabolism in the adipose tissue of dairy cows
- Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through SIRT1-FXR signaling pathway
- Pharmacological and fasting-induced activation of SIRT1/LXRα signaling alleviates diabetes-induced retinopathy
- Genistein inhibits AOM/DSS-induced colon cancer by regulating lipid droplet accumulation and the SIRT1/FOXO3a pathway in high-fat diet-fed female mice
- Clinical, pathological and prognostic implications of USP22, SIRT1 and E-cadherin expression in papillary thyroid cancer (PTC) and adjacent non-neoplastic …
- Correction to: activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes
- 201-LB: The Neuronal SIRT1 Regulate the Metabolic Imbalance in Ischemic Stroke
- Ursolic acid increases SIRT1 protein level and β-cells number in diabetic rats
- Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo
- miR-124 and miR-142 enhance cisplatin sensitivity of non-small cell lung cancer cells through repressing autophagy via directly targeting SIRT1
- Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus
- Breaking the intergenerational cycle of obesity with SIRT1
- SIRT1 Knockdown Enhances the Differentiation of Human Embryonic Stem Cells into Pancreatic β Cells
- FGF21 inhibits lipid accumulation and inflammation induced by palmitate in human hepatocytes via SIRT1 pathway
- FP259 abnormal CCAT1/micro-155/SIRT1 axis promoted inflammatory response and apoptosis of tubular epithelial cells in LPS caused acute kidney injury
- SIRT1 mediates the effect of stress on hypothalamic clock genes and food intake regulators in rainbow trout, Oncorhynchus mykiss
- Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats
- Silencing of miR-486 alleviates LPS-stimulated inflammatory response of macrophages through targeting SIRT1
- 2019-P: Deletion of Hepatic SIRT1 Enhances the Effect of Ketogenic Diets on Ameliorating Obesity and Metabolic Disorders
- Activation of liver x receptors prevents the spinal LTP induced by skin/muscle retraction in the thigh via SIRT1/NF-Κb pathway
- Effects of SIRT1 on the in vitro maturation and aging of yak oocytes.
- SIRT1 in the Regulation of Interferon Gamma in Severe Aplastic Anemia
- Correction for Morgan et al.,“Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation”
- The decreased SIRT1 level may account for the lipid profile in chronic kidney disease
- Resveratrol inhibits ovarian cancer cell growth and Wnt signaling pathway by regulating SIRT1
- Resveratrol ameliorates long-term structural, functional and metabolic perturbations in a rat model of donor nephrectomy: Implication of SIRT1
- Role of Acidic pH in Linking SIRT1 and Cardioprotective Metabolism
- Biochemical insight into pseudouridine synthase 7 (PUS7) as a novel interactor of sirtuin, SIRT1
- A yeast suppressor screen used to identify mammalian SIRT1 as a proviral factor for MERS-CoV replication
- Lutein Prevents the Excessive Fat Deposition in Liver and Abdominal Tissues by Activating SIRT1 and Up-regulating ATGL and HSL in High Fat Diet Rats (FS06-01 …
- … Article: MicroRNA-1271 modulates hepatitis B virus replication, cell proliferation and apoptosis in hepatitis B virus-related hepatocellular carcinoma by targeting SIRT1
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- Effect of SIRT1 on Bone Marrow Stromal Stem Cells in High Glucose Environment and Related Mechanisms
- Vitamin K2 Alleviates Insulin Resistance in Skeletal Muscle by Improving Mitochondrial Biogenesis Through Modulating SIRT1 Signaling
- MiR-34a regulates the glucose metabolism of Blunt snout bream (Megalobrama amblycephala) fed high-carbohydrate diets through the mediation of the SIRT1/FoxO1 …
- Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells
- A Meta-Analysis of the Association Between SIRT1 Expression with Tumors Drug-Resistance
- FOXQ1 promotes proliferation and metastasis of epithelial ovarian cancer via activation of SIRT1/NRF2 signaling pathway
- A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo
- LncRNA SIRT1-AS Up-Regulates SIRT1 to Improve the Aging-Related Deep Venous Thrombosis
- SIRT1-dependent response is crucial for the resveratrolinduced upregulation of antioxidant and antiglycative defence in high glucose-challenged HUVECs_2
- HIC2 activates transcription of SIRT1 gene
- In Silico Study Of SIRT1 Activators Using A Molecular Dynamic Approach
- Pgc1a Activation by Pterostilbene Ameliorates Acute Doxorubicin Cardiotoxicity via Reducing Mitochondrial Oxidative Stress Through Enhancing Ampk and SIRT1 …
- SIRT1 in SF1 neurons links light inputs to circadian function in skeletal muscle
- SIRT1-dependent response is crucial for the resveratrol-induced upregulation of antioxidant and antiglycative defence in high glucose-challenged HUVECs
- SIRT1 and energy metabolism in rodent Sertoli cells
- Forskolin modulate silent information regulator 1 (SIRT1) gene expression and halts experimentally-induced acute kidney injury
- RETRACTED ARTICLE: Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer through regulating miR-124-3p/SIRT1 axis and activating PI3K …
- Temporal gating of SIRT1 functions by O-GlcNAcylation prevents hyperglycemia and enables physiological transitions in liver
- Xuefu Zhuyu Oral Liquid () Prevents Apoptosis of Ischemic Myocardium Cells in Rats by Regulating SIRT1 and Its Pathway-Related Genes.
- Polimorfismo rs7895833 en el gen SIRT1 y su asociación con dislipidemia en el anciano
- 2032-P: The Effects of Liraglutide on Ameliorating Diabetic Kidney Disease Is via SIRT1/TXNIP Pathway
- Effects of omega 3 and vitamin E supplementation on Gene Expression of SIRT1, hTERT and serum level of hsCRP in CAD male patients: a randomized clinical trial …
- SIRT1 cleavage: from cartilage degeneration to osteoarthritic biomarker
- NAD+-dependent deacetylase SIRT1 is essential for meiotic progression and controls repair-recombination efficiency
- SNPs Detected in the SIRT1 and H-FABP Genes and Their Association with Growth Traits in Yak
- 1819-P: Growth Hormone Receptor (GHR) in AgRP Neurons Modulates Energy Balance and Metabolic Adaptation to Fasting via Sirtuin 1 (SIRT1)
- BS59 Loss of SIRT1 in diabetes enhances dna damage and reduces MRN complex activation resulting in increased vascular calcification
- Neuroprotective effect of Estrogen Receptor α against neuroinflammation induced by hypoxia/ischemia via SIRT1-dependent AMPK pathway
- microRNA-30c promotes myocardial ischemia reperfusion injury by activating SIRT1 mediating NF-κB pathway
- THE EFFECTS OF CIRCULATING ESTROGEN ON SIRT1 LEVELS IN PREMENOPAUSAL WOMEN
- Tanshinone IIA attenuates hydrogen peroxide-induced senescence of human umbilical vein endothelial cells through activating SIRT1/eNOS pathway
- Expression and correlation of SIRT1 and inflammatory factors in peripheral blood of patients with major depressive disorder
- Integration of the deacetylase SIRT1 in the response to nucleolar stress
- Role of the AMPK-C/EBPα/PPARγ and AMPK-UCP1/SIRT1 Axes in the Anti-obesogenic Activities of Gallotannin Derivatives from Mango (Mangifera indica L.)
- A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo
- Naringenin increases pituitary SIRT1/TSH ratio and induces ultrastructural changes in the thyroids of old-aged male Wistar rats
- Abstract TP588: Underlying Mechanisms Of Preconditioning Against Stroke: Lack Of Ischemic Neuroprotectant SIRT1 Increases Long-term Potentiation Induction In …
- Ginsenoside Rg_1 induces leukemia stem cell senescence via SIRT1/TSC_2 signal axis
- Defining molecular mechanisms regulating SIRT1 expression and its roles in human granulosa-lutein cells
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- Using Enzyme Kinetics and Small Angle X‐ray Scattering to Understand the Allosteric Regulation of SIRT1
- Creating Gene Therapy With SIRT1 Signaling for Neuro-protection in Optic Nerve Disease
- Alterations in SIRT1 Attenuate Host Defense to Pneumococcal Infection in Sickle Cell Disease
- SIRT1 is essential for beneficial effect of resveratrol on HG-induced endothelial dysfunction
- Estrogen signaling interacts with SIRT1 in adipocyte autophagy
- Effects of SIRT1 gene on proliferation and cell cycle of bovine granulosa cells.
- SIRT1 Inhibits Adipose Tissue Inflammation by Foxos/mTOR/S6K1 Signal Pathway in Mice
- Therapeutic ultrasound potentiates the anti-nociceptive and anti-inflammatory effects of curcumin to postoperative pain via SIRT1/NF-κB signaling pathway [Retraction]
- The effect of melatonin on the SIRT1 and LC3 expressions in mature oocysts
- Role of SIRT1 and SIRT6 in the inflammation process of chronic obstructive pulmonary disease
- microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma
- Role of SIRT1 signaling pathway in endotoxin-induced acute lung injury in rats
- The Effects of Melatonin Administration on Bone Tissue SIRT1 levels in old Female Rats with Diabetic
- [Corrigendum] microRNA‑34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma
- SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494
- Differentiation of bone marrow mesenchymal stem cells into nucleus pulposusk-like cells induced by Nampt/NAD/SIRT1 axis of Achyranthes bidentata Bl. saponins
- Melatonin Ameliorates PINK1/Parkin-Mediated Mitophagy by Enhancing SIRT1 Expression in Granulosa Cells of Polycystic Ovary Syndrome Patients
- Leptin‐induced neuroinflammatory effects in the hypothalamic neurons: role of SIRT1 and FoxO1
- THE ROLE OF THE SIRT1/LXR SIGNALING AXIS IN RETINAL ENDOTHELIAL CELL INFLAMMATION AND METABOLISM.
- The Effects of Resveratrol Supplementation on Bone Tissue SIRT1 levels in old Female Rats with Diabetic
- Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis
- SIRT1 Ameliorates High Fat Diet-induced Diastolic Heart Failure
- Secreted Klotho Protects Against Aging‐associated Coronary Endothelial Dysfunction via SIRT1 Activation
- SIRT1-DEPENDENT RESPONSE IS ESSENTIAL FOR RESVERATROL TO UPREGULATE ANTIOXIDANT AND ANTIGLYCATIVE DEFENCES IN HIGH GLUCOSE …
- The role of early increased SIRT1 expression on chromosomal instability in Glycogen Storage Disease type 1a: Protection against chromosomal instability?
- Esculetin and its similar compounds: Implications in binding SIRT1 and treating diabetic nephropathy
- Isorhamnetin activates SIRT1/PGC-1α signaling pathway to inhibit MPP+-induced SH-SY5Y cell injury
- Hydralazine Improves Mitochondrial Function via SIRT1/SIRT5 Activation and Protects against Glucose Toxicity
- Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis
- Age-related SIRT1 Regulates Mitochondrial SIRT3 in Ischemic Heart
- EFFECT OF SERUM STARVATION ON THE SIRT1-LXR SIGNALING PATHWAY IN RETINAL ENDOTHELIAL CELLS
- Control of retinal cholesterol levels by fasting-induced activation of SIRT1-LXR pathway in diabetic retinopathy.
- Effect of tyrosol on myocardial ischemia-reperfusion injury in diabetic rats and the role of SIRT1/AMPK/eNOS signaling pathway
- 47-OR: Regulation of SIRT1 as a Target of Prevention of Diabetic Retinopathy in db/db Mice
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- Disturbed Flow-induced Acetylation of Copper Chaperone Atox1 via Oxidative Inactivation of SIRT1 Promotes Inflammation and Atherosclerosis
- Late Breaking Abstract-Vitamin D suppresses LPS-induced ER stress and inflammation via modulation of mir-34a/SIRT1 axis in acute lung injury
- Dapagliflozin, attenuated neuropathic pain in rats via SIRT1 in spinal dorsal horn
- … attenuates pulmonary ischemia reperfusion injury in cardiopulmonary bypass via mitigating ER stress and inducing autophagy depend on SIRT1 activation in rat model …
- Effects of Resveratrol Postconditioning on Cerebral Ischemia in mice: Role of the Sirtuin-1 (SIRT1) Pathway
- Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin II-Induced Adipocyte Dysfunction
- 1704-P: SIRT1 rs7896005 SNP and Incidence of Major Vascular Events in Type 2 Diabetes: A 13-Year, Single-Centre, Follow-Up Study
- Sirtuin 1 (SIRT1) and activated caspase 3 expression on rat spinal cord in acute phase after Sciatic nerve injury
- Abstract LB-040: SIRT1 requires for mammary stem cell self-renewal and maintenance
- Sirtuin 1 (SIRT1) Content and Angiotensin II Receptor Type I (AT1) Expression in Human Umbilical Vein Endothelial Cells (HUVECs) in Response to Resveratrol …
- Abstract LB-243: Curcumin suppresses oncogenicity of human colon cancer cells through covalent modification of oncogenic SIRT1
- Effect of Capsaicin in Inhibiting Migration and Invasion of Breast Cancer MCF-7 Cells by Down-regulating SIRT1
- The expression relationship and significance of miR-217 and SIRT1 in lens epithelial cells of senile cataract.
- SIRT1 activation by natural phytochemicals: an overview
- SIRT1 and aging related signaling pathways
- SIRT1 is downregulated by autophagy in senescence and ageing
- The critical role of SIRT1 in Parkinson’s Disease: mechanism and therapeutic considerations
- CSAG2 is a cancer‐specific activator of SIRT1
- The beneficial roles of SIRT1 in neuroinflammation-related diseases
- The systemic role of SIRT1 in exercise mediated adaptation
- Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1
- Flavonoids-mediated SIRT1 signaling activation in hepatic disorders
- SIRT1 antisense long non-coding RNA attenuates pulmonary fibrosis through SIRT1-mediated epithelial-mesenchymal transition
- SIRT1 directly activates autophagy in human chondrocytes
- SIRT1 regulation in ageing and obesity
- Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence
- SIRT1 sustains female fertility by slowing age‐related decline in oocyte quality required for post‐fertilization embryo development
- SIRT1-PPARS Cross-talk in complex metabolic diseases and inherited disorders of the one carbon metabolism
- Nicotinamide pathway-dependent SIRT1 activation restores calcium homeostasis to achieve neuroprotection in spinocerebellar ataxia type 7
- SIRT1 is a key regulatory target for the treatment of the endoplasmic reticulum stress-related organ damage
- Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases
- Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases
- Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia
- SIRT1 modulates cell cycle progression by regulating CHK2 acetylation− phosphorylation
- Natural SIRT1 modifiers as promising therapeutic agents for improving diabetic wound healing
- SIRT1 accelerates the progression of activity-based anorexia
- Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway
- The citrus flavonoid naringenin protects the myocardium from ageing-dependent dysfunction: potential role of SIRT1
- Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway
- Exosomes from SIRT1-overexpressing ADSCs restore cardiac function by improving angiogenic function of EPCs
- Relevance of SIRT1-NF-κB axis as therapeutic target to ameliorate inflammation in liver disease
- Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer’s disease models
- Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting [S]
- Two novel SIRT1 activators, SCIC2 and SCIC2. 1, enhance SIRT1-mediated effects in stress response and senescence
- Neuroprotective effect of resveratrol via activation of SIRT1 signaling in a rat model of combined diabetes and Alzheimer’s disease
- Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1
- SIRT1 alleviates LPS-induced IL-1β production by suppressing NLRP3 inflammasome activation and ROS production in trophoblasts
- Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer’s disease by up‐regulating SIRT1
- Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway
- SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion
- Impact of circadian disruption on health; SIRT1 and Telomeres
- Adipose tissue SIRT1 regulates insulin sensitizing and anti-inflammatory effects of berberine
- Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1
- SIRT1 activation by minocycline on regulation of microglial polarization homeostasis
- SIRT1–NOX4 signaling axis regulates cancer cachexia
- Synergistic effect of dietary betaines on SIRT1-mediated apoptosis in human oral squamous cell carcinoma Cal 27
- Intestinal SIRT1 deficiency protects mice from ethanol-induced liver injury by mitigating ferroptosis
- Role of liraglutide in brain repair promotion through SIRT1‐mediated mitochondrial improvement in stroke
- Emerging Roles of SIRT1 in Alcoholic Liver Disease
- Taurine protects against cardiac dysfunction induced by pressure overload through SIRT1–p53 activation
- Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice
- SIRT1 Regulates N6‐Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2‐Dependent FTO SUMOylation
- SIRT1 Activity in PBMCs as a Biomarker of Different Heart Failure Phenotypes
- Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1
- Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1‐Nrf2 signaling pathway
- SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride
- Hepatocellular expression of SIRT1 and its effect on hepatocellular carcinoma progression: a future therapeutic perspective
- MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1
- Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway
- Dulcitol suppresses proliferation and migration of hepatocellular carcinoma via regulating SIRT1/p53 pathway
- Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice
- Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice
- Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway
- Base-pair conformational switch modulates miR-34a targeting of SIRT1 mRNA
- SIRT1 protects the heart from ER stress-induced injury by promoting eEF2K/eEF2-dependent autophagy
- Resveratrol mitigates sevoflurane-induced neurotoxicity by the SIRT1-dependent regulation of BDNF expression in developing mice
- SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic …
- Analysis of SIRT1 expression in plasma and in an in vitro model of preeclampsia
- SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells
- Metformin alleviates renal injury in diabetic rats by inducing SIRT1/FoxO1 autophagic signal axis
- Resveratrol protects retinal ganglion cell axons through regulation of the SIRT1-JNK pathway
- SIRT1/SIRT3 modulates redox homeostasis during ischemia/reperfusion in the aging heart
- Resveratrol induces SIRT1-Dependent autophagy to prevent H2O2-Induced oxidative stress and apoptosis in HTR8/SVneo cells
- SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop
- Regulation of the SIRT1 signaling pathway in NMDA-induced Excitotoxicity
- Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human …
- SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages
- Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis
- Development of activity-based probes for the protein deacylase SIRT1
- Astragalus polysaccharides inhibits tumorigenesis and lipid metabolism through miR-138-5p/SIRT1/SREBP1 pathway in prostate cancer
- Hydrogen sulfide ameliorates lung ischemia-reperfusion injury through SIRT1 signaling pathway in type 2 diabetic rats
- … mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection …
- Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway
- Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting SIRT1/NF-κB pathway
- Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant …
- Moderate SIRT1 overexpression protects against brown adipose tissue inflammation
- Melatonin act as an antidepressant via attenuation of neuroinflammation by targeting SIRT1/Nrf2/HO-1 signaling
- B cell SIRT1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
- Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway
- Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis
- Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC‐1α pathway
- Araloside C attenuates atherosclerosis by modulating macrophage polarization via SIRT1-mediated autophagy
- Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mice
- Swimming exercise stimulates IGF1/PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus
- Pirfenidone is an agonistic ligand for PPARα and improves NASH by activation of SIRT1/LKB1/pAMPK
- Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling
- Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway
- SIRT1-overexpressing Mesenchymal stem cells drive the anti-tumor effect through their pro-inflammatory capacity
- Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles
- Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice
- Melatonin protects mouse testes from palmitic acid‐induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1‐dependent manner
- Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats
- Cryptotanshinone from the Salvia miltiorrhiza bunge attenuates ethanol-induced liver injury by activation of AMPK/SIRT1 and Nrf2 signaling pathways
- AMPK ameliorates tau acetylation and memory impairment through SIRT1
- Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke
- Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo …
- Doxorubicin cardiomyopathy is ameliorated by acacetin via SIRT1‐mediated activation of AMPK/Nrf2 signal molecules
- SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy
- Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells
- Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma
- Melatonin ameliorates excessive PINK1/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS
- lncRNA Oip5‐as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR‐29a to activate the SIRT1/AMPK/PGC1α pathway
- Bakuchiol alleviates hyperglycemia-induced diabetic cardiomyopathy by reducing myocardial oxidative stress via activating the SIRT1/Nrf2 signaling pathway
- A Comprehensive Analysis of the Effect of SIRT1 Variation on the Risk of Schizophrenia and Depressive Symptoms
- Melatonin improves uterine‐conceptus interaction via regulation of SIRT1 during early pregnancy
- MicroRNA-29b-3p promotes human retinal microvascular endothelial cell apoptosis via blocking SIRT1 in diabetic retinopathy
- CTRP1 prevents sepsis-induced cardiomyopathy via SIRT1-dependent pathways
- Colchicine alleviates cholesterol crystal-induced endothelial cell pyroptosis through activating AMPK/SIRT1 pathway
- Inhibiting microRNA-29a protects myocardial ischemia-reperfusion injury by targeting SIRT1 and suppressing oxidative stress and NLRP3-mediated pyroptosis …
- Protective mechanism of SIRT1 on Hcy‐induced atrial fibrosis mediated by TRPC3
- Isoorientin attenuates cisplatin-induced nephrotoxicity through the inhibition of oxidative stress and apoptosis via activating the SIRT1/SIRT6/Nrf-2 pathway
- Epigenetic regulation of chondrocyte hypertrophy and apoptosis through SIRT1/P53/P21 pathway in surgery-induced osteoarthritis
- SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage
- SIRT1 mediates melatonin’s effects on microglial activation in hypoxia: in vitro and in vivo evidence
- Quercetin suppresses apoptosis and attenuates intervertebral disc degeneration via the SIRT1-autophagy pathway
- Embelin averts MPTP-induced dysfunction in mitochondrial bioenergetics and biogenesis via activation of SIRT1
- SIRT1 regulates oxidative stress in oxygen-glucose deprived hippocampal neurons
- Pyrroloquinoline quinone inhibits the production of inflammatory cytokines via the SIRT1/NF-κB signal pathway in weaned piglet jejunum
- Salidroside ameliorates diabetic nephropathy in rats by activating renal AMPK/SIRT1 signaling pathway
- Association between SIRT1, cytokines, and metabolic syndrome in schizophrenia patients with olanzapine or clozapine monotherapy
- PARP1 impedes SIRT1-mediated autophagy during degeneration of the retinal pigment epithelium under oxidative stress
- Cardiac Dysfunction after Burn Injury: Role of the AMPK-SIRT1-PGC1α-NFE2L2-ARE Pathway
- Prospective protective effect of ellagic acid as a SIRT1 activator in iron oxide nanoparticle-induced renal damage in rats
- Combining a high dose of metformin with the SIRT1 activator, SRT1720, reduces life span in aged mice fed a high-fat diet
- Shikonin ameliorates LPS-induced cardiac dysfunction by SIRT1-dependent pathways in mice
- Kaempferol improves lung ischemia-reperfusion injury via antiinflammation and antioxidative stress regulated by SIRT1/HMGB1/NF-κB Axis
- Differential expression of KRAS and SIRT1 in ovarian cancers with and without endometriosis
- Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway
- Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway
- Resveratrol protects against ethanol-induced impairment of insulin secretion in INS-1 cells through SIRT1-UCP2 axis
- Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis
- XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition
- The protective effect of DiDang Tang against AlCl3-Induced oxidative stress and apoptosis in PC12 cells through the activation of SIRT1-mediated Akt/Nrf2 …
- HBx mediated increase of SIRT1 contributes to HBV-related hepatocellular carcinoma tumorigenesis
- SIRT1-mediated expression of CD24 and epigenetic suppression of novel tumor suppressor miR-1185-1 increases colorectal cancer stemness
- Prednisolone suppresses adriamycin-induced vascular smooth muscle cell senescence and inflammatory response via the SIRT1-AMPK signaling pathway
- Laminar flow inhibits the Hippo/YAP pathway via autophagy and SIRT1-mediated deacetylation against atherosclerosis
- SIRT1 mediates septic cardiomyopathy in a murine model of polymicrobial sepsis
- Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF‐κB, and MCP‐1 in patients with coronary artery disease: A …
- Formononetin ameliorates diabetic neuropathy by increasing expression of SIRT1 and NGF
- Induction of SIRT1 by melatonin improves alcohol‐mediated oxidative liver injury by disrupting the CRBN‐YY1‐CYP2E1 signaling pathway
- Effects of Huang-Lian-Jie-Du decoction on oxidative stress and AMPK-SIRT1 pathway in Alzheimer’s disease rat
- Antrodan alleviates high-fat and high-fructose diet-induced fatty liver disease in C57BL/6 mice model via AMPK/SIRT1/SREBP-1c/PPARγ pathway
- Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia
- Resveratrol regulates muscle fiber type conversion via miR-22-3p and AMPK/SIRT1/PGC-1α pathway
- SIRT1 mediates improvement of cardiac surgery-induced postoperative cognitive dysfunction via the TLR4/NF-κB pathway
- Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling
- A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53
- FNDC5 attenuates oxidative stress and NLRP3 inflammasome activation in vascular smooth muscle cells via activating the AMPK-SIRT1 signal pathway
- Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and …
- Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation
- Resveratrol, a SIRT1 activator, ameliorates mK-801-Induced cognitive and motor impairments in a neonatal rat model of schizophrenia
- Resveratrol promotes white adipocytes browning and improves metabolic disorders in SIRT1‐dependent manner in mice
- SIRT1 decreases emotional pain vulnerability with associated CaMKIIα deacetylation in central amygdala
- Citrus flavanones upregulate thyrotroph SIRT1 and differently affect thyroid Nrf2 expressions in old-aged Wistar rats
- Baicalin ameliorates cognitive impairment and protects microglia from LPS-induced neuroinflammation via the SIRT1/HMGB1 pathway
- Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach
- LncRNA MST1P2/miR‐133b axis affects the chemoresistance of bladder cancer to cisplatin‐based therapy via SIRT1/p53 signaling
- Vitexin protects against ethanol-induced liver injury through SIRT1/p53 signaling pathway
- Salvianolic acid B attenuates epithelial-mesenchymal transition in renal fibrosis rats through activating SIRT1-mediated autophagy
- miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload
- Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice
- Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway
- SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice
- CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis
- Trimetazidine inhibits renal tubular epithelial cells to mesenchymal transition in diabetic rats via upregulation of SIRT1
- Seminal SIRT1‐oxidative stress relationship in infertile oligoasthenoteratozoospermic men with varicocele after its surgical repair
- Septin4 prevents PDGF-BB-induced HAVSMC phenotypic transformation, proliferation and migration by promoting SIRT1-STAT3 deacetylation and …
- … reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid …
- Hepatic proteomic changes and SIRT1/AMPK signaling activation by oxymatrine treatment in rats with non-alcoholic steatosis
- Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis
- Hydrogen sulfide protects against particle‐induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening
- Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase
- DHA protects against hepatic steatosis by activating SIRT1 in a high fat diet-induced nonalcoholic fatty liver disease mouse model
- Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via SIRT1‐Foxo1 and PI3K‐Akt signalling pathways
- Hydrogen sulfide inhibits homocysteine-induced neuronal senescence by up-regulation of SIRT1
- SIRT1/FOXO3a axis plays an important role in the prevention of mandibular bone loss induced by 1, 25 (OH) 2D deficiency
- A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells
- … human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway
- SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence
- Puerarin protects against myocardial ischemia/reperfusion injury by inhibiting inflammation and the NLRP3 inflammasome: the role of the SIRT1/NF-κB pathway
- Crucial role of histone deacetylase SIRT1 in myeloid-derived suppressor cell-mediated reprogramming of CD4+ T-cell differentiation
- Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, SIRT1 and Runx2
- Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial …
- Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis
- The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary …
- Ghrelin induces autophagy and CXCR4 expression via the SIRT1/AMPK axis in lymphoblastic leukemia cell lines
- Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and SIRT1/AMPK signaling in obese mice
- Acupuncture targeting SIRT1 in the hypothalamic arcuate nucleus can improve obesity in high-fat-diet-induced rats with insulin resistance via an anorectic effect
- The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/-mice based on SIRT1-NF-κB-GnRH expression
- The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-SIRT1-Pgc-1α signalling pathway
- Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model
- … ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating SIRT1
- Hydrogen sulfide prevents sleep deprivation-induced hippocampal damage by upregulation of SIRT1 in the hippocampus
- Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p‐Akt pathway in methamphetamine‐induced chronic lung injury
- TOPK inhibition accelerates oxidative stress‑induced granulosa cell apoptosis via the p53/SIRT1 axis
- Astragalin exerted antidepressant-like action through SIRT1 signaling modulated NLRP3 inflammasome deactivation
- Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor …
- Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in …
- Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1
- Salvianolic acid B improves chronic mild stress-induced depressive behaviors in rats: involvement of AMPK/SIRT1 signaling pathway
- SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle
- Downregulation of SIRT1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease
- SIRT1-ROS-TRAF6 signaling-induced pyroptosis contributes to early injury in ischemic mice
- Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study …
- Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice
- Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent
- The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor
- The soybean bioactive peptide VHVV alleviates hypertension-induced renal damage in hypertensive rats via the SIRT1-PGC1α/Nrf2 pathway
- Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway
- Nicotinamide supplementation during the in vitro maturation of oocytes improves the developmental competence of preimplantation embryos: potential link to SIRT1 …
- Melatonin rescues the Ti particle-impaired osteogenic potential of bone marrow mesenchymal stem cells via the SIRT1/SOD2 signaling pathway
- Obesity caused by a high-fat diet regulates the SIRT1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older …
- Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway
- Synovium stem cell-derived matrix enhances anti-inflammatory properties of rabbit articular chondrocytes via the SIRT1 pathway
- Role of AMPK/SIRT1-SIRT3 signaling pathway in affective disorders in unpredictable chronic mild stress mice
- Combination of luteolin and lycopene effectively protect against the “two-hit” in NAFLD through SIRT1/AMPK signal pathway
- Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα
- Src promotes tamoxifen resistance in breast cancer via up-regulating SIRT1
- Effect of lycopene on pain facilitation and the SIRT1/mTOR pathway in the dorsal horn of burn injury rats
- The effect of aerobic, resistance, and combined training on PPAR-α, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats
- miR-29a modulates GSK3β/SIRT1-linked mitochondrial proteostatic stress to ameliorate mouse non-alcoholic steatohepatitis
- SIRT1 mediates effects of FGF21 to ameliorate cisplatin-induced acute kidney injury
- SIRT1-dependent effects of resveratrol and grape juice in an in vitro model of preeclampsia
- Resveratrol-mediated SIRT1 activation attenuates ovalbumin-induced allergic rhinitis in mice
- Nicotinamide increases the sensitivity of chronic myeloid leukemia cells to doxorubicin via the inhibition of SIRT1
- Up-regulation of SIRT1/miR-149-5p signaling may play a role in resveratrol induced protection against ischemia via p53 in rat brain
- Safflower yellow alleviates osteoarthritis and prevents inflammation by inhibiting PGE2 release and regulating NF-κB/SIRT1/AMPK signaling pathways
- The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress
- Activation of TGR5 protects blood brain barrier via the BRCA1/SIRT1 pathway after middle cerebral artery occlusion in rats
- Ginsenoside Rd ameliorates auditory cortex injury associated with military aviation noise-induced hearing loss by activating SIRT1/PGC-1α signaling pathway
- Notoginseng leaf triterpenes ameliorates OGD/R-induced neuronal injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α signaling pathways mediated by the NAMPT …
- Aucubin alleviates diabetic nephropathy by inhibiting NF-κB activation and inducing SIRT1/SIRT3-FOXO3a signaling pathway in high-fat diet/streptozotocin …
- Jiang Gui Fang activated interscapular brown adipose tissue and induced epididymal white adipose tissue browning through the PPARγ/SIRT1-PGC1α pathway
- WWP2 regulates SIRT1‐STAT3 acetylation and phosphorylation involved in hypertensive angiopathy
- IRF9 promotes apoptosis and innate immunity by inhibiting SIRT1-p53 axis in fish
- SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis
- MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy
- Inhibition of miRNA‑135a‑5p ameliorates TGF‑β1‑induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy
- … -Quinazoline Derivative, a Potential Anti-Cancer Agent, Induced Apoptosis in Hepatocellular Carcinoma Through Mediating SIRT1/Caspase 3 Signaling …
- Resveratrol improves left ventricular remodeling in chronic kidney disease via SIRT1‐mediated regulation of FoxO1 activity and MnSOD expression
- Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for β-catenin or MITF in colon cancer and …
- Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through SIRT1/p53 signaling pathway
- Quercetin modulates AMPK/SIRT1/NF‑κB signaling to inhibit inflammatory/oxidative stress responses in diabetic high fat diet‑induced atherosclerosis in the rat carotid …
- Changes in PGC‐1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model
- Fibroblast growth factor 21 alleviates acute pancreatitis via activation of the SIRT1‐autophagy signalling pathway
- 17β-Estradiol improves osteoblastic cell function through the SIRT1/NF-κB/MMP-8 pathway
- Cilostazol protects against acetic acid-induced colitis in rats: possible role for cAMP/SIRT1 pathway
- Melatonin inhibits Benzo (a) pyrene-Induced apoptosis through activation of the Mir-34a/SIRT1/autophagy pathway in mouse liver
- Notoginseng leaf triterpenes ameliorates mitochondrial oxidative injury via the NAMPT-SIRT1/2/3 signaling pathways in cerebral ischemic model rats
- s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand–foot skin reaction that can …
- Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SIRT1/NF-κB signaling pathway
- Inhibition of miR-34a reduces cellular senescence in human adipose tissue-derived mesenchymal stem cells through the activation of SIRT1
- Catalpol‑mediated microRNA‑34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer
- CTRP3 activates the AMPK/SIRT1-PGC-1α pathway to protect mitochondrial biogenesis and functions in cerebral ischemic stroke
- Pemafibrate, a selective PPARα modulator, and fenofibrate suppress microglial activation through distinct PPARα and SIRT1-dependent pathways
- Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis
- Silencing of lncRNA UCA1 curbs proliferation and accelerates apoptosis by repressing SIRT1 signals by targeting miR‐204 in pediatric AML
- Involvement of activation of PLIN5-SIRT1 axis in protective effect of glycycoumarin on hepatic lipotoxicity
- SIRT1 promotes pulmonary artery endothelial cell proliferation by targeting the Akt signaling pathway
- Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC‑1α signaling
- SIRT1/FoxO1-Associated MAO-A Upregulation Promotes Depressive-Like Behavior in Transgenic Mice Expressing Human A53T α-Synuclein
- MiR-140 resensitizes cisplatin-resistant NSCLC cells to cisplatin treatment through the SIRT1/ROS/JNK pathway
- Ticagrelor increases SIRT1 and HES1 mRNA levels in peripheral blood cells from patients with stable coronary artery disease and chronic obstructive pulmonary …
- Adiponectin/SIRT1 axis induces white adipose browning after vertical sleeve gastrectomy of obese rats with type 2 diabetes
- Daphnetin attenuated cisplatin-induced acute nephrotoxicity with enhancing antitumor activity of cisplatin by upregulating SIRT1/SIRT6-Nrf2 pathway
- Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- Intracranial self-stimulation modulates levels of SIRT1 protein and neural plasticity-related microRNAs
- COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity
- Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation
- Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery
- Aspirin alleviates denervation-induced muscle atrophy via regulating the SIRT1/PGC-1α axis and STAT3 signaling
- SIRT1-modified human umbilical cord mesenchymal stem cells ameliorate experimental peritoneal fibrosis by inhibiting the TGF-β/Smad3 pathway
- Nicotinamide mononucleotide attenuates glucocorticoid‑induced osteogenic inhibition by regulating the SIRT1/PGC‑1α signaling pathway
- Resveratrol inhibits neointimal growth after arterial injury in high-fat-fed rodents: the roles of SIRT1 and AMPK
- Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia
- … Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity
- Tropisetron attenuates pancreas apoptosis in the STZ-induced diabetic rats: involvement of SIRT1/NF-κB signaling
- Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFκB-Dependent Proliferation and …
- Loganin inhibits macrophage M1 polarization and modulates SIRT1/NF-κB signaling pathway to attenuate ulcerative colitis
- Long non‑coding RNA SNHG7 inhibits NLRP3‑dependent pyroptosis by targeting the miR‑34a/SIRT1 axis in liver cancer
- … inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 …
- Multiscale landscape of molecular mechanism of SIRT1 activation by STACs
- Cordyceps cicadae prevents renal tubular epithelial cell apoptosis by regulating the SIRT1/p53 pathway in hypertensive renal injury
- ING4 alleviated lipopolysaccharide‐induced inflammation by regulating the NF‐κB pathway via a direct interaction with SIRT1
- Oxypaeoniflorin improves myocardial ischemia/reperfusion injury by activating the SIRT1/Foxo1 signaling pathway
- Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy
- USP22 protects against myocardial ischemia–reperfusion injury via the SIRT1-p53/SLC7A11–dependent inhibition of ferroptosis–induced cardiomyocyte …
- SIRT1 regulates O-GlcNAcylation of tau through OGT
- Thymoquinone is a novel potential inhibitor of SIRT1 in cancers with p53 mutation: Role in the reactivation of tumor suppressor p73
- Febuxostat, a novel inhibitor of xanthine oxidase, reduces ER stress through upregulation of SIRT1-AMPK-HO-1/thioredoxin expression
- β-mercaptoethanol promotes osteogenesis of human mesenchymal stem cells via SIRT1-ERK pathway
- Acacetin protects against high glucose-induced endothelial cells injury by preserving mitochondrial function via activating SIRT1/Sirt3/AMPK signals
- Parental SIRT1 overexpression attenuate metabolic disorders due to maternal high-fat feeding
- EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation
- Expression of SIRT1, SIRT3 and SIRT6 genes for predicting survival in triple-negative and hormone receptor-positive subtypes of breast cancer
- Pterostilbene improves hepatic lipid accumulation via the MiR-34a/SIRT1/SREBP-1 pathway in fructose-fed rats
- SIRT1 mediates neuropathic pain induced by sciatic nerve chronic constrictive injury in the VTA-NAc pathway
- Resveratrol protects H9c2 cells against hypoxia-induced apoptosis through miR-30d-5p/SIRT1/NF-κB axis
- Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet‐Streptozotocin Induced Type 2 Diabetes in Rats
- Nicotinamide: Oversight of Metabolic Dysfunction Through SIRT1, mTOR, and Clock Genes
- Alisol a alleviates arterial plaque by activating AMPK/SIRT1 signaling pathway in apoE-deficient mice
- NAMPT/SIRT1 attenuate Ang II-induced vascular remodeling and vulnerability to hypertension by inhibiting the ROS/MAPK pathway
- … systematic understanding of geniposide in ameliorating inflammatory responses in colitis through suppression of NLRP3 inflammasome in macrophage by AMPK/SIRT1 …
- CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis
- SIRT1 relieves Necrotizing Enterocolitis through inactivation of Hypoxia-inducible factor (HIF)-1a
- Upregulation of SIRT1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus …
- Decreased levels and activity of SIRT1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity …
- NED416, a novel synthetic SIRT1 activator, promotes cutaneous wound healing via the MAPK/Rho pathway
- Axonal protection by nicotinamide riboside via SIRT1-autophagy pathway in TNF-induced optic nerve degeneration
- A novel PDE4D inhibitor BPN14770 reverses scopolamine-induced cognitive deficits via cAMP/SIRT1/Akt/Bcl-2 pathway
- Down‐regulation of microRNA‐34c‐5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve
- … improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via APPL1–SIRT1 …
- Mogroside IIIE alleviates high glucose-induced inflammation, oxidative stress and apoptosis of podocytes by the activation of AMPK/SIRT1 signaling pathway
- HIF1α deficiency in dendritic cells attenuates symptoms and inflammatory indicators of allergic rhinitis in a SIRT1-Dependent manner
- Piceatannol protects against cerebral ischemia/reperfusion‑induced apoptosis and oxidative stress via the SIRT1/FoxO1 signaling pathway
- Ginsenoside Rp1, A ginsenoside derivative, augments anti-cancer effects of Actinomycin D via downregulation of an AKT-SIRT1 pathway
- Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM
- IgA Nephropathy Benefits from Compound K Treatment by Inhibiting NF-κB/NLRP3 Inflammasome and Enhancing Autophagy and SIRT1
- DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia
- SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
- MiR-221/SIRT1/Nrf2 signal axis regulates high glucose induced apoptosis in human retinal microvascular endothelial cells
- Postprandial triglyceride-rich lipoproteins-induced premature senescence of adipose-derived mesenchymal stem cells via the SIRT1/p53/Ac-p53/p21 axis …
- … derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1 …
- Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma
- Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-κB via activation of SIRT1 in mice
- … the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK/SIRT1/PGC-1α/pFOXO3 …
- Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1
- Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1
- Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein–Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis
- Ginsenoside Rg1 protects against Sca‑1+ HSC/HPC cell aging by regulating the SIRT1‑FOXO3 and SIRT3‑SOD2 signaling pathways in a γ‑ray irradiation‑induced …
- Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis
- Nicotinamide‐induced silencing of SIRT1 by miR‐22‐3p increases periodontal ligament stem cell proliferation and differentiation
- Mast cell stabilizer modulates SIRT1/Nrf2/TNF pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of cyclophosphamide hepatotoxicity
- USP7 deubiquitinates and stabilizes SIRT1
- SIRT1 Is the Target Gene for 2, 3, 5, 4′-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence
- Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy
- LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice
- Atorvastatin promotes bone formation in aged apoE–/–mice through the SIRT1–Runx2 axis
- lncRNA ANRIL protects H9c2 cells against hypoxia‐induced injury through targeting the miR‐7‐5p/SIRT1 axis
- TUDCA Ameliorates Liver Injury Via Activation of SIRT1–FXR Signaling in a Rat Hemorrhagic Shock Model
- SIRT1 deacetylates mitochondrial trifunctional enzyme α subunit to inhibit ubiquitylation and decrease insulin resistance
- SIRT1 antagonizes oxidative stress in diabetic vascular complication
- SIRT1/IGFBPrP1/TGF β1 axis involved in cucurbitacin B ameliorating concanavalin A‐induced mice liver fibrosis
- PACAP ameliorates fertility in obese male mice via PKA/CREB pathway‐dependent SIRT1 activation and p53 deacetylation
- Melatonin inhibits Müller cell activation and pro‐inflammatory cytokine production via upregulating the MEG3/miR‐204/SIRT1 axis in experimental diabetic retinopathy
- Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear SIRT1 Expression in Nondiabetic Humans
- Discovery of small molecule SIRT1 activator using high-throughput virtual screening, molecular dynamics simulation, molecular mechanics generalized born/surface …
- Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NFκB/SIRT1 pathway and mitigating oxidative stress
- Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1‐dependent regulation of oxidative stress and vascular smooth muscle cell loss
- miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis
- Association between single nucleotide polymorphisms in SIRT1 and SIRT2 loci and growth in Tibetan sheep
- RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression
- The Lyn-SIRT1 signaling pathway is involved in imatinib resistance in chronic myeloid leukaemia
- … and miR‑543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF‑κB …
- Dietary DHA affects muscle fiber development by activating AMPK/SIRT1 pathway in blunt snout bream (Megalobrama amblycephala)
- The beneficial role of SIRT1 activator on chemo-and radiosensitization of breast cancer cells in response to IL-6
- Role of SIRT1 in HIV-associated kidney disease
- MiR-128-3p mediates TNF-α-induced inflammatory responses by regulating SIRT1 expression in bone marrow mesenchymal stem cells
- Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway
- Isoparvifuran isolated from Dalbergia odorifera attenuates H2O2-induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition
- … in CD34+ CD38− Leukemia Stem Cells Derived from KG1α Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 …
- CYP2J2-produced epoxyeicosatrienoic acids attenuate ischemia/reperfusion-induced acute kidney injury by activating the SIRT1-FoxO3a pathway
- Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells
- Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells
- Short ELF-EMF exposure targets SIRT1/Nrf2/HO-1 signaling in THP-1 cells
- Exosome-shuttled circSHOC2 from IPASs regulates neuronal autophagy and ameliorates ischemic brain injury via the miR-7670-3p/SIRT1 axis
- MicroRNA‐33 and SIRT1 influence the coronary thrombus burden in hyperglycemic STEMI patients
- Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension
- Ginsenoside Rg3 alleviates inflammation in a rat model of myocardial infarction via the SIRT1/NF-κB pathway
- SSEA3 and Sialyl Lewis a glycan expression is controlled by B3GALT5 LTR through Lamin A-NFYA and SIRT1-STAT3 signaling in human ES cells
- Genistein protects against acetaminophen-induced liver toxicity through augmentation of SIRT1 with induction of Nrf2 signalling
- Neuroprotection of melatonin on spinal cord injury by activating autophagy and inhibiting apoptosis via SIRT1/AMPK signaling pathway
- Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with …
- PPARα Agonist WY-14643 Relieves Neuropathic Pain through SIRT1-Mediated Deacetylation of NF-κB
- SIRT1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming
- Cyanidin‐3‐O‐glucoside attenuates endothelial cell dysfunction by modulating miR‐204‐5p/SIRT1‐mediated inflammation and apoptosis
- Cartilage-specific knockout of SIRT1 significantly reduces bone quality and catch-up growth efficiency
- Cumulative effect of cardiovascular risk factors on regulation of AMPK/SIRT1-PGC-1α-SIRT3 pathway in the human erectile tissue
- PGRN exerts inflammatory effects via SIRT1-NF-κB in adipose insulin resistance
- … peritoneal macrophages enhances proliferation, migration, and invasion of ectopic endometrial stromal cells through regulation of the SIRT1/NF-κB signaling …
- Exendin-4 ameliorates cardiac remodeling in experimentally induced myocardial infarction in rats by inhibiting PARP1/NF-κB axis in A SIRT1-dependent mechanism
- DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing—a possible predictive biomarker for malignant transformation
- Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-κB pathway and targeting SIRT1
- Protective effect of hydrogen sulfide on endothelial cells through SIRT1-FoxO1-mediated autophagy
- Physiological profile regulation during weight gain and loss by ovariectomized females: importance of SIRT1 and SIRT4
- Axonal protection by a small molecule SIRT1 activator, SRT2104, with alteration of autophagy in TNF-induced optic nerve degeneration
- Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation.
- Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1
- MiR-7-5p Enhances Cerebral Ischemia–Reperfusion Injury by Degrading SIRT1 mRNA
- SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation
- Curcumin improves necrotising microscopic colitis and cell pyroptosis by activating SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats
- Resveratrol attenuates aortic dissection by increasing endothelial barrier function through the SIRT1 pathway
- Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism
- … Non-Coding RNA SNHG7 Alleviates Oxygen and Glucose Deprivation/Reoxygenation-Induced Neuronal Injury by Modulating miR-9/SIRT1 Axis in PC12 …
- Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal …
- MicroRNA-506-3p inhibits proliferation and promotes apoptosis in ovarian cancer cell via targeting SIRT1/AKT/FOXO3a signaling pathway
- miR-138 increases depressive-like behaviors by targeting SIRT1 in hippocampus
- Typhae pollen polysaccharides protect hypoxia-induced PC12 cell injury via regulation of miR-34a/SIRT1
- SIRT1: Mechanism and Protective in Diabetic Nephropathy.
- Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐1α expression during ovarian hypoxia
- Dietary fenofibrate attenuated high-fat-diet-induced lipid accumulation and inflammation response partly through regulation of pparα and SIRT1 in juvenile black …
- 4-hydroxybenzaldehyde restricts the intracellular growth of Toxoplasma gondii by inducing SIRT1-mediated autophagy in macrophages
- Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice
- Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion …
- The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 …
- ERK dephosphorylation through MKP1 deacetylation by SIRT1 attenuates RAS-driven tumorigenesis
- … insulin sensitivity and mitochondrial respiration in skeletal muscle of type-2 diabetic mice through insulin signaling pathway and AMPK/SIRT1/PGC-1α/PPAR-γ …
- Chronic Polyphenon-60 or Catechin treatments increase brain monoamines syntheses and hippocampal SIRT1 levels improving cognition in aged rats
- NaSH increases SIRT1 activity and autophagy flux through sulfhydration to protect SH-SY5Y cells induced by MPP~+
- Acrocomia aculeata (Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance
- Elucidating the Neuroprotective Role of Formulated Camel α-Lactalbumin–Oleic Acid Complex by Curating the SIRT1 Pathway in Parkinson’s Disease Model
- … effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT …
- … preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) …
- BDMC protects AD in vitro via AMPK and SIRT1
- AMPK-SIRT1-PGC1α Signal Pathway Influences the Cognitive Function of Aged Rats in Sevoflurane-Induced Anesthesia
- Novel coronavirus: hypothesis of treatment with SIRT1 inhibitors
- Downregulation of CDK5 restores sevoflurane-induced cognitive dysfunction by promoting SIRT1-mediated autophagy
- High Expression of SIRT1 Associates with the Doxorubicin Resistance of Breast Cancer through the Activation of Akt
- Potential antiosteoporotic effect of ginkgo biloba extract via regulation of SIRT1-NF-kB signaling pathway
- Modulation of bleomycin‐induced oxidative stress and pulmonary fibrosis by N‐acetylcysteine in rats via AMPK/SIRT1/NF‐κβ
- A novel mechanism of protection against isoproterenol-induced cardiac inflammation via regulation of the SIRT1/NRF2 signaling pathway with a natural SIRT1 agonist
- Panax notoginseng saponins alleviates advanced glycation end product‑induced apoptosis by upregulating SIRT1 and antioxidant expression levels in HUVECs
- Duck oil-loaded nanoemulsion inhibits senescence of angiotensin II-treated vascular smooth muscle cells by upregulating SIRT1
- Shrimp SIRT1 activates of the WSSV IE1 promoter independently of the NF-κB binding site
- Sesamin promotes neurite outgrowth under insufficient nerve growth factor condition in PC12 cells through ERK1/2 pathway and SIRT1 modulation
- LncRNA MALAT1 Enhances ox-LDL-Induced Autophagy through the SIRT1/MAPK/NF-κB Pathway in Macrophages
- Bergenin-activated SIRT1 inhibits TNF-α-induced proinflammatory response by blocking the NF-κB signaling pathway
- SIRT1 suppresses MCP-1 production during the intervertebral disc degeneration by inactivating AP-1 subunits c-Fos/c-Jun
- 3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway
- DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression
- … activity against oxidative stress and improve long-term activation of the mineralization process in human osteoblast-like SaOS-2 cells: involvement of SIRT1
- Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the SIRT1/NF-κB signaling pathway in vascular smooth muscle cells
- Fruit of Hovenia dulcis Thunb. Induces Nonshivering Thermogenesis through Mitochondrial Biogenesis and Activation by SIRT1 in High-Fat Diet-Fed Obese Mice and …
- Decreased SIRT1 expression in the peripheral blood of patients with Graves’ disease
- SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice
- CMH-Small Molecule Docks into SIRT1, Elicits Human IPF-Lung Fibroblast Cell Death, Inhibits Ku70-deacetylation, FLIP and Experimental Pulmonary Fibrosis
- lncRNA TUG1 promotes the brown remodeling of white adipose tissue by regulating miR‑204‑targeted SIRT1 in diabetic mice
- Magnolol Alleviates IL-1β-Induced Dysfunction of Chondrocytes Through Repression of SIRT1/AMPK/PGC-1α Signaling Pathway
- Abnormal lncRNA CCAT1/microRNA-155/SIRT1 axis promoted inflammatory response and apoptosis of tubular epithelial cells in LPS caused acute kidney injury
- Resveratrol, SIRT1, oxidative stress, and brain aging
- Ligustilide alleviates podocyte injury via suppressing the SIRT1/NF-κB signaling pathways in rats with diabetic nephropathy
- miR-22 inhibits synovial fibroblasts proliferation and proinflammatory cytokine production in RASF via targeting SIRT1
- SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade …
- An insulin-inducible transcription factor, SHARP-1, represses transcription of the SIRT1 longevity gene
- Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring …
- … of sepsis-induced lung injury are mediated through the adenosine monophosphate-activated protein kinase (AMPK)/silent information regulator 1 (SIRT1) …
- Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double …
- Pum2 mediates SIRT1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis
- Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat)
- Amelioration of adrenaline induced oxidative gastrointestinal damages in rat by melatonin through SIRT1-NFκB and PGC1α-AMPKα cascades
- Effect of atorvastatin on Aβ1–42-induced alteration of SESN2, SIRT1, LC3II and TPP1 protein expressions in neuronal cell cultures
- Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice
- MicroRNA-22 inhibition prevents doxorubicin-induced cardiotoxicity via upregulating SIRT1
- Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway
- N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation
- Overexpression of histone deacetylase SIRT1 exerts an antiangiogenic role in diabetic retinopathy via miR-20a elevation and YAP/HIF1α/VEGFA depletion
- … 40-Hz light flicker rescues circadian behavior and abnormal lipid metabolism induced by acute ethanol exposure via improving SIRT1 and the circadian clock …
- Teaghrelin Protects SH-SY5Y Cells against MPP+-Induced Neurotoxicity through Activation of AMPK/SIRT1/PGC-1α and ERK1/2 Pathways
- Functional Food XingJiuTang Attenuates Alcohol‐Induced Liver Injury by Regulating SIRT1/Nrf‐2 Signaling Pathway
- miR-34a promotes liver fibrosis in patients with chronic hepatitis via mediating SIRT1/p53 signaling pathway
- Mitochondrial Respiratory Chain and Its Regulatory Elements SIRT1 and SIRT3 Play Important Role in the Initial Process of Energy Conversion after …
- Activation of LKB1 rescues 3T3-L1 adipocytes from senescence induced by SIRT1 knock-down: a pivotal role of LKB1 in cellular aging
- Latifolin inhibits oxidative stress-induced senescence via upregulation of SIRT1 in human dermal fibroblasts
- miR‑195 promotes LPS‑mediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a
- Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1‐and SIRT3‐mediated autophagy induction
- SIRT1 during childhood is associated with microvascular function later in life
- Paeonol prevents lipid metabolism dysfunction in palmitic acid-induced HepG2 injury through promoting SIRT1-FoxO1-ATG14-dependent autophagy
- miR-9-5p promotes the invasion and migration of endometrial stromal cells in endometriosis patients through the SIRT1/NF-κB pathway
- UVA influenced the SIRT1‐miR‐27a‐5p‐SMAD2‐MMP1/COL1/BCL2 axis in human skin primary fibroblasts
- SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation
- GDF-15 prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1
- Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to …
- … ‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1
- LncRNA SNHG12 Improves Cerebral Ischemic-reperfusion Injury by Activating SIRT1/FOXO3a Pathway through I nhibition of Autophagy and Oxidative Stress
- Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a
- Spatholobi Caulis dispensing granule reduces deep vein thrombus burden through antiinflammation via SIRT1 and Nrf2
- SIRT1 Activation by Equisetum arvense L.(Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats
- Knockdown of circ0082374 inhibits cell viability, migration, invasion and glycolysis in glioma cells by miR-326/SIRT1
- Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents
- Effect of SIRT1 Activators on Human Follicular Thyroid Cancer
- Hsa-miR-217 inhibits the proliferation, migration, and invasion in non-small cell lung cancer cells via targeting SIRT1 and P53/KAI1 signaling
- … -155 inhibition alleviates suppression of osteoblastic differentiation by high glucose and free fatty acids in human bone marrow stromal cells by upregulating SIRT1
- miR-29a-5p targets SATB2 and regulates the SIRT1/Smad3 deacetylation pathway to inhibit thoracic ligamentum flavum cell osteogenesis
- … -Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 …
- Grape seed procyanidins suppress the apoptosis and senescence of chondrocytes and ameliorates osteoarthritis via the DPP4-SIRT1 pathway
- Long Noncoding RNA SNHG10 sponges miR-543 to upregulate tumor suppressive SIRT1 in nonsmall cell lung cancer
- Nicotinamide phosphoribosyltransferase knockdown leads to lipid accumulation in HepG2 cells through the SIRT1-AMPK pathway
- Activation of SIRT1 enhances epidermal permeability barrier formation through ceramide synthase 2-and 3-dependent mechanisms
- … upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)
- MiR-181a-5p is involved in the cardiomyocytes apoptosis induced by hypoxia–reoxygenation through regulating SIRT1
- Mechanism of action of energy metabolism molecule SIRT1 in improving bone metabolism of type 2 diabetes
- Dl-3-n-butylphthalide promotes remyelination and suppresses inflammation by regulating AMPK/SIRT1 and STAT3/NF-κB signaling in chronic cerebral …
- Noninvasive quantification of SIRT1 expression–activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI
- Regulation of left atrial fibrosis induced by mitral regurgitation by SIRT1
- Activation of SIRT1/PGC1α pathway attenuates neuroinflammation injury in Parkinson’s disease
- Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1
- LINC00987 ameliorates COPD by regulating LPS-induced cell apoptosis, oxidative stress, inflammation and autophagy through let-7b-5p/SIRT1 Axis
- ZG02 Improved Hepatic Glucose Metabolism and Insulin Sensitivity via Activation of AMPK/SIRT1 Signaling Pathways in a High-fat Diet/Streptozotocin-induced …
- Impact of structurally diverse BET inhibitors on SIRT1
- Effect of Selenium Supplementation on Expression of SIRT1 and PGC-1α Genes in Ulcerative Colitis Patients: a Double Blind Randomized Clinical Trial
- Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling
- Activating SIRT1 by resveratrol suppresses Nav1. 7 expression in DRG through miR-182 and alleviates neuropathic pain in rats
- Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
- Evidence supporting the role of telomerase, MMP-9, and SIRT1 in attention-deficit/hyperactivity disorder (ADHD)
- Maca modulates fat and liver energy metabolism markers insulin, IRS1, leptin, and SIRT1 in rats fed normal and high-fat diets
- Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population
- Kallistatin alleviates heart failure in rats by inhibiting myocardial inflammation and apoptosis via regulating SIRT1
- MiR-199a-5p represses the stemness of cutaneous squamous cell carcinoma stem cells by targeting SIRT1 and CD44ICD cleavage signaling
- Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1 …
- CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway
- MiR-204-5p promotes lipid synthesis in mammary epithelial cells by targeting SIRT1
- Altered expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 genes in MKN-45 cell line after docetaxel treatment
- LncRNA HCG11 inhibits adipocyte differentiation in human adipose-derived mesenchymal stem cells by sponging miR-204-5p to upregulate SIRT1
- A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine
- Molecular dynamics simulation reveals new pocket for the design of novel amino acid coupled SIRT1 selective inhibitor
- The role of miR-141/SIRT1 in colon cancer
- SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy
- 1α,25-Dihydroxyvitamin D3 prevents renal oxidative damage via the PARP1/SIRT1/NOX4 pathway in Zucker diabetic fatty rats
- Combination therapy with cilostazol, aripiprazole, and donepezil protects neuronal cells from β-amyloid neurotoxicity through synergistically enhanced SIRT1 …
- SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD
- LncRNA MIR497HG inhibits proliferation and migration of retinal endothelial cells under high-level glucose treatment via miRNA-128-3p/SIRT1 axis
- SIRT1‐mediated amelioration of oxidative stress in kidney of alcohol‐aflatoxin‐B1‐induced hepatocellular carcinoma by resveratrol is catalase dependent and GPx …
- SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells
- miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells
- MiRNA-12129 suppresses cell proliferation and block cell cycle progression by targeting SIRT1 in GASTRIC cancer
- Type 2 diabetes–associated polymorphisms correlate with SIRT1 and TGF‐β1 gene expression
- … Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting …
- MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions
- Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice
- 3, 4, 5-Trihydroxycinnamic acid inhibits LPS-induced inflammatory response by increasing SIRT1 expression in human umbilical vein endothelial cells
- The effect of SIRT1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes
- MicroRNA‑138‑5p regulates the development of spinal cord injury by targeting SIRT1
- … Hemorrhagic Shock and Blood Replenish Resuscitation-Induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and …
- CO ameliorates cellular senescence and aging by modulating the miR-34a/SIRT1 pathway
- Effects of osmotic stress on Na+/K+-ATPase, caspase 3/7 activity, and the expression profiling of SIRT1, hsf1, and hsp70 in the roughskin sculpin (Trachidermus …
- miRNA‑384‑5p regulates the progression of Parkinson’s disease by targeting SIRT1 in mice and SH‑SY5Y cell
- SIRT1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1α mitochondrial metabolic pathway
- Effect of SIRT1 activators and inhibitors on CD44+/CD133+‑enriched non‑small cell lung cancer cells
- SIRT1 Inhibits High Shear Stress-Induced Apoptosis in Rat Cortical Neurons
- Evidence supporting the role of telomerase, MMP-9, and SIRT1 in attention-deficit/hyperactivity disorder (ADHD).
- Design and Synthesis of Amino Acid Derivatives of Substituted Benzimidazoles and Pyrazoles as Selective SIRT1 Inhibitors
- Correction for: Swimming exercise stimulates IGF1/PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging …
- Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating SIRT1/FoxO1/Rab7 Signal Pathway
- MiR-34a Regulates Nasopharyngeal Carcinoma Radiosensitivity by Targeting SIRT1
- Formononetin alleviates diabetic cardiomyopathy by inhibiting oxidative stress and upregulating SIRT1 in rats
- Momordica charantia polysaccharides modulate the differentiation of neural stem cells via SIRT1/Β-catenin axis in cerebral ischemia/reperfusion
- SIRT1 regulates the expression of critical metabolic genes in chicken hepatocytes
- Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of SIRT1, Nrf2 and Rev-erbα in the SCN of male …
- … cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model
- Exendin‐4 exhibits a tumour suppressor effect in SKOVR‐3 and OVACR‐3 ovarian cancer cells lines by the activation of SIRT1 and inhibition of NF‐κB
- Testosterone antagonizes paraquat-induced cardiomyocyte senescence via the mIGF-1/SIRT1 signaling pathway
- Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first-episode medication-naïve major depression
- Exenatide Improves Endometrial Glands in PCOS Rats through AMPKα-SIRT1
- Cerebellar Predominant Increase in mRNA Expression Levels of SIRT1 and Sirt3 Isoforms in a Transgenic Mouse Model of Huntington’s Disease
- Long non-coding RNA XIST protects chondrocytes ATDC5 and CHON-001 from IL-1β-induced injury via regulating miR-653-5p/SIRT1 axis.
- Liuweidihuang Pill Alleviates Inflammation of the Testis via AMPK/SIRT1/NF-κB Pathway in Aging Rats
- Comparison of apoptosis between bovine subcutaneous and intramuscular adipocytes by resveratrol via SIRT1
- SIRT1 as a Potential Biomarker for Obesity
- The probable role of insulin resistance and SIRT1 proteins in the Alzheimer’s disease.
- Evaluation of SIRT1 Gene Expression and rs3758391 C/T Polymorphism in Coronary Atherosclerosis.
- Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome
- Research progress on SIRT1 improving ovarian reservation by inhibiting oocyte senescence
- Effect of electroacupuncture on SIRT1/NF-κB signaling pathway in adipose tissue of obese rats
- Down-regulation of SIRT1 and PGC-1α expression caused by hyperoxia induces mitochondrial dysfunction in human alveolar epithelial cells
- Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases
- Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling
- Activation of SIRT1/PGC 1α/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury
- Using ultrasound three-dimensional speckle tracking technology to explore the role of SIRT1 in ventricular remodeling after myocardial infarction
- Association of the rs3758391 polymorphism in the SIRT1 gene with diabetic nephropathy and decreased estimated glomerular filtration rate (GFR) in a population …
- Evidence for NAD+-dependent histone dynamics and tunneling associated conformational transitions in circadian deacetylase SIRT1
- IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1/HIF-1α signaling pathway
- Mechanism underlying the significant role of the miR‑4262/SIRT1 axis in children with inflammatory bowel disease
- SIRT1 is overexpressed in endometrial adenocarcinoma: a tissue microarray analysis
- Punicalagin Inhibits Palmitate Acid-induced Lipoapoptosis through Inhibition of ER Stress, and Activation of SIRT1/Autophagy in HepG2 Cells
- The relationship between coronary artery disease and SIRT1 protein
- Corrigendum to” Vitexin Protects Against Ethanol-Induced Liver Injury Through SIRT1/p53 Signaling Pathway”[Eur. J. Pharmacol. 873 (2020) 173007]
- Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes
- Leptin promotes proliferation and invasion of osteosarcoma cells by upregulating the expression of SIRT1
- Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells
- Calcitonin gene-related peptide attenuates LPS-induced acute kidney injury by regulating SIRT1
- Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells
- Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway
- Elevated Glucose and Insulin Levels Decrease DHA Transfer across Human Trophoblasts via SIRT1-Dependent Mechanism
- MicroRNA-141 participates in milk lipid metabolism by targeting SIRT1 in bovine mammary epithelial cells
- MiR-204 reduces apoptosis in rats with myocardial infarction by targeting SIRT1/p53 signaling pathway
- SIRT1-Mediated Anti-Aging Effects of Houttuynia cordata Extract in a High Glucose-Induced Endothelial Cell-Aging Model
- Design, Synthesis, and Biological Evaluation of 8-Mercapto-3, 7-Dihydro-1H-Purine-2, 6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5
- The evolution of human SIRT1 for multi-specificity is enabled by active-site adaptation
- Atherosclerosis is attenuated by acacetin via SIRT1-mediated activation of AMPK/Sirt3 signals in diabetic ApoE-/-mice
- Lactobacillus plantarum and Lactobacillus helveticus modulate SIRT1, Caspase3 and Bcl-2 in the testes of high-fructose-fed rats.
- Particulate Matter Activates SIRT1‐SREBP1‐PIR Pathway to Promote Pulmonary Fibroblast Inflammation and Enhance Lung Fibrosis
- … IMPROVES INSULIN SENSITIVITY IN HIGH-FAT DIET-INDUCED INSULIN RESISTANT RATS BY ACTIVATING SIRT1 AND GLUT4 IN QUADRICEPS …
- CircRNA malignant fibrous histiocytoma amplified Sequence 1 (MFHAS1) reduced inflammatory responses in a Colitis Model via SIRT1/NF-κB
- Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats
- A novel microRNA-365/SIRT1/β-catenin/GLUT1 signaling axis affects the initiation of diabetic retinopathy.
- Chrysanthemum morifolium Flower Extract Inhibits Adipogenesis of 3T3-L1 Cells via AMPK/SIRT1 Pathway Activation
- SIRT1 is a novel therapeutic target in T-ALL
- SIRT1 activity orchestrates ECM expression during hESC-chondrogenic differentiation
- Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial …
- Correction to: Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
- Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines
- Mixed-ligand coordination polymers: structural diversity and protective effect on cardiac arrest induced by anesthesia via inducing SIRT1 pathway
- Reciprocal Regulation of AMPK-SIRT1 Complex Control of Colorectal Cancer Cell Metastasis by Metformin
- Cardioprotective effect of ivabradine via the AMPK/SIRT1/PGC-1α signaling pathway in myocardial ischemia/reperfusion injury induced in H9c2 cell
- SIRT1 AND PROGESTERONE (P4) RESISTANCE AND ENDOMETRIOSIS: IMPLICATIONS FOR INFERTILITY MANAGEMENT
- SIRT1 overexpression attenuates high-fat diet induced aortic stiffening
- Upregulation of SIRT1 and FOXO3a Contributes to The Protective Role of Estrogen on HPH in Rats
- Purple sweet potato color protects against hepatocyte apoptosis through SIRT1 activation in high-fat-diet-treated mice
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- Effects of Exercise Training on Aging-Related NAD+/SIRT1 Pathway in Middle-Aged and Aged Mice
- Fezf2 transient expression via modRNA with concurrent SIRT1 inhibition enhances differentiation of cortical subcerebral/corticospinal neuron identity from mES cells
- The Function of SIRT1 and Its Role in Regulating Follicular Development and Oocyte Maturation
- Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair
- SIRT1 Protects Cartilage Against Degradation through FoxO1 Nucleo-cytoplasmic Shuttling and Positive Regulation of Autophagy
- A nanomicelle with miR-34a and doxorubicin reverses the drug resistance of cisplatin in esophageal carcinoma cells by inhibiting SIRT1 signal pathway
- SRT2183 and SRT1720, but not Resveratrol, Inhibit Osteoclast Formation and Resorption in the Presence or Absence of SIRT1
- Differential TM4SF5-mediated SIRT1 modulation and signaling for chronic liver disease
- SIRT1 attenuates the neurotoxicity associated with Alzheimer’s disease, via a mechanism which may involve regulation of peroxisome proliferator-activated receptor γ …
- … -Liposomes Modulate the Inflammatory Response and Oxidative Stress in Stroke-Associated Pneumonia by Increasing OIP5-AS1 to Regulate the miR-128-3p/SIRT1 …
- VASH-1 Regulates Oxidative Stress and Fibrosis in Diabetic Kidney Disease via SIRT1/HIF1α and TGFβ1/Smad3 Signaling Pathways
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- Two Co(II)-based coordination polymers: structural diversity and treatment effect on the cardiac arrest induced by anesthesia by regulating SIRT1 expression
- Ferulic Acid Alleviates Lipotoxicity-induced Hepatocellular Death Through SIRT1 Activating-regulated Autophagy Pathway, and Independently of AMPK and Akt …
- Glycyrrhizin improves the pathogenesis of psoriasis through IL-17A and the SIRT1-STAT3 axis
- SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell
- Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, SIRT1 and Runx2
- Exosomes derived from mmu_circ_0000250-modified ADSCs promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1 mediated autophagy.
- SIRT1 Mediated High-Glucose-Induced Aβ Deposition and Cognitive Impairment through Activation of the TLR9/p53 Pathway
- Lactobacillus plantarum and Lactobacillus helveticus modulate SIRT1, Caspase3 and Bcl-2 in the testes of high-fructose-fed rats
- The effect of high intensity interval training on SIRT1 and PGC1-α gene expression in soleus muscle of type 2 diabetes in male rat
- Hydrogen Sulfide Ameliorates High Glucose-induced Inflammation Through SIRT1-mTOR/NF-κB Signaling Pathway in HT-22 cells
- INVESTIGATION OF THE EFFECTS OF SIRT1 AND SIRT2 MODULATORS IN NEUROINFLAMMATORY MODELS OF DEPRESSION
- Acute lung injury inhibition by juglone in LPS induced sepsis mouse model involves SIRT1 activation
- SIRT1 Expression and BRAF V600E Mutation in Papillary Thyroid Cancer: Implications for Diagnosis and Prognosis
- Natural activators of SIRT1 protect cardiac cells from severe ER stress
- SIRT1 promotes EMT, migration and invasion by regulating mTORC1/4E-BP1 in colorectal cancer
- Correction: Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice
- SIRT1 Gene Single Nucleotide Polymorphisms and Female Infertility: A Cross Sectional Study In Pakistan
- Conformational dynamics in microRNAs: the example of miR-34a targeting SIRT1 mRNA
- miR-34a Suppression Ameliorates Bone Marrow Mesenchymal Stem Cell Senescence by Targeting Nampt and Regulating NAD +-SIRT1 Pathway
- SIRT1 and HSP90alpha Are Functionally Linked and Control Mitotic Chromosome Segregation and Cell Viability in a Subset of Dlbcls
- Elucidating the Anti-aging Ursolic Acid through Evaluation of SIRT1 and SIRT6 in the Mice Skeletal Muscle Tissue
- Nutritional Regulation of Mitochondrial Health and Its Implication in Treating Obesity and Diabetes: Lessons Learned From the Resveratrol–SIRT1 Axis
- Role of SIRT1 in neutrophil migration during inflammation
- Propofol relieves oxidative stress response of cerebral ischemiareperfusion injury through SIRT1 signaling pathway.
- Bergenin-activated SIRT1 inhibits TNF-a-induced pro-inflammatory response via blocking NF-kB signaling pathway
- Effect of Combined and Isometric Exercise Training on SIRT1 Level in Elderly Women with Osteopenia
- Research of SIRT1 on promoting the proliferation, migration and lipid metabolism of nasopharyngeal carcinoma
- Role of some MiRNA affecting polycystic ovarian syndrome and SIRT1 levels
- Activation of SIRT1 by Hyperbaric Oxygenation Promotes Recovery of Motor Dysfunction in Spinal Cord Injury Rats
- AB0053 BERGENIN, ACTING AS AN AGONIST OF SIRT1, REDUCE SERUM URATE IN MICE THROUGH THE UPREGULATION OF ABCG2
- The effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats
- Association of genetic variants in SIRT1 and Nrf2 gene with metabolic syndrome risk in a Chinese Han population
- Value of serum and follicular fluid SIRT1, Sirt2 protein levels in predicting the outcome of assisted reproduction
- Correction to: Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SIRT1 axis
- Research Article Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PGC-1α-SIRT3 Pathway in the Human Erectile Tissue
- Paeonol Ameliorates Inflammation and Cartilage of Chondrocytes in Osteoarthritis by Upregulating SIRT1
- The histone deacetylase SIRT1 mediates the proper DNA repair response by targeting histone H2AX to protect against doxorubicin-induced cardiotoxicity
- Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFkB-Dependent Proliferation and …
- C/EBP-β and SIRT1 regulate IL-18 expression in the proliferative phase endometrium of patients with polycystic ovary syndrome (PCOS)
- SIRT1 Protects against Oxidative Stress-Induced Apoptosis in Fibroblasts from Psoriatic Patients: A
- The role of microRNA-34a in BACH1، PTEN and SIRT1 expression in T-cell acute lymphoblastic leukemia cell line (Jurkat)
- Expression and significance of SIRT1 in colorectal cancer
- SIRT1 Level Differences among Old Rats, Streptozotocin-Induced Diabetic Rats, and D-Galactose-Induced Aging Rats
- Activation of SIRT1 Alleviates Mitochondrial Dysfunction in The Trigeminal Nucleus Caudalis in a Rat Model of Chronic Migraine
- SIRT1-dependent response is crucial for the resveratrolinduced upregulation of antioxidant and antiglycative defence in high glucose-challenged HUVECs
- 3-Iodothyronamine and 3, 5, 3′-triiodo-L-thyronine reduce SIRT1 protein expression in the HepG2 cell line
- Coumestrol inhibits inflammation, apoptosis and oxidative stress in retinal cells of diabetic retinopathy rats by SIRT1 Running title: CMS & SIRT1 on DR rats
- Effects of electroacupuncture on miR-34a-5p/SIRT1 signaling in the trigeminal ganglion of rats with migraine
- Effect of Diet Intervention on SIRT1 Regulation and Depressive Symptoms
- Does exposure to chronic stress in rodents alter the level of SIRT1 in the nucleus accumbens?
- Assessment of Serum Level of SIRT1 in Patients with Acne Vulgaris
- Effect of miR-181a on acute lung injury induced by sepsis in mice by targeting SIRT1 and its mechanism
- Resveratrol-Induced SIRT1 Activation Derives from SIRT1 Phosphorylation by LKB1
- Study of the Fluorescence Intensity of Histones HP1gamma, H3K9me3, H3K27me3, and Histone Deacetylases SIRT1 and SIRT6 in Dermal Fibroblasts of …
- Moderate low temperature protects the ischemic brain injury by activating SIRT1 through inhibition of FOXO1/PINK1/Parkin axis mediated mitophagy in a mouse
- Tetrahydroxystilbene glucoside alleviates Ang Ⅱ-induced senescence of HUVECs via SIRT1
- Senescent stromal cells promote cancer resistance via SIRT1 loss-potentiated biogenesis of small extracellular vesicles
- Association of SIRT1 gene with major depression and its clinical features
- Retraction: Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis
- Concomitant inhibition of SIRT1 and SIRT3 reduces melanoma growth and metastasis in BRAFV600E/PTENNULL transgenic mice
- Diabetes Attenuation of the Estrogen-Mediated Increase in Endothelial Function is Associated with Circulating SIRT1
- 520-P: Exenatide Ameliorates Diabetic Kidney Disease by Inhibiting Apoptosis via SIRT1/TXNIP Signal Pathway
- Resveratrol reverses myogenic induction supression caused by high glucose through activating SIRT1/AKT/FOXO1 pathway
- Effect of SIRT1 on H2O2-induced oxidative damage in human ovarian granulosa cells
- Author Correction: SIRT1 negatively regulates FcεRI-mediated mast cell activation through AMPK-and PTP1B-dependent processes
- Two Novel InDels within the 5’UTR of SIRT1 are Associated with Growth Traits in Chickens
- Retraction Note to: MiR-138-5p exacerbates hypoxia/reperfusion-induced heart injury through the inactivation of SIRT1-PGC-1α.
- Mesenchymal Stem Cell Conditioned Medium Improves Non-alcoholic Fatty Liver Disease in Type 2 Diabetic Mice by Regulating SIRT1
- Estradiol signaling interacts with SIRT1 in the regulation of autophagy and adipogenesis
- Exon 8-defient SIRT1 splicing variant opposes SIRT1 full-length in regulating oxidative damage of 293T cells# br
- Bergenin-activated SIRT1 inhibits TNF-a-induced pro-inflammatory response via blocking NF-kB signaling pathway
- miR-29a Modulates GSK3ß/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
- Identifying Key Residues Involved in Allosteric Regulation of Human SIRT1 Deacetylation Activity
- Cigarette-decreased NAD/SIRT1 aggravates pulmonary fibrosis by promoting senescence of alveolar type 2 cells through autophagy inhibition and mitochondrial …
- Allosteric Modulation of SIRT1 Activity Affects Substrate Recognition and Protein Conformation
- Deletion of SIRT1 in the skeletal muscle decreases type IIa oxidative muscle fiber in mice.
- Interplay between Exercise and SIRT1 in Skeletal Muscle of Diabetic Male Rats
- Fumonisin B1 increases the NAD-dependant deacetylase SIRT1 to disrupt cholesterol flux in galactose supplemented HepG2 cells.
- SIRT1 Activation and mitochondrial dynamics in Retinal Endothelial Cells.
- P157: Screening of a phytochemical library for the identification of SIRT1-dependent lipid synthesis effects in keratinocytes
- SIRT1: A novel target to regulate corneal myofibroblast formation
- Abstract WP321: The Role of Neuronal SIRT1 in Ischemic Stroke: Regulation of the Metabolic Imbalance
- Resveratrol reverses myogenic induction supression caused by high glucose through activating SIRT1/AKT/FOXO1 pathway
- Deacetylase SIRT1 O-GlcNAcylation Regulates Metabolic Switching and Prevents Hyperglycemia and Inflammation in the Liver
- Relationship between SIRT1 and NLRP3 inflammasomes during myocardial ischemia-reperfusion in diabetic rats
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- Nicotinamide Inhibits Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) …
- 1751-P: Induction of SIRT1-AMPK Pathway by GLP-1RA Liraglutide Reduces Hepatic Lipid Accumulation and Insulin Resistance
- P0986 NO/CGMP PATHWAY MODULATES GLUCOSE UPTAKE VIA REGULATION OF SIRT1 DEACETYLASE EXPRESSION AND ACTIVITY IN PODOCYTES …
- Novel antitumor semi-synthetic heliomycin derivatives direct targeting tNOX-NAD+-SIRT1 axis to activate apoptosis/autophagy, as determined by the cellular thermal …
- SIRT1 Overexpression Prevents RGC Loss and Delays Loss of Function Following Experimental Closed Head Blunt Trauma.
- Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: Role of AMPK/SIRT1 activation and DPP-4 inhibition
- … against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, SIRT1, and PGC-1α …
- Base-pair conformational switch modulates miR-34a targeting of SIRT1 mRNA
- Effect of miR-181a on acute lung injury induced by sepsis in mice by targeting SIRT1 and its mechanism
- Inhibition of Src, SIRT1 or HDAC6 Reduces Transendothelial Migration of Acute Lymphoblastic Leukemia B cells
- miR-34a-5p up-regulates the IL-1ß/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons.
- … -Regulation of Mir-21 Alleviates Lung Injury Induced by Burns Through Activating Silent Mating Type Information Regulation 2 Homolog 1 (SIRT1)-Protein Kinase B …
- Elderberry Extracts increase Rat L6 Myocyte proliferation, reduce Apoptosis and act as HDAC1/SIRT1 Agonists in vitro
- 1138-P: Empagliflozin Ameliorates Kidney Injury in Diabetic Nephropathy via SIRT1 and TXNIP
- 488-P: Isoliquiritigenin Protects Renal Tubular Epithelial Cells from Inflammatory and Oxidative Injuries via Directly Activating SIRT1 in Type 1 Diabetic Nephropathy
- 1806-P: Vitamin D Deficiency Impairs mTORC2/Akt Signaling through Downregulating SIRT1 and Results in Increased Hepatic Gluconeogenesis
- CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKa2-SIRT1-PPARa signaling pathway
- … B20: Repurposing of fenofibrate to prevent and treat PM-induced pulmonary fibroblast-mediated inflammation: Mechanism involved in SIRT1-SREBP1-PIR/NLRP3 …
- Cigarette-Decreased NAD+/SIRT1 of Alveolar Type 2 Cells Aggravates Pulmonary Fibrosis by Promoting Cellular Senescence Through Autophagy Inhibition and …
- 2131-P: BET Bromodomain Inhibition Upregulates SIRT1 In Pancreatic ß-Cells
- Activation of Sirtuin 1 (SIRT1) Signaling by Resveratrol Increases Human Beta‐Defensins‐2 and‐3 (HBD2, HBD3) Production in Response to Lipopolysaccharide …
- Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors [Cardiovasc Res 2014 …
- PE-205: MiR-22-3p Alleviated Hepatic Lipogenesis via Inhibiting the SIRT1-PPAR Gamma Signal Pathway in Non-Alcoholic Fatty Liver Disease
- miR-150-5p enhances radiotherapy sensitivity of hepatocellular carcinoma cell line HepG2 through targeting SIRT1
- … Current Developments in Nutrition. The abstract “Lutein Prevents the Excessive Fat Deposition in Liver and Abdominal Tissues by Activating SIRT1 and Up-regulating …
- SIRT1, a promising regulator of bone homeostasis
- Recent advances of SIRT1 and implications in chemotherapeutics resistance in cancer
- Human SIRT1 multispecificity is modulated by active-site vicinity substitutions during natural evolution
- Ketogenesis and SIRT1 as a tool in managing obesity
- Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium
- SIRT1 activity in the brain: Simultaneous effects on energy homeostasis and reproduction
- SIRT1-Related Signaling Pathways and Their Association With Bronchopulmonary Dysplasia
- The Role of SIRT1 in Neuropathic Pain from the Viewpoint of Neuroimmunity
- SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival
- Trending topics of SIRT1 in tumorigenicity
- SIRT1 Gene SNP rs932658 Is Associated With Medication‐Related Osteonecrosis of the Jaw
- Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-SIRT1/SIRT1 axis
- The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling
- Elucidation of Structural Determinants Delineates the Residues Playing Key Roles in Differential Dynamics and Selective Inhibition of SIRT1–3
- SIRT1–a new mammalian substrate of nuclear autophagy
- Identification of novel SIRT1 activators endowed with cardioprotective profile
- Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification
- SIRT1 activation by polydatin alleviates oxidative damage and elevates mitochondrial biogenesis in experimental diabetic neuropathy
- A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
- Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS
- SIRT1-FOXOs activity regulates diabetic complications
- SIRT1 is involved in adrenocortical cancer growth and motility
- SIRT1 and SIRT2 activity control in neurodegenerative diseases
- Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3
- SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis
- SIRT1: A promising therapeutic target in type 2 diabetes mellitus
- Endothelial SIRT1 as a Target for the Prevention of Arterial Aging: Promises and Challenges
- pH sensitive liposomes assisted specific and improved breast cancer therapy using co-delivery of SIRT1 shRNA and Docetaxel
- A SIRT1 activator, ginsenoside Rc, promotes energy metabolism in cardiomyocytes and neurons
- SIRT1 and SIRT2 modulators: potential anti-inflammatory treatment for depression?
- Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1
- The role of SIRT1 in the basolateral amygdala in depression‐like behaviors in mice
- SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis
- SIRT1 and gynecological malignancies
- SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways
- Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis
- Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy
- Vitamin K2 Alleviates Insulin Resistance in Skeletal Muscle by Improving Mitochondrial Function Via SIRT1 Signaling
- ESC-sEVs rejuvenate aging hippocampal NSCs by transferring SMADs to regulate the MYT1-Egln3-SIRT1 axis
- A review study on the modulation of SIRT1 expression by miRNAs in aging and age-associated diseases
- SIRT1 reduces epigenetic and non-epigenetic changes to maintain the quality of postovulatory aged oocytes in mice
- SIRT1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy
- SIRT1 coordinates with ERα to regulate autophagy and adiposity
- Apple polyphenol extract alleviates lipid accumulation in free‐fatty‐acid‐exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling
- SIRT1 Protects Dopaminergic Neurons in Parkinson’s Disease Models via PGC-1α-Mediated Mitochondrial Biogenesis
- Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction
- Flavonostilbenes Isolated from the Stems of Rhamnoneuron balansae as Potential SIRT1 Activators
- Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of …
- Sesamin and sesamol attenuate H2O2-induced oxidative stress on human neuronal cells via the SIRT1-SIRT3-FOXO3a signaling pathway
- SIRT1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis
- Evaluation of BCL6 and SIRT1 as Non-Invasive Diagnostic Markers of Endometriosis
- Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood
- NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
- Differential role of SIRT1/MAPK pathway during cerebral ischemia in rats and humans
- Role of the SIRT1/p53 regulatory axis in oxidative stress‑mediated granulosa cell apoptosis
- DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells
- AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane
- Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling …
- Positive association of a SIRT1 variant and parameters of oxidative stress on Alzheimer’s disease
- Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice
- Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells
- The anti-diabetic effects of betanin in streptozotocin-induced diabetic rats through modulating AMPK/SIRT1/NF-κB signaling pathway
- Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe−/− mice: role of SIRT1
- SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing
- MAPK pathway and SIRT1 are involved in the down-regulation of secreted osteopontin expression by genistein in metastatic cancer cells
- Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice
- SIRT1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy
- LncRNA H19 inhibits high glucose‐induced inflammatory responses of human retinal epithelial cells by targeting miR‐19b to increase SIRT1 expression
- GDF11 alleviates pathological myocardial remodeling in diabetic cardiomyopathy through SIRT1-dependent regulation of oxidative stress and apoptosis
- Hypothalamic GHR—SIRT1 Axis in Fasting
- Differential TM4SF5‐mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression
- Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-κB/SIRT1 and apoptosis signaling in acute pancreatitis model
- Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway
- Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the SIRT1 pathway
- Vitamin D exerts neuroprotection via SIRT1/nrf-2/NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice
- Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation Mediated by SIRT1-Induced Changes in Cellular Levels of cAMP and Ca2+
- IBF-R, a botanical extract of Rhus verniciflua controls obesity in which AMPK-SIRT1 axis and ROS regulatory mechanism are involved in mice
- Physical exercise may exert its therapeutic influence on Alzheimer’s disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1 …
- Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling
- SIRT1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice
- SIRT1‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils
- SIRT1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade
- Circ_0001103 alleviates IL-1β-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375
- Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages
- Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy
- Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/SIRT1/p53 axis
- Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation
- FGF21 promotes non-small cell lung cancer progression by SIRT1/PI3K/AKT signaling
- Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein …
- Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation
- Berbamine induced activation of the SIRT1/LKB1/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats
- … morifolium flower extract ameliorates obesity-induced inflammation and increases the muscle mitochondria content and AMPK/SIRT1 activities in obese rats
- Regulation of SIRT1 on energy metabolism and immune response in rheumatoid arthritis
- Gypenoside inhibits ox-LDL uptake and foam cell formation through enhancing SIRT1-FOXO1 mediated autophagy flux restoration
- Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1–3 Inhibitors
- Role of SIRT1 in isoflurane conditioning-induced neurovascular protection against delayed cerebral ischemia secondary to subarachnoid hemorrhage
- AMPK/SIRT1 Pathway is Involved in Arctigenin-Mediated Protective Effects Against Myocardial Ischemia-Reperfusion Injury
- Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1α Signaling Pathway
- LincRNA‐p21 alleviates atherosclerosis progression through regulating the miR‐221/SIRT1/Pcsk9 axis
- Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway
- The beneficial efficacy of liposomal resveratrol against doxorubicin-induced hepatotoxicity in rats: Role of TGF-β1 and SIRT1
- Naringenin protects RPE cells from NaIO3-induced oxidative damage in vivo and in vitro through up-regulation of SIRT1
- Myeloid ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver
- SIRT1 promotes neuronal fortification in neurodegenerative diseases through attenuation of pathological hallmarks and enhancement of cellular lifespan
- SYT8 promotes pancreatic cancer progression via the TNNI2/ERRα/SIRT1 signaling pathway
- Intrathecal Injection of SIRT1-modified Human Mesenchymal Stem Cells Alleviates Neuropathic Pain in Rat
- SIRT1 activator SRT2104 protects against oxygen-glucose deprivation/reoxygenation-induced injury via regulating microglia polarization by modulating SIRT1/NF-κB …
- Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation
- LncRNA XIST restrains the activation of Müller cells and inflammation in diabetic retinopathy via stabilizing SIRT1
- Exogenous NAD+ Postpones the D-Gal-Induced Senescence of Bone Marrow-Derived Mesenchymal Stem Cells via SIRT1 Signaling
- Quercetin induces pro‐apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro
- Modulation of antioxidant enzymes, SIRT1 and NF‐κB by resveratrol and nicotinamide in alcohol‐aflatoxin B1‐induced hepatocellular carcinoma
- Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 …
- Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson’s disease
- … hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 …
- SIRT1 attenuates renal fibrosis by repressing HIF-2α
- Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
- Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1–AMPK crosstalk in podocytes: Impact on glucose uptake
- Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in BrafV600E/PtenNULL Mice
- Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota
- Echinacoside improves diabetic liver injury by regulating the AMPK/SIRT1 signaling pathway in db/db mice
- Lactobacillus rhamnosus GG Colonization in Early Life Ameliorates Inflammaging of Offspring by Activating SIRT1/AMPK/PGC-1α Pathway
- Ameliorative effect of SIRT1 in postpartum depression mediated by upregulation of the glucocorticoid receptor
- Modulation of SIRT1 and FoxO1 on Hypothalamic Leptin‐Mediated Sympathetic Activation and Inflammation in Diet‐Induced Obese Rats
- LncRNA SIRT1-AS upregulates SIRT1 to attenuate aging related deep venous thrombosis
- Nuclear receptor TLX may be through regulating the SIRT1/NF-κB pathway to ameliorate cognitive impairment in chronic cerebral hypoperfusion
- METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of SIRT1
- Adiponectin ameliorates lung ischemia–reperfusion injury through SIRT1-PINK1 signaling-mediated mitophagy in type 2 diabetic rats
- Difference of pain vulnerability in adult and juvenile rodents: the role of SIRT1-mediated ClC-3 trafficking in sensory neurons
- … 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in …
- Hyperbaric oxygen via mediating SIRT1‐induced deacetylation of HMGB1 improved cReperfusion inj/reperfusion injury
- The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI
- Rutin and gallic acid regulates mitochondrial functions via the SIRT1 pathway in C2C12 myotubes
- Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation
- Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis
- NF-κB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasome
- The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis
- Cyproheptadine causes apoptosis and decreases inflammation by disrupting thiol/disulfide balance and enhancing the levels of SIRT1 in C6 glioblastoma cells
- Role of SIRT1 in Hepatic Encephalopathy: In Vivo and In Vitro Studies Focusing on the NLRP3 Inflammasome
- SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation
- LncRNA LUADT1 regulates miR‐34a/SIRT1 to participate in chondrocyte apoptosis
- Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer
- Astaxanthin Ameliorates high-fat diet-induced cardiac damage and fibrosis by upregulating and activating SIRT1
- Resveratrol attenuates excessive ethanol exposure-induced β-cell senescence in rats: A critical role for the NAD+/SIRT1-p38MAPK/p16 pathway
- Resveratrol suppresses severe acute pancreatitis-induced microcirculation disturbance through targeting SIRT1-FOXO1 Axis
- Cilostazol preconditioning alleviates cyclophosphamide-induced cardiotoxicity in male rats: Mechanistic insights into SIRT1 signaling pathway
- Cannabidiol induces autophagy to protects neural cells from mitochondrial dysfunction by upregulating SIRT1 to inhibits NF-κB and NOTCH pathways
- Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML …
- Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis: role of SIRT1/Nrf2 pathway
- Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation
- Maternal nicotine exposure impairs brown adipose tissue via AMPK-SIRT1-PGC-1α signals in male offspring
- Melatonin alleviated oxidative stress induced by energy restriction on sheep Leydig cells through SIRT1/Sod2 pathway
- Vinpocetine ameliorates L-arginine induced acute pancreatitis via SIRT1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis
- … iodate-induced retinal autophagy by regulating mitochondrial reactive oxygen species homeostasis through enhanced deacetyl-SOD2 via the Nrf2-PGC-1α-SIRT1 …
- The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients
- SIRT1 and Nrf2: regulation of Leydig cell oxidant/antioxidant intracellular environment and steroid formation†
- The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats
- Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity
- Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats
- An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation
- Improving SIRT1 by trehalose supplementation reduces oxidative stress, inflammation, and histopathological scores in the kidney of aged rats
- Coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of SIRT1
- Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling–Mediated Neuroinflammation
- N6-Methyladenosine Induced Mir-34a-5p Promotes Tnf-α-Induced Nucleus Pulposus Cell Senescence by Targeting SIRT1
- Theaflavin protects against oxalate calcium-induced kidney oxidative stress injury via upregulation of SIRT1
- SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B
- Calorie Restriction and SIRT1 Overexpression Induce Different Gene Expression Profiles in White Adipose Tissue in Association with Metabolic Improvement
- SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor
- Trpv4 regulates Nlrp3 inflammasome via SIRT1/PGC-1α pathway in a cuprizone-induced mouse model of demyelination
- Silymarin modulates catabolic cytokine expression through SIRT1 and SOX9 in human articular chondrocytes
- Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/SIRT1 and Nrf2/HO‐1 pathways
- Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models
- Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1α pathway
- Helicobacter pylori inhibits autophagic flux and promotes its intracellular survival and colonization by down‐regulating SIRT1
- Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1
- Protective Effect of SIRT1 against Radiation-Induced Damage
- Advanced Maternal Age‐associated SIRT1 Deficiency Compromises Trophoblast Epithelial− Mesenchymal Transition through an Increase in Vimentin Acetylation
- Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation
- Resveratrol attenuates radiation enteritis through the SIRT1/FOXO3a and PI3K/AKT signaling pathways
- Down-Regulation of the Longevity-Associated Protein SIRT1 in Peripheral Blood Mononuclear Cells of Treated HIV Patients
- Design, synthesis and pharmacological evaluation of naphthofuran derivatives as potent SIRT1 activators
- Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by SIRT1
- MiR-200a-3p Aggravates DOX-Induced Cardiotoxicity by Targeting PEG3 Through SIRT1/NF-κB Signal Pathway
- miR‑135a‑5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy
- Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress
- Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling
- l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells
- Anxiety and Cognition in Cre-Collagen Type II SIRT1 K/O Male Mice
- Skeletal Muscle Gene Expression Profile in Response to Caloric Restriction and Aging: A Role for SIRT1
- Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways
- SIRT1 Expression and Regulation in the Primate Testis
- DDIT3/CHOP promotes autophagy in chondrocytes via SIRT1-AKT pathway
- Relationship between SIRT1 gene and adolescent depressive disorder with nonsuicidal self-injury behavior: Based on gene methylation and mRNA …
- Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway
- SIRT1 attenuates diabetic keratopathy by regulating the endoplasmic reticulum stress pathway
- LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/SIRT1 signalling axis
- Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway
- B7-H3 suppresses doxorubicin-induced senescence-like growth arrest in colorectal cancer through the AKT/TM4SF1/SIRT1 pathway
- miR-19a/b-3p promotes inflammation during cerebral ischemia/reperfusion injury via SIRT1/FoxO3/SPHK1 pathway
- FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer
- Downregulated SIRT1 in the CeA is involved in chronic pain-depression comorbidity
- Circ-SIRT1 inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes
- KCNQ1OT1 regulates the retinoblastoma cell proliferation, migration and SIRT1/JNK signaling pathway by targeting miR-124/SP1 axis
- Attenuation of Pb-induced Aβ generation and autophagic dysfunction via activation of SIRT1: neuroprotective properties of resveratrol
- Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
- Hydrogen sulfide restores sevoflurane postconditioning mediated cardioprotection in diabetic rats: Role of SIRT1/Nrf2 signaling‐modulated mitochondrial dysfunction …
- Metabolic regulation of macrophages by SIRT1 determines activation during cholestatic liver disease in mice
- SRT1720 induces SIRT1‐independent cell death in adult T‐cell leukemia/lymphoma
- Isoliquiritigenin prevents Doxorubicin-induced hepatic damage in rats by upregulating and activating SIRT1
- SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure
- Feeding frequency affects glucose and lipid metabolism through SIRT1/AMPK pathway in growing pigs with the same amount of daily feed
- Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARγ/SIRT1-Mediated NF-κB Pathway
- Melatonin ameliorates lipopolysaccharide-induced microglial inflammation via triggering SIRT1/HMGB1 signaling axis
- Role of SIRT1/AMPK signaling in the proliferation, migration and invasion of renal cell carcinoma cells
- ALDH2/SIRT1 Contributes to Type 1 and Type 2 Diabetes-Induced Retinopathy through Depressing Oxidative Stress
- Increased SIRT1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice
- E3 ubiquitin ligase Grail promotes hepatic steatosis through SIRT1 inhibition
- Role of the SENP1–SIRT1 pathway in hyperoxia-induced alveolar epithelial cell injury
- Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice
- Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway
- SIRT1 Attenuates Apoptosis of Nucleus Pulposus Cells by Targeting Interactions between LC3B and Fas under High-Magnitude Compression
- Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis
- Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron …
- SIRT1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function
- Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the SIRT1/PGC-1α Signaling Pathway in db/db Mice
- SIRT1 alleviates hepatic ischemia-reperfusion injury via the miR-182-mediated XBP1/NLRP3 pathway
- MDM2-dependent SIRT1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers
- Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1
- IL-1β induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1
- Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice
- … Cardiac Function in Rats With Myocardial Infarction by Low-Intensity to Moderate-Intensity Endurance Exercise Is Associated With Normalization of Klotho and SIRT1
- The protective effects of activating SIRT1/NF-κB pathway for neurological disorders
- Adverse childhood events and cardiovascular diseases: the potential role of SIRT1
- FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1‐dependent autophagy
- FGF21 alleviates acute liver injury by inducing the SIRT1‐autophagy signalling pathway
- Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1
- AMPK/SIRT1 signaling through p38MAPK mediates Interleukin-6 induced neuroendocrine differentiation of LNCaP prostate cancer cells
- The deacetylation of Foxk2 by SIRT1 reduces chemosensitivity to cisplatin
- Protective Effect of SIRT1 Activator on the Knee With Osteoarthritis
- Hesperetin modulates the SIRT1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and …
- Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy
- Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms
- Clusterin is involved in mediating the metabolic function of adipose SIRT1
- … attenuates microglial inflammation response and blood–brain barrier damage in ischemic stroke through regulating miR‐425‐5p mediated SIRT1/NF‐κB signaling
- Lipopolysaccharide-induced depression is associated with estrogen receptor-α/SIRT1/NF-κB signaling pathway in old female mice
- Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats
- Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease
- Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells
- MiR-34a/SIRT1/p53 signaling pathway contributes to cadmium-induced nephrotoxicity: A preclinical study in mice
- Madecassoside Inhibits Body Weight Gain via Modulating SIRT1-AMPK Signaling Pathway and Activating Genes Related to Thermogenesis
- Cdk5-mediated phosphorylation of SIRT1 contributes to podocyte mitochondrial dysfunction in diabetic nephropathy
- … -Signal-Regulated Kinase Inhibition Switches APP Processing from β-to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling
- SIRT1 suppresses cellular senescence and inflammatory cytokine release in human dermal fibroblasts by promoting the deacetylation of NF-κB and activating …
- Neuroprotective Effect of Astragaloside IV on Cerebral Ischemia/Reperfusion Injury Rats Through SIRT1/Mapt Pathway
- Depleting microRNA-146a-3p attenuates lipopolysaccharide-induced acute lung injury via up-regulating SIRT1 and mediating NF-κB pathway
- Phosphocreatine Promotes Osteoblastic Activities in H2O2-Induced MC3T3-E1 Cells by Regulating SIRT1/FOXO1/PGC-1α Signaling Pathway
- Lutein attenuates excessive lipid accumulation in differentiated 3T3-L1 cells and abdominal adipose tissue of rats by the SIRT1-mediated pathway
- The protective effects of 17-β estradiol and SIRT1 against cardiac hypertrophy: a review
- The modulation of SIRT1 and SIRT3 by natural compounds as a therapeutic target in doxorubicin‐induced cardiotoxicity: A review
- Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling
- Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury
- Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1‐dependent pathway
- Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1
- SIRT1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury
- L-Threonine upregulates β-defensins expression by activating NF-κB signaling pathway and suppressing SIRT1 expression in porcine intestinal epithelial cells
- Pterostilbene protects the optic nerves and retina in a murine model of experimental autoimmune encephalomyelitis via activation of SIRT1 signaling
- A novel stilbene derivative (GMQ3) suppressed proliferation and induced apoptosis in lung cancer via the p38-MAPK/SIRT1 pathway
- … oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway
- … marrow-derived mesenchymal stem cells ameliorate sepsis-induced acute kidney injury by promoting mitophagy of renal tubular epithelial cells via the SIRT1 …
- TNFα expression by Porphyromonas gingivalis‐stimulated macrophages relies on SIRT1 cleavage
- Comparison of the effects of different dietary regimens on susceptibility to experimental acute kidney injury: the role of SIRT1 and TGF-β1
- The serum SIRT1 protein is associated with the severity of injury and neurological recovery in mice with traumatic spinal cord injury
- Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a
- Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNFα-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice
- … endothelial progenitor cells derived extracellular vesicles confers anti-inflammatory macrophage polarization in sepsis via impairing miR-9-5p-targeted SIRT1 …
- The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting SIRT1
- The MFF-SIRT1/3 axis, regulated by miR-340-5p, restores mitochondrial homeostasis of hypoxia-induced pulmonary artery smooth muscle cells
- … Tryptophan on Neurodegeneration and Inflammation in d-Galactose-Induced Aging Mice with the Potential Mechanism Relying on AMPK/SIRT1/PGC-1α Pathway …
- Involvement of SIRT1 in amelioration of schistosomiasis-induced hepatic fibrosis by genistein
- Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI)(effect of SIRT1 activators on acute kidney injury)
- Empagliflozin alleviates ethanol‐induced cardiomyocyte injury through inhibition of mitochondrial apoptosis via a SIRT1/PTEN/Akt pathway
- Hypoxia: Role of SIRT1 and the protective effect of resveratrol in ovarian function
- Dual Role of SIRT1 in Autophagy and Lipid Metabolism Regulation in Osteoarthritic Chondrocytes
- Potent PDE4 inhibitor activates AMPK and SIRT1 to induce mitochondrial biogenesis
- NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer
- … growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway
- DRG2 Accelerates Senescence via Negative Regulation of SIRT1 in Human Diploid Fibroblasts
- TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study
- Vitamin B12 Attenuates Acute Pancreatitis by Suppressing Oxidative Stress and Improving Mitochondria Dysfunction via CBS/SIRT1 Pathway
- Lithium chloride represses abdominal aortic aneurysm via regulating GSK3β/SIRT1/NF-κB signaling pathway
- Selenite supplementation modulates the hepatic metabolic sensors AMPK and SIRT1 in binge drinking exposed adolescent rats by avoiding oxidative stress
- MicroRNA-326 impairs chemotherapy resistance in non small cell lung cancer by suppressing histone deacetylase SIRT1-mediated HIF1α and elevating VEGFA …
- Exendin-4 protects against myocardial ischemia-reperfusion injury by upregulation of SIRT1 and SIRT3 and activation of AMPK
- Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation
- Interplay between Oxidative stress, SIRT1, Reproductive and Metabolism Functions
- SIRT1 Activation Enhancing 8, 3′-Neolignans from the Twigs of Corylopsis coreana Uyeki
- Ameliorative role of SIRT1 in peritoneal fibrosis: an in vivo and in vitro study
- Anagliptin prevented interleukin 1β (IL-1β)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1)
- Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling
- Ubiquitin-like protein FAT10 suppresses SIRT1-mediated autophagy to protect against ischemic myocardial injury
- Lactobacillus plantarum 69-2 Combined with Galacto-Oligosaccharides Alleviates d-Galactose-Induced Aging by Regulating the AMPK/SIRT1 Signaling Pathway and …
- Targeting SIRT1 to inhibit the proliferation of multiple myeloma cells
- Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis
- Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression
- SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging
- miR-34a induces immunosuppression in colorectal carcinoma through modulating a SIRT1/NF-κB/B7-H3/TNF-α axis
- Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts
- L‐Arginine protects cementoblasts against hypoxia‐induced apoptosis through SIRT1‐enhanced autophagy
- circ-SIRT1 Promotes Colorectal Cancer Proliferation and EMT by Recruiting and Binding to eIF4A3
- The Anti-Inflammatory Effect of Zhibaidihuang Decoction on Recurrent Oral Ulcer with SIRT1 as the Key Regulatory Target
- SIRT1 induces the accumulation of TAMs at colorectal cancer tumor sites via the CXCR4/CXCL12 axis
- Hypoglycemic effect of astragaloside IV via modulating gut microbiota and regulating AMPK/SIRT1 and PI3K/AKT pathway
- Cyanidin-3-O-glucoside attenuates high glucose–induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK …
- … and Nanocurcumin on Aluminium Phosphide‑Induced Subacute Lung Injury in Rats: Modulation of Oxidative Stress through SIRT1/FOXO3 Signalling Pathway
- Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson’s disease: Impact of the SIRT1-AMPK signaling pathway
- Protection against Doxorubicin-Related Cardiotoxicity by Jaceosidin Involves the SIRT1 Signaling Pathway
- … inhibition ameliorates oxygen‑glucose deprivation‑induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA‑29b/SIRT1/PGC‑1α axis
- Attenuated SIRT1 activity leads to PER2 cytoplasmic localization and dampens the amplitude of Bmal1 promoter-driven circadian oscillation
- Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1
- Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
- Camphorquinone Promotes the Antisenescence Effect via Activating AMPK/SIRT1 in Stem Cells and D-Galactose-Induced Aging Mice
- Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: Role of AMPK/SIRT1 activation and DPP-4 inhibition
- Diosmetin alleviated cerebral ischemia/reperfusion injury in vivo and in vitro by inhibiting oxidative stress via the SIRT1/Nrf2 signaling pathway
- Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases
- Genetic ablation of fas-activated serine/threonine kinase ameliorates alcoholic liver disease through modulating HuR-SIRT1 mRNA complex stability
- Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure
- Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells
- SIRT1 Contributes as an Invasiveness Marker in Pituitary Adenoma
- Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling
- Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1α via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model
- Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway
- Circadian Transcription Factor NPAS2 and the NAD+‐Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward
- SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin
- Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets
- Klotho and SIRT1 changes from pre-diabetes to diabetes and pre-hypertension to hypertension
- Effect of DEHP and DnOP on mitochondrial damage and related pathways of Nrf2 and SIRT1/PGC-1α in HepG2 cells
- Pinocembrin ameliorates acute liver failure via activating the SIRT1/PPARα pathway in vitro and in vivo
- Ghrelin Alleviates Intestinal Dysfunction in Sepsis Through the KLF4/MMP2 Regulatory Axis by Activating SIRT1
- The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway
- LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/SIRT1 pathway
- Resveratrol-induced SIRT1 phosphorylation by LKB1 mediates mitochondrial metabolism
- The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1
- SIRT1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax
- Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating SIRT1 pathway in cholestatic mice
- Dapagliflozin attenuates pressure overload-induced myocardial remodeling in mice via activating SIRT1 and inhibiting endoplasmic reticulum stress
- Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK …
- … IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 …
- NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway
- The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer’s Disease
- Thymoquinone ameliorates age-related hearing loss in C57BL/6J mice by modulating SIRT1 activity and Bak1 expression
- Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis depending on SIRT1 in HG-induced GMCs and STZ-induced diabetic rats
- Nicotinamide riboside enhances endothelial precursor cell function to promote refractory wound healing through mediating the SIRT1/AMPK pathway
- A new series of benzoxazole‐based SIRT1 modulators for targeted therapy of non‐small‐cell lung cancer
- 17β-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes via the SIRT1-Mediated AMPK/mTOR Signaling Pathway
- Transgenic Immortalization of Human Dermal Fibroblasts Mediated Through the MicroRNA/SIRT1 Pathway
- SIRT1-mediated deacetylation of NF-κB inhibits the MLCK/MLC2 pathway and the expression of ET-1, thus alleviating the development of coronary artery spasm
- Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury
- Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway
- Perfluorooctane sulfonate continual exposure impairs glucose-stimulated insulin secretion via SIRT1-induced upregulation of UCP2 expression
- Soluble Epoxide Hydrolase Deletion Attenuated Nicotine-induced Arterial Stiffness via Limiting the Loss of SIRT1
- MiR-155-5p promotes renal interstitial fibrosis in obstructive nephropathy via inhibiting SIRT1 signaling pathway
- Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways
- Deacetylation of FOXO4 by SIRT1 stabilizes chondrocyte extracellular matrix upon activating SOX9
- Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns
- … Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK–AMPK–SIRT1-Associated Signaling Pathway in …
- MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-SIRT1 pathway
- Shikimic acid protects skin cells from UV-induced senescence through activation of the NAD+-dependent deacetylase SIRT1
- SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury
- SIRT1/PGC-1α signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells
- Function and mechanism of trimetazidine in myocardial infarction-induced myocardial energy metabolism disorder through the SIRT1-AMPK pathway
- Cystathionine-β-synthase (CBS)/H2S System Promotes Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) by Activating SIRT1
- SIRT1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response
- The Protective Role of Bmal1-Regulated Autophagy Mediated by HDAC3/SIRT1 Pathway in Myocardial Ischemia/Reperfusion Injury of Diabetic Rats
- miR-22-3p regulates muscle fiber-type conversion through inhibiting AMPK/SIRT1/PGC-1α pathway
- Echinacoside Upregulates SIRT1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation In Vitro and Ameliorates Osteoarthritis …
- Melanoidins, extracted from Chinese traditional vinegar powder, inhibit alcohol-induced inflammation and oxidative stress in macrophages via activation of SIRT1 and …
- Berberine Ameliorates Hepatic Insulin Resistance by Regulating microRNA-146b/SIRT1 Pathway
- SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients
- Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis
- … D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKα/SIRT1/Foxo3a signaling pathway
- Beneficial and Dimorphic Response to Combined HDAC Inhibitor Valproate and AMPK/SIRT1 Pathway Activator Resveratrol in the Treatment of ALS Mice
- Ameliorative effect of white tea from 50-year-old tree of Camellia sinensis L.(Theaceae) on kidney damage in diabetic mice via SIRT1/AMPK pathway
- Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a/SIRT1/FXR/p53 axis
- Urolithin A prevents streptozotocin-induced diabetic cardiomyopathy in rats by activating SIRT1
- Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of SIRT1 in Mice
- Acupuncture Delays Cartilage Degeneration through Upregulating SIRT1 Expression in Rats with Osteoarthritis
- SIRT1 Activation Attenuates the Cardiac Dysfunction Induced by Endothelial Cell-Specific Deletion of CRIF1
- Inhibition of miR‐181a attenuates sepsis‐induced inflammation and apoptosis by activating Nrf2 and inhibiting NF‐κB pathways via targeting SIRT1
- Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway
- Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed …
- Lactobacillus casei Strain Shirota Enhances the Ability of Geniposide to Activate SIRT1 and Decrease Inflammation and Oxidative Stress in Septic Mice
- 2′-Fucosyllactose Ameliorates Oxidative Stress Damage in d-Galactose-Induced Aging Mice by Regulating Gut Microbiota and AMPK/SIRT1/FOXO1 Pathway
- Effect of the traditional Chinese medicine Pinggan-Qianyang decoction on SIRT1–PTEN signaling in vascular aging in spontaneously hypertensive rats
- Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a SIRT1-Dependent Manner
- Dietary betaine mitigates hepatic steatosis and inflammation induced by a high-fat-diet by modulating the SIRT1/Srebp-1/Pparɑ pathway in juvenile black …
- MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21
- Bhlhe40/SIRT1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta
- Nicotinic acid against acetaminophen-induced hepatotoxicity via SIRT1/Nrf2 antioxidative pathway in mice
- SIRT1: Mechanism and Protective Effect in Diabetic Nephropathy
- Candidate oncogene circularNOP10 mediates gastric cancer progression by regulating miR-204/SIRT1 pathway
- Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-SIRT1 and inhibiting the entry of NF-κB into the nucleus
- Identification of Stabilization of Malvid Anthocyanins and Antioxidant Stress Activation via the AMPK/SIRT1 Signaling Pathway
- Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/SIRT1 pathway
- SIRT1 deacetylates TET2 and promotes its ubiquitination degradation to achieve neuroprotection against Parkinson’s disease
- The Effect of Repeated Whole-Body Cryotherapy on SIRT1 and Sirt3 Concentrations and Oxidative Status in Older and Young Men Performing Different Levels of …
- Terretonin as a New Protective Agent against Sepsis-Induced Acute Lung Injury: Impact on SIRT1/Nrf2/NF-κBp65/NLRP3 Signaling
- 20‐HETE synthesis inhibition attenuates traumatic brain injury–induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC‐1α pathway: A …
- Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induced pulmonary endothelial glycocalyx loss via ALX/SIRT1/NF-kappa B axis
- LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1α/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury
- Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-year Prospective Longitudinal Cohort Study
- Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA-and UVB-irradiated epidermal keratinocytes
- Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/SIRT1 axis
- Effects of manganese on microglia M1/M2 polarization and SIRT1‐mediated transcription of STAT3‐dependent genes in mouse
- Sodium nitroprusside protects HFD induced gut dysfunction via activating AMPKα/SIRT1 signaling
- Mangiferin prevents myocardial infarction‐induced apoptosis and heart failure in mice by activating the SIRT1/FoxO3a pathway
- Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats
- Time-course miRNA alterations and SIRT1 inhibition triggered by adolescent lead exposure in mice
- High concentration of hydrogen ameliorates lipopolysaccharide-induced acute lung injury in a SIRT1-dependent manner
- Perampanel Stimulates Mitochondrial Biogenesis in Neuronal Cells through Activation of the SIRT1/PGC-1α Signaling Pathway
- Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway
- Anti-inflammatory Effects of Sweroside on LPS-Induced ALI in Mice Via Activating SIRT1
- miR-376a inhibits glioma proliferation and angiogenesis by regulating YAP1/VEGF signalling via targeting of SIRT1
- SIRT1 Inhibits Apoptosis by Promoting Autophagic Flux in Human Nucleus Pulposus Cells in the Key Stage of Degeneration via ERK Signal Pathway
- Atractylodes chinensis Water Extract Ameliorates Obesity via Promotion of the SIRT1/AMPK Expression in High-Fat Diet-Induced Obese Mice
- SIRT1 Mediates H 2 S-Ameliorated Diabetes-Associated Cognitive Dysfunction in Rats: Possible Involvement of Inhibiting Hippocampal Endoplasmic Reticulum …
- Gardeniae Fructus Attenuates Thioacetamide-Induced Liver Fibrosis in Mice via Both AMPK/SIRT1/NF-κB Pathway and Nrf2 Signaling
- Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1
- Urolithin A protects dopaminergic neurons in experimental models of Parkinson’s disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling …
- Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis
- Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1
- Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy‐sensing of AMPK/SIRT1 in malnutrition
- LncRNA MIAT Inhibits MPP+-Induced Neuronal Damage Through Regulating the miR-132/SIRT1 Axis in PC12 Cells
- … promotes oxidative stress damage to regulate the occurrence and development of cerebral ischemia/reperfusion injury by targeting the miR-141/SIRT1 axis
- The correlation of salivary telomere length and single nucleotide polymorphisms of the ADIPOQ, SIRT1 and FOXO3A genes with lifestyle-related diseases …
- Two novel InDels within the Promoter of SIRT1 are associated with growth traits in chickens
- Resveratrol reduces DRP1‐mediated mitochondrial dysfunction via the SIRT1‐PGC1α signaling pathway in manganese‐induced nerve damage in mice
- Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma
- Genome Edited SIRT1-Overexpressing Human Mesenchymal Stem Cells Exhibit Therapeutic Effects in Treating Collagen-Induced Arthritis
- Deletion of intestinal SIRT1 exacerbated muscle wasting in cirrhotic mice by decreasing the intestinal concentration of short-chain fatty acids and inflammation
- SIRT1/mTOR pathway‐mediated autophagy dysregulation promotes Pb‐induced hepatic lipid accumulation in HepG2 cells
- Reduction of SIRT1 Mediates Monosodium Iodoacetate-Induced Osteoarthritic Pain by Upregulating p53 Expression in Rats
- Arjunolic acid from Cyclocarya paliurus ameliorates nonalcoholic fatty liver disease in mice via activating SIRT1/AMPK, triggering autophagy and improving gut …
- … OIP5-AS1 overexpression promotes viability and inhibits high glucose-induced oxidative stress of cardiomyocytes by targeting microRNA-34a/SIRT1 axis in diabetic …
- … malignant progression by regulating macroautophagy and forms a negative feedback regulatory loop with the miR‑34a/mTOR/SIRT1 pathway in colorectal …
- Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats
- MiR-22 inhibition alleviates cardiac dysfunction in doxorubicin induced cardiomyopathy by targeting SIRT1/PGC-1α pathway
- Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS
- … and attenuates hippocampal damage in cadmium chloride-intoxicated male rats by suppressing acetylcholinesterase and concomitant activation of SIRT1 …
- Dose dependent effect of cilostazol in induced testicular ischemia reperfusion via modulation of HIF/VEGF and cAMP/SIRT1 pathways
- … by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 …
- … stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1
- CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving …
- Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis
- Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild …
- SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation
- MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway
- High glucose mediates apoptosis and osteogenesis of MSCs via downregulation of AKT-SIRT1-TWIST
- Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway
- Ginsenoside Rg3 alleviates septic liver injury by regulating the lncRNA TUG1/miR-200c-3p/SIRT1 axis
- LncRNA TUG1/miR-29c-3p/SIRT1 axis regulates endoplasmic reticulum stress-mediated renal epithelial cells injury in diabetic nephropathy model in vitro
- Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 …
- Protective Effect of Dihydrokaempferol on Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway
- Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis
- Paeoniflorin Protects against ANIT-Induced Cholestatic Liver Injury in Rats via the Activation of SIRT1-FXR Signaling Pathway
- New dammarane-type triterpenoid saponins from Gynostemma pentaphyllum and their SIRT1 agonist activity
- miR-146a-5p targets SIRT1 to regulate bone mass
- Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress
- Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress
- Resveratrol Ameliorates Aortic Calcification in Ovariectomized Rats via SIRT1 Signaling
- Effect of Porcine Whole Blood Protein Hydrolysate on Slow-Twitch Muscle Fiber Expression and Mitochondrial Biogenesis via the AMPK/SIRT1 Pathway
- Hydrogen sulfide antagonizes sleep deprivation-induced depression-and anxiety-like behaviors by inhibiting neuroinflammation in a hippocampal SIRT1-dependent …
- Modulation of NAD+ biosynthesis activates SIRT1 and resist cisplatin-induced ototoxicity
- Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity?
- Sonochemical synthesis of 2-substituted nicotinic acid ethyl ester derivatives: Their in vitro and in silico evaluation against SIRT1
- Protective role of SIRT1-mediated Sonic Hedgehog signaling pathway in the preeclampsia rat models
- Sulforaphane inhibits blue light–induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial …
- Formononetin activates the Nrf2/ARE signaling pathway via SIRT1 to improve diabetic renal fibrosis
- Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/β-Catenin and Sonic Hedgehog Pathways
- Melatonin attenuates prostatic inflammation and pelvic pain via SIRT1‐dependent inhibition of the NLRP3 inflammasome in an EAP mouse model
- SIRT1 decelerates morphological processing of oligodendrocyte cell lines and regulates the expression of cytoskeleton-related oligodendrocyte proteins
- Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamide
- Melatonin-induced lncRNA LINC01512 prevents Treg/Th17 imbalance by promoting SIRT1 expression in necrotizing enterocolitis
- … , an SGLT2 Inhibitor, Ameliorates High-Fat Diet-Induced Metabolic Changes by Upregulating Energy Expenditure through Activation of the AMPK/SIRT1 …
- Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1-FoxO1-SREBP2 pathway for cholesterol synthesis
- Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway
- Sulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1ɑ pathway
- Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and …
- Ovatodiolide protects ischemia-reperfusion-induced neuronal injury via microglial neuroinflammation via mediating SIRT1/NF-κB pathway
- Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
- Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of SIRT1 in Type 2 Diabetes Mellitus
- Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1
- Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1
- Effect of main ingredients of Danhong Injection against oxidative stress induced autophagy injury via miR-19a/SIRT1 pathway in endothelial cells
- The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and SIRT1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different …
- Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis
- The role of SIRT1 in the retinal ganglion cells cultured by high glucose
- SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro
- Yunnan Black Tea Flavonoids Can Improve Cognitive Dysfunction in Septic Mice by Activating SIRT1
- … 00958 (LINC00958) for oral squamous cell carcinoma (OSCC) cells death through absent in melanoma 2 (AIM2) depending on microRNA-4306 and Sirtuin1 (SIRT1) …
- Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPARα/γ-AMPK-SIRT1 Pathway and Fatty Acid Metabolism
- … hypoxia/reoxygenation injury-induced oxidative stress and endoplasmic reticulum stress-dependent apoptosis of cardiomyocytes via SIRT1/CHOP signaling pathway
- SIRT1 siRNA-loaded lipid nanoparticles enhanced doxorubicin-induced cell death in prostate cancer cell lines
- VK2 regulates slow-twitch muscle fibers expression and mitochondrial function via SIRT1/SIRT3 signaling
- Role of blueberry anthocyanin extract in the expression of SIRT1 and NF-κB in rat lens epithelial cells in experimentally induced DM
- Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway
- miR-34c inhibits PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-β/SIRT1 pathway
- Bovine-derived MFG-E8 alleviating mitochondrial dysfunction via Akt/SIRT1/PGC-1α and MAPK/ERK signaling cascades
- Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and …
- Silencing of miR-150-5p Ameliorates Diabetic Nephropathy by Targeting SIRT1/p53/AMPK Pathway
- D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in HFD-induced SD rats
- Curcumin attenuates isoniazid‐induced hepatotoxicity by the upregulating SIRT1/PGC‐1α/NRF1 pathway
- Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways
- … resveratrol and mesenchymal stem cell monotherapy and combined treatment in management of osteoporosis in ovariectomized rats: Role of SIRT1/FOXO3a and Wnt …
- Allicin alleviates lead-induced bone loss by preventing oxidative stress and osteoclastogenesis via SIRT1/FOXO1 pathway in mice
- Melatonin ameliorates cerebral ischemia‐reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1‐BMAL1 pathway
- … Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways
- Genistein suppresses ox‐LDL‐elicited oxidative stress and senescence in HUVECs through the SIRT1‐p66shc‐Foxo3a pathways
- c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression
- Exercise training ameliorates early diabetic kidney injury by regulating the H2S/SIRT1/p53 pathway
- … L. Leaf Extracts Protect Against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway …
- Skip participates in formation and lipid metabolism of beige adipose and might mediate the effects of SIRT1 activator BTM-0512 on beige remodeling
- The Protective Activity of Penehyclidine Hydrochloride against Renal Ischemia/Reperfusion-Mediated NLRP3 Inflammasome Activation is Induced by SIRT1
- Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2 and MMP-9 via the AMPK/SIRT1 pathway in non-small cell lung cancer
- LncRNA SNHG8 sponges miR‐449c‐5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood‐brain barrier permeability in ischemic stroke
- MicroRNA-135b-5p Downregulation Causes Antidepressant Effects by Regulating SIRT1 Expression
- Peptides GWN and GW protect kidney cells against Dasatinib induced mitochondrial injury in a SIRT1 dependent manner
- Mitoquinone intravitreal injection ameliorates retinal ischemia–reperfusion injury in rats involving SIRT1/Notch1/NADPH axis
- Reduced serum SIRT1 levels in patients with Parkinson’s disease: a cross-sectional study in China
- CircHIPK3 alleviates high glucose toxicity to human renal tubular epithelial HK-2 cells through regulation of miR-326/miR-487a-3p/SIRT1
- Advanced oxidation protein products aggravate age‑related bone loss by increasing sclerostin expression in osteocytes via ROS‑dependent downregulation of SIRT1
- Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through SIRT1/AMPK Pathway
- Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1α pathway
- Resveratrol‐enhanced SIRT1‐mediated osteogenesis in porous endplates attenuates low back pain and anxiety behaviors
- Cordycepin, a major bioactive component of Cordyceps militaris, ameliorates diabetes‐induced testicular damage through the SIRT1/Foxo3a pathway
- Piceatannol promotes hepatic and renal AMPK/SIRT1/PGC-1α mitochondrial pathway in rats exposed to reserpine or gamma-radiation
- Corrigendum to “Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway”
- miR‑34a increases inflammation and oxidative stress levels in patients with necrotizing enterocolitis by downregulating SIRT1 expression
- Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB
- SIRT1 Promotes Osteogenic Differentiation in Human Dental Pulp Stem Cells through Counteracting the Activation of STAT3
- … angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway
- Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-κB signaling pathway
- SIRT1-autophagy axis may inhibit oxidative stress-induced ferroptosis in human nucleus pulposus cells
- Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL‐7702 cells
- Molecular imaging of NAD+‐dependent deacetylase SIRT1 in the brain
- Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD-CD38 Axis
- miR-217 through SIRT1 regulates the immunotoxicity of cadmium in Cyprinus carpio
- Inhibition of p53/miR-34a/SIRT1 axis ameliorates podocyte injury in diabetic nephropathy
- Abdominal Massage Alleviates Skeletal Muscle Insulin Resistance by Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway
- SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18
- Upregulation of mir-132 induces dopaminergic neuronal death via activating SIRT1/P53 pathway
- The down-regulation of melanogenesis via MITF and FOXO1 signaling pathways in SIRT1 knockout cells using CRISPR/Cas9 system
- Antioxidant SIRT1/Akt axis expression in resveratrol pretreated adipose‐derived stem cells increases regenerative capability in a rat model with cardiomyopathy …
- Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1
- FGF21 attenuates high uric acid‑induced endoplasmic reticulum stress, inflammation and vascular endothelial cell dysfunction by activating SIRT1
- Cellular molecular and proteomic profiling deciphers the SIRT1 controlled cell death pathways in esophageal adenocarcinoma cells
- Metoprolol Protects Against Arginine Vasopressin-Induced Cellular Senescence in H9C2 Cardiomyocytes by Regulating the SIRT1/p53/p21 Axis
- MiRNA-124-3p. 1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1
- Four new dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus and their SIRT1 activation activities
- Long non-coding RNA ZFAS1 alleviates sepsis-induced myocardial injury via target miR-34b-5p/SIRT1
- Yunpi Heluo decoction attenuates insulin resistance by regulating SIRT1-FoxO1 autophagy pathway in skeletal muscle of Zucker diabetic fatty rats
- Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489–3p/SIRT1 axis
- … inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ …
- Retraction: Lakhani et al. Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin II-Induced Adipocyte Dysfunction. Int. J. Mol. Sci. 2019, 20, 3205
- The ameliorative effect of terpinen-4-ol on ER stress-induced vascular calcification depends on SIRT1-mediated regulation of PERK acetylation
- … lead-induced cognitive impairment, depression-and anxiety-like behavior in mice through abating oxidative stress, inflammation and apoptosis via miR-22-3p/SIRT1 …
- … -3-galactoside from Aronia melanocarpa ameliorates PM10 induced pulmonary injury by modulating M1/M2 macrophage polarization and NRF2/SIRT1 MAPK …
- Modulation of SIRT1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury
- Phytochemical wedelolactone reverses obesity by prompting adipose browning through SIRT1/AMPK/PPARα pathway via targeting nicotinamide N-methyltransferase
- SIRT1 and Klotho expression in the heart and kidneys of rats with acute and chronic renovascular hypertension
- Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/SIRT1 pathway
- Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy
- Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging
- Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice
- Gliquidone improves retinal injury to relieve diabetic retinopathy via regulation of SIRT1/Notch1 pathway
- HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation
- Icariin ameliorate Alzheimer’s disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis
- lncRNA-CRNDE regulates BMSC chondrogenic differentiation and promotes cartilage repair in osteoarthritis through SIRT1/SOX9
- Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol
- … -Dependent Apoptosis of the Dorsal Root Ganglion in Diabetic Peripheral Neuropathy Rats Through Modulation of the SIRT1/p53 Signaling Pathway
- MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model
- Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the SIRT1/NF-κ B p65 pathway
- Melatonin Alleviates Cardiac Dysfunction Via Increasing SIRT1-Mediated Beclin-1 Deacetylation and Autophagy During Sepsis
- Bazedoxifene activates the angiotensin II‑induced HUVEC hypertension model by targeting SIRT1
- Lapachol-Induced Upregulation of SIRT1/Sirt3 is linked with Improved Skin Wound Healing in Alloxan-induced Diabetic Mice
- IL-10 ameliorates PM2. 5-induced lung injury by activating the AMPK/SIRT1/PGC-1α pathway
- Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway
- N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway
- Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: Involvement of SIRT1-mTOR/NF-κB signaling pathway
- MiR-217 promotes endothelial cell senescence through the SIRT1/p53 signaling pathway
- Ameliorative effect of betanin on experimental cisplatin‐induced liver injury; the novel impact of miRNA‐34a on the SIRT1/PGC‐1α signaling pathway
- Follicle‐stimulating hormone regulates glycolysis of water buffalo follicular granulosa cells through AMPK/SIRT1 signalling pathway
- SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH)
- Protective Effect of NGR1 against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells by Upregulating the SIRT1/Wnt/β-Catenin Pathway
- Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of …
- The neuroprotective role of SIRT1/PGC-1α signaling in limb postconditioning in cerebral ischemia/reperfusion injury
- Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis
- QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1‐PPARγ‐PGC‐1α axis
- Evaluation of the relationship among the levels of SIRT1 and SIRT3 with oxidative stress and DNA fragmentation in asthenoteratozoospermic men
- … 27-Hydroxycholesterol-Induced Senescence in Nerve Cells and Affects Zebrafish Locomotor Behavior via Activation of SIRT1-Mediated STAT3 Signaling
- Effects of SIRT1 on proliferation, migration, and apoptosis of endothelial progenitor cells in peripheral blood of SD rats with chronic obstructive pulmonary …
- microRNA-145 Inhibition Upregulates SIRT1 and Attenuates Autophagy in a Mouse Model of Lung Ischemia/Reperfusion Injury via NF-κB-dependent Beclin 1
- Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1
- 6, 4′-dihydroxy-7-methoxyflavanone protects against H 2 O 2-induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt …
- Sulforaphane protects human umbilical vein endothelial cells from oxidative stress via the miR‑34a/SIRT1 axis by upregulating nuclear factor erythroid‑2‑related factor …
- Nephroprotective effect of umbelliferone against cisplatin‐induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO‐3, and NF‐ kB‐p65 …
- Tetrahydroxystilbene glucoside alleviates angiotensin II induced HUVEC senescence via SIRT1
- Quercetin 3, 5, 7, 3′, 4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
- MiR-181a-5p inhibits goose granulosa cell viability by targeting SIRT1
- Agomelatine prevents gentamicin nephrotoxicity by attenuating oxidative stress and TLR-4 signaling, and upregulating PPARγ and SIRT1
- Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated …
- C1q/tumor necrosis factor‐related protein‐6 attenuates TNF‐α‐induced apoptosis in salivary acinar cells via AMPK/SIRT1‐modulated miR‐34a‐5p expression
- ACE2 Promotes the Synthesis of Pulmonary Surfactant to Improve AT II Cell Injury via SIRT1/eNOS Pathway
- Mangiferin inhibits hypoxia/reoxygenation‑induced alveolar epithelial cell injury via the SIRT1/AMPK signaling pathway
- Co‐culture with SIRT1-overexpressed chondrocytes delays the nucleus pulposus cells degeneration
- Critical role of SIRT1 upregulation on the protective effect of lncRNA ANRIL against hypoxia/reoxygenation injury in H9c2 cardiomyocytes
- Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue
- Voluntary exercise improves spermatogenesis and testicular apoptosis in type 2 diabetic rats through alteration in oxidative stress and mir-34a/SIRT1/p53 …
- Characterization the performances of twofold resveratrol integrated compounds in binding with SIRT1 by molecular dynamics simulation and molecular mechanics …
- … Inflammatory Response in Human Umbilical Vein Endothelial Cells Induced by High Glucose and Palmitic Acid Induced Through Regulating SIRT1/FOXO3a/NF-κB …
- Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through SIRT1 in MCAO rats
- Melatonin alleviates d‐galactose‐decreased hyaluronic acid production in synovial membrane cells via SIRT1 signalling
- Puerarin prevents cadmium‐induced disorder of testicular lactic acid metabolism in rats by activating 5′ AMP‐activated protein kinase (AMPK)/sirtuin 1 (SIRT1) …
- miR-373 Suppresses Cell Proliferation and Apoptosis via Regulation of SIRT1/PGC-1α/NRF2 Axis in Pancreatic Cancer
- Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2. 5) on all-cause mortality: a longitudinal cohort study in China
- Uncarboxylated osteocalcin promotes osteogenesis and inhibits adipogenesis of mouse bone marrow‑derived mesenchymal stem cells via the PKA‑AMPK‑SIRT1 axis
- Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral …
- Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1
- Activation of SIRT1 by Resveratrol Alleviates Pressure Overload-Induced Cardiac Hypertrophy via Suppression of TGF-β1 Signaling
- Depleting microRNA-183-3p improves renal tubulointerstitial fibrosis after acute kidney injury via SIRT1/PUMA/FOXO3a deacetylation
- Suggested role of silent information regulator 1 (SIRT1) gene in female infertility: A cross‐sectional study in Pakistan
- Resveratrol protects intestinal epithelial cells against radiation-induced damage by promoting autophagy and inhibiting apoptosis through SIRT1 activation
- Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1
- Thrombin Aggravates Hypoxia/Reoxygenation Injury of Cardiomyocytes by Activating an Autophagy Pathway-Mediated by SIRT1
- Dual roles of SIRT1 in the BAX switch through the P53 module: A mathematical modeling study
- MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21
- Quercetin Nanoparticle Ameliorates Lipopolysaccharide-Triggered Renal Inflammatory Impairment by Regulation of SIRT1/NF-KB Pathway
- B7‑H3 promotes the epithelial‑mesenchymal transition of NSCLC by targeting SIRT1 through the PI3K/AKT pathway
- Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway
- Faster lipid β‐oxidation rate by acetyl‐CoA carboxylase 2 inhibition alleviates high‐glucose‐induced insulin resistance via SIRT1/PGC‐1α in human podocytes
- MiR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression
- Moderate calorie restriction ameliorates reproduction via attenuating oxidative stress-induced apoptosis through SIRT1 signaling in obese mice
- miR-9-5p promotes wear-particle-induced osteoclastogenesis through activation of the SIRT1/NF-κB pathway
- Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a/SIRT1/p53 and apoptosis
- Regulation of Rothmund–Thomson syndrome protein RecQL4 functions in DNA replication by SIRT1-mediated deacetylation
- Artesunate alleviates diabetic retinopathy by activating autophagy via the regulation of AMPK/SIRT1 pathway
- … Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 …
- Association of SIRT1 single gene nucleotide polymorphisms and serum SIRT1 levels with laryngeal squamous cell carcinoma patient survival rate
- SIRT1 Regulates Tau Expression and Tau Synaptic Pathology
- Lingbao Huxin Pill Alleviates Apoptosis and Inflammation at Infarct Border Zone through SIRT1-Mediated FOXO1 and NF-κ B Pathways in Rat Model of Acute …
- Astragaloside IV Ameliorates Streptozotocin Induced Pancreatic β-Cell Apoptosis and Dysfunction Through SIRT1/P53 and Akt/GSK3β/Nrf2 Signaling …
- Liraglutide ameliorates myocardial damage in experimental diabetic rats by inhibiting pyroptosis via SIRT1/AMPK signaling.
- Estrogen promotes lncRNA H19 expression to regulate osteogenic differentiation of BMSCs and reduce osteoporosis via miR-532-3p/SIRT1 axis
- Emodin alleviates sepsis‐mediated lung injury via inhibition and reduction of NF‐kB and HMGB1 pathways mediated by SIRT1
- Sodium hydrosulfide alleviates dexamethasone‑induced cell senescence and dysfunction through targeting the miR‑22/SIRT1 pathway in osteoblastic MC3T3‑E1 cells
- Resveratrol protects human luteinised granulosa cells against hydrogen peroxide-induced oxidative injury through the SIRT1
- Salidroside prevents PM2. 5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function
- Discovery of 5-Benzylidene-2-phenyl-1, 3-dioxane-4, 6-diones as Highly Potent and Selective SIRT1 Inhibitors
- Exploration the potential mechanism of the SIRT1 and its target gene FOXO1/PPARGC1A in uteropelvic junction obstruction
- NOX4 stimulates ANF secretion via activation of the SIRT1/Nrf2/ATF3/4 axis in hypoxic beating rat atria
- Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti‐gastric cancer resistance by inhibiting SIRT1 and inducing autophagy
- Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling …
- Knockdown of SIRT1 Gene in Mice Results in Lipid Accumulation in the Liver Mediated via PGC-1α-Induced Mitochondrial Dysfunction and Oxidative Stress
- SIRT1 Mediates Sestrin1-Induced Improvement in Hepatic Insulin Resistance
- LncRNA MALAT1 improves cerebral ischemia-reperfusion injury and cognitive dysfunction by regulating miR-142-3p/SIRT1 axis
- … HT22 Cells Against Oxygen-Glucose Deprivation/Reperfusion-Induced Oxidative Stress and Mitochondrial Dysfunction by Promoting SIRT1-Mediated PINK1/Parkin …
- Exosomes Derived by SIRT1-Overexpressing Bone Marrow Mesenchymal Stem Cells Improve Pubococcygeus Muscle Injury in Rats
- Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating SIRT1/miRNA-134/GSK3β …
- miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway
- Ferulic acid suppresses interleukin‐1β‐induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC‐1α signaling …
- … effects of HIIT vs. CET exercise training on high-fat-high-fructose diet-induced hyperglycemia, hyperlipidemia, and histopathology of liver in rats: regulation of SIRT1 …
- Circ‐SIRT1 inhibits vascular smooth muscle cells proliferation via the c‐Myc/cyclin B1 axis
- Pro-oxidant and degenerative effects of haloperidol under inflammatory conditions in rat; the involvement of SIRT1 and NF-κB signaling pathways
- SIRT1 suppresses burn injury-induced inflammatory response through activating autophagy in RAW264. 7 macrophages
- Moringa oleifera leaf extract influences oxidative metabolism in C2C12 myotubes through SIRT1-PPARα pathway
- Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol …
- Overexpression of HOTAIR attenuates Pi-induced vascular calcification by inhibiting Wnt/β-catenin through regulating miR-126/Klotho/SIRT1 axis
- MiR‐138 plays an important role in diabetic nephropathy through SIRT1–p38–TTP regulatory axis
- Effect and mechanism of Angelic Shaoyaosan mediated AMPK/SIRT1 positive feedback loop to promote autophagy and regulate the systemic inflammatory response …
- Mitotic H3K9ac is controlled by phase-specific activity of HDAC2, HDAC3 and SIRT1
- HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis
- Role of sirtuin-1 (SIRT1) in hypoxic injury in pancreatic β-cells
- Rutaecarpine Prevents High Glucose-Induced Endothelial Cell Senescence Through Transient Receptor Potential Vanilloid Subtype 1/SIRT1 Pathway
- Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/SIRT1/AMPKα pathway
- miR‑425 regulates lipophagy via SIRT1 to promote sorafenib resistance in liver cancer
- Long non‑coding RNA TUG1 sponges microRNA‑9 to protect podocytes from high glucose‑induced apoptosis and mitochondrial dysfunction via SIRT1 upregulation
- … inhibits hypoxia‐inducible factor‐1 alpha and carbonic anhydrase expression through activation of AMP‐activated protein kinase/HO‐1/SIRT1 pathway in glioblastoma …
- Effects of edaravone combined with Oxiracetam on neuronal apoptosis in rats with cerebral infarction through targeting SIRT1/NF-κB inflammatory pathway
- miR‐34a‐5p up‐regulates the IL‐1β/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons
- SIRT1 protects the heart against doxorubicin-induced cardiotoxicity by mediating the DNA damage response via deacetylation of histone H2AX
- SIRT1 functional polymorphisms (rs12778366, rs3758391) as genetic biomarkers of susceptibility to type 2 diabetes mellitus in Iranians: a case-control study and …
- Overexpression of G protein-coupled receptor 40 protects obesity-induced cardiomyopathy through the SIRT1/LKB1/AMPK pathway
- Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling
- Epigallocatechin Gallate Reduces Homocysteine-Caused Oxidative Damages through Modulation SIRT1/AMPK Pathway in Endothelial Cells
- MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury
- Administration of rTMS Alleviates Stroke-Induced Cognitive Deficits by Modulating miR-409-3p/CTRP3/AMPK/SIRT1 Axis
- Hsa-miR-34a-5p reverses multidrug resistance in gastric cancer cells by targeting the 3′-UTR of SIRT1 and inhibiting its expression
- MicroRNA-506-3p targets SIRT1 and suppresses AMPK pathway activation to promote hepatic steatosis
- … D alleviates skeletal muscle loss and insulin resistance by inducing vitamin D receptor expression and regulating the AMPK/SIRT1 signaling pathway in mice
- Allylpyrocatechol ameliorates sepsis-induced lung injury via SIRT1-mediated suppression of p65 and nucleocytoplasmic translocation of HMGB1
- Puerarin Attenuates Complete Freund’s Adjuvant-Induced Trigeminal Neuralgia and Inflammation in a Mouse Model via SIRT1-Mediated TGF-β1/Smad3 …
- Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating SIRT1 in Septic Cardiomyopathy
- Progranulin (PGRN) is serves as an inflammation-response biomarker and promotes lung damage in burn-induced Sepsis via the SIRT1 Pathways by ROS
- Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels
- Changes in PGCd1a/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model
- miR-1301-3p promotes cell proliferation and facilitates cell cycle progression via targeting SIRT1 in gastric cancer
- Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease
- miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21 …
- C/EBP-β and SIRT1 regulate IL-18 expression in the proliferative phase endometria of polycystic ovary syndrome (PCOS) patients
- Upregulated IRF9 promotes cell apoptosis of hyperlipidemia acute pancreatitis with heart injury by regulating SIRT1
- Vinca herbacea Extract Suppresses NF-kB Signaling and Modulates SIRT1/AMPK/PGC1α Axis to Exert Antidiabetic Effects in Streptozotocin-Induced Diabetic …
- … a Promotes Angiogenesis in Rat Brain Microvascular Endothelial Cells Injured by Oxygen-glucose Deprivation/reoxygenation (OGD/R) through SIRT1-HIF-1α-VEGFA …
- Resveratrol ameliorates neuronal apoptosis and cognitive impairment by activating the SIRT1/RhoA pathway in rats after anesthesia with sevoflurane
- Circ-SIRT1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating SIRT1 expression.
- Role of SIRT1/Nrf2 signaling pathway in sleep deprivation-induced cognitive dysfunction in rats
- 5, 7, 3′, 4′-tetramethoxyflavone ameliorates cholesterol dysregulation by mediating SIRT1/FOXO3a/ABCA1 signaling in osteoarthritis chondrocytes
- Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition. Biomolecules 2021, 11, 312
- JNK‐mediated Ser27 phosphorylation and stabilization of SIRT1 promote growth and progression of colon cancer through deacetylation‐dependent activation of Snail
- Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice
- SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer
- Retraction: Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet
- Hawthorn polyphenols reduce high glucose‐induced inflammation and apoptosis in ARPE‐19 cells by regulating miR‐34a/SIRT1 to reduce acetylation
- Reciprocal Antagonism between MicroRNA-138 and SIRT1 and Its Implications for the Angiogenesis of Endothelial Cells
- Quercetin Protects Hepatocytes against CCl4-Induced Apoptosis via SIRT1 Regulation
- Effect of miR-132 on lung injury in sepsis rats via regulating SIRT1 expression
- MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway
- MiR-9-5p promotes M1 cell polarization in osteoarthritis progression by regulating NF-κB and AMPK signaling pathways by targeting SIRT1
- … assisted Cu-catalyzed decarbonylative Sonogashira coupling-cyclization strategy: Synthesis and evaluation of 3-heteroarylmethylene isoindolin-1-ones against SIRT1
- Nobiletin alleviates the hypoxia/reoxygenation‐induced damage in myocardial cells by modulating the miR‐433/SIRT1 axis
- Long non-coding RNA MCM3AP-AS1 protects chondrocytes ATDC5 and CHON-001 from IL-1β-induced inflammation via regulating miR-138-5p/SIRT1
- Decreased Expression of SIRT1 Contributes to Ocular Behçet’s Disease Progression via Th17 and Th22 Response
- Down–regulating miR-217-5p Protects Cardiomyocytes against Ischemia/Reperfusion Injury by Restoring Mitochondrial Function via Targeting SIRT1
- Expression Patterns of TOP2A and SIRT1 Are Predictive of Survival in Patients with High-Risk Soft Tissue Sarcomas Treated with a Neoadjuvant Anthracycline-Based …
- Toll-Like Receptor 4 Mediated Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation in Vascular Smooth Muscle Cells via Src and SIRT1/3 Pathway
- SIRT1 activation by Taurine: In vitro evaluation, molecular docking and molecular dynamics simulation studies
- Studying the multi-specificity of SIRT1
- Inhibition of glioblastoma progression by Urolithin A in vitro and in vivo by regulating SIRT1-FOXO1 axis via ERK/AKT signaling pathways.
- Resveratrol Relieves Hyperoxia-Induced Brain Injury in Neonatal Rats by Activating SIRT1
- Isoastilbin inhibits neuronal apoptosis and oxidative stress in a rat model of ischemia-reperfusion injury in the brain: Involvement of SIRT1/3/6.
- Dihydroartemisinin ameliorates palmitate-induced apoptosis in cardiomyocytes via regulation on miR-133b/SIRT1 axis
- Wang-OSO3H catalyzed green synthesis of 2-arylamino-3-cyanopyridine derivatives under ultrasound: their assessment as potential inhibitors of SIRT1
- Oxidative stress impairs the Nur77-SIRT1 axis resulting in a decline in organism homeostasis during aging
- Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1
- Circ 0006282/miR-155 reduced inflammation in diabetic nephropathy via expression of SIRT1/NLRP3 signaling pathway
- Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
- Amyloid-β (25–35) regulates neuronal damage and memory loss via SIRT1/Nrf2 in the cortex of mice
- Correlations of Silent Information Regulator of Transcription 1 (SIRT1) Expression, Inflammatory Factors, and Oxidative Stress with Pulmonary Function in …
- MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting SIRT1
- Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
- Resveratrol inhibits LPS-induced apoptosis in VSC4. 1 motoneurons through enhancing SIRT1-mediated autophagy
- Altered expression of Lnc-OC1 and SIRT1 genes in colorectal cancer tissue
- miR-34a/SIRT1 Axis Plays a Critical Role in Regulating Chondrocyte Senescence in Type 2 Diabetes Mellitus
- Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPAR?/?-AMPK-SIRT1 Pathway and Fatty Acid Metabolism.
- … attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway …
- Combination of botulinum toxin and minocycline ameliorates neuropathic pain through antioxidant stress and anti-inflammation via promoting SIRT1 pathway
- … NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2 …
- The AIRE G228W mutation results in a longer-lasting AIRE-SIRT1 interaction
- Design of Mitochondrial Targeting Peptide-Based SIRT1 Activators
- Crosstalk Between SIRT1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer
- Modeling the dual role of SIRT1 in p53-dependent mitochondrial apoptosis
- Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way
- #VALUE!
- Paramylon extracted from Euglena gracilis EOD-1 augmented the expression of SIRT1
- The role and mechanism of SIRT1 gene in depression
- Research on the Mechanism of SIRT1/AMPK Inducing Resistance to Imatinib in K562 Cells By Inhibiting Srebp to Promote Lipid Metabolism
- Edaravone Ameliorates Depressive and Anxiety-like Behaviors via SIRT1/Nrf2/HO-1/Gpx4 Pathway
- MiR-34a reverses radiation resistance on ECA-109 cells by inhibiting PI3K/AKT/mTOR signal pathway through downregulating the expression of SIRT1
- NQO1 binds and supports SIRT1 function
- Role of Pterostilbene in Metabolic Diseases through SIRT1 pathway-A Review
- Mogroside V attenuates gestational diabetes mellitus via SIRT1 pathway in a rat model
- RNAa-Mediated Epigenetic Attenuation of The Cell Senescence via Locus Specific Induction of Endogenous SIRT1
- Corrigendum to” Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway”[Pulm. Pharmacol. Therapeut. 65 (2020) 102000]
- MiR-155 regulates Th9 differentiation in children with methicillin-resistant Staphylococcus aureus pneumonia by targeting SIRT1
- #VALUE!
- Development of an assay to determine expression levels of ERBB2 and SIRT1 mRNA in saliva
- SIRT1 improves endothelial function by suppressing oxidative stress in diabetic mice
- Sulforaphane ameliorates amyloid-β-induced inflammatory injury by suppressing the PARP1/SIRT1 pathway in retinal pigment epithelial cells
- SIRT1 Protects Against Hippocampal Atrophy and its Induced Cognitive Impairment in Middle-aged Mice
- Nicotinamide Riboside Promotes Mfn2-mediated Mitochondrial Fusion in Diabetic Hearts through the SIRT1-PGC1α-PPARα Pathway
- Berberine improves hepatic insulin resistance by activating the SIRT1/Opa1 pathway: An in vitro and in vivo study
- SIRT1 Is a Novel Therapeutic Target in T-ALL
- Angiotensin Ⅱ inhibits AMPK/SIRT1 pathway by inducing oxidative stress in RAW264. 7 macrophages
- … microcirculatory system in severe acute pancreatitis by down-regulating HMGB-TLR-4-IL-23-IL-17A mediated neutrophil activation by targeting SIRT1
- Zafirlukast ameliorates Docetaxel-induced activation of NOD-like receptor protein 3 (NLRP3) inflammasome, mediated by sirtuin1 (SIRT1) in hepatocytes
- SIRT1 Activation Attenuates Microglia Mediated Synaptic Engulfment in Postoperative Cognitive Dysfunction
- Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation SIRT1
- The Protective Mechanism of SIRT1 on Cartilage Through Regulation of LEF-1
- Resveratrol Supplementation Prevents Retinal Tissue Damage by Increasing Antioxidant Activity Through SIRT1 Gene Expression in Diabetic Elderly Female …
- Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1
- SIRT1 Regulates the Phosphorylation and Degradation of P27 by Deacetylating CDK2 to Promote T-cell Acute Lymphoblastic Leukemia Progression
- PCAF and SIRT1 modulate βTrCP1 protein stability in an acetylation-dependent manner
- Kaempferol protects against streptozotocin-induced diabetic cardiomyopathy in rats by a hypoglycemic effect and upregulating SIRT1.
- In Situ Gene Therapy Rescues Doxorubicin-induced Ovarian Damage via Adenovirus Mediated SIRT1 and Tgfbr2
- Mesenchymal Stem Cells Ameliorate Mitochondrial Dysfunction in α-cells and Hyperglucagonemia in type 2 Diabetes via SIRT1/FoxO3a Signaling
- Two Zn(II)-based coordination polymers: treatment effect on the cardiac arrest induced by anesthesia by regulating SIRT1 expression
- Influence of heat stress on SIRT1 transfected chondrocytes
- Mechanism underlying resveratrol’s attenuation of paclitaxel cytotoxicity in human breast cancer cells: Role of the SIRT1-FOXO1-HER3 signaling pathway
- … By Ameliorating Mitochondrial Damage and Decreasing ROS Production in Chronic Cerebral Hypoperfusion Models Through SIRT1/PGC-1α Pathway
- Evaluation of SIRT1 And Foxo’s In Primary Tumor And Distant Organ Metastasis Invaded By Benign And Highly Metastatic Breast Carcinoma Cells Under In Vitro …
- AMPK-SIRT1 Pathway Modulates The Apoptosis, Proliferation and Migration of AR42J Cells By Regulating p53 and NF-κB
- Correction to Pterostilbene Improves Hepatic Lipid Accumulation via the MiR-34a/SIRT1/SREBP-1 Pathway in Fructose-Fed Rats
- LncRNA TUG1 alleviates the injury of small intestinal epithelial cells induced by lipopolysaccharide via regulating microrNa-132-3P/SIRT1
- Single Base-Pair Conformational Switch Modulates miR-34a Targeting of SIRT1 mRNA
- Exogenous NAD+ Postpones the D-Gal-Induced Senescence of Bone Marrow-Derived Mesenchymal Stem Cells via SIRT1 Signaling. Antioxidants 2021, 10, 254
- IL-4 Mediated Upregulation of AMPK/SIRT1/PGC-1α Signalling Pathway Is Bypassed By Mitochondrial Complex I Downregulation By NAMPT Inhibition in Venetoclax …
- Melatonin Modulates Microglia Activation in Neuro-inflammation by Regulating the ER Stress/PPARd/SIRT1 Signaling Pathway
- Retinoic acid inhibits the pyroptosis of degenerated nucleus pulposus cells by activating SIRT1-SOD2 signaling
- The effect of 12 weeks of training in water on serum levels of SIRT1 and FGF-21, glycemic index, and lipid profile in patients with type 2 diabetes
- Thrombopoietin Receptor Agonist Eltrombopag Prevents Insulin Resistance and Synaptic Pathology via HIF1α/COX2/SIRT1 Signaling Pathway
- MicroRNA-217 modulates inflammation, oxidative stress, and lung injury in septic mice via SIRT1
- Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst and stromal cell decidualization in mice
- Chaihu Guizhi decoction produces antidepressant-like effects via SIRT1-p53 signaling pathway
- The role of miRNA-624-5p in congenital hypothyroidism and its molecular mechanism by targeting SIRT1
- A new Cu (II)-based coordination polymer: crystal structure and protective effect on cardiac arrest induced by anesthesia via inducing SIRT1 signaling pathway
- Involvement of SIRT1-eNOS Axis in Vascular Senescence Responses to Ursolic Acid and Exercise Training in Aged Type 2 Diabetes Model of Rats
- LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity
- … Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose via Regulating AMPK/SIRT1/NF-κB Signaling Pathway
- Effects of Macamide B on the Expression of SIRT1 in Brain Tissue of Neonatal Mice with Hypoxic-ischemic Brain Damage
- Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells via SIRT1/p66SHC pathway and promotes osteogenesis
- Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and PPARγ/SIRT1 signaling pathways in rats
- Exendin-4 inhibits the survival and invasiveness of two colorectal cancer cell lines via suppressing GS3Kβ/β-catenin/NF-κB axis through activating SIRT1
- Nicotinamide Mononucleotide Adenylyltransferase 1 Regulates Cerebral Ischemia-Induced Blood–Brain Barrier Disruption Through NAD+/SIRT1 Signaling …
- … , Alone and in a Mixture, Impaired Male Fertility and Sexual Behavior in Adult Rats via Suppression of Steroidogenic Genes and SIRT1/TERT/PGC-1α Pathway
- Artemisinin ameliorates diabetic retinopathy by upregulating CASC2/miR-155/SIRT1 axis
- Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus
- SIRT1 promotes proliferation, migration, and invasion of cervical cancer cell and is upregulated by human papillomavirus 16 E7 oncoprotein.
- tiRNA-Val promotes angiogenesis via SIRT1–Hif-1α axis in mice with diabetic retinopathy
- Laminar Shear Stress Protects Against Premature Endothelial Senescence by SIRT1-Dependent Mechanisms
- Protective effect of USP22 against paraquat-induced lung injury via activation of SIRT1/NRF2 pathway
- Grape Seed Proanthocyanindin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway
- miR-138 from Adipose-Derived Stem-Cell Exosomes Accelerates Wound Healing in Diabetic Rats Through Targeting SIRT1/PTEN Signaling to Promote …
- Effect of zinc on SIRT1 and PGC-1 alpha gene expression among ulcerative colitis patients
- Chlorogenic Acid Exerts Neuroprotective Effect Against Hypoxia-Ischemia Brain Injury in Neonatal Rats by activating SIRT1 to Regulate the Nrf2-NF-κB Signaling …
- SIRT1 contributes to polarization of peripheral blood monocytes by increasing STAT6 expression in young people with overweight and low-risk obesity
- Autophagy-Sirtuin1 (SIRT1) Modulated The Endothelial Progenitor Cells (EPCs) Proliferation and Migration Via wnt/β-Catenin/GSK3β Signaling Pathway and …
- SIRT1 Suppresses Pituitary Tumor Progression by Downregulating PTTG1 Expression
- SIRT1 and Mitochondrial Homeostasis in Heart Failure
- Thrombopoietin receptor agonist eltrombopag prevents insulin resistance-mediated synaptic pathology via HIF1α/GSK3β/SIRT1 pathway
- Electroacupuncture postpones growth of tumors by activating SIRT1 expression to reduce inflammatory reaction and facilitate cellular autophagy in mice with …
- Silencing of miR-324-5p alleviates rat spinal cord injury by SIRT1
- SIRT1 promotes macrophage polarization to enhance efferocytosis by regulating TXNIP/NLRP3 inflammasome pathway
- Salvianolic Acid B Activates Chondrocytes Autophagy and Reduces Chondrocyte Apoptosis in Obese Mice via the KCNQ1OT1/Mir-128-3p/SIRT1 Signaling …
- P53/miR-34a/SIRT1 Positive Feedback Loop regulates cell proliferation and promotes cell apoptosis in the termination stage of liver regeneration.
- P53/miR-34a/SIRT1 Positive Feedback Loop regulates cell proliferation and promotes cell apoptosis in the termination stage of liver regeneration.
- Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node
- Novel mechanisms in control of SIRT1 stability during DNA damage response.
- Effect of Sirtuin1 (SIRT1) on Bone Marrow Mesenchymal Stem Cells (BMSCs) Osteogenesis/Adipogenesis via β-Catenin/The Transcription Factor T Cell Factor 1 (TCF1) …
- (-)-Epicatechin Inhibits Cardiac Fibrosis via SIRT1/AKT/GSK3β Pathway
- LncRNA SAL-RNA1 Knockdown Suppressed Pink1-Mediated Mitophagy Protects Against CS-Induced Alveolar Cells Senescence Through Regulation of SIRT1
- Polydatin effects on apoptosis of nucleus pulposus cells and SIRT1/mTOR pathway in mice with lumbar disc degeneration
- Mechanism of electroacupuncture for regulation of lipid production and improvement in obesity by mediating Wnt/β-catenin pathway through activating SIRT1
- A KDM4-DBC1-SIRT1 axis contributes to TGF-b induced mesenchymal transition of intestinal epithelial cells
- Reply to letter by Ye et al., blocking lncRNA H19/miR-194-5p/SIRT1 axis in cardiac myocyte is responsible for doxycycline inhibiting autophagy
- Salidroside improves skeletal muscle dysfunction in COPD rats by down regulating SIRT1 signaling pathway
- Corrigendum to” TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARγ-SIRT1 feedback loop in human bladder cancer cells”[Cancer Lett. 414 (1 …
- Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells
- Association of serum SIRT1 with extent of coronary artery lesion in acute coronary syndrome patients
- Long Non-coding RNA PANDAR Promotes Radioresistance in Nasopharyngeal Carcinoma via SIRT1/Ku70/PI3K/Akt Pathway
- Preliminary research on long non-coding RNA related signaling pathways regulated by SIRT1 in human trabecular meshwork cells
- Lipid-soluble cigarette smoke particles induced vascular endothelin type B receptor regulation through AMPK-SIRT1 and ERK1/2 signal pathways.
- Effect of Reynoutria Japonic and Resveratrol on SIRT1/SOD/MDA of Adriamycin-Induced Renal Injury: A Randomised Trial
- Kappa-Carrageenan Inhibited the High-Fat-Diet-Induced Obesity Through Up-Regulating the Hepatic SIRT1 Gene Expression
- Neuroprotective Role of Camel α-Lactalbumin Via Regulating SIRT1/FOXO3a Pathway Against Rotenone-Induced Neurotoxicity
- Melatonin modulates neonatal brain inflammation through ER stress, autophagy and miR-34a/SIRT1 pathway
- Rutaecarpine prevents high glucose-induced endothelial cell senescence through TRPV1/SIRT1 pathway.
- SIRT1 regulates ovarian cancer metastasis via altering the exosome release and glycogen deposition
- Effect of Reynoutria Japonica and its Extract on SIRT1 in Cisplatin-Induced Renal Injury
- A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of SIRT1
- Adaptation-Driven Evolution of Sirtuin 1 (SIRT1), a Key Regulator of Metabolism and Aging, in Marmot Species
- Abstract MP256: CCCTC-binding Factor Site Mutation In SIRT1 Promoter Reduces Systolic Cardiac Function In Mice
- Erratum to protective effect of hydrogen sulfide on endothelial cells through SIRT1-FOXO1 mediated autophagy
- Retraction: Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway
- Targeting SIRT1 rescues age-and obesity-induced human microvascular dysfunction
- Corrigendum to SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation (Stem …
- MiR-26a-1 Promotes DNA Damage Repair by Inhibiting SIRT1 and KDM5A in Human Liver Cancer Stem Cells
- SIRT1 gene polymorphism and its plasma concentration in men with no signs of cardiovascular pathology, residents of Podilia region of Ukraine
- Psoralen regulates SKP2/PTHrP/SIRT1 axis to relieve the degeneration of nucleus pulposus cells in an inflammatory environment
- SIRT1 Ameliorates High Fat Diet-Induced Diastolic Heart Failure
- SIRT1 and the clock gene machinery in colorectal cancer
- The Roles of RARRES1 and SIRT1/2 in B Cell Function and Homeostasis
- CircWEE1/miR-138 axis promotes the malignant progression of glioma by regulating SIRT1
- SIRT1: a potential therapeutic target in autoimmune diseases
- The Association between Silent Mating Type Information Regulator 2 Homolog 1 (SIRT1) Gene Polymorphism and Systemic Lupus Erythromatosis (SLE)
- Ginsenoside Rg1 attenuates premature ovarian failure of D-gal induced POF mice through downregulating p16INK4a and upregulating SIRT1 expression.
- Anti‐contractile activity of SIRT1 in the perivascular adipose tissue
- Salvianolic acid A activates AMPK and SIRT1 to reduce palmitic acid-induced lipotoxicity in hepatocyte
- Endothelial overexpression of P25 causes premature vascular aging by promoting SIRT1 protein degradation
- Anthocyanins Inhibit Airway Inflammation by Downregulating the NF-κB Pathway via the miR-138-5p/SIRT1 Axis in Asthmatic Mice
- Deacetylation of Histone H2AX by SIRT1 Regulates DNA Damage Response and Protects Cardiomyocytes Against Doxorubicin-Induced Injury
- The effect of NAD+ precursor supplementation and SIRT1 overexpression in mice with glycogen storage disease type 1a
- Clusterin mediates the metabolic function of adipose SIRT1
- Maslinic Acid Alleviates Atherosclerosis by Suppressing Mitochondrial ROS-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 …
- AMPK/SIRT1/PGC-1α/SIRT3 pathway-independent activation of GPx1 expression by metformin in the heart of a mouse model of endometriosis
- Dissecting the Effects of Resveratrol on SIRT1 Activity Against Different Peptide Substrates
- … LYPLAL1-DT in Type 2 Diabetes With Macrovascular Complication Contributes Protective Effects on Endothelial Cells via Regulating the miR-204-5p/SIRT1 …
- Proto‐oncoprotein Zbtb7c and SIRT1 repression: implications in high‐fat diet and age‐dependent obesity
- SIRT1 Inhibition Impairs Ca2+ Buffering in Coronary Smooth Muscle Cells of Ossabaw Miniature Swine
- Myeloid Ikaros–SIRT1 signaling axis regulates hepatic inflammation and
- BRD4 Inhibition by JQ1 Protects Against LPS-Induced Cardiac Dysfunction by Inhibiting SIRT1-Dependent Activation of NLRP3 Inflammasomes
- SIRT1 Restoration Enhances Chondrocyte Autophagy in Osteoarthritis Through PTEN-Mediated EGFR Ubiquitination
- Overexpression of endothelial SIRT1 prevents the development of hypertension in PER2 mutant mice
- Metabolic Syndrome and SIRT1 Mutation Impair Ca2+ Channels in Coronary Smooth Muscle Cells of Ossabaw Miniature Swine
- SIRT1 alleviates kidney ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-mediated autophagy
- Heat-Induced SIRT1-Mediated H4K16ac Deacetylation Impairs Resection and SMARCAD1 Recruitment to Double Strand Breaks
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- Mechanism of SIRT1-mediated Energy Deprivation (Calorie Restriction and Exercise) Against Sarcopenia
- Interaction of Sirtuin 1 (SIRT1) ongevity gene and particulate matter (PM2. 5) on all-cause mortality: a longitudinal cohort study
- Evaluation of SIRT1 and PGC-1α gene expression in testicular tissue of azoospermic rats treated with busulfan after a period of swimming training
- SIRT1 Alleviates IL-1β Induced Nucleus Pulposus Cells Pyroptosis Via Mitophagy in Intervertebral Disc Degeneration
- SIRT1 Contributes to Enhance Epidermal Permeability Barrier Function Through Activation of Ceramide-Metabolizing Enzymes
- A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation
- … Microcirculatory in Severe Acute Pancreatitis via Down-regulating HMGB-TLR-4-IL-23-IL-17A Mediated Neutrophil Activation Though Targeting SIRT1
- MDM2-dependent SIRT1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers
- The beneficial effect of Coix lacryma-jobi var. ma-yuen (Roman.) Stapf sprout the activation of LKB1/AMPK/SIRT1 signaling pathway on obesity
- Arginine Regulates NLRP3 Inflammasome Activation Through SIRT1 in Vascular Endothelial Cells
- Pterostilbene Alleviates Cholestasis by Promoting SIRT1 Activity in Hepatocytes and Macrophages.
- Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through SIRT1.
- circ-SIRT1 Decelerates Senescence by Inhibiting p53 Activation in Vascular Smooth Muscle Cells, Ameliorating Neointima Formation
- Salinity and Temperature Effects on Cholesterol Accumulation through SIRT1/LXRα/SREBP1 Pathway in Livers of the Indian Medaka (Oryzias dancena)
- … : MicroRNA-1271 modulates hepatitis B virus replication, cell proliferation and apoptosis in hepatitis B virus-related hepatocellular carcinoma by targeting SIRT1
- β-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice.
- Exenatide Attenuates Obesity-Induced Mitochondrial Dysfunction by Activating SIRT1 in Renal Tubular Cells
- Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal mu…
- Shikonin treatment ameliorates Lipopolysaccharides (LPS) induced acute liver failure in mice via regulating the miR-106/MCL1 and miR-34a/SIRT1/TP53 signaling
- … moderate endurance exercise on heart resistance to experimental ischemia in male rats: Investigation of some signaling pathways (SIRT1, Sirt3، apoptpsis and …
- SIRT1 promotes the restoration of hepatic progenitor cells (HPCs)-mediated liver fatty injury in NAFLD through activating Wnt/β-catenin signal pathway
- Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity
- SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage
- [Retracted] MicroRNA‑22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
- Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis
- Exosomes Derived From Adipose-Derived Mesenchymal Stem Cells Ameliorate Radiation-Induced Brain Injury by Activating the SIRT1 Pathway
- Antioxidant Effects of Sophora davidi (Franch.) Skeels on d-Galactose-Induced Aging Model in Mice via Activating the SIRT1/p53 Pathway.
- 8-Methoxypsoralen has Anti-inflammatory and Antioxidant Roles in Osteoarthritis Through SIRT1/NF-κB Pathway
- Berberine Potentiates Insulin Secretion and Prevents β-cell Dysfunction Through the miR-204/SIRT1 Signaling Pathway
- Rapid modulation of the silent information regulator 1 (SIRT1) by melatonin after hypoxia-ischemia in the neonatal rat brain
- Extracellular vesicles long non-coding RNA AGAP2-AS1 contributes to cervical cancer cell proliferation through regulating the miR-3064-5p/SIRT1 axis
- [Retracted] MicroRNA‑22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1
- HDAC6 and CXCL13 mediate Atopic Dermatitis by regulating Cellular Interactions and Expression levels of miR-9 and SIRT1
- [Retracted] Function of miR‑212 as a tumor suppressor in thyroid cancer by targeting SIRT1
- MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
